JP2005508292A5 - - Google Patents
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- Publication number
- JP2005508292A5 JP2005508292A5 JP2002591459A JP2002591459A JP2005508292A5 JP 2005508292 A5 JP2005508292 A5 JP 2005508292A5 JP 2002591459 A JP2002591459 A JP 2002591459A JP 2002591459 A JP2002591459 A JP 2002591459A JP 2005508292 A5 JP2005508292 A5 JP 2005508292A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- ylidene
- benzamide
- diisopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 3
- -1 CF 3 Chemical group 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical group NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims 1
- LVVTUSIQQJFKSG-UHFFFAOYSA-N 4-[(3-aminophenyl)-(1-benzylpiperidin-4-ylidene)methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2C=CC=CC=2)CC1 LVVTUSIQQJFKSG-UHFFFAOYSA-N 0.000 claims 1
- FCUFYGZDXREGDR-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(1,3-thiazol-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2SC=CN=2)CC1 FCUFYGZDXREGDR-UHFFFAOYSA-N 0.000 claims 1
- GWCOLJIAYSEBGJ-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(1h-imidazol-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2NC=CN=2)CC1 GWCOLJIAYSEBGJ-UHFFFAOYSA-N 0.000 claims 1
- XKUWGEDGGUNCNC-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(1h-imidazol-5-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2N=CNC=2)CC1 XKUWGEDGGUNCNC-UHFFFAOYSA-N 0.000 claims 1
- SGFBRVPPNLSBRR-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(furan-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2OC=CC=2)CC1 SGFBRVPPNLSBRR-UHFFFAOYSA-N 0.000 claims 1
- GPVPMCJYERJRDS-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(furan-3-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC2=COC=C2)CC1 GPVPMCJYERJRDS-UHFFFAOYSA-N 0.000 claims 1
- HTALEWNNFQJXAO-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(pyridin-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2N=CC=CC=2)CC1 HTALEWNNFQJXAO-UHFFFAOYSA-N 0.000 claims 1
- NCHDOXABXNSRNY-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(pyridin-4-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2C=CN=CC=2)CC1 NCHDOXABXNSRNY-UHFFFAOYSA-N 0.000 claims 1
- UJYDPHJVZYKMHX-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(thiophen-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2SC=CC=2)CC1 UJYDPHJVZYKMHX-UHFFFAOYSA-N 0.000 claims 1
- RLGLXNCCLQIKDA-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(thiophen-3-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC2=CSC=C2)CC1 RLGLXNCCLQIKDA-UHFFFAOYSA-N 0.000 claims 1
- JWPQNSOKCGQNRI-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-[(4-bromophenyl)methyl]piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2C=CC(Br)=CC=2)CC1 JWPQNSOKCGQNRI-UHFFFAOYSA-N 0.000 claims 1
- UNQIZPYSMSJZNH-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-[(4-methoxyphenyl)methyl]piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(OC)=CC=C1CN(CC1)CCC1=C(C=1C=C(N)C=CC=1)C1=CC=C(C(=O)N(C(C)C)C(C)C)C=C1 UNQIZPYSMSJZNH-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- JMZFEHDNIAQMNB-UHFFFAOYSA-N m-aminophenylboronic acid Chemical compound NC1=CC=CC(B(O)O)=C1 JMZFEHDNIAQMNB-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101766A SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| PCT/SE2002/000954 WO2002094786A1 (en) | 2001-05-18 | 2002-05-16 | 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508292A JP2005508292A (ja) | 2005-03-31 |
| JP2005508292A5 true JP2005508292A5 (OSRAM) | 2005-12-22 |
Family
ID=20284169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591459A Pending JP2005508292A (ja) | 2001-05-18 | 2002-05-16 | ４−（フェニル−ピペリジン−４−イリデン−メチル）−ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7022715B2 (OSRAM) |
| EP (1) | EP1395559A1 (OSRAM) |
| JP (1) | JP2005508292A (OSRAM) |
| KR (1) | KR20040000468A (OSRAM) |
| CN (1) | CN1509271A (OSRAM) |
| AR (1) | AR033755A1 (OSRAM) |
| BG (1) | BG108327A (OSRAM) |
| BR (1) | BR0209677A (OSRAM) |
| CA (1) | CA2446155A1 (OSRAM) |
| CO (1) | CO5540303A2 (OSRAM) |
| CZ (1) | CZ20033086A3 (OSRAM) |
| EE (1) | EE200300527A (OSRAM) |
| HU (1) | HUP0401113A2 (OSRAM) |
| IL (1) | IL158703A0 (OSRAM) |
| IS (1) | IS7027A (OSRAM) |
| MX (1) | MXPA03010443A (OSRAM) |
| NO (1) | NO20035115D0 (OSRAM) |
| PL (1) | PL367214A1 (OSRAM) |
| RU (1) | RU2003131971A (OSRAM) |
| SE (1) | SE0101766D0 (OSRAM) |
| SK (1) | SK13962003A3 (OSRAM) |
| WO (1) | WO2002094786A1 (OSRAM) |
| ZA (1) | ZA200308634B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60230869D1 (de) | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| EP1641757A1 (en) * | 2003-05-16 | 2006-04-05 | AstraZeneca AB | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| HRP20120343T1 (hr) | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) * | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) * | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) * | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| ATE306472T1 (de) | 1997-12-24 | 2005-10-15 | Ortho Mcneil Pharm Inc | (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
| US6552036B2 (en) * | 2000-03-03 | 2003-04-22 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| US6556387B1 (en) * | 2000-03-31 | 2003-04-29 | Seagate Technology Llc | Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly |
| SE0001207D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101766A patent/SE0101766D0/xx unknown
-
2002
- 2002-05-16 SK SK13962003A patent/SK13962003A3/sk unknown
- 2002-05-16 CN CNA028101863A patent/CN1509271A/zh active Pending
- 2002-05-16 AR ARP020101811A patent/AR033755A1/es not_active Application Discontinuation
- 2002-05-16 WO PCT/SE2002/000954 patent/WO2002094786A1/en not_active Ceased
- 2002-05-16 MX MXPA03010443A patent/MXPA03010443A/es unknown
- 2002-05-16 KR KR10-2003-7014942A patent/KR20040000468A/ko not_active Withdrawn
- 2002-05-16 EP EP02771798A patent/EP1395559A1/en not_active Ceased
- 2002-05-16 HU HU0401113A patent/HUP0401113A2/hu unknown
- 2002-05-16 CA CA002446155A patent/CA2446155A1/en not_active Abandoned
- 2002-05-16 BR BR0209677-3A patent/BR0209677A/pt not_active Application Discontinuation
- 2002-05-16 RU RU2003131971/04A patent/RU2003131971A/ru not_active Application Discontinuation
- 2002-05-16 IL IL15870302A patent/IL158703A0/xx unknown
- 2002-05-16 CZ CZ20033086A patent/CZ20033086A3/cs unknown
- 2002-05-16 JP JP2002591459A patent/JP2005508292A/ja active Pending
- 2002-05-16 EE EEP200300527A patent/EE200300527A/xx unknown
- 2002-05-16 PL PL02367214A patent/PL367214A1/xx not_active Application Discontinuation
- 2002-05-16 US US10/477,851 patent/US7022715B2/en not_active Expired - Fee Related
-
2003
- 2003-11-05 ZA ZA200308634A patent/ZA200308634B/en unknown
- 2003-11-07 BG BG108327A patent/BG108327A/bg unknown
- 2003-11-11 IS IS7027A patent/IS7027A/is unknown
- 2003-11-12 CO CO03100159A patent/CO5540303A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035115A patent/NO20035115D0/no not_active Application Discontinuation
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