AU2619800A - Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists - Google Patents

Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists

Info

Publication number
AU2619800A
AU2619800A AU26198/00A AU2619800A AU2619800A AU 2619800 A AU2619800 A AU 2619800A AU 26198/00 A AU26198/00 A AU 26198/00A AU 2619800 A AU2619800 A AU 2619800A AU 2619800 A AU2619800 A AU 2619800A
Authority
AU
Australia
Prior art keywords
aminoalkylbenzofurans
serotonin
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU26198/00A
Inventor
Karin Briner
Joseph Paul Burkhart
Timothy Paul Burkholder
Matthew Joseph Fisher
William Harlan Gritton
Daniel Timothy Kohlman
Sidney Xi Liang
Shawn Christopher Miller
Jeffrey Thomas Mullaney
Yanping Xu
Yao-Chang Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2619800A publication Critical patent/AU2619800A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
AU26198/00A 1999-01-27 2000-01-19 Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists Abandoned AU2619800A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11738599P 1999-01-27 1999-01-27
US60117385 1999-01-27
PCT/US2000/001342 WO2000044737A1 (en) 1999-01-27 2000-01-19 Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists

Publications (1)

Publication Number Publication Date
AU2619800A true AU2619800A (en) 2000-08-18

Family

ID=22372628

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26198/00A Abandoned AU2619800A (en) 1999-01-27 2000-01-19 Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists

Country Status (5)

Country Link
EP (1) EP1149085A1 (en)
JP (1) JP2002535396A (en)
AU (1) AU2619800A (en)
CA (1) CA2361516A1 (en)
WO (1) WO2000044737A1 (en)

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SE0004245D0 (en) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CA2449899C (en) 2000-11-20 2010-04-06 Biovitrum Ab Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
WO2003051352A1 (en) * 2001-12-14 2003-06-26 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
MXPA04012711A (en) 2002-06-19 2005-03-23 Biovitrum Ab Novel compounds, their use and preparation.
MXPA05002259A (en) * 2002-08-30 2005-07-05 Alcon Inc Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma.
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
CL2004000826A1 (en) 2003-04-25 2005-03-04 Pfizer USE OF AN AGONIST FOR THE 5-HT2C RECEPTOR TO PREPARE A USEFUL MEDICINAL PRODUCT IN THE TREATMENT OF URINARY INCONTINENCE CAUSED BY STRESS, WITH THE CONDITION THAT THE AGONIST IS NOT 1- [6-CHLORINE-5- (TRIFLUOROMETIL) -2- PIRIDINIL] PIPERAZINA (ORG-129
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
WO2006000902A1 (en) * 2004-06-25 2006-01-05 Pfizer Products Inc. Dihydrobenzofuran compounds and uses thereof
US8685924B2 (en) 2004-08-25 2014-04-01 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
EA200701853A1 (en) 2005-03-31 2008-08-29 Пфайзер Продактс Инк. DERIVATIVES OF CYCLOPENTAPIRIDINE AND TETRAHYDROCHINOLINE
WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
CN101175740A (en) * 2005-04-22 2008-05-07 惠氏公司 Dihydrobenzofuran derivatives and uses thereof
JP2008538581A (en) * 2005-04-22 2008-10-30 ワイス Crystal form of {[(2R) -7- (2,6-dichlorophenyl) -5-fluoro-2,3-dihydro-1-benzofuran-2-yl] methyl} amine hydrochloride
CA2629962A1 (en) * 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP5528699B2 (en) 2006-05-16 2014-06-25 武田薬品工業株式会社 Fused heterocyclic compounds and uses thereof
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
KR101062376B1 (en) 2008-04-10 2011-09-06 한국화학연구원 Novel indole carboxylic acid bispyridyl carboxamide derivatives, preparation method thereof and composition containing the same as an active ingredient
JPWO2011071136A1 (en) 2009-12-11 2013-04-22 アステラス製薬株式会社 Fibromyalgia treatment
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN104529962B (en) * 2014-12-22 2016-08-17 中科院广州化学有限公司 A kind of 2-alkylamino-3-cyano group benzofuran compounds and preparation method
JPWO2019131902A1 (en) 2017-12-27 2020-12-10 武田薬品工業株式会社 Remedies for stress urinary incontinence and fecal incontinence
CN110317129A (en) * 2019-05-30 2019-10-11 杭州迈世腾药物科技有限公司 The synthetic method of the bromo- 5- metoxyphenol of 2-
CN110684000B (en) * 2019-10-18 2021-08-31 上海皓元医药股份有限公司 Process for preparing benzofuran derivatives

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Publication number Priority date Publication date Assignee Title
US4374527A (en) 1978-07-19 1983-02-22 Medtronic, Inc. Body stimulation lead
US4414986A (en) 1982-01-29 1983-11-15 Medtronic, Inc. Biomedical stimulation lead
US5433729A (en) 1991-04-12 1995-07-18 Incontrol, Inc. Atrial defibrillator, lead systems, and method
EP0634907B1 (en) 1992-04-10 1997-01-29 Cardiorhythm Intracardiac electrical potential reference catheter
SE9203732D0 (en) 1992-12-11 1992-12-11 Siemens Elema Ab ELECTRIC SYSTEM FOR DEFIBRILLATOR
CN1129443A (en) * 1993-06-14 1996-08-21 美国辉瑞有限公司 Secondary amines as antidiabetic and antiobesity agents
US5423772A (en) 1993-08-13 1995-06-13 Daig Corporation Coronary sinus catheter
US5476498A (en) 1994-08-15 1995-12-19 Incontrol, Inc. Coronary sinus channel lead and method
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
US5683445A (en) 1996-04-29 1997-11-04 Swoyer; John M. Medical electrical lead
WO1997043272A2 (en) * 1996-05-14 1997-11-20 Glaxo Group Limited Benzofurans and benzopyrans as chronobiological agents

Also Published As

Publication number Publication date
WO2000044737A1 (en) 2000-08-03
JP2002535396A (en) 2002-10-22
EP1149085A1 (en) 2001-10-31
CA2361516A1 (en) 2000-08-03

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase