JP2005508293A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005508293A5 JP2005508293A5 JP2002591467A JP2002591467A JP2005508293A5 JP 2005508293 A5 JP2005508293 A5 JP 2005508293A5 JP 2002591467 A JP2002591467 A JP 2002591467A JP 2002591467 A JP2002591467 A JP 2002591467A JP 2005508293 A5 JP2005508293 A5 JP 2005508293A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- phenyl
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- -1 4-fluoro-3-hydroxy-phenyl Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 claims 2
- HTLHMIALIFKABS-UHFFFAOYSA-N 4-[(3-aminophenyl)-(4-benzylpiperazin-1-yl)methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 HTLHMIALIFKABS-UHFFFAOYSA-N 0.000 claims 1
- AQJCXKVOPRUSOL-UHFFFAOYSA-N 4-[(3-aminophenyl)-(4-benzylpiperazin-1-yl)methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 AQJCXKVOPRUSOL-UHFFFAOYSA-N 0.000 claims 1
- QZZACLAJJQPESF-UHFFFAOYSA-N 4-[(3-aminophenyl)-[4-(1h-imidazol-2-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC=2NC=CN=2)CC1 QZZACLAJJQPESF-UHFFFAOYSA-N 0.000 claims 1
- NZXYDHJFJFWXKL-UHFFFAOYSA-N 4-[(3-aminophenyl)-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC2=CSC=C2)CC1 NZXYDHJFJFWXKL-UHFFFAOYSA-N 0.000 claims 1
- BHPNFYBHNQPYEY-UHFFFAOYSA-N 4-[(3-aminophenyl)-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC2=CSC=C2)CC1 BHPNFYBHNQPYEY-UHFFFAOYSA-N 0.000 claims 1
- MNUZJZQILRFDRM-UHFFFAOYSA-N 4-[(4-benzylpiperazin-1-yl)-(4-fluoro-3-hydroxyphenyl)methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(O)C(F)=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 MNUZJZQILRFDRM-UHFFFAOYSA-N 0.000 claims 1
- DCZPTCGNXVKMTI-UHFFFAOYSA-N 4-[(4-fluoro-3-hydroxyphenyl)-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(O)C(F)=CC=1)N1CCN(CC2=CSC=C2)CC1 DCZPTCGNXVKMTI-UHFFFAOYSA-N 0.000 claims 1
- AKCMIUUHQWRJRW-UHFFFAOYSA-N 4-[[3-(methanesulfonamido)phenyl]-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(NS(C)(=O)=O)C=CC=1)N1CCN(CC2=CSC=C2)CC1 AKCMIUUHQWRJRW-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101772A SE0101772D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| SE0103820A SE0103820D0 (sv) | 2001-11-15 | 2001-11-15 | Novel compounds |
| PCT/SE2002/000956 WO2002094794A1 (en) | 2001-05-18 | 2002-05-16 | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010002450A Division JP5028500B2 (ja) | 2001-05-18 | 2010-01-08 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508293A JP2005508293A (ja) | 2005-03-31 |
| JP2005508293A5 true JP2005508293A5 (OSRAM) | 2005-12-22 |
| JP4549024B2 JP4549024B2 (ja) | 2010-09-22 |
Family
ID=26655470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591467A Expired - Fee Related JP4549024B2 (ja) | 2001-05-18 | 2002-05-16 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
| JP2010002450A Expired - Fee Related JP5028500B2 (ja) | 2001-05-18 | 2010-01-08 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010002450A Expired - Fee Related JP5028500B2 (ja) | 2001-05-18 | 2010-01-08 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US7229994B2 (OSRAM) |
| EP (2) | EP1395567B1 (OSRAM) |
| JP (2) | JP4549024B2 (OSRAM) |
| KR (2) | KR100915263B1 (OSRAM) |
| CN (1) | CN1269805C (OSRAM) |
| AR (1) | AR035974A1 (OSRAM) |
| AT (1) | ATE420866T1 (OSRAM) |
| AU (1) | AU2002305994B2 (OSRAM) |
| BG (1) | BG108333A (OSRAM) |
| BR (1) | BR0209678A (OSRAM) |
| CA (1) | CA2446326C (OSRAM) |
| CO (1) | CO5540309A2 (OSRAM) |
| CY (1) | CY1108913T1 (OSRAM) |
| CZ (1) | CZ20033092A3 (OSRAM) |
| DE (1) | DE60230869D1 (OSRAM) |
| DK (1) | DK1395567T3 (OSRAM) |
| EE (1) | EE05243B1 (OSRAM) |
| ES (1) | ES2319876T3 (OSRAM) |
| HU (1) | HUP0401086A3 (OSRAM) |
| IL (2) | IL158631A0 (OSRAM) |
| IS (1) | IS2625B (OSRAM) |
| MX (1) | MXPA03010445A (OSRAM) |
| MY (1) | MY140070A (OSRAM) |
| NO (1) | NO326632B1 (OSRAM) |
| NZ (2) | NZ529401A (OSRAM) |
| PL (1) | PL367142A1 (OSRAM) |
| PT (1) | PT1395567E (OSRAM) |
| RU (1) | RU2297412C2 (OSRAM) |
| SI (1) | SI1395567T1 (OSRAM) |
| SK (1) | SK287555B6 (OSRAM) |
| WO (1) | WO2002094794A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60230869D1 (de) | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
| WO2003037342A1 (en) | 2001-10-29 | 2003-05-08 | Ardent Pharmaceuticals, Inc. | Method of treating depression with delta receptor agonist compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| HRP20120343T1 (hr) * | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| CN101128447A (zh) * | 2005-02-28 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 二芳基甲基哌嗪衍生物，其制备及其用途 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| TWI410406B (zh) | 2005-05-13 | 2013-10-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物 |
| WO2007018459A1 (en) * | 2005-08-08 | 2007-02-15 | Astrazeneca Ab | Therapeutic agents |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP2024364A1 (en) * | 2006-05-26 | 2009-02-18 | Neuromed Pharmaceuticals, Ltd. | Heterocyclic compounds as calcium channel blockers |
| AU2007294968A1 (en) | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| PL2307389T3 (pl) | 2008-06-20 | 2013-05-31 | Astrazeneca Ab | Pochodne dibenzotiazepiny i ich zastosowanie |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| US10208016B2 (en) | 2013-06-21 | 2019-02-19 | Takeda Pharmaceutical Company Limited | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors |
| GB201314286D0 (en) | 2013-08-08 | 2013-09-25 | Takeda Pharmaceutical | Therapeutic Compounds |
| GB201318222D0 (en) | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
| GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
| TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| CN104163788A (zh) * | 2014-07-07 | 2014-11-26 | 湖南华腾制药有限公司 | 一种吡啶衍生物的制备方法 |
| GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
| GB201619514D0 (en) | 2016-11-18 | 2017-01-04 | Takeda Pharmaceuticals Co | Novel compounds |
| JP2021138648A (ja) | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
| CN112245432B (zh) * | 2020-11-05 | 2021-12-21 | 东南大学 | 一种1-二苯甲基-4-甲基哌嗪类化合物在制备抗抑郁症药物中的应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583713A5 (OSRAM) | 1973-06-29 | 1977-01-14 | Cermol Sa | |
| DE2900810A1 (de) | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| IT1196150B (it) | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
| SE8500573D0 (sv) | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5028610A (en) | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4829065A (en) | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| US4826844A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| US5840896A (en) * | 1989-11-22 | 1998-11-24 | Janssen Pharmaceutica, N.V. | Method of preventing or limiting reperfusion damage |
| CA2044143C (en) | 1989-11-22 | 2002-11-19 | Herman Van Belle | Method of preventing or limiting reperfusion damage |
| HUT65943A (en) | 1990-08-29 | 1994-08-29 | Upjohn Co | Process for producing benzothiazolylmethyl- and pyperazinomethyl-2,4,6-cycloheptatriene-1-one derivatives and pharmaceutical preparations containing them |
| AU646519B2 (en) | 1990-10-10 | 1994-02-24 | Schering Corporation | Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5681830A (en) | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5807858A (en) | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| SE9201956D0 (sv) * | 1992-06-25 | 1992-06-25 | Kabi Pharmacia Ab | Novel nicotinicacid esters |
| FR2696744B1 (fr) | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| HU221726B1 (hu) | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| JP3352184B2 (ja) | 1993-11-12 | 2002-12-03 | 株式会社アズウェル | ピペラジン不飽和脂肪酸誘導体 |
| IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| ATE306472T1 (de) | 1997-12-24 | 2005-10-15 | Ortho Mcneil Pharm Inc | (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
| US6011035A (en) | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| DE60230869D1 (de) * | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
| SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| WO2003037342A1 (en) * | 2001-10-29 | 2003-05-08 | Ardent Pharmaceuticals, Inc. | Method of treating depression with delta receptor agonist compounds |
| US8476280B2 (en) | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300105D0 (sv) | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| HRP20120343T1 (hr) | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| CN101128447A (zh) | 2005-02-28 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 二芳基甲基哌嗪衍生物，其制备及其用途 |
| JP2011520956A (ja) | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
-
2002
- 2002-05-16 DE DE60230869T patent/DE60230869D1/de not_active Expired - Lifetime
- 2002-05-16 CA CA2446326A patent/CA2446326C/en not_active Expired - Fee Related
- 2002-05-16 EP EP02733712A patent/EP1395567B1/en not_active Expired - Lifetime
- 2002-05-16 MX MXPA03010445A patent/MXPA03010445A/es active IP Right Grant
- 2002-05-16 AU AU2002305994A patent/AU2002305994B2/en not_active Ceased
- 2002-05-16 BR BR0209678-1A patent/BR0209678A/pt not_active IP Right Cessation
- 2002-05-16 SI SI200230797T patent/SI1395567T1/sl unknown
- 2002-05-16 PT PT02733712T patent/PT1395567E/pt unknown
- 2002-05-16 DK DK02733712T patent/DK1395567T3/da active
- 2002-05-16 KR KR1020087026556A patent/KR100915263B1/ko not_active Expired - Fee Related
- 2002-05-16 WO PCT/SE2002/000956 patent/WO2002094794A1/en not_active Ceased
- 2002-05-16 EP EP08171062A patent/EP2042495A1/en not_active Withdrawn
- 2002-05-16 IL IL15863102A patent/IL158631A0/xx unknown
- 2002-05-16 AR ARP020101817A patent/AR035974A1/es active IP Right Grant
- 2002-05-16 PL PL02367142A patent/PL367142A1/xx unknown
- 2002-05-16 CZ CZ20033092A patent/CZ20033092A3/cs unknown
- 2002-05-16 KR KR1020037014950A patent/KR100885100B1/ko not_active Expired - Fee Related
- 2002-05-16 MY MYPI20021785A patent/MY140070A/en unknown
- 2002-05-16 EE EEP200300545A patent/EE05243B1/xx not_active IP Right Cessation
- 2002-05-16 RU RU2003131964/04A patent/RU2297412C2/ru not_active IP Right Cessation
- 2002-05-16 CN CNB028141695A patent/CN1269805C/zh not_active Expired - Fee Related
- 2002-05-16 AT AT02733712T patent/ATE420866T1/de active
- 2002-05-16 HU HU0401086A patent/HUP0401086A3/hu unknown
- 2002-05-16 JP JP2002591467A patent/JP4549024B2/ja not_active Expired - Fee Related
- 2002-05-16 NZ NZ529401A patent/NZ529401A/en unknown
- 2002-05-16 NZ NZ539828A patent/NZ539828A/en unknown
- 2002-05-16 SK SK1398-2003A patent/SK287555B6/sk not_active IP Right Cessation
- 2002-05-16 US US10/477,642 patent/US7229994B2/en not_active Expired - Fee Related
- 2002-05-16 ES ES02733712T patent/ES2319876T3/es not_active Expired - Lifetime
-
2003
- 2003-10-27 IL IL158631A patent/IL158631A/en not_active IP Right Cessation
- 2003-11-07 BG BG108333A patent/BG108333A/bg unknown
- 2003-11-12 CO CO03100169A patent/CO5540309A2/es not_active Application Discontinuation
- 2003-11-13 IS IS7032A patent/IS2625B/is unknown
- 2003-11-17 NO NO20035120A patent/NO326632B1/no not_active IP Right Cessation
-
2007
- 2007-05-03 US US11/743,824 patent/US7915413B2/en not_active Expired - Fee Related
-
2009
- 2009-03-19 CY CY20091100308T patent/CY1108913T1/el unknown
-
2010
- 2010-01-08 JP JP2010002450A patent/JP5028500B2/ja not_active Expired - Fee Related
- 2010-10-25 US US12/911,167 patent/US8022074B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005508293A5 (OSRAM) | ||
| RU2003131964A (ru) | Производные 4-(фенил-пиперазинил-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств | |
| RU2470910C2 (ru) | Соединения, представляющие собой алкинилфенильные производные, для лечения офтальмических заболеваний и расстройств | |
| JP2002534519A5 (OSRAM) | ||
| JP2010526025A5 (OSRAM) | ||
| JP2005522480A5 (OSRAM) | ||
| JP2006524222A5 (OSRAM) | ||
| RU2007143073A (ru) | Азольные соединения с нейтротерапевтической активностью | |
| CZ20032588A3 (cs) | Deriváty N-(arylsulfonyl)beta-aminokyseliny obsahující aminomethylovou skupinu, způsob jejich přípravy a farmaceutické prostředky, které je obsahují | |
| JP2005510457A5 (OSRAM) | ||
| JP2007503941A5 (OSRAM) | ||
| JP2005505583A5 (OSRAM) | ||
| RU2003131970A (ru) | Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств | |
| WO2001051473A1 (de) | 1,2-diarylbenzimidazole zur behandlung von krankungen die mit einer microglia-aktivierung assoziiert sind | |
| JP2006522797A5 (OSRAM) | ||
| JP2005508292A5 (OSRAM) | ||
| JP2003529597A5 (OSRAM) | ||
| JP2003522741A5 (OSRAM) | ||
| JP2003518022A5 (OSRAM) | ||
| JPS62212354A (ja) | 環状中間体を用いたフエノ−ルエ−テルの製法 | |
| JP2003529598A5 (OSRAM) | ||
| JP2005508858A5 (OSRAM) | ||
| RU2005111983A (ru) | Производные 4-(фенил-пиперазинил-метил)бензамида и их применение для лечения боли или желудочно-кишечных расстройств | |
| JP2008510719A5 (OSRAM) | ||
| RU2005121491A (ru) | Производные диарилметилиденпиперидина, их препараты и их применение |