JP2005508341A - ３−ヒドロキシ−（４−トリフルオロメチルフェニル）−メチル−７−スピロシクロブチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびコレステロールエステル転送タンパク質（ｃｅｔｐ）阻害剤としてのその使用 - Google Patents
３−ヒドロキシ−（４−トリフルオロメチルフェニル）−メチル−７−スピロシクロブチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびコレステロールエステル転送タンパク質（ｃｅｔｐ）阻害剤としてのその使用 Download PDFInfo
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- JP2005508341A JP2005508341A JP2003532059A JP2003532059A JP2005508341A JP 2005508341 A JP2005508341 A JP 2005508341A JP 2003532059 A JP2003532059 A JP 2003532059A JP 2003532059 A JP2003532059 A JP 2003532059A JP 2005508341 A JP2005508341 A JP 2005508341A
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
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- 108010037401 tendamistate Proteins 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical class C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10148436A DE10148436A1 (de) | 2001-10-01 | 2001-10-01 | Tetrahydrochinoline |
| PCT/EP2002/010444 WO2003028727A1 (de) | 2001-10-01 | 2002-09-18 | 3-`hydroxy- (-4-trifluoromethylphenyl) -methyl!-7-spirocyclobutyl-5,6,7,8- tetrahydrochinolin-5-ol-derivate und ihre verwendung als cholesterin-ester-transfer-protein (cetp) - inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508341A true JP2005508341A (ja) | 2005-03-31 |
| JP2005508341A5 JP2005508341A5 (enExample) | 2006-01-05 |
Family
ID=7701007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532059A Pending JP2005508341A (ja) | 2001-10-01 | 2002-09-18 | ３−ヒドロキシ−（４−トリフルオロメチルフェニル）−メチル−７−スピロシクロブチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびコレステロールエステル転送タンパク質（ｃｅｔｐ）阻害剤としてのその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050043341A1 (enExample) |
| EP (1) | EP1434581A1 (enExample) |
| JP (1) | JP2005508341A (enExample) |
| AR (1) | AR036583A1 (enExample) |
| CA (1) | CA2462030A1 (enExample) |
| DE (1) | DE10148436A1 (enExample) |
| DO (1) | DOP2002000457A (enExample) |
| GT (1) | GT200200195A (enExample) |
| HN (1) | HN2002000278A (enExample) |
| PE (1) | PE20030604A1 (enExample) |
| UY (1) | UY27458A1 (enExample) |
| WO (1) | WO2003028727A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011513361A (ja) * | 2008-03-05 | 2011-04-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 三環式ピリジン誘導体、そのような化合物を含有する医薬、それらの使用及びそれらの調製方法 |
| WO2012005343A1 (ja) | 2010-07-09 | 2012-01-12 | 第一三共株式会社 | 置換ピリジン化合物 |
| WO2013103150A1 (ja) | 2012-01-06 | 2013-07-11 | 第一三共株式会社 | 置換ピリジン化合物の酸付加塩 |
| JP2017526750A (ja) * | 2014-09-09 | 2017-09-14 | ベーリンガー インゲルハイム インターナショナル トレイディング （シャンハイ） カンパニー リミテッド | スピロ［２．５］オクタン−５，７−ジオンおよびスピロ［３．５］ノナン−６，８−ジオンの調製のための新規なプロセス |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060080214A (ko) | 2003-09-26 | 2006-07-07 | 니뽄 다바코 산교 가부시키가이샤 | 잔여 리포프로테인 생산 저해 방법 |
| US7749992B2 (en) | 2003-10-08 | 2010-07-06 | Eli Lilly And Company | Compounds and methods for treating dislipidemia |
| BRPI0508966A (pt) | 2004-03-26 | 2007-08-21 | Lilly Co Eli | composto, composição farmacêutica, e, uso de um composto |
| AU2005324127A1 (en) * | 2004-12-18 | 2006-07-13 | Bayer Healthcare Ag | (5S) -3-[(S)-fluoro (4-trifluoromethylphenyl) methyl]-5,6,7,8-tetrahydroquinoline-5-ol derivatives and use thereof as CETP inhibitors |
| US8124775B2 (en) * | 2004-12-18 | 2012-02-28 | Bayer Pharma Aktiengesellschaft | Chemical compound and its use |
| DE102006012548A1 (de) | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
| US20080145498A1 (en) * | 2006-12-14 | 2008-06-19 | Kraft Foods Holdings, Inc. | Texture and shape control process for acidified food products |
| US9029544B2 (en) * | 2010-02-19 | 2015-05-12 | Boehringer Ingelheim International Gmbh | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| JP5947382B2 (ja) | 2011-08-17 | 2016-07-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フロ［３，４−ｃ］キノリン誘導体、このような化合物を含む薬物、それらの使用及びそれらの調製方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP970330B1 (en) * | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
| DE19741051A1 (de) * | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
| MA24643A1 (fr) * | 1997-09-18 | 1999-04-01 | Bayer Ag | Tetrahydro-naphtalenes substitues et composes analogues |
| DE19741399A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
-
2001
- 2001-10-01 DE DE10148436A patent/DE10148436A1/de not_active Withdrawn
-
2002
- 2002-09-02 DO DO2002000457A patent/DOP2002000457A/es unknown
- 2002-09-18 EP EP02772317A patent/EP1434581A1/de not_active Withdrawn
- 2002-09-18 US US10/491,465 patent/US20050043341A1/en not_active Abandoned
- 2002-09-18 CA CA002462030A patent/CA2462030A1/en not_active Abandoned
- 2002-09-18 JP JP2003532059A patent/JP2005508341A/ja active Pending
- 2002-09-18 WO PCT/EP2002/010444 patent/WO2003028727A1/de not_active Ceased
- 2002-09-25 AR ARP020103608A patent/AR036583A1/es unknown
- 2002-09-27 UY UY27458A patent/UY27458A1/es not_active Application Discontinuation
- 2002-09-27 GT GT200200195A patent/GT200200195A/es unknown
- 2002-09-30 PE PE2002000962A patent/PE20030604A1/es not_active Application Discontinuation
- 2002-10-01 HN HN2002000278A patent/HN2002000278A/es unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011513361A (ja) * | 2008-03-05 | 2011-04-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 三環式ピリジン誘導体、そのような化合物を含有する医薬、それらの使用及びそれらの調製方法 |
| WO2012005343A1 (ja) | 2010-07-09 | 2012-01-12 | 第一三共株式会社 | 置換ピリジン化合物 |
| US9187450B2 (en) | 2010-07-09 | 2015-11-17 | Daiichi Sankyo Company, Limited | Substituted pyridine compound |
| WO2013103150A1 (ja) | 2012-01-06 | 2013-07-11 | 第一三共株式会社 | 置換ピリジン化合物の酸付加塩 |
| JPWO2013103150A1 (ja) * | 2012-01-06 | 2015-05-11 | 第一三共株式会社 | 置換ピリジン化合物の酸付加塩 |
| US9321747B2 (en) | 2012-01-06 | 2016-04-26 | Daiichi Sankyo Company, Limited | Acid addition salt of substituted pyridine compound |
| JP2017526750A (ja) * | 2014-09-09 | 2017-09-14 | ベーリンガー インゲルハイム インターナショナル トレイディング （シャンハイ） カンパニー リミテッド | スピロ［２．５］オクタン−５，７−ジオンおよびスピロ［３．５］ノナン−６，８−ジオンの調製のための新規なプロセス |
Also Published As
| Publication number | Publication date |
|---|---|
| UY27458A1 (es) | 2003-04-30 |
| AR036583A1 (es) | 2004-09-15 |
| CA2462030A1 (en) | 2003-04-10 |
| DE10148436A1 (de) | 2003-04-17 |
| DOP2002000457A (es) | 2003-04-15 |
| US20050043341A1 (en) | 2005-02-24 |
| WO2003028727A1 (de) | 2003-04-10 |
| WO2003028727A9 (de) | 2003-11-13 |
| GT200200195A (es) | 2003-08-22 |
| HN2002000278A (es) | 2002-12-20 |
| EP1434581A1 (de) | 2004-07-07 |
| PE20030604A1 (es) | 2003-09-07 |
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