GT200200195A - Tetrahidroquinolinas - Google Patents
TetrahidroquinolinasInfo
- Publication number
- GT200200195A GT200200195A GT200200195A GT200200195A GT200200195A GT 200200195 A GT200200195 A GT 200200195A GT 200200195 A GT200200195 A GT 200200195A GT 200200195 A GT200200195 A GT 200200195A GT 200200195 A GT200200195 A GT 200200195A
- Authority
- GT
- Guatemala
- Prior art keywords
- tetrahydroquinolins
- cholesterol
- hypertrigliceridemias
- hdlcolesterina
- aterosclerosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A TETRAHIDROQUINOLINAS DE FORMULA GENERAL (I) EN DONDE A,B, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES ALTAMENTE EFICACES DE LAS PROTEINAS DE TRANSFERENCIA DE ESTER DE COLESTERINA (CETP) QUE POR LA INHIBICION ESTIMULAN EL TRANSPORTE INVERSO DE COLESTERINA EN LA SANGRE AUMENTANDO SIMULTANEAMENTE EL NIVEL DE HDLCOLESTERINA POR LO QUE SON DE UTILIDAD EN CUADROS DE HIPOLIPOPROTEINEMIA, DISLIPIDEMIAS, HIPERTRIGLICERIDEMIAS, ATEROSCLEROSIS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10148436A DE10148436A1 (de) | 2001-10-01 | 2001-10-01 | Tetrahydrochinoline |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200200195A true GT200200195A (es) | 2003-08-22 |
Family
ID=7701007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200200195A GT200200195A (es) | 2001-10-01 | 2002-09-27 | Tetrahidroquinolinas |
Country Status (12)
Country | Link |
---|---|
US (1) | US20050043341A1 (es) |
EP (1) | EP1434581A1 (es) |
JP (1) | JP2005508341A (es) |
AR (1) | AR036583A1 (es) |
CA (1) | CA2462030A1 (es) |
DE (1) | DE10148436A1 (es) |
DO (1) | DOP2002000457A (es) |
GT (1) | GT200200195A (es) |
HN (1) | HN2002000278A (es) |
PE (1) | PE20030604A1 (es) |
UY (1) | UY27458A1 (es) |
WO (1) | WO2003028727A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ546732A (en) | 2003-09-26 | 2009-10-30 | Japan Tobacco Inc | Method of inhibiting remnant lipoprotein production |
DE602004023100D1 (de) | 2003-10-08 | 2009-10-22 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidemie |
WO2005097805A1 (en) | 2004-03-26 | 2005-10-20 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
MX2007007187A (es) * | 2004-12-18 | 2007-08-14 | Bayer Healthcare Ag | Derivados de (5s)-3-[(s)-fluoro-(4-trifluorometilfenil)metil]-5,6, 7,8-tetrahidroquinolin-5-ol y su uso como inhibidores de la proteina de transferencia de ester de colesterol. |
EP1828137B1 (de) * | 2004-12-18 | 2012-04-25 | Bayer Pharma Aktiengesellschaft | 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente |
DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
US20080145498A1 (en) * | 2006-12-14 | 2008-06-19 | Kraft Foods Holdings, Inc. | Texture and shape control process for acidified food products |
WO2009109549A1 (en) * | 2008-03-05 | 2009-09-11 | Boehringer Ingelheim International Gmbh | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
MX2012009149A (es) * | 2010-02-19 | 2012-09-28 | Boehringer Ingelheim Int | Derivados de piridina triciclicos, medicamentos que contienen tales compuestos, su uso y proceso para su preparacion. |
JP5739426B2 (ja) | 2010-07-09 | 2015-06-24 | 宇部興産株式会社 | 置換ピリジン化合物 |
AR087577A1 (es) | 2011-08-17 | 2014-04-03 | Boehringer Ingelheim Int | Derivados de furo[3,4-c]quinolina, medicamentos que contienen dichos compuestos, su uso y proceso para su preparacion |
EP2801574B1 (en) | 2012-01-06 | 2016-07-27 | Daiichi Sankyo Company, Limited | Acid adduct salts of substituted pyridine compound as cholesteryl ester transfer protein (cetp) inhibitors |
JP6742316B2 (ja) * | 2014-09-09 | 2020-08-19 | ベーリンガー インゲルハイム インターナショナル トレイディング (シャンハイ) カンパニー リミテッド | スピロ[2.5]オクタン−5,7−ジオンおよびスピロ[3.5]ノナン−6,8−ジオンの調製のための新規なプロセス |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP970330B1 (en) * | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
MA24643A1 (fr) * | 1997-09-18 | 1999-04-01 | Bayer Ag | Tetrahydro-naphtalenes substitues et composes analogues |
DE19741051A1 (de) * | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
DE19741399A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
-
2001
- 2001-10-01 DE DE10148436A patent/DE10148436A1/de not_active Withdrawn
-
2002
- 2002-09-02 DO DO2002000457A patent/DOP2002000457A/es unknown
- 2002-09-18 CA CA002462030A patent/CA2462030A1/en not_active Abandoned
- 2002-09-18 EP EP02772317A patent/EP1434581A1/de not_active Withdrawn
- 2002-09-18 US US10/491,465 patent/US20050043341A1/en not_active Abandoned
- 2002-09-18 JP JP2003532059A patent/JP2005508341A/ja active Pending
- 2002-09-18 WO PCT/EP2002/010444 patent/WO2003028727A1/de active Application Filing
- 2002-09-25 AR ARP020103608A patent/AR036583A1/es unknown
- 2002-09-27 UY UY27458A patent/UY27458A1/es not_active Application Discontinuation
- 2002-09-27 GT GT200200195A patent/GT200200195A/es unknown
- 2002-09-30 PE PE2002000962A patent/PE20030604A1/es not_active Application Discontinuation
- 2002-10-01 HN HN2002000278A patent/HN2002000278A/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20030604A1 (es) | 2003-09-07 |
HN2002000278A (es) | 2002-12-20 |
DE10148436A1 (de) | 2003-04-17 |
JP2005508341A (ja) | 2005-03-31 |
WO2003028727A9 (de) | 2003-11-13 |
EP1434581A1 (de) | 2004-07-07 |
US20050043341A1 (en) | 2005-02-24 |
CA2462030A1 (en) | 2003-04-10 |
UY27458A1 (es) | 2003-04-30 |
DOP2002000457A (es) | 2003-04-15 |
WO2003028727A1 (de) | 2003-04-10 |
AR036583A1 (es) | 2004-09-15 |
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