CN1268334C - 新颖的苯并二呋喃咪唑啉和苯并呋喃咪唑啉衍生物及其用于制备治疗青光眼药物的用途 - Google Patents

新颖的苯并二呋喃咪唑啉和苯并呋喃咪唑啉衍生物及其用于制备治疗青光眼药物的用途 Download PDF

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Publication number
CN1268334C
CN1268334C CNB028254643A CN02825464A CN1268334C CN 1268334 C CN1268334 C CN 1268334C CN B028254643 A CNB028254643 A CN B028254643A CN 02825464 A CN02825464 A CN 02825464A CN 1268334 C CN1268334 C CN 1268334C
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China
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compositions
alkyl
compound
imidazoline
key
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Expired - Fee Related
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CNB028254643A
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English (en)
Chinese (zh)
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CN1606441A (zh
Inventor
冯子侠
M·R·赫尔伯格
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Alcon Inc
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Alcon Inc
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Publication of CN1268334C publication Critical patent/CN1268334C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB028254643A 2001-12-20 2002-12-09 新颖的苯并二呋喃咪唑啉和苯并呋喃咪唑啉衍生物及其用于制备治疗青光眼药物的用途 Expired - Fee Related CN1268334C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34337801P 2001-12-20 2001-12-20
US60/343,378 2001-12-20

Publications (2)

Publication Number Publication Date
CN1606441A CN1606441A (zh) 2005-04-13
CN1268334C true CN1268334C (zh) 2006-08-09

Family

ID=23345873

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028254643A Expired - Fee Related CN1268334C (zh) 2001-12-20 2002-12-09 新颖的苯并二呋喃咪唑啉和苯并呋喃咪唑啉衍生物及其用于制备治疗青光眼药物的用途

Country Status (13)

Country Link
US (1) US7208512B2 (enExample)
EP (1) EP1455780A4 (enExample)
JP (1) JP2005513103A (enExample)
KR (1) KR20040068315A (enExample)
CN (1) CN1268334C (enExample)
AR (1) AR037880A1 (enExample)
AU (1) AU2002353088B2 (enExample)
BR (1) BR0215172A (enExample)
CA (1) CA2469904A1 (enExample)
MX (1) MXPA04006029A (enExample)
TW (1) TW593302B (enExample)
WO (1) WO2003053436A1 (enExample)
ZA (1) ZA200404473B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
EP1581209A4 (en) 2002-12-13 2009-03-11 Alcon Inc NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
AR046890A1 (es) 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES323985A1 (es) 1966-02-26 1966-12-16 Blade Pique Juan Procedimiento para la obtenciën de derivados del imidazol
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0445073A1 (de) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurane
EP1293525A3 (en) 1990-06-26 2005-09-07 AorTech Biomaterials Pty Ltd Polyurethane or polyurethan-urea elastomeric compositions
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
JPH06508354A (ja) * 1991-06-21 1994-09-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー トリプタミン類似体、その合成法およびその５−ｈｔ↓１様または５−ｈｔ↓２受容体作用物質としての使用
GB9216380D0 (en) 1992-07-31 1992-09-16 Glaxo Group Ltd Medicaments
US5290781A (en) * 1993-01-05 1994-03-01 Iolab Corporation Ketaneserinol as an agent to reduce intraocular pressure
US5891131A (en) * 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
TW270114B (enExample) * 1993-10-22 1996-02-11 Hoffmann La Roche
TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
US5538974A (en) * 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
ATE166227T1 (de) * 1994-03-18 1998-06-15 Senju Pharma Co Sarpogrelat enthaltende opthalmologische zubereitungen zur senkung des intraokularen druckes
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
US5874477A (en) * 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
US5998467A (en) 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
WO1997035579A1 (en) 1996-03-27 1997-10-02 Merck & Co., Inc. A method for inhibiting clot formation
US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
AU4249297A (en) 1996-10-31 1998-05-22 Alcon Laboratories, Inc. Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
GB9700899D0 (en) 1997-01-17 1997-03-05 Smithkline Beecham Plc Novel treatment
US6107324A (en) * 1998-04-14 2000-08-22 Arena Pharmaceuticals Inc. 5-HT2A receptor inverse agonists
WO1999059499A2 (en) 1998-05-19 1999-11-25 Alcon Laboratories, Inc. Serotonergic 5ht7 receptor compounds for treating ocular and cns disorders
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
GB9819033D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
AU755119B2 (en) 1998-09-18 2002-12-05 Alcon Laboratories, Inc. Serotonergic 5HT2 agonists for treating glaucoma
EA200100671A1 (ru) 1998-12-17 2001-12-24 Американ Хоум Продактс Корпорейшн ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C
GB9902047D0 (en) 1999-01-29 1999-03-17 Cerebrus Ltd Chemical compounds XI
WO2001040183A1 (en) 1999-12-03 2001-06-07 Alcon Universal Ltd. 1-aminoalkyl-1h-indoles for treating glaucoma
WO2001070705A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
WO2001070223A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma
WO2001070701A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. 5-hydroxy indazole derivatives for treating glaucoma
US6806285B1 (en) * 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
TR200400424T4 (tr) 2000-03-17 2004-03-22 Alcon, Inc. IOP'nin kontrolü ve glokom tedavisi için 5HT2 agonistleri
AU2001216072A1 (en) 2000-03-17 2001-10-03 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
DE60005566T2 (de) 2000-03-17 2004-07-29 Alcon, Inc. Pyranoindole zur glaukombehandlung
JP2004532887A (ja) 2001-06-01 2004-10-28 アルコン，インコーポレイテッド 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用
MXPA03010806A (es) 2001-06-01 2004-11-22 Alcon Inc Nuevos analogos de arilaminopropano y su uso para el tratamiento de glaucoma.
WO2002098350A2 (en) 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
WO2003051352A1 (en) 2001-12-14 2003-06-26 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
AU2002364711A1 (en) 2001-12-14 2003-06-30 Alcon, Inc. Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2004019874A2 (en) 2002-08-30 2004-03-11 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
JP2006506355A (ja) 2002-09-24 2006-02-23 ヴァージニア コモンウェルス ユニバーシティ β−ヒドロキシフェニルアルキルアミンおよびその緑内障治療への使用
EP1581209A4 (en) 2002-12-13 2009-03-11 Alcon Inc NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM
US20060052613A1 (en) 2002-12-23 2006-03-09 Pete Delgado 1-alkyl-3-aminoindazoles

Also Published As

Publication number Publication date
EP1455780A4 (en) 2005-04-06
MXPA04006029A (es) 2004-09-27
BR0215172A (pt) 2004-10-19
AU2002353088B2 (en) 2006-09-21
TW200301257A (en) 2003-07-01
US20060009503A1 (en) 2006-01-12
US7208512B2 (en) 2007-04-24
CN1606441A (zh) 2005-04-13
AU2002353088A1 (en) 2003-07-09
KR20040068315A (ko) 2004-07-30
TW593302B (en) 2004-06-21
AR037880A1 (es) 2004-12-09
JP2005513103A (ja) 2005-05-12
ZA200404473B (en) 2005-06-07
CA2469904A1 (en) 2003-07-03
WO2003053436A1 (en) 2003-07-03
EP1455780A1 (en) 2004-09-15

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060809

Termination date: 20100111