JP2005511764A5 - - Google Patents
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- Publication number
- JP2005511764A5 JP2005511764A5 JP2003552285A JP2003552285A JP2005511764A5 JP 2005511764 A5 JP2005511764 A5 JP 2005511764A5 JP 2003552285 A JP2003552285 A JP 2003552285A JP 2003552285 A JP2003552285 A JP 2003552285A JP 2005511764 A5 JP2005511764 A5 JP 2005511764A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydrogen
- alkyl
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 27
- 239000001257 hydrogen Substances 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 150000002825 nitriles Chemical class 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 150000001356 alkyl thiols Chemical class 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000003547 miosis Effects 0.000 claims 1
- 239000003604 miotic agent Substances 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34036101P | 2001-12-14 | 2001-12-14 | |
| PCT/US2002/038908 WO2003051352A1 (en) | 2001-12-14 | 2002-12-05 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511764A JP2005511764A (ja) | 2005-04-28 |
| JP2005511764A5 true JP2005511764A5 (enExample) | 2006-01-05 |
Family
ID=23333027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552285A Pending JP2005511764A (ja) | 2001-12-14 | 2002-12-05 | 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7005448B2 (enExample) |
| EP (1) | EP1461030A4 (enExample) |
| JP (1) | JP2005511764A (enExample) |
| AU (1) | AU2002346671B2 (enExample) |
| CA (1) | CA2469663A1 (enExample) |
| WO (1) | WO2003051352A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| EP1581209A4 (en) | 2002-12-13 | 2009-03-11 | Alcon Inc | NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM |
| US7476687B2 (en) | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| AR046890A1 (es) | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
| TW200838550A (en) * | 2007-02-09 | 2008-10-01 | Novartis Ag | Organic compounds |
| WO2010015643A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| EP0410384B1 (en) | 1989-07-28 | 1995-04-05 | Nippon Oil Co. Ltd. | Process for the continuous production of high-strength and high-modulus polyethylene material |
| US5135954A (en) | 1991-05-24 | 1992-08-04 | The Regents Of The University Of California | Use of formoterol for treatment of tissue injury |
| IT1249678B (it) | 1991-07-12 | 1995-03-09 | Ciro Costagliola | Collirio per il trattamento della ipertensione oculare |
| GB9216380D0 (en) | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
| US5290781A (en) | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
| JP2887430B2 (ja) * | 1993-06-21 | 1999-04-26 | 株式会社三井ハイテック | 積層鉄心の製造方法 |
| US5538974A (en) | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| ATE166227T1 (de) | 1994-03-18 | 1998-06-15 | Senju Pharma Co | Sarpogrelat enthaltende opthalmologische zubereitungen zur senkung des intraokularen druckes |
| US5998467A (en) | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| TR199800827T2 (xx) | 1995-11-09 | 1999-02-22 | Synthelabo | 5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri. |
| AU2619800A (en) | 1999-01-27 | 2000-08-18 | Eli Lilly And Company | Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists |
| US20030092774A1 (en) | 2001-10-17 | 2003-05-15 | Parkinson Thomas M. | Methods for treating neoplastic, angiogenic, vascular, fibroblastic, and/or immunosuppressive iregularities of the eye and/or joint via administration of combretastatin based medicaments, and iontophoretic devices for delivering combretastatin based medicaments |
-
2002
- 2002-12-05 WO PCT/US2002/038908 patent/WO2003051352A1/en not_active Ceased
- 2002-12-05 EP EP02784741A patent/EP1461030A4/en not_active Withdrawn
- 2002-12-05 AU AU2002346671A patent/AU2002346671B2/en not_active Ceased
- 2002-12-05 JP JP2003552285A patent/JP2005511764A/ja active Pending
- 2002-12-05 CA CA002469663A patent/CA2469663A1/en not_active Abandoned
- 2002-12-05 US US10/498,835 patent/US7005448B2/en not_active Expired - Fee Related
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