BR0215172A - Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma - Google Patents

Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma

Info

Publication number
BR0215172A
BR0215172A BR0215172-3A BR0215172A BR0215172A BR 0215172 A BR0215172 A BR 0215172A BR 0215172 A BR0215172 A BR 0215172A BR 0215172 A BR0215172 A BR 0215172A
Authority
BR
Brazil
Prior art keywords
derivatives
benzofuranimidazoline
benzodifuranimidazoline
glaucoma
treatment
Prior art date
Application number
BR0215172-3A
Other languages
English (en)
Inventor
Zixia Feng
Mark R Hellberg
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BR0215172A publication Critical patent/BR0215172A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

"DERIVADOS DE BENZODIFURANIMIDAZOLINA E BENZOFURANIMIDAZOLINA E SEU EMPREGO PARA O TRATAMENTO DE GLAUCOMA". A presente invenção refere-se a derivados imidazolina de benzodifurano e derivados de imidazolina de benzofurano para redução da pressão intra-ocular e provimento de neuroproteção ocular.
BR0215172-3A 2001-12-20 2002-12-09 Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma BR0215172A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34337801P 2001-12-20 2001-12-20
PCT/US2002/039316 WO2003053436A1 (en) 2001-12-20 2002-12-09 Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma

Publications (1)

Publication Number Publication Date
BR0215172A true BR0215172A (pt) 2004-10-19

Family

ID=23345873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215172-3A BR0215172A (pt) 2001-12-20 2002-12-09 Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma

Country Status (13)

Country Link
US (1) US7208512B2 (pt)
EP (1) EP1455780A4 (pt)
JP (1) JP2005513103A (pt)
KR (1) KR20040068315A (pt)
CN (1) CN1268334C (pt)
AR (1) AR037880A1 (pt)
AU (1) AU2002353088B2 (pt)
BR (1) BR0215172A (pt)
CA (1) CA2469904A1 (pt)
MX (1) MXPA04006029A (pt)
TW (1) TW593302B (pt)
WO (1) WO2003053436A1 (pt)
ZA (1) ZA200404473B (pt)

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TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
JP2006511556A (ja) 2002-12-13 2006-04-06 アルコン，インコーポレイテッド 新規のベンゾピラン類似体及び緑内障の治療のためのそれらの使用
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
WO2007149728A2 (en) * 2006-06-20 2007-12-27 Alcon Research, Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

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US5891131A (en) 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
TW270114B (pt) 1993-10-22 1996-02-11 Hoffmann La Roche
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US5874477A (en) 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
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EA200100671A1 (ru) 1998-12-17 2001-12-24 Американ Хоум Продактс Корпорейшн ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C
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CN100361977C (zh) 2002-12-23 2008-01-16 爱尔康公司 1-烷基-3-氨基吲唑

Also Published As

Publication number Publication date
EP1455780A1 (en) 2004-09-15
CN1606441A (zh) 2005-04-13
KR20040068315A (ko) 2004-07-30
MXPA04006029A (es) 2004-09-27
US20060009503A1 (en) 2006-01-12
TW593302B (en) 2004-06-21
US7208512B2 (en) 2007-04-24
EP1455780A4 (en) 2005-04-06
TW200301257A (en) 2003-07-01
AU2002353088B2 (en) 2006-09-21
JP2005513103A (ja) 2005-05-12
ZA200404473B (en) 2005-06-07
WO2003053436A1 (en) 2003-07-03
AU2002353088A1 (en) 2003-07-09
CN1268334C (zh) 2006-08-09
CA2469904A1 (en) 2003-07-03
AR037880A1 (es) 2004-12-09

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. A61K 31/4178; C07D 403/06; A61P 27/02; A61P 27/06

Ipc: A61K 31/4178 (2011.01), C07D 403/06 (2011.01), A61

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.