JP2005511606A5 - - Google Patents

Download PDF

Info

Publication number
JP2005511606A5
JP2005511606A5 JP2003542164A JP2003542164A JP2005511606A5 JP 2005511606 A5 JP2005511606 A5 JP 2005511606A5 JP 2003542164 A JP2003542164 A JP 2003542164A JP 2003542164 A JP2003542164 A JP 2003542164A JP 2005511606 A5 JP2005511606 A5 JP 2005511606A5
Authority
JP
Japan
Prior art keywords
alkyl
group
aryl
phenyl
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003542164A
Other languages
English (en)
Japanese (ja)
Other versions
JP4491235B2 (ja
JP2005511606A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/035365 external-priority patent/WO2003040118A1/en
Publication of JP2005511606A publication Critical patent/JP2005511606A/ja
Publication of JP2005511606A5 publication Critical patent/JP2005511606A5/ja
Application granted granted Critical
Publication of JP4491235B2 publication Critical patent/JP4491235B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003542164A 2001-11-08 2002-11-05 メラノコルチン受容体調節剤としての新規な１，２，４−チアジアゾリウム誘導体 Expired - Fee Related JP4491235B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33776201P 2001-11-08 2001-11-08
PCT/US2002/035365 WO2003040118A1 (en) 2001-11-08 2002-11-05 Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators

Publications (3)

Publication Number Publication Date
JP2005511606A JP2005511606A (ja) 2005-04-28
JP2005511606A5 true JP2005511606A5 (enExample) 2006-01-05
JP4491235B2 JP4491235B2 (ja) 2010-06-30

Family

ID=23321888

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003542164A Expired - Fee Related JP4491235B2 (ja) 2001-11-08 2002-11-05 メラノコルチン受容体調節剤としての新規な１，２，４−チアジアゾリウム誘導体

Country Status (25)

Country Link
US (4) US7319107B2 (enExample)
EP (1) EP1444215B1 (enExample)
JP (1) JP4491235B2 (enExample)
CN (1) CN100422164C (enExample)
AR (1) AR037284A1 (enExample)
AT (1) ATE333449T1 (enExample)
AU (1) AU2002340372B2 (enExample)
BR (1) BR0214023A (enExample)
CA (1) CA2466145A1 (enExample)
CY (1) CY1105233T1 (enExample)
DE (1) DE60213276T2 (enExample)
DK (1) DK1444215T3 (enExample)
ES (1) ES2268108T3 (enExample)
IL (2) IL161830A0 (enExample)
MX (1) MXPA04004457A (enExample)
MY (1) MY134994A (enExample)
NO (1) NO328194B1 (enExample)
NZ (1) NZ532884A (enExample)
PT (1) PT1444215E (enExample)
RS (1) RS51199B (enExample)
RU (1) RU2323932C2 (enExample)
SI (1) SI1444215T1 (enExample)
TW (1) TWI317358B (enExample)
WO (1) WO2003040118A1 (enExample)
ZA (1) ZA200404487B (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
WO2003013571A1 (en) 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7319107B2 (en) * 2001-11-08 2008-01-15 Johnson & Johnson Consumer Companies, Inc. 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators
DK1446394T3 (da) * 2001-11-08 2007-03-12 Ortho Mcneil Pharm Inc Hidtil ukendte 1,2,4-thiadiazolderivater som melanocortinreceptormodulatorer
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) * 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US8460243B2 (en) * 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US7722536B2 (en) * 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
WO2005082341A2 (en) * 2004-02-23 2005-09-09 Prolexys Pharmaceuticals Inc. NON-PEPTIDYL AGENTS WITH pHSP20-LIKE ACTIVITY, AND USES THEREOF
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
CA3090413C (en) 2004-06-04 2023-10-10 Abbott Diabetes Care Inc. Glucose monitoring and graphical representations in a data management system
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
US20090043365A1 (en) * 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US20070060988A1 (en) * 2005-07-18 2007-03-15 Grenon Stephen M Melting meibomian gland obstructions
US8950405B2 (en) 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US7981095B2 (en) 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
US7981146B2 (en) * 2006-05-15 2011-07-19 Tearscience Inc. Inner eyelid treatment for treating meibomian gland dysfunction
US20080114423A1 (en) 2006-05-15 2008-05-15 Grenon Stephen M Apparatus for inner eyelid treatment of meibomian gland dysfunction
US8915253B2 (en) * 2005-07-18 2014-12-23 Tearscience, Inc. Method and apparatus for treating gland dysfunction employing heated medium
WO2013003594A2 (en) 2011-06-28 2013-01-03 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US7981145B2 (en) * 2005-07-18 2011-07-19 Tearscience Inc. Treatment of meibomian glands
US8128674B2 (en) 2006-05-15 2012-03-06 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8137390B2 (en) * 2006-05-15 2012-03-20 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
US7981147B2 (en) * 2006-05-15 2011-07-19 Tearscience, Inc. Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8527313B2 (en) * 2006-05-15 2013-09-03 Sap Ag Document instantiation triggering a business action
US8128673B2 (en) * 2006-05-15 2012-03-06 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8007524B2 (en) * 2006-05-15 2011-08-30 Tearscience, Inc. Heat treatment and heat loss reduction for treating meibomian gland dysfunction
US9314369B2 (en) 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction
US7976573B2 (en) * 2006-05-15 2011-07-12 Tearscience, Inc. Inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
WO2008027069A1 (en) * 2006-08-21 2008-03-06 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid
USD617443S1 (en) 2008-02-06 2010-06-08 Tearscience, Inc. Eye treatment goggles
USD614303S1 (en) 2008-02-06 2010-04-20 Tearscience, Inc. Eye treatment apparatus
USD613408S1 (en) 2008-02-06 2010-04-06 Tearscience, Inc. Eye treatment head gear
WO2009105647A1 (en) 2008-02-21 2009-08-27 Janssen Pharmaceutica N.V. Methods for the treatment of dermatological disorders
US8008291B2 (en) * 2008-02-29 2011-08-30 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists
US8343958B2 (en) 2008-02-29 2013-01-01 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5-receptor antagonists
US8377925B2 (en) * 2008-02-29 2013-02-19 Mimetica Pty Ltd Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor
JP5514831B2 (ja) 2008-11-17 2014-06-04 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病の治療のための置換二環式アミン
DK2387563T4 (da) 2009-01-16 2022-07-18 Exelixis Inc Malatsalt af n-(4-{ [ 6, 7-bis(methyloxy)quinolin-4-yl]oxy}phenyl-n'-(4-fluorphenyl)cyclopropan-1,1-dicarboxamid, og krystallinske former deraf til behandling af cancer
WO2010124175A1 (en) * 2009-04-24 2010-10-28 Johnson & Johnson Consumer Companies, Inc. Stable topical compositions for 1,2,4-thiadiazole derivatives
WO2011011506A1 (en) 2009-07-23 2011-01-27 Schering Corporation Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
CA2768577A1 (en) 2009-07-23 2011-01-27 Schering Corporation Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
ES2360783B1 (es) * 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
USD638128S1 (en) 2009-10-06 2011-05-17 Tearscience, Inc. Ocular device design
US8785634B2 (en) 2010-04-26 2014-07-22 Merck Sharp & Dohme Corp Spiropiperidine prolylcarboxypeptidase inhibitors
EP2568812B1 (en) 2010-05-11 2016-10-26 Merck Sharp & Dohme Corp. Novel prolylcarboxypeptidase inhibitors
EP2579873A4 (en) 2010-06-11 2013-11-27 Merck Sharp & Dohme NOVEL PROLYLCARBOXYPEPTIDASE HEMMER
RU2449997C1 (ru) * 2011-02-15 2012-05-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) 5-амино-3-(2-аминопропил)-[1,2,4]тиадиазолы
WO2012050484A2 (ru) * 2010-10-15 2012-04-19 Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) Производные 5-амино [1,2,4]тиадиазола
CA2825098C (en) 2011-01-27 2020-03-10 Universite De Montreal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
EP3320902B1 (en) * 2011-03-07 2021-02-17 Amgen (Europe) GmbH Methods for treating diseases using isoindoline compounds
LT3539551T (lt) 2011-12-29 2022-01-10 Rhythm Pharmaceuticals, Inc. Su melanokortino-4 receptoriumi susijusių sutrikimų gydymo būdas heterozigotiniuose nešiotojuose
US10842670B2 (en) 2012-08-22 2020-11-24 Johnson & Johnson Vision Care, Inc. Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices
ES2821002T3 (es) 2013-04-30 2021-04-23 Alcon Inc Sistemas para el tratamiento de enfermedades del ojo
US9763827B2 (en) 2013-04-30 2017-09-19 Tear Film Innovations, Inc. Systems and methods for the treatment of eye conditions
ES2814552T3 (es) 2014-10-31 2021-03-29 Lipotec S A U Composición cosmética y/o farmacéutica que contiene un producto extracelular bacteriano de la Pseudoalteromonas antarctica y su uso
PT3356386T (pt) 2015-09-30 2024-05-17 Rhythm Pharmaceuticals Inc Método de tratamento de distúrbios associados à via do receptor da melanocortina-4
US10974063B2 (en) 2016-06-30 2021-04-13 Alcon Inc. Light therapy for eyelash growth
EP3773897A1 (en) 2018-04-06 2021-02-17 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
CN115381955B (zh) * 2021-05-24 2024-05-17 中国科学技术大学 黑皮质素受体mc5r的用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE131373C (enExample)
DE1670960A1 (de) * 1967-12-08 1971-02-18 Bayer Ag Verfahren zur Herstellung von salzartigen heterocyclischen Verbindungen
DD131373A1 (de) 1977-06-17 1978-06-21 Juergen Liebscher Verfahren zur herstellung von 2,3-disubstituierten 5-dialkylamino-1,2,4-thiadiazoliumsalzen
JPS6011481A (ja) 1983-06-30 1985-01-21 Nippon Soda Co Ltd １，２，４−チアジアゾ−ル系誘導体及び農園芸用殺菌剤
JPH02173165A (ja) 1988-12-27 1990-07-04 Nippon Soda Co Ltd 防汚剤
DE69708198T2 (de) * 1996-04-30 2002-03-28 Pfizer Inc., New York Muscarinische Rezeptor-Agonisten
US20020103194A1 (en) * 1997-04-30 2002-08-01 Anabella Villalobos Novel muscarinic receptor agonists
ID24231A (id) * 1997-06-24 2000-07-13 Janssen Pharmaceutica Nv Derivat-derivat 5-disubstitusi-1,2,4-tiadiazolil yang menghambat angiogenesis
US6127381A (en) 1998-04-28 2000-10-03 Basu; Amaresh Isoquinoline compound melanocortin receptor ligands and methods of using same
US6500956B1 (en) * 1998-04-29 2002-12-31 Axiva Gmbh Method for the catalytic production of substituted bipyridyl derivatives
JP2002517444A (ja) 1998-06-11 2002-06-18 メルク エンド カムパニー インコーポレーテッド メラノコルチン受容体作動薬としてのスピロピペリジン誘導体
US6294534B1 (en) * 1998-06-11 2001-09-25 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
AU1324300A (en) 1998-10-26 2000-05-15 Vertex Pharmaceuticals Incorporated Pentacyclic compounds useful as inhibitors of hepatitis c virus ns3 helicase
AU2001228681A1 (en) 2000-01-28 2001-08-07 Melacure Therapeutics Ab Novel aromatic amines and amides acting on the melanocortin receptors
AU4928101A (en) * 2000-03-23 2001-10-03 Merck & Co Inc Spiropiperidine derivatives as melanocortin receptor agonists
US6728804B1 (en) 2000-10-27 2004-04-27 Emware, Inc. Remotely reprogrammable communications adapter for providing access to an electronic device
DK1446394T3 (da) * 2001-11-08 2007-03-12 Ortho Mcneil Pharm Inc Hidtil ukendte 1,2,4-thiadiazolderivater som melanocortinreceptormodulatorer
US7319107B2 (en) * 2001-11-08 2008-01-15 Johnson & Johnson Consumer Companies, Inc. 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators
US7435429B2 (en) * 2002-02-07 2008-10-14 Trustees Of Columbia University In The City Of New York Zinc salt compositions for the prevention of dermal and mucosal irritation
WO2009105647A1 (en) 2008-02-21 2009-08-27 Janssen Pharmaceutica N.V. Methods for the treatment of dermatological disorders
WO2010124175A1 (en) * 2009-04-24 2010-10-28 Johnson & Johnson Consumer Companies, Inc. Stable topical compositions for 1,2,4-thiadiazole derivatives

Similar Documents

Publication Publication Date Title
JP2005511606A5 (enExample)
RU2004114208A (ru) Новые производные 1, 2, 4-тиадиазолия в каестве модуляторов рецепторов меланокортина
JP2005511605A5 (enExample)
RU2004114214A (ru) Новые производные 1,2,4-тиадиазола в качестве модуляторов рецепторов меланокортина
RU2374239C2 (ru) Производные арилпиридина
US20100056444A1 (en) Treatment of Alzheimer's Disease Using Compounds that Reduce the Activity of Non Selective Ca Activated ATP- Sensitive Cation Channels Regulated by SUR1 Receptors
Alley et al. Recent progress on the topical therapy of onychomycosis
JP2004512328A5 (enExample)
JP2003528872A5 (enExample)
JP2006514095A5 (enExample)
JP2006516251A5 (enExample)
JP2007530493A5 (enExample)
US20210161932A1 (en) Treatment of sleep apnea with a combination of a carbonic anhydrase inhibitor and an aldosterone antagonist
US20180344692A1 (en) Methods of treating alpha adrenergic mediated conditions
WO2003066100A1 (fr) Stimulants de la pousse de cheveux, preparations percutanees et procede de stimulation de la pousse de cheveux
DK2303264T3 (en) METHODS FOR TREATING ALPHA-ADRENERG-MEDIATED CONDITIONS USING IMIDAZOLINE DERIVATIVES
Jain et al. Itraconazole: an effective oral antifungal for onychomycosis.
US10624877B2 (en) Composition and method for treatment of symptoms associated with various skin conditions
AU2017374450B2 (en) Parenteral liquid preparation comprising carbamate compound
JP2008543813A5 (enExample)
BR112020019577A2 (pt) Combinação farmacêutica tripla compreendendo dabrafenibe, trametinibe e um inibidor de erk
JP2003238406A5 (enExample)
Rosen et al. Naftifine treatment of resistant dermatophytosis
JPWO2020064560A5 (enExample)
WO1999034797A1 (en) Method for treating multiple sclerosis