JP2011527340A5 - - Google Patents
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- Publication number
- JP2011527340A5 JP2011527340A5 JP2011517314A JP2011517314A JP2011527340A5 JP 2011527340 A5 JP2011527340 A5 JP 2011527340A5 JP 2011517314 A JP2011517314 A JP 2011517314A JP 2011517314 A JP2011517314 A JP 2011517314A JP 2011527340 A5 JP2011527340 A5 JP 2011527340A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkenyl group
- compound
- composition according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 150000001412 amines Chemical class 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical group C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 claims 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 229910052810 boron oxide Inorganic materials 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical group CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1641CH2008 | 2008-07-07 | ||
| IN1641/CHE/2008 | 2008-07-07 | ||
| PCT/IN2009/000382 WO2010004579A2 (en) | 2008-07-07 | 2009-07-06 | Orally active curcuminoid compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011527340A JP2011527340A (ja) | 2011-10-27 |
| JP2011527340A5 true JP2011527340A5 (enExample) | 2012-08-23 |
Family
ID=41507515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517314A Pending JP2011527340A (ja) | 2008-07-07 | 2009-07-06 | 経口活性クルクミノイド化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8680143B2 (enExample) |
| EP (1) | EP2294049A4 (enExample) |
| JP (1) | JP2011527340A (enExample) |
| CN (1) | CN102131765A (enExample) |
| AU (1) | AU2009269530A1 (enExample) |
| WO (1) | WO2010004579A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015186144A2 (en) * | 2014-06-07 | 2015-12-10 | Laila Pharmaceuticals Pvt. Ltd. | Method of inhibition of beta-secretase by using bis-o-demethylcurcumin for the prevention, management and treatment of neurodegenerative diseases |
| US10085951B2 (en) | 2014-12-11 | 2018-10-02 | Designs For Health, Inc. | Curcuminoid formulations and related methods of treatment |
| JP6814240B2 (ja) | 2018-03-23 | 2021-01-13 | メリー ライフ ビオメディカル カンパニー，リミテッドＭｅｒｒｙ Ｌｉｆｅ Ｂｉｏｍｅｄｉｃａｌ Ｃｏｍｐａｎｙ，Ｌｔｄ． | クルクミン誘導体の使用 |
| CN112315953B (zh) * | 2020-11-06 | 2023-03-07 | 中国海洋大学 | 一种姜黄素酯在改善急性肾损伤制品中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004031122A1 (de) * | 2002-10-01 | 2004-04-15 | Dr. André Rieks - Labor Für Enzymtechnologie Gmbh | Neue curcumin/tetrahydrocurcumin-derivate für den einsatz in kosmetika, pharmazeutika und bei der ernährung |
| EP1876908A1 (en) | 2005-05-03 | 2008-01-16 | DSMIP Assets B.V. | Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives |
| WO2007103435A2 (en) * | 2006-03-06 | 2007-09-13 | The Regents Of The University Of California | Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders |
| CN101454267B (zh) * | 2006-03-29 | 2012-09-26 | 帝斯曼知识产权资产管理有限公司 | 姜黄素的合成 |
| EP2813145A1 (en) * | 2006-10-12 | 2014-12-17 | Research Foundation Of The City University Of New York | Novel curcumin and tetrahydrocurcumin derivatives |
-
2009
- 2009-07-06 AU AU2009269530A patent/AU2009269530A1/en not_active Abandoned
- 2009-07-06 CN CN2009801136580A patent/CN102131765A/zh active Pending
- 2009-07-06 US US13/002,588 patent/US8680143B2/en not_active Expired - Fee Related
- 2009-07-06 EP EP09794105A patent/EP2294049A4/en not_active Withdrawn
- 2009-07-06 WO PCT/IN2009/000382 patent/WO2010004579A2/en not_active Ceased
- 2009-07-06 JP JP2011517314A patent/JP2011527340A/ja active Pending
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