JP2011524362A5 - - Google Patents
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- Publication number
- JP2011524362A5 JP2011524362A5 JP2011513674A JP2011513674A JP2011524362A5 JP 2011524362 A5 JP2011524362 A5 JP 2011524362A5 JP 2011513674 A JP2011513674 A JP 2011513674A JP 2011513674 A JP2011513674 A JP 2011513674A JP 2011524362 A5 JP2011524362 A5 JP 2011524362A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- halo
- neurofibromatosis
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000001475 halogen functional group Chemical group 0.000 claims 14
- 208000009905 Neurofibromatoses Diseases 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 201000004931 neurofibromatosis Diseases 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 208000013355 benign neoplasm of brain Diseases 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 208000004378 Choroid plexus papilloma Diseases 0.000 claims 3
- 208000009798 Craniopharyngioma Diseases 0.000 claims 3
- 201000002222 hemangioblastoma Diseases 0.000 claims 3
- 206010027191 meningioma Diseases 0.000 claims 3
- 208000007538 neurilemmoma Diseases 0.000 claims 3
- 210000004560 pineal gland Anatomy 0.000 claims 3
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 3
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6115608P | 2008-06-13 | 2008-06-13 | |
| US61/061,156 | 2008-06-13 | ||
| PCT/US2009/046971 WO2009152288A1 (en) | 2008-06-13 | 2009-06-11 | Substituted benzimidazoles for neurofibromatosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011524362A JP2011524362A (ja) | 2011-09-01 |
| JP2011524362A5 true JP2011524362A5 (OSRAM) | 2012-07-26 |
Family
ID=40956523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513674A Withdrawn JP2011524362A (ja) | 2008-06-13 | 2009-06-11 | 神経線維腫症用の置換ベンゾイミダゾール |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110092546A1 (OSRAM) |
| EP (1) | EP2288354A1 (OSRAM) |
| JP (1) | JP2011524362A (OSRAM) |
| KR (1) | KR20110025827A (OSRAM) |
| CN (1) | CN102065859B (OSRAM) |
| AU (1) | AU2009257487B2 (OSRAM) |
| BR (1) | BRPI0915106A2 (OSRAM) |
| CA (1) | CA2726376A1 (OSRAM) |
| MX (1) | MX2010013683A (OSRAM) |
| RU (1) | RU2011100106A (OSRAM) |
| TW (1) | TW201004621A (OSRAM) |
| WO (1) | WO2009152288A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2668210T3 (da) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
| CN110256559B (zh) | 2012-07-25 | 2023-05-26 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
| CN113908269A (zh) | 2014-05-23 | 2022-01-11 | 塞尔德克斯医疗公司 | 嗜酸性粒细胞或肥大细胞相关病症的治疗 |
| KR101880015B1 (ko) | 2017-12-08 | 2018-07-19 | 아주대학교산학협력단 | 인터페론 감마를 유효성분으로 함유하는 신경섬유육종 예방 또는 치료용 조성물 |
| CA3126021A1 (en) | 2019-01-11 | 2020-07-16 | Naegis Pharmaceuticals Inc. | Leukotriene synthesis inhibitors |
| CN117460509B (zh) * | 2021-06-23 | 2025-03-28 | 正大天晴药业集团股份有限公司 | 作为c-Met激酶抑制剂的化合物治疗I型神经纤维瘤病的用途 |
| JP2024534693A (ja) * | 2021-10-08 | 2024-09-20 | ウニベルシテ クロード ベルナール リヨン １ | 組織球症若しくは頭蓋咽頭腫の治療又は予防における使用のためのベンズイミダゾール誘導体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE447404T1 (de) * | 2002-03-29 | 2009-11-15 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
| WO2009018238A1 (en) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof |
| TWI387592B (zh) * | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
| GB0609378D0 (en) * | 2006-05-11 | 2006-06-21 | Novartis Ag | Organic compounds |
| PE20080766A1 (es) * | 2006-08-30 | 2008-06-15 | Novartis Ag | Sales de benzimidazolil piridil eteres y formulaciones que las contienen |
| WO2008070616A2 (en) * | 2006-12-01 | 2008-06-12 | University Of Utah Research Foundation | METHODS AND COMPOSITIONS RELATED TO HIF-1α |
| WO2009114703A2 (en) * | 2008-03-12 | 2009-09-17 | Fox Chase Cancer Center | Combination therapy for the treatment of cancer |
-
2009
- 2009-06-11 AU AU2009257487A patent/AU2009257487B2/en not_active Ceased
- 2009-06-11 US US12/997,770 patent/US20110092546A1/en not_active Abandoned
- 2009-06-11 EP EP09763578A patent/EP2288354A1/en not_active Ceased
- 2009-06-11 WO PCT/US2009/046971 patent/WO2009152288A1/en not_active Ceased
- 2009-06-11 RU RU2011100106/15A patent/RU2011100106A/ru not_active Application Discontinuation
- 2009-06-11 MX MX2010013683A patent/MX2010013683A/es not_active Application Discontinuation
- 2009-06-11 CA CA2726376A patent/CA2726376A1/en not_active Abandoned
- 2009-06-11 JP JP2011513674A patent/JP2011524362A/ja not_active Withdrawn
- 2009-06-11 CN CN2009801221827A patent/CN102065859B/zh not_active Expired - Fee Related
- 2009-06-11 BR BRPI0915106A patent/BRPI0915106A2/pt not_active IP Right Cessation
- 2009-06-11 KR KR1020117000776A patent/KR20110025827A/ko not_active Withdrawn
- 2009-06-12 TW TW098119822A patent/TW201004621A/zh unknown
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