JP2005511764A - 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 - Google Patents
緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 Download PDFInfo
- Publication number
- JP2005511764A JP2005511764A JP2003552285A JP2003552285A JP2005511764A JP 2005511764 A JP2005511764 A JP 2005511764A JP 2003552285 A JP2003552285 A JP 2003552285A JP 2003552285 A JP2003552285 A JP 2003552285A JP 2005511764 A JP2005511764 A JP 2005511764A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkyl
- composition
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GIKPTWKWYXCBEC-UHFFFAOYSA-N CC(Cc(c1c2[o]cc1)c1[o]ccc1c2Br)N Chemical compound CC(Cc(c1c2[o]cc1)c1[o]ccc1c2Br)N GIKPTWKWYXCBEC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34036101P | 2001-12-14 | 2001-12-14 | |
| PCT/US2002/038908 WO2003051352A1 (en) | 2001-12-14 | 2002-12-05 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511764A true JP2005511764A (ja) | 2005-04-28 |
| JP2005511764A5 JP2005511764A5 (enExample) | 2006-01-05 |
Family
ID=23333027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552285A Pending JP2005511764A (ja) | 2001-12-14 | 2002-12-05 | 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7005448B2 (enExample) |
| EP (1) | EP1461030A4 (enExample) |
| JP (1) | JP2005511764A (enExample) |
| AU (1) | AU2002346671B2 (enExample) |
| CA (1) | CA2469663A1 (enExample) |
| WO (1) | WO2003051352A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| EP1581209A4 (en) | 2002-12-13 | 2009-03-11 | Alcon Inc | NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM |
| US7476687B2 (en) | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| AR046890A1 (es) | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
| TW200838550A (en) * | 2007-02-09 | 2008-10-01 | Novartis Ag | Organic compounds |
| WO2010015643A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| EP0410384B1 (en) | 1989-07-28 | 1995-04-05 | Nippon Oil Co. Ltd. | Process for the continuous production of high-strength and high-modulus polyethylene material |
| US5135954A (en) | 1991-05-24 | 1992-08-04 | The Regents Of The University Of California | Use of formoterol for treatment of tissue injury |
| IT1249678B (it) | 1991-07-12 | 1995-03-09 | Ciro Costagliola | Collirio per il trattamento della ipertensione oculare |
| GB9216380D0 (en) | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
| US5290781A (en) | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
| JP2887430B2 (ja) * | 1993-06-21 | 1999-04-26 | 株式会社三井ハイテック | 積層鉄心の製造方法 |
| US5538974A (en) | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| ATE166227T1 (de) | 1994-03-18 | 1998-06-15 | Senju Pharma Co | Sarpogrelat enthaltende opthalmologische zubereitungen zur senkung des intraokularen druckes |
| US5998467A (en) | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| TR199800827T2 (xx) | 1995-11-09 | 1999-02-22 | Synthelabo | 5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri. |
| AU2619800A (en) | 1999-01-27 | 2000-08-18 | Eli Lilly And Company | Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists |
| US20030092774A1 (en) | 2001-10-17 | 2003-05-15 | Parkinson Thomas M. | Methods for treating neoplastic, angiogenic, vascular, fibroblastic, and/or immunosuppressive iregularities of the eye and/or joint via administration of combretastatin based medicaments, and iontophoretic devices for delivering combretastatin based medicaments |
-
2002
- 2002-12-05 WO PCT/US2002/038908 patent/WO2003051352A1/en not_active Ceased
- 2002-12-05 EP EP02784741A patent/EP1461030A4/en not_active Withdrawn
- 2002-12-05 AU AU2002346671A patent/AU2002346671B2/en not_active Ceased
- 2002-12-05 JP JP2003552285A patent/JP2005511764A/ja active Pending
- 2002-12-05 CA CA002469663A patent/CA2469663A1/en not_active Abandoned
- 2002-12-05 US US10/498,835 patent/US7005448B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1461030A4 (en) | 2005-06-01 |
| US20040259941A1 (en) | 2004-12-23 |
| US7005448B2 (en) | 2006-02-28 |
| CA2469663A1 (en) | 2003-06-26 |
| AU2002346671B2 (en) | 2005-08-11 |
| EP1461030A1 (en) | 2004-09-29 |
| WO2003051352A1 (en) | 2003-06-26 |
| AU2002346671A1 (en) | 2003-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051110 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20051110 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090702 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20091201 |