JP2005508341A5 - - Google Patents
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- Publication number
- JP2005508341A5 JP2005508341A5 JP2003532059A JP2003532059A JP2005508341A5 JP 2005508341 A5 JP2005508341 A5 JP 2005508341A5 JP 2003532059 A JP2003532059 A JP 2003532059A JP 2003532059 A JP2003532059 A JP 2003532059A JP 2005508341 A5 JP2005508341 A5 JP 2005508341A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- medicament
- disease
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 claims 2
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000006722 reduction reaction Methods 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000006989 Alzheimer disease 9 Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010021024 Hypolipidaemia Diseases 0.000 claims 1
- 238000008214 LDL Cholesterol Methods 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 238000011917 diastereoselective reduction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 208000026621 hypolipoproteinemia Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000004141 reverse cholesterol transport Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 208000023516 stroke disease Diseases 0.000 claims 1
- 0 Bc1c(C(c2ccc(C(F)(F)F)cc2)O)c(*)c(C(CC2(CCC2)C2)O)c2n1 Chemical compound Bc1c(C(c2ccc(C(F)(F)F)cc2)O)c(*)c(C(CC2(CCC2)C2)O)c2n1 0.000 description 6
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10148436A DE10148436A1 (de) | 2001-10-01 | 2001-10-01 | Tetrahydrochinoline |
| PCT/EP2002/010444 WO2003028727A1 (de) | 2001-10-01 | 2002-09-18 | 3-`hydroxy- (-4-trifluoromethylphenyl) -methyl!-7-spirocyclobutyl-5,6,7,8- tetrahydrochinolin-5-ol-derivate und ihre verwendung als cholesterin-ester-transfer-protein (cetp) - inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508341A JP2005508341A (ja) | 2005-03-31 |
| JP2005508341A5 true JP2005508341A5 (enExample) | 2006-01-05 |
Family
ID=7701007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532059A Pending JP2005508341A (ja) | 2001-10-01 | 2002-09-18 | ３−ヒドロキシ−（４−トリフルオロメチルフェニル）−メチル−７−スピロシクロブチル−５，６，７，８−テトラヒドロキノリン−５−オール誘導体およびコレステロールエステル転送タンパク質（ｃｅｔｐ）阻害剤としてのその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050043341A1 (enExample) |
| EP (1) | EP1434581A1 (enExample) |
| JP (1) | JP2005508341A (enExample) |
| AR (1) | AR036583A1 (enExample) |
| CA (1) | CA2462030A1 (enExample) |
| DE (1) | DE10148436A1 (enExample) |
| DO (1) | DOP2002000457A (enExample) |
| GT (1) | GT200200195A (enExample) |
| HN (1) | HN2002000278A (enExample) |
| PE (1) | PE20030604A1 (enExample) |
| UY (1) | UY27458A1 (enExample) |
| WO (1) | WO2003028727A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060080214A (ko) | 2003-09-26 | 2006-07-07 | 니뽄 다바코 산교 가부시키가이샤 | 잔여 리포프로테인 생산 저해 방법 |
| US7749992B2 (en) | 2003-10-08 | 2010-07-06 | Eli Lilly And Company | Compounds and methods for treating dislipidemia |
| BRPI0508966A (pt) | 2004-03-26 | 2007-08-21 | Lilly Co Eli | composto, composição farmacêutica, e, uso de um composto |
| AU2005324127A1 (en) * | 2004-12-18 | 2006-07-13 | Bayer Healthcare Ag | (5S) -3-[(S)-fluoro (4-trifluoromethylphenyl) methyl]-5,6,7,8-tetrahydroquinoline-5-ol derivatives and use thereof as CETP inhibitors |
| US8124775B2 (en) * | 2004-12-18 | 2012-02-28 | Bayer Pharma Aktiengesellschaft | Chemical compound and its use |
| DE102006012548A1 (de) | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
| US20080145498A1 (en) * | 2006-12-14 | 2008-06-19 | Kraft Foods Holdings, Inc. | Texture and shape control process for acidified food products |
| AU2009221179A1 (en) * | 2008-03-05 | 2009-09-11 | Boehringer Ingelheim International Gmbh | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| US9029544B2 (en) * | 2010-02-19 | 2015-05-12 | Boehringer Ingelheim International Gmbh | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| RU2572606C2 (ru) | 2010-07-09 | 2016-01-20 | Дайити Санкио Компани, Лимитед | Замещенное пиридиновое соединение |
| JP5947382B2 (ja) | 2011-08-17 | 2016-07-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フロ［３，４−ｃ］キノリン誘導体、このような化合物を含む薬物、それらの使用及びそれらの調製方法 |
| TWI570118B (zh) * | 2012-01-06 | 2017-02-11 | 第一三共股份有限公司 | 經取代之吡啶化合物的酸加成鹽 |
| US9938228B2 (en) | 2014-09-09 | 2018-04-10 | Boehringer Ingelheim International Gmbh | Process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP970330B1 (en) * | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
| DE19741051A1 (de) * | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
| MA24643A1 (fr) * | 1997-09-18 | 1999-04-01 | Bayer Ag | Tetrahydro-naphtalenes substitues et composes analogues |
| DE19741399A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
-
2001
- 2001-10-01 DE DE10148436A patent/DE10148436A1/de not_active Withdrawn
-
2002
- 2002-09-02 DO DO2002000457A patent/DOP2002000457A/es unknown
- 2002-09-18 EP EP02772317A patent/EP1434581A1/de not_active Withdrawn
- 2002-09-18 US US10/491,465 patent/US20050043341A1/en not_active Abandoned
- 2002-09-18 CA CA002462030A patent/CA2462030A1/en not_active Abandoned
- 2002-09-18 JP JP2003532059A patent/JP2005508341A/ja active Pending
- 2002-09-18 WO PCT/EP2002/010444 patent/WO2003028727A1/de not_active Ceased
- 2002-09-25 AR ARP020103608A patent/AR036583A1/es unknown
- 2002-09-27 UY UY27458A patent/UY27458A1/es not_active Application Discontinuation
- 2002-09-27 GT GT200200195A patent/GT200200195A/es unknown
- 2002-09-30 PE PE2002000962A patent/PE20030604A1/es not_active Application Discontinuation
- 2002-10-01 HN HN2002000278A patent/HN2002000278A/es unknown
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