JP2005505583A5 - - Google Patents
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- Publication number
- JP2005505583A5 JP2005505583A5 JP2003532465A JP2003532465A JP2005505583A5 JP 2005505583 A5 JP2005505583 A5 JP 2005505583A5 JP 2003532465 A JP2003532465 A JP 2003532465A JP 2003532465 A JP2003532465 A JP 2003532465A JP 2005505583 A5 JP2005505583 A5 JP 2005505583A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- carbamoylphenyl
- ylidene
- benzamide
- diethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- -1 CF 3 Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 208000020431 spinal cord injury Diseases 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- OHVDEDNAKONCCN-UHFFFAOYSA-N 3-[[4-(diethylcarbamoyl)phenyl]-piperidin-4-ylidenemethyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(C=CC=1)C(N)=O)=C1CCNCC1 OHVDEDNAKONCCN-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000016702 sympathetic nervous system disease Diseases 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0103313A SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Novel compounds |
| PCT/SE2002/001804 WO2003029215A1 (en) | 2001-10-03 | 2002-10-02 | 4[piperidin-4-yliden-(3-carbamoylphenyl)methyl] benzamide derivatives and their use for the treatment of pain, spinal injuries or gastrointestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505583A JP2005505583A (ja) | 2005-02-24 |
| JP2005505583A5 true JP2005505583A5 (OSRAM) | 2006-01-05 |
Family
ID=20285553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532465A Abandoned JP2005505583A (ja) | 2001-10-03 | 2002-10-02 | ４［ピペリジン−４−イリデン−（３−カルバモイルフェニル）メチル］ベンズアミド誘導体、および疼痛、脊髄損傷または胃腸疾患の治療のためのその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7205317B2 (OSRAM) |
| EP (1) | EP1440060A1 (OSRAM) |
| JP (1) | JP2005505583A (OSRAM) |
| KR (1) | KR20040039469A (OSRAM) |
| CN (1) | CN1692100A (OSRAM) |
| AR (1) | AR036649A1 (OSRAM) |
| BR (1) | BR0212959A (OSRAM) |
| CA (1) | CA2460168A1 (OSRAM) |
| CO (1) | CO5580822A2 (OSRAM) |
| HU (1) | HUP0401915A2 (OSRAM) |
| IL (1) | IL160889A0 (OSRAM) |
| IS (1) | IS7203A (OSRAM) |
| MX (1) | MXPA04003056A (OSRAM) |
| NO (1) | NO20041964L (OSRAM) |
| PL (1) | PL368804A1 (OSRAM) |
| RU (1) | RU2004107854A (OSRAM) |
| SE (1) | SE0103313D0 (OSRAM) |
| WO (1) | WO2003029215A1 (OSRAM) |
| ZA (1) | ZA200402514B (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60230869D1 (de) | 2001-05-18 | 2009-03-05 | Astrazeneca Ab | 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| EP1572029B1 (en) | 2002-11-07 | 2010-03-24 | Abbott Laboratories | Method of loading beneficial agent to a prosthesis by fluid-jet application |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| EP1641757A1 (en) * | 2003-05-16 | 2006-04-05 | AstraZeneca AB | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| WO2005003131A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| JP4949227B2 (ja) | 2004-03-19 | 2012-06-06 | アボット・ラボラトリーズ | バルーンおよびプロテーゼからの多剤送達 |
| US20100030183A1 (en) | 2004-03-19 | 2010-02-04 | Toner John L | Method of treating vascular disease at a bifurcated vessel using a coated balloon |
| HRP20120343T1 (hr) | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| AU2007294968A1 (en) | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
| PT3233825T (pt) * | 2014-12-19 | 2020-07-15 | Pharmnovo Ab | Derivados de diarilmetilideno-piperidina e sua utilização como agonistas do recetor opioide delta |
| WO2016099394A1 (en) * | 2014-12-19 | 2016-06-23 | Pharmnovo Ab | Novel selective delta-opioid receptor agonists useful for the treatment of pain, anxiety and depression. |
| JP2023533874A (ja) * | 2020-07-17 | 2023-08-04 | ファームノヴォ エービー | Ｐｎ６０４７の塩酸塩の多形体 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| ATE306472T1 (de) | 1997-12-24 | 2005-10-15 | Ortho Mcneil Pharm Inc | (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
| SE0001207D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-10-03 SE SE0103313A patent/SE0103313D0/xx unknown
-
2002
- 2002-09-27 AR ARP020103670A patent/AR036649A1/es unknown
- 2002-10-02 CA CA002460168A patent/CA2460168A1/en not_active Abandoned
- 2002-10-02 HU HU0401915A patent/HUP0401915A2/hu unknown
- 2002-10-02 CN CNA028195825A patent/CN1692100A/zh active Pending
- 2002-10-02 PL PL02368804A patent/PL368804A1/xx not_active Application Discontinuation
- 2002-10-02 KR KR10-2004-7004780A patent/KR20040039469A/ko not_active Withdrawn
- 2002-10-02 WO PCT/SE2002/001804 patent/WO2003029215A1/en not_active Ceased
- 2002-10-02 MX MXPA04003056A patent/MXPA04003056A/es unknown
- 2002-10-02 RU RU2004107854/04A patent/RU2004107854A/ru not_active Application Discontinuation
- 2002-10-02 IL IL16088902A patent/IL160889A0/xx unknown
- 2002-10-02 EP EP02775640A patent/EP1440060A1/en not_active Withdrawn
- 2002-10-02 JP JP2003532465A patent/JP2005505583A/ja not_active Abandoned
- 2002-10-02 US US10/491,263 patent/US7205317B2/en not_active Expired - Fee Related
- 2002-10-02 BR BR0212959-0A patent/BR0212959A/pt not_active Application Discontinuation
-
2004
- 2004-03-30 ZA ZA200402514A patent/ZA200402514B/xx unknown
- 2004-03-31 IS IS7203A patent/IS7203A/is unknown
- 2004-03-31 CO CO04030712A patent/CO5580822A2/es not_active Application Discontinuation
- 2004-04-27 NO NO20041964A patent/NO20041964L/no not_active Application Discontinuation
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