|
DE69841320D1
(de)
|
1997-02-10 |
2010-01-07 |
Harvard College |
Verfahren zur modulation von hämatopoese und vaskulärem wachstum
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
US20040060568A1
(en)
|
2000-10-13 |
2004-04-01 |
Henryk Dudek |
Hedgehog antagonists, methods and uses related thereto
|
|
US7708998B2
(en)
*
|
2000-10-13 |
2010-05-04 |
Curis, Inc. |
Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
|
|
TW200304820A
(en)
*
|
2002-03-25 |
2003-10-16 |
Avanir Pharmaceuticals |
Use of benzimidazole analogs in the treatment of cell proliferation
|
|
NZ536190A
(en)
|
2002-04-17 |
2007-08-31 |
Cytokinetics Inc |
Compounds for treating cellular proliferative diseases by modulating the activity of the mitotic kinesin KSP
|
|
EP1496905B1
(en)
*
|
2002-04-22 |
2008-08-13 |
Johns Hopkins University School of Medicine |
Modulators of hedgehog signaling pathways, compositions and uses related thereto
|
|
DE60326248D1
(de)
|
2002-07-17 |
2009-04-02 |
Cytokinetics Inc |
Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
|
|
TWI276631B
(en)
*
|
2002-09-12 |
2007-03-21 |
Avanir Pharmaceuticals |
Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
|
|
US7132440B2
(en)
|
2003-04-17 |
2006-11-07 |
Janssen Pharmaceutica, N.V. |
Substituted benzimidazoles and imidazo-[4,5]-pyridines
|
|
WO2005030206A1
(en)
*
|
2003-09-24 |
2005-04-07 |
Imclone Systems Incorporated |
Aryl-1,3-azole derivatives and methods for inhibiting heparnase activity
|
|
WO2005097207A2
(en)
|
2004-03-26 |
2005-10-20 |
Curis, Inc. |
Rna interference modulators of hedgehog signaling and uses thereof
|
|
ES2362102T3
(es)
|
2004-06-30 |
2011-06-28 |
Janssen Pharmaceutica Nv |
Eteres de bencimidazol e imidazopiridina sustituidos con arilo como agentes anticáncer.
|
|
ES2377430T3
(es)
|
2004-09-02 |
2012-03-27 |
Genentech, Inc. |
Inhibidores piridílicos de la señalización de hedgehog
|
|
EP1807074B1
(en)
|
2004-11-03 |
2013-10-23 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
EP1853610A1
(en)
*
|
2005-03-03 |
2007-11-14 |
Sirtris Pharmaceuticals, Inc. |
N-phenyl benzamide derivatives as sirtuin modulators
|
|
WO2006094246A2
(en)
*
|
2005-03-03 |
2006-09-08 |
Sirtris Pharmaceuticals, Inc. |
N-arylmethyl benzamide sirtuin modulators
|
|
WO2006124780A2
(en)
*
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
|
|
US8093401B2
(en)
*
|
2005-08-04 |
2012-01-10 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
DK1910384T3
(da)
*
|
2005-08-04 |
2012-12-17 |
Sirtris Pharmaceuticals Inc |
Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser
|
|
US7855289B2
(en)
*
|
2005-08-04 |
2010-12-21 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US8088928B2
(en)
|
2005-08-04 |
2012-01-03 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
CA2628255C
(en)
|
2005-10-31 |
2016-04-19 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
US7625759B2
(en)
*
|
2005-12-19 |
2009-12-01 |
Genentech, Inc. |
Method for using BOC/CDO to modulate hedgehog signaling
|
|
US20080019961A1
(en)
*
|
2006-02-21 |
2008-01-24 |
Regents Of The University Of Michigan |
Hedgehog signaling pathway antagonist cancer treatment
|
|
AU2007243946B2
(en)
|
2006-04-05 |
2012-11-29 |
Curis, Inc. |
Method for using BOC/CDO to modulate hedgehog signaling
|
|
AU2007329678A1
(en)
*
|
2006-10-31 |
2008-06-12 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Smoothened polypeptides and methods of use
|
|
CA2672815A1
(en)
*
|
2006-12-15 |
2008-06-26 |
Pfizer Products Inc. |
Benzimidazole derivatives for use in treating abnormal cell growth
|
|
TWI433674B
(zh)
|
2006-12-28 |
2014-04-11 |
Infinity Discovery Inc |
環杷明(cyclopamine)類似物類
|
|
WO2008092002A2
(en)
|
2007-01-24 |
2008-07-31 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing pancreatic cancer
|
|
CL2008001822A1
(es)
*
|
2007-06-20 |
2009-03-13 |
Sirtris Pharmaceuticals Inc |
Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
|
|
TW200918542A
(en)
|
2007-06-20 |
2009-05-01 |
Sirtris Pharmaceuticals Inc |
Sirtuin modulating compounds
|
|
GEP20125702B
(en)
|
2007-06-29 |
2012-12-10 |
Pfizer |
Benzimidazole derivatives
|
|
WO2009058348A1
(en)
*
|
2007-11-01 |
2009-05-07 |
Sirtris Pharmaceuticals, Inc. |
Amide derivatives as sirtuin modulators
|
|
MX2010005186A
(es)
*
|
2007-11-08 |
2010-05-27 |
Sirtris Pharmaceuticals Inc |
Tiazolopiridinas solubilizadas.
|
|
CA2710858A1
(en)
|
2007-12-27 |
2009-07-09 |
Infinity Pharmaceuticals, Inc. |
Methods for stereoselective reduction
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
FR2930552B1
(fr)
*
|
2008-04-24 |
2012-10-12 |
Centre Nat Rech Scient |
N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog
|
|
WO2010021381A1
(ja)
*
|
2008-08-22 |
2010-02-25 |
武田薬品工業株式会社 |
縮合複素環誘導体およびその用途
|
|
CN102170873B
(zh)
*
|
2008-10-01 |
2014-07-30 |
诺华股份有限公司 |
用于治疗与hedgehog通路有关的病症的smoothened拮抗
|
|
BRPI0922435A2
(pt)
|
2008-12-19 |
2018-09-11 |
Sirtris Pharmaceuticals Inc |
"composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso."
|
|
JP2012529449A
(ja)
*
|
2009-06-11 |
2012-11-22 |
シエナ ビオテク ソシエタ ペル アチオニ |
ヘッジホッグ経路アンタゴニストおよびそれらの治療的応用
|
|
AR077014A1
(es)
*
|
2009-06-19 |
2011-07-27 |
Lilly Co Eli |
Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
|
|
FR2948367A1
(fr)
|
2009-07-24 |
2011-01-28 |
Centre Nat Rech Scient |
Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog
|
|
AU2010279325B2
(en)
|
2009-08-05 |
2016-10-20 |
Infinity Pharmaceuticals, Inc. |
Enzymatic transamination of cyclopamine analogs
|
|
EP3103452A1
(en)
|
2009-08-25 |
2016-12-14 |
Abraxis BioScience, LLC |
Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
|
|
CA2799579A1
(en)
|
2010-05-21 |
2011-11-24 |
Intellikine, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
US9394313B2
(en)
|
2010-09-14 |
2016-07-19 |
Infinity Pharmaceuticals, Inc. |
Transfer hydrogenation of cyclopamine analogs
|
|
JP2013545749A
(ja)
|
2010-11-10 |
2013-12-26 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
複素環化合物及びその使用
|
|
TWI617559B
(zh)
*
|
2010-12-22 |
2018-03-11 |
江蘇恆瑞醫藥股份有限公司 |
2-芳基咪唑并[1,2-b]嗒.2-苯基咪唑并[1,2-a]吡啶,和2-苯基咪唑并[1,2-a]吡衍生物
|
|
US9708299B2
(en)
|
2011-01-03 |
2017-07-18 |
Genentech, Inc. |
Hedgehog antagonists having zinc binding moieties
|
|
ES2637113T3
(es)
|
2011-01-10 |
2017-10-10 |
Infinity Pharmaceuticals, Inc. |
Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
|
|
HK1198443A1
(en)
|
2011-07-19 |
2015-04-24 |
无限药品股份有限公司 |
Heterocyclic compounds and uses thereof
|
|
AR088218A1
(es)
|
2011-07-19 |
2014-05-21 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos utiles como inhibidores de pi3k
|
|
MX2014002542A
(es)
|
2011-08-29 |
2014-07-09 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y usos de los mismos.
|
|
WO2013049332A1
(en)
|
2011-09-29 |
2013-04-04 |
Infinity Pharmaceuticals, Inc. |
Inhibitors of monoacylglycerol lipase and methods of their use
|
|
EP2784152B1
(en)
|
2011-11-25 |
2019-04-10 |
Sumitomo Chemical Company, Limited |
Methods for producing retinal tissue and retina-related cell
|
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
CN103570625A
(zh)
*
|
2012-07-19 |
2014-02-12 |
南京英派药业有限公司 |
N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
|
|
AU2013337717B2
(en)
|
2012-11-01 |
2018-10-25 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using PI3 kinase isoform modulators
|
|
EP2925363A4
(en)
|
2012-11-29 |
2016-11-09 |
Strasspharma Llc |
METHOD FOR MODULATING FOLLICLE-STIMULATING HORMONACTIVITY
|
|
WO2014151729A1
(en)
|
2013-03-15 |
2014-09-25 |
Irm Llc |
Compounds and compositions for the treatment of parasitic diseases
|
|
WO2014151630A2
(en)
*
|
2013-03-15 |
2014-09-25 |
Irm Llc |
Compounds and compositions for the treatment of parasitic diseases
|
|
WO2014151386A1
(en)
|
2013-03-15 |
2014-09-25 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
US9296754B2
(en)
|
2013-03-15 |
2016-03-29 |
Novartis Ag |
Compounds and compositions for the treatment of parasitic diseases
|
|
US9192609B2
(en)
|
2013-04-17 |
2015-11-24 |
Hedgepath Pharmaceuticals, Inc. |
Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
|
|
CA2914284A1
(en)
|
2013-05-30 |
2014-12-04 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
WO2015036405A1
(en)
|
2013-09-10 |
2015-03-19 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating basal cell carcinoma
|
|
US9751888B2
(en)
|
2013-10-04 |
2017-09-05 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
PT3052485T
(pt)
|
2013-10-04 |
2021-10-22 |
Infinity Pharmaceuticals Inc |
Compostos heterocíclicos e suas utilizações
|
|
US20160244452A1
(en)
|
2013-10-21 |
2016-08-25 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
WO2015073691A1
(en)
|
2013-11-14 |
2015-05-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for treating cancer by activation of bmp signaling
|
|
BR112016014004B1
(pt)
|
2013-12-19 |
2022-11-01 |
Novartis Ag |
Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas
|
|
MX382033B
(es)
|
2014-03-19 |
2025-03-13 |
Infinity Pharmaceuticals Inc |
Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
|
|
US20150320754A1
(en)
|
2014-04-16 |
2015-11-12 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
WO2015168079A1
(en)
|
2014-04-29 |
2015-11-05 |
Infinity Pharmaceuticals, Inc. |
Pyrimidine or pyridine derivatives useful as pi3k inhibitors
|
|
CN104151250B
(zh)
*
|
2014-07-22 |
2016-08-31 |
大连理工大学 |
一类含苯并咪唑基团的二芳基酰胺类化合物及其合成和应用
|
|
WO2016054491A1
(en)
|
2014-10-03 |
2016-04-07 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
PL3302428T3
(pl)
|
2015-06-04 |
2026-04-13 |
Sol-Gel Technologies Ltd. |
Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie
|
|
JP6802194B2
(ja)
*
|
2015-06-22 |
2020-12-16 |
アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd |
Nadphオキシダーゼ4阻害剤
|
|
WO2017048702A1
(en)
|
2015-09-14 |
2017-03-23 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
|
WO2017139497A1
(en)
|
2016-02-11 |
2017-08-17 |
PellePharm, Inc. |
Hedgehog inhibitor for use in relief of and treatment of pruritus or itching
|
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
SG11201811237WA
(en)
|
2016-06-24 |
2019-01-30 |
Infinity Pharmaceuticals Inc |
Combination therapies
|
|
US10767164B2
(en)
|
2017-03-30 |
2020-09-08 |
The Research Foundation For The State University Of New York |
Microenvironments for self-assembly of islet organoids from stem cells differentiation
|
|
CN107056723A
(zh)
*
|
2017-04-21 |
2017-08-18 |
云南大学 |
一种具有抑制血管内皮生长因子受体信号传导的化合物
|
|
US11389434B2
(en)
|
2017-05-18 |
2022-07-19 |
Inserm |
Methods and pharmaceutical compositions for the treatment of mast cell diseases
|
|
WO2022019920A1
(en)
|
2020-07-24 |
2022-01-27 |
Verastem, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
CN112511569B
(zh)
*
|
2021-02-07 |
2021-05-11 |
杭州筋斗腾云科技有限公司 |
网络资源访问请求的处理方法、系统及计算机设备
|
|
CN115477615B
(zh)
*
|
2022-10-17 |
2024-06-18 |
黄山学院 |
N-(3-(苯并咪唑-2-基)苯基)酰胺类化合物及其制备方法和应用
|