BR0215172A - Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma - Google Patents
Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucomaInfo
- Publication number
- BR0215172A BR0215172A BR0215172-3A BR0215172A BR0215172A BR 0215172 A BR0215172 A BR 0215172A BR 0215172 A BR0215172 A BR 0215172A BR 0215172 A BR0215172 A BR 0215172A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- benzofuranimidazoline
- benzodifuranimidazoline
- glaucoma
- treatment
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title abstract 2
- XZTDMGMENDDGMC-UHFFFAOYSA-N 1-benzofuran;4,5-dihydro-1h-imidazole Chemical class C1CN=CN1.C1=CC=C2OC=CC2=C1.C1=CC=C2OC=CC2=C1 XZTDMGMENDDGMC-UHFFFAOYSA-N 0.000 abstract 1
- ZGQQPCXSRVVQTG-UHFFFAOYSA-N 1-benzofuran;4,5-dihydro-1h-imidazole Chemical class C1CN=CN1.C1=CC=C2OC=CC2=C1 ZGQQPCXSRVVQTG-UHFFFAOYSA-N 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 230000004112 neuroprotection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34337801P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/039316 WO2003053436A1 (en) | 2001-12-20 | 2002-12-09 | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0215172A true BR0215172A (pt) | 2004-10-19 |
Family
ID=23345873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0215172-3A BR0215172A (pt) | 2001-12-20 | 2002-12-09 | Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7208512B2 (enExample) |
| EP (1) | EP1455780A4 (enExample) |
| JP (1) | JP2005513103A (enExample) |
| KR (1) | KR20040068315A (enExample) |
| CN (1) | CN1268334C (enExample) |
| AR (1) | AR037880A1 (enExample) |
| AU (1) | AU2002353088B2 (enExample) |
| BR (1) | BR0215172A (enExample) |
| CA (1) | CA2469904A1 (enExample) |
| MX (1) | MXPA04006029A (enExample) |
| TW (1) | TW593302B (enExample) |
| WO (1) | WO2003053436A1 (enExample) |
| ZA (1) | ZA200404473B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| EP1581209A4 (en) | 2002-12-13 | 2009-03-11 | Alcon Inc | NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM |
| US7476687B2 (en) * | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| AR046890A1 (es) | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES323985A1 (es) | 1966-02-26 | 1966-12-16 | Blade Pique Juan | Procedimiento para la obtenciën de derivados del imidazol |
| US5011846A (en) * | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| EP0445073A1 (de) * | 1990-02-27 | 1991-09-04 | Ciba-Geigy Ag | Benzofurane |
| EP1293525A3 (en) | 1990-06-26 | 2005-09-07 | AorTech Biomaterials Pty Ltd | Polyurethane or polyurethan-urea elastomeric compositions |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| JPH06508354A (ja) * | 1991-06-21 | 1994-09-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | トリプタミン類似体、その合成法およびその５−ｈｔ↓１様または５−ｈｔ↓２受容体作用物質としての使用 |
| GB9216380D0 (en) | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
| US5290781A (en) * | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
| US5891131A (en) * | 1993-02-01 | 1999-04-06 | Arizona Board Of Regents | Method and apparatus for automated simulation and design of corneal refractive procedures |
| TW270114B (enExample) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| US5538974A (en) * | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| ATE166227T1 (de) * | 1994-03-18 | 1998-06-15 | Senju Pharma Co | Sarpogrelat enthaltende opthalmologische zubereitungen zur senkung des intraokularen druckes |
| TW403738B (en) * | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| US5874477A (en) * | 1994-08-12 | 1999-02-23 | The University Of Hawaii | Method of treatment for malaria utilizing serotonin receptor ligands |
| US5998467A (en) | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| WO1997035579A1 (en) | 1996-03-27 | 1997-10-02 | Merck & Co., Inc. | A method for inhibiting clot formation |
| US5902815A (en) * | 1996-09-03 | 1999-05-11 | Washington University | Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction |
| AU4249297A (en) | 1996-10-31 | 1998-05-22 | Alcon Laboratories, Inc. | Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma |
| GB9700899D0 (en) | 1997-01-17 | 1997-03-05 | Smithkline Beecham Plc | Novel treatment |
| US6107324A (en) * | 1998-04-14 | 2000-08-22 | Arena Pharmaceuticals Inc. | 5-HT2A receptor inverse agonists |
| WO1999059499A2 (en) | 1998-05-19 | 1999-11-25 | Alcon Laboratories, Inc. | Serotonergic 5ht7 receptor compounds for treating ocular and cns disorders |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| AU755119B2 (en) | 1998-09-18 | 2002-12-05 | Alcon Laboratories, Inc. | Serotonergic 5HT2 agonists for treating glaucoma |
| EA200100671A1 (ru) | 1998-12-17 | 2001-12-24 | Американ Хоум Продактс Корпорейшн | ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C |
| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| WO2001040183A1 (en) | 1999-12-03 | 2001-06-07 | Alcon Universal Ltd. | 1-aminoalkyl-1h-indoles for treating glaucoma |
| WO2001070705A1 (en) * | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| WO2001070223A1 (en) | 2000-03-17 | 2001-09-27 | Alcon, Inc. | Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma |
| WO2001070701A1 (en) | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 5-hydroxy indazole derivatives for treating glaucoma |
| US6806285B1 (en) * | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
| TR200400424T4 (tr) | 2000-03-17 | 2004-03-22 | Alcon, Inc. | IOP'nin kontrolü ve glokom tedavisi için 5HT2 agonistleri |
| AU2001216072A1 (en) | 2000-03-17 | 2001-10-03 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
| DE60005566T2 (de) | 2000-03-17 | 2004-07-29 | Alcon, Inc. | Pyranoindole zur glaukombehandlung |
| JP2004532887A (ja) | 2001-06-01 | 2004-10-28 | アルコン，インコーポレイテッド | 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用 |
| MXPA03010806A (es) | 2001-06-01 | 2004-11-22 | Alcon Inc | Nuevos analogos de arilaminopropano y su uso para el tratamiento de glaucoma. |
| WO2002098350A2 (en) | 2001-06-01 | 2002-12-12 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
| US6884816B2 (en) * | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
| WO2003051352A1 (en) | 2001-12-14 | 2003-06-26 | Alcon, Inc. | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
| AU2002364711A1 (en) | 2001-12-14 | 2003-06-30 | Alcon, Inc. | Substituted 5-hydroxy-indole compounds for the treatment of glaucoma |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| WO2004019874A2 (en) | 2002-08-30 | 2004-03-11 | Alcon, Inc. | Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma |
| JP2006506355A (ja) | 2002-09-24 | 2006-02-23 | ヴァージニア コモンウェルス ユニバーシティ | β−ヒドロキシフェニルアルキルアミンおよびその緑内障治療への使用 |
| EP1581209A4 (en) | 2002-12-13 | 2009-03-11 | Alcon Inc | NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM |
| US20060052613A1 (en) | 2002-12-23 | 2006-03-09 | Pete Delgado | 1-alkyl-3-aminoindazoles |
-
2002
- 2002-11-29 TW TW091134883A patent/TW593302B/zh not_active IP Right Cessation
- 2002-12-09 AU AU2002353088A patent/AU2002353088B2/en not_active Ceased
- 2002-12-09 JP JP2003554193A patent/JP2005513103A/ja active Pending
- 2002-12-09 WO PCT/US2002/039316 patent/WO2003053436A1/en not_active Ceased
- 2002-12-09 CN CNB028254643A patent/CN1268334C/zh not_active Expired - Fee Related
- 2002-12-09 EP EP02790063A patent/EP1455780A4/en not_active Withdrawn
- 2002-12-09 BR BR0215172-3A patent/BR0215172A/pt not_active IP Right Cessation
- 2002-12-09 KR KR10-2004-7009781A patent/KR20040068315A/ko not_active Withdrawn
- 2002-12-09 MX MXPA04006029A patent/MXPA04006029A/es active IP Right Grant
- 2002-12-09 US US10/525,410 patent/US7208512B2/en not_active Expired - Fee Related
- 2002-12-09 CA CA002469904A patent/CA2469904A1/en not_active Abandoned
- 2002-12-17 AR ARP020104911A patent/AR037880A1/es unknown
-
2004
- 2004-06-07 ZA ZA200404473A patent/ZA200404473B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1455780A4 (en) | 2005-04-06 |
| MXPA04006029A (es) | 2004-09-27 |
| AU2002353088B2 (en) | 2006-09-21 |
| TW200301257A (en) | 2003-07-01 |
| US20060009503A1 (en) | 2006-01-12 |
| US7208512B2 (en) | 2007-04-24 |
| CN1606441A (zh) | 2005-04-13 |
| AU2002353088A1 (en) | 2003-07-09 |
| KR20040068315A (ko) | 2004-07-30 |
| CN1268334C (zh) | 2006-08-09 |
| TW593302B (en) | 2004-06-21 |
| AR037880A1 (es) | 2004-12-09 |
| JP2005513103A (ja) | 2005-05-12 |
| ZA200404473B (en) | 2005-06-07 |
| CA2469904A1 (en) | 2003-07-03 |
| WO2003053436A1 (en) | 2003-07-03 |
| EP1455780A1 (en) | 2004-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2006066103A3 (en) | Ophthalmic implant for treatment of glaucoma | |
| ES2062102T3 (es) | Derivados de prostaglandinas para el tratamiento de glaucoma o hipertension ocular. | |
| DK1239774T3 (da) | Apparat til behandling af öjensygdomme | |
| BR9307077A (pt) | Processo para ajuste do formato da córnea de um olho e anel corneal intra-estromático | |
| MX9702349A (es) | Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma. | |
| DE602004022526D1 (de) | Mikrochirurgische instrumente für die ophthalmologie | |
| WO2002089699A3 (en) | Medical device and methods of use for glaucoma treatment | |
| AU2002338483A1 (en) | Drainage implant for draining aqueous humour from the anterior aqueous chamber of the eye into schlemm's canal | |
| DE69634414D1 (de) | Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie | |
| DE60225815D1 (de) | Glaukom-stent für die glaukom-behandlung | |
| BR0215172A (pt) | Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma | |
| CY1108490T1 (el) | Στατινες για την αντιμετωπιση της οφθαλμικης υπερτασης και του γλαυκωματος | |
| BR0210013A (pt) | Gel oftálmico de pirenzepina | |
| ATE359794T1 (de) | 3, 7 thiaprostansäurederivate als mittel zur verminderung des augeninnendruckes | |
| AU5446299A (en) | Medicinal compositions for treating eye diseases | |
| NO20052751L (no) | Oftalmisk preparat for behandling av okulaer hypertensjon. | |
| BR0017163A (pt) | Derivados 5-hidróxi-indazol para tratamento do glaucoma | |
| BR0210238A (pt) | Novos análogos de aril-amino-propano e seu uso para o tratamento de glaucoma | |
| WO2004043354A3 (en) | Ophthalmic compositions for treating ocular hypertension | |
| MXPA03005922A (es) | Metodo para tratar glaucoma ib. | |
| BR0316775A (pt) | Novos análogos de benzopirano e seu uso para o tratamento de glaucoma | |
| AU2001267864A1 (en) | Remedial agent for optic nerve disease and the like | |
| BR0212151A (pt) | Uso de compostos para tratar condições resultantes de dano ao nervo corneano após cirurgias de lasik e outras oculares ou traumas | |
| BR0109192A (pt) | Tratamento de hipertensão ocular e glaucoma. | |
| ATE215824T1 (de) | Mittel zur verminderung des augeninnendrucks |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. A61K 31/4178; C07D 403/06; A61P 27/02; A61P 27/06 Ipc: A61K 31/4178 (2011.01), C07D 403/06 (2011.01), A61 |
|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE 8A. ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |