JP2017505293A5 - - Google Patents
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- Publication number
- JP2017505293A5 JP2017505293A5 JP2016541177A JP2016541177A JP2017505293A5 JP 2017505293 A5 JP2017505293 A5 JP 2017505293A5 JP 2016541177 A JP2016541177 A JP 2016541177A JP 2016541177 A JP2016541177 A JP 2016541177A JP 2017505293 A5 JP2017505293 A5 JP 2017505293A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- amino
- butanoic acid
- tetrazol
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 31
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 125000005843 halogen group Chemical group 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
- 125000005842 heteroatom Chemical group 0.000 claims description 10
- 150000002367 halogens Chemical group 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims description 5
- 125000002950 monocyclic group Chemical group 0.000 claims description 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 4
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 101000619898 Homo sapiens Leukotriene A-4 hydrolase Proteins 0.000 claims description 3
- 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- AJYSLYWMYBDWJJ-CYBMUJFWSA-N (3R)-3-amino-4-[3-[4-(4-chlorophenoxy)phenyl]-1,2,4-oxadiazol-5-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CC1=NC(=NO1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl AJYSLYWMYBDWJJ-CYBMUJFWSA-N 0.000 claims description 2
- VBELOCUBMPPWLD-CYBMUJFWSA-N (3R)-3-amino-4-[5-(3-phenoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(O)=O)Cn1nnc(n1)-c1cccc(Oc2ccccc2)c1 VBELOCUBMPPWLD-CYBMUJFWSA-N 0.000 claims description 2
- XBZMWHJDOWZNMN-OAHLLOKOSA-N (3R)-3-amino-4-[5-(3-phenylmethoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OCC1=CC=CC=C1 XBZMWHJDOWZNMN-OAHLLOKOSA-N 0.000 claims description 2
- RGMVLBIPDAEPCG-GFCCVEGCSA-N (3R)-3-amino-4-[5-(4-butoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OCCCC RGMVLBIPDAEPCG-GFCCVEGCSA-N 0.000 claims description 2
- UBJBMJVCOROOEO-CYBMUJFWSA-N (3R)-3-amino-4-[5-(4-pentoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OCCCCC UBJBMJVCOROOEO-CYBMUJFWSA-N 0.000 claims description 2
- FLTRUVRXQVPFKZ-OAHLLOKOSA-N (3R)-3-amino-4-[5-(4-phenylmethoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OCC1=CC=CC=C1 FLTRUVRXQVPFKZ-OAHLLOKOSA-N 0.000 claims description 2
- WVQUADUONXDXFD-GFCCVEGCSA-N (3R)-3-amino-4-[5-[3-(1,3-benzothiazol-2-yloxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC=1SC2=C(N=1)C=CC=C2 WVQUADUONXDXFD-GFCCVEGCSA-N 0.000 claims description 2
- WSYHVXHEKZGHQY-CYBMUJFWSA-N (3R)-3-amino-4-[5-[3-(3,5-difluorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=CC(=CC(=C1)F)F WSYHVXHEKZGHQY-CYBMUJFWSA-N 0.000 claims description 2
- WAUSGRYCAMLOIZ-GFCCVEGCSA-N (3R)-3-amino-4-[5-[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=NC=C(C=C1)C(F)(F)F WAUSGRYCAMLOIZ-GFCCVEGCSA-N 0.000 claims description 2
- WOCAXANSPDAXAZ-GFCCVEGCSA-N (3R)-3-amino-4-[5-[4-(1,3-benzothiazol-2-yloxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC=1SC2=C(N=1)C=CC=C2 WOCAXANSPDAXAZ-GFCCVEGCSA-N 0.000 claims description 2
- SMOJYQNGBVHPTC-LLVKDONJSA-N (3R)-3-amino-4-[5-[4-(3-chloro-4-fluorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC(=C(C=C1)F)Cl SMOJYQNGBVHPTC-LLVKDONJSA-N 0.000 claims description 2
- DXKOUSSDXQOMCK-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-chlorophenoxy)phenyl]-1,3,4-oxadiazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CC=1OC(=NN=1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl DXKOUSSDXQOMCK-CYBMUJFWSA-N 0.000 claims description 2
- VSQILWJHLPJYGP-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-chlorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl VSQILWJHLPJYGP-CYBMUJFWSA-N 0.000 claims description 2
- UYFSPUCKNPJDAQ-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-fluorophenoxy)phenyl]-1,3,4-oxadiazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CC=1OC(=NN=1)C1=CC=C(C=C1)OC1=CC=C(C=C1)F UYFSPUCKNPJDAQ-CYBMUJFWSA-N 0.000 claims description 2
- FOCXWYINTPLCHG-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-fluorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)F FOCXWYINTPLCHG-CYBMUJFWSA-N 0.000 claims description 2
- LPZGCTYDLGGZAA-CQSZACIVSA-N (3R)-3-amino-4-[5-[4-(4-methylphenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)C LPZGCTYDLGGZAA-CQSZACIVSA-N 0.000 claims description 2
- ZEGMEJVULDALSH-LLVKDONJSA-N (3R)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1F)Cl ZEGMEJVULDALSH-LLVKDONJSA-N 0.000 claims description 2
- SGMMCFXAIWSCKS-GFCCVEGCSA-N (3R)-3-amino-4-[5-[4-(5-chloropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1)Cl SGMMCFXAIWSCKS-GFCCVEGCSA-N 0.000 claims description 2
- JVHCOXOIUBKBEW-OAHLLOKOSA-N (3R)-3-amino-4-[5-[4-[4-(1,3-oxazol-2-yl)phenoxy]phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)C=1OC=CN=1 JVHCOXOIUBKBEW-OAHLLOKOSA-N 0.000 claims description 2
- QKWKGNNRYDXRSQ-GFCCVEGCSA-N (3R)-3-amino-4-[5-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1)C(F)(F)F QKWKGNNRYDXRSQ-GFCCVEGCSA-N 0.000 claims description 2
- QGUBGJLWZLQAET-INIZCTEOSA-N (3S)-3-amino-4-[4-[4-(4-chlorophenoxy)phenyl]pyrazol-1-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=CC(=C1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl QGUBGJLWZLQAET-INIZCTEOSA-N 0.000 claims description 2
- VBELOCUBMPPWLD-ZDUSSCGKSA-N (3S)-3-amino-4-[5-(3-phenoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=CC=CC=C1 VBELOCUBMPPWLD-ZDUSSCGKSA-N 0.000 claims description 2
- WOCAXANSPDAXAZ-LBPRGKRZSA-N (3S)-3-amino-4-[5-[4-(1,3-benzothiazol-2-yloxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC=1SC2=C(N=1)C=CC=C2 WOCAXANSPDAXAZ-LBPRGKRZSA-N 0.000 claims description 2
- LPZGCTYDLGGZAA-AWEZNQCLSA-N (3S)-3-amino-4-[5-[4-(4-methylphenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)C LPZGCTYDLGGZAA-AWEZNQCLSA-N 0.000 claims description 2
- VSQILWJHLPJYGP-ZDUSSCGKSA-N (3s)-3-amino-4-[5-[4-(4-chlorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound OC(=O)C[C@H](N)CN1N=NC(C=2C=CC(OC=3C=CC(Cl)=CC=3)=CC=2)=N1 VSQILWJHLPJYGP-ZDUSSCGKSA-N 0.000 claims description 2
- YAZLIBDHESBJAD-CYBMUJFWSA-N N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=CC=C1 Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=CC=C1 YAZLIBDHESBJAD-CYBMUJFWSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- GRPSEETXRKKMSI-CYBMUJFWSA-N (3R)-3-amino-4-[5-[3-(4-chlorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=CC=C(C=C1)Cl GRPSEETXRKKMSI-CYBMUJFWSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000000203 mixture Substances 0.000 description 2
- ZEGMEJVULDALSH-NSHDSACASA-N (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1F)Cl ZEGMEJVULDALSH-NSHDSACASA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199138.2 | 2013-12-20 | ||
| EP13199138 | 2013-12-20 | ||
| EP14181155.4 | 2014-08-15 | ||
| EP14181155 | 2014-08-15 | ||
| PCT/IB2014/067086 WO2015092740A1 (en) | 2013-12-20 | 2014-12-18 | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505293A JP2017505293A (ja) | 2017-02-16 |
| JP2017505293A5 true JP2017505293A5 (OSRAM) | 2017-12-28 |
| JP6500024B2 JP6500024B2 (ja) | 2019-04-10 |
Family
ID=52434892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541177A Active JP6500024B2 (ja) | 2013-12-20 | 2014-12-18 | Ｌｔａ４ｈ阻害剤としてのヘテロアリールブタン酸誘導体 |
Country Status (38)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016008247A (es) | 2013-12-20 | 2016-10-21 | Novartis Ag | Derivados de acido heteroaril butanoico como inhibidores de lta4h. |
| WO2017175185A1 (en) | 2016-04-08 | 2017-10-12 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
| CN112469439A (zh) | 2018-05-15 | 2021-03-09 | 万能溶剂有限公司 | 用白三烯a4水解酶调节剂治疗衰老相关性疾病 |
| CN112424207B (zh) | 2018-07-25 | 2024-03-19 | 诺华股份有限公司 | Nlrp3炎性小体抑制剂 |
| KR102858471B1 (ko) * | 2018-07-31 | 2025-09-12 | 노파르티스 아게 | Lta4h 저해제의 결정질 형태 |
| WO2020095983A1 (ja) * | 2018-11-07 | 2020-05-14 | 中外製薬株式会社 | Ｏ－置換セリン誘導体の製造方法 |
| EP3908279B1 (en) * | 2019-01-11 | 2024-08-28 | Novartis AG | Lta4h inhibitor for the treatment or prevention of hidradenitis suppurativa |
| US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
| UY38687A (es) | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| WO2021044351A1 (en) | 2019-09-06 | 2021-03-11 | Novartis Ag | Methods of treating liver disease using lta4h inhibitors |
| KR20230051227A (ko) | 2020-08-14 | 2023-04-17 | 노파르티스 아게 | 헤테로아릴 치환된 스피로피페리디닐 유도체 및 이의 제약 용도 |
| US11932630B2 (en) * | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
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| MX2016008247A (es) | 2013-12-20 | 2016-10-21 | Novartis Ag | Derivados de acido heteroaril butanoico como inhibidores de lta4h. |
-
2014
- 2014-12-18 MX MX2016008247A patent/MX2016008247A/es active IP Right Grant
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