CL2016001255A1 - Compuestos heteroarilo derivados de 3-amino-(fenil(tetrazol, pirazol, oxadiazol))- butanoico, inhibidores de lta4h, composicion farmaceutica; combinación farmaceutica; utiles en enfermedades como alergia, enfermedades pulmonares, fibroticas, inflamatorias, cardiovasculares, entre otras - Google Patents

Compuestos heteroarilo derivados de 3-amino-(fenil(tetrazol, pirazol, oxadiazol))- butanoico, inhibidores de lta4h, composicion farmaceutica; combinación farmaceutica; utiles en enfermedades como alergia, enfermedades pulmonares, fibroticas, inflamatorias, cardiovasculares, entre otras

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Publication number
CL2016001255A1
CL2016001255A1 CL2016001255A CL2016001255A CL2016001255A1 CL 2016001255 A1 CL2016001255 A1 CL 2016001255A1 CL 2016001255 A CL2016001255 A CL 2016001255A CL 2016001255 A CL2016001255 A CL 2016001255A CL 2016001255 A1 CL2016001255 A1 CL 2016001255A1
Authority
CL
Chile
Prior art keywords
diseases
tetrazol
fibrotic
oxadiazole
allergy
Prior art date
Application number
CL2016001255A
Other languages
English (en)
Spanish (es)
Inventor
Bollbuck Birgit
Markert Christian
Miltz Wofgang
Roehn Till
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2016001255A1 publication Critical patent/CL2016001255A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C—CHEMISTRY; METALLURGY
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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CL2016001255A 2013-12-20 2016-05-24 Compuestos heteroarilo derivados de 3-amino-(fenil(tetrazol, pirazol, oxadiazol))- butanoico, inhibidores de lta4h, composicion farmaceutica; combinación farmaceutica; utiles en enfermedades como alergia, enfermedades pulmonares, fibroticas, inflamatorias, cardiovasculares, entre otras CL2016001255A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13199138 2013-12-20
EP14181155 2014-08-15

Publications (1)

Publication Number Publication Date
CL2016001255A1 true CL2016001255A1 (es) 2016-11-18

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CL2016001255A CL2016001255A1 (es) 2013-12-20 2016-05-24 Compuestos heteroarilo derivados de 3-amino-(fenil(tetrazol, pirazol, oxadiazol))- butanoico, inhibidores de lta4h, composicion farmaceutica; combinación farmaceutica; utiles en enfermedades como alergia, enfermedades pulmonares, fibroticas, inflamatorias, cardiovasculares, entre otras

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US (4) US9981926B2 (OSRAM)
EP (1) EP3083564B1 (OSRAM)
JP (1) JP6500024B2 (OSRAM)
KR (2) KR102368958B1 (OSRAM)
CN (1) CN105829286B (OSRAM)
AP (1) AP2016009301A0 (OSRAM)
AU (1) AU2014369180B2 (OSRAM)
BR (1) BR112016011170B1 (OSRAM)
CA (1) CA2927564C (OSRAM)
CL (1) CL2016001255A1 (OSRAM)
CR (1) CR20160279A (OSRAM)
CU (1) CU24360B1 (OSRAM)
CY (1) CY1120715T1 (OSRAM)
DK (1) DK3083564T3 (OSRAM)
EA (1) EA034436B1 (OSRAM)
EC (1) ECSP16062173A (OSRAM)
ES (1) ES2690790T3 (OSRAM)
GT (1) GT201600132A (OSRAM)
HR (1) HRP20181506T1 (OSRAM)
HU (1) HUE039615T2 (OSRAM)
IL (1) IL245011B (OSRAM)
LT (1) LT3083564T (OSRAM)
MX (1) MX2016008247A (OSRAM)
MY (1) MY180165A (OSRAM)
NZ (1) NZ719169A (OSRAM)
PE (1) PE20160899A1 (OSRAM)
PH (1) PH12016500814B1 (OSRAM)
PL (1) PL3083564T3 (OSRAM)
PT (1) PT3083564T (OSRAM)
RS (1) RS57642B1 (OSRAM)
SG (1) SG11201602787YA (OSRAM)
SI (1) SI3083564T1 (OSRAM)
SV (1) SV2016005230A (OSRAM)
TN (1) TN2016000127A1 (OSRAM)
UA (1) UA117498C2 (OSRAM)
UY (1) UY36178A (OSRAM)
WO (1) WO2015092740A1 (OSRAM)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11344542B2 (en) 2018-05-15 2022-05-31 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase
US11957671B2 (en) 2021-11-01 2024-04-16 Alkahest, Inc. Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016008247A (es) 2013-12-20 2016-10-21 Novartis Ag Derivados de acido heteroaril butanoico como inhibidores de lta4h.
WO2017175185A1 (en) 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
CN112424207B (zh) 2018-07-25 2024-03-19 诺华股份有限公司 Nlrp3炎性小体抑制剂
KR102858471B1 (ko) * 2018-07-31 2025-09-12 노파르티스 아게 Lta4h 저해제의 결정질 형태
WO2020095983A1 (ja) * 2018-11-07 2020-05-14 中外製薬株式会社 Ｏ－置換セリン誘導体の製造方法
EP3908279B1 (en) * 2019-01-11 2024-08-28 Novartis AG Lta4h inhibitor for the treatment or prevention of hidradenitis suppurativa
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
WO2021044351A1 (en) 2019-09-06 2021-03-11 Novartis Ag Methods of treating liver disease using lta4h inhibitors
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