ZA200308634B - 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders. - Google Patents
4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders. Download PDFInfo
- Publication number
- ZA200308634B ZA200308634B ZA200308634A ZA200308634A ZA200308634B ZA 200308634 B ZA200308634 B ZA 200308634B ZA 200308634 A ZA200308634 A ZA 200308634A ZA 200308634 A ZA200308634 A ZA 200308634A ZA 200308634 B ZA200308634 B ZA 200308634B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- methyl
- ylidene
- piperidin
- benzamide
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title claims description 9
- 230000036407 pain Effects 0.000 title claims description 9
- 208000019901 Anxiety disease Diseases 0.000 title claims description 7
- 230000036506 anxiety Effects 0.000 title claims description 7
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims description 6
- TZKLMPPHEAGFJR-UHFFFAOYSA-N 4-[phenyl(piperidin-4-ylidene)methyl]benzamide Chemical class C1=CC(C(=O)N)=CC=C1C(C=1C=CC=CC=1)=C1CCNCC1 TZKLMPPHEAGFJR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 9
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- 238000000034 method Methods 0.000 claims description 6
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- HTALEWNNFQJXAO-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(pyridin-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2N=CC=CC=2)CC1 HTALEWNNFQJXAO-UHFFFAOYSA-N 0.000 claims 1
- NCHDOXABXNSRNY-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(pyridin-4-ylmethyl)piperidin-4-ylidene]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2C=CN=CC=2)CC1 NCHDOXABXNSRNY-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101766A SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200308634B true ZA200308634B (en) | 2005-05-25 |
Family
ID=20284169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200308634A ZA200308634B (en) | 2001-05-18 | 2003-11-05 | 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7022715B2 (OSRAM) |
| EP (1) | EP1395559A1 (OSRAM) |
| JP (1) | JP2005508292A (OSRAM) |
| KR (1) | KR20040000468A (OSRAM) |
| CN (1) | CN1509271A (OSRAM) |
| AR (1) | AR033755A1 (OSRAM) |
| BG (1) | BG108327A (OSRAM) |
| BR (1) | BR0209677A (OSRAM) |
| CA (1) | CA2446155A1 (OSRAM) |
| CO (1) | CO5540303A2 (OSRAM) |
| CZ (1) | CZ20033086A3 (OSRAM) |
| EE (1) | EE200300527A (OSRAM) |
| HU (1) | HUP0401113A2 (OSRAM) |
| IL (1) | IL158703A0 (OSRAM) |
| IS (1) | IS7027A (OSRAM) |
| MX (1) | MXPA03010443A (OSRAM) |
| NO (1) | NO20035115D0 (OSRAM) |
| PL (1) | PL367214A1 (OSRAM) |
| RU (1) | RU2003131971A (OSRAM) |
| SE (1) | SE0101766D0 (OSRAM) |
| SK (1) | SK13962003A3 (OSRAM) |
| WO (1) | WO2002094786A1 (OSRAM) |
| ZA (1) | ZA200308634B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7229994B2 (en) | 2001-05-18 | 2007-06-12 | Astrazeneca Ab | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| US20070099957A1 (en) * | 2003-05-16 | 2007-05-03 | Astra Zeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| AU2004278414B2 (en) | 2003-10-01 | 2012-05-24 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) * | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) * | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) * | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| DK1049676T3 (da) | 1997-12-24 | 2006-01-16 | Ortho Mcneil Pharm Inc | 4-[Aryl(piperidin-4-yl)]aminobenzamider, som binder til delta-opioidreceptoren |
| US6552036B2 (en) * | 2000-03-03 | 2003-04-22 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| US6556387B1 (en) * | 2000-03-31 | 2003-04-29 | Seagate Technology Llc | Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly |
| SE0001207D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101766A patent/SE0101766D0/xx unknown
-
2002
- 2002-05-16 JP JP2002591459A patent/JP2005508292A/ja active Pending
- 2002-05-16 MX MXPA03010443A patent/MXPA03010443A/es unknown
- 2002-05-16 SK SK13962003A patent/SK13962003A3/sk unknown
- 2002-05-16 PL PL02367214A patent/PL367214A1/xx not_active Application Discontinuation
- 2002-05-16 RU RU2003131971/04A patent/RU2003131971A/ru not_active Application Discontinuation
- 2002-05-16 KR KR10-2003-7014942A patent/KR20040000468A/ko not_active Withdrawn
- 2002-05-16 CZ CZ20033086A patent/CZ20033086A3/cs unknown
- 2002-05-16 EE EEP200300527A patent/EE200300527A/xx unknown
- 2002-05-16 CN CNA028101863A patent/CN1509271A/zh active Pending
- 2002-05-16 WO PCT/SE2002/000954 patent/WO2002094786A1/en not_active Ceased
- 2002-05-16 BR BR0209677-3A patent/BR0209677A/pt not_active Application Discontinuation
- 2002-05-16 EP EP02771798A patent/EP1395559A1/en not_active Ceased
- 2002-05-16 HU HU0401113A patent/HUP0401113A2/hu unknown
- 2002-05-16 IL IL15870302A patent/IL158703A0/xx unknown
- 2002-05-16 CA CA002446155A patent/CA2446155A1/en not_active Abandoned
- 2002-05-16 US US10/477,851 patent/US7022715B2/en not_active Expired - Fee Related
- 2002-05-16 AR ARP020101811A patent/AR033755A1/es not_active Application Discontinuation
-
2003
- 2003-11-05 ZA ZA200308634A patent/ZA200308634B/en unknown
- 2003-11-07 BG BG108327A patent/BG108327A/bg unknown
- 2003-11-11 IS IS7027A patent/IS7027A/is unknown
- 2003-11-12 CO CO03100159A patent/CO5540303A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035115A patent/NO20035115D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5540303A2 (es) | 2005-07-29 |
| WO2002094786A1 (en) | 2002-11-28 |
| NO20035115D0 (no) | 2003-11-17 |
| IS7027A (is) | 2003-11-11 |
| SK13962003A3 (en) | 2004-10-05 |
| EE200300527A (et) | 2004-02-16 |
| KR20040000468A (ko) | 2004-01-03 |
| SE0101766D0 (sv) | 2001-05-18 |
| EP1395559A1 (en) | 2004-03-10 |
| CA2446155A1 (en) | 2002-11-28 |
| IL158703A0 (en) | 2004-05-12 |
| US7022715B2 (en) | 2006-04-04 |
| CZ20033086A3 (cs) | 2004-05-12 |
| MXPA03010443A (es) | 2004-03-09 |
| HUP0401113A2 (hu) | 2004-09-28 |
| JP2005508292A (ja) | 2005-03-31 |
| BR0209677A (pt) | 2004-07-27 |
| CN1509271A (zh) | 2004-06-30 |
| PL367214A1 (en) | 2005-02-21 |
| AR033755A1 (es) | 2004-01-07 |
| BG108327A (bg) | 2004-12-30 |
| RU2003131971A (ru) | 2005-05-10 |
| US20040147556A1 (en) | 2004-07-29 |
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