JP2005513026A - 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環 - Google Patents

高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環 Download PDF

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JP2005513026A
JP2005513026A JP2003545635A JP2003545635A JP2005513026A JP 2005513026 A JP2005513026 A JP 2005513026A JP 2003545635 A JP2003545635 A JP 2003545635A JP 2003545635 A JP2003545635 A JP 2003545635A JP 2005513026 A JP2005513026 A JP 2005513026A
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substituted
compound
alkyl
radical
cancer
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JP2005513026A5 (https=
Inventor
マグナス ファール，
キャサリーン タチジャン，
ライル ダブリュー． スプラス，
ハスレン エー． アル−シャマ，
モハメッド ボージェラル，
アンドレア エヌ． ファンジュル，
トーステン アール． ウィーマン，
デービッド ピー．エム． プレイネット，
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インサイト サン ディエゴ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2003545635A 2001-11-15 2002-11-15 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環 Pending JP2005513026A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33479401P 2001-11-15 2001-11-15
US36270202P 2002-03-08 2002-03-08
US36273202P 2002-03-08 2002-03-08
PCT/US2002/036583 WO2003043998A1 (en) 2001-11-15 2002-11-15 N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases

Publications (2)

Publication Number Publication Date
JP2005513026A true JP2005513026A (ja) 2005-05-12
JP2005513026A5 JP2005513026A5 (https=) 2006-01-12

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JP2003545635A Pending JP2005513026A (ja) 2001-11-15 2002-11-15 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環

Country Status (5)

Country Link
US (2) US7071218B2 (https=)
EP (1) EP1456187A4 (https=)
JP (1) JP2005513026A (https=)
AU (1) AU2002352706A1 (https=)
WO (1) WO2003043998A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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JP2010533724A (ja) * 2007-07-13 2010-10-28 ボード オブ リージェンツ， ザ ユニバーシティー オブ テキサス システム カンナビノイド受容体の複素環式モジュレーター
JP2013512903A (ja) * 2009-12-04 2013-04-18 サイリーン ファーマシューティカルズ インコーポレーティッド Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物

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Publication number Priority date Publication date Assignee Title
JP2010533724A (ja) * 2007-07-13 2010-10-28 ボード オブ リージェンツ， ザ ユニバーシティー オブ テキサス システム カンナビノイド受容体の複素環式モジュレーター
JP2013512903A (ja) * 2009-12-04 2013-04-18 サイリーン ファーマシューティカルズ インコーポレーティッド Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物

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EP1456187A1 (en) 2004-09-15
US20060160796A1 (en) 2006-07-20
WO2003043998A1 (en) 2003-05-30
AU2002352706A1 (en) 2003-06-10
US7071218B2 (en) 2006-07-04
US20030144329A1 (en) 2003-07-31
EP1456187A4 (en) 2005-02-09

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