EA007339B1 - Медиаторы путей передачи сигналов генами hedgehog, содержащие их композиции и способы применения указанных веществ - Google Patents
Медиаторы путей передачи сигналов генами hedgehog, содержащие их композиции и способы применения указанных веществ Download PDFInfo
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- EA007339B1 EA007339B1 EA200400080A EA200400080A EA007339B1 EA 007339 B1 EA007339 B1 EA 007339B1 EA 200400080 A EA200400080 A EA 200400080A EA 200400080 A EA200400080 A EA 200400080A EA 007339 B1 EA007339 B1 EA 007339B1
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- Eurasian Patent Office
- Prior art keywords
- independently
- aryl
- heteroaryl
- cycloalkyl
- heterocyclyl
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Classifications
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- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
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- Chemical & Material Sciences (AREA)
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
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| US30844901P | 2001-07-27 | 2001-07-27 | |
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| PCT/US2002/024073 WO2003011219A2 (en) | 2001-07-27 | 2002-07-29 | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
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| DE69841320D1 (de) | 1997-02-10 | 2010-01-07 | Harvard College | Verfahren zur modulation von hämatopoese und vaskulärem wachstum |
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| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US20040060568A1 (en) | 2000-10-13 | 2004-04-01 | Henryk Dudek | Hedgehog antagonists, methods and uses related thereto |
| US7708998B2 (en) * | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
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| EP1496905B1 (en) * | 2002-04-22 | 2008-08-13 | Johns Hopkins University School of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| DE60326248D1 (de) | 2002-07-17 | 2009-04-02 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
| TWI276631B (en) * | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| US7132440B2 (en) | 2003-04-17 | 2006-11-07 | Janssen Pharmaceutica, N.V. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
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| BR0211513A (pt) | 2005-08-30 |
| US20050085519A1 (en) | 2005-04-21 |
| CA2455100C (en) | 2013-05-28 |
| EP1482928A2 (en) | 2004-12-08 |
| AU2002327390B2 (en) | 2008-06-26 |
| WO2003011219A2 (en) | 2003-02-13 |
| JP4658473B2 (ja) | 2011-03-23 |
| EA200400080A1 (ru) | 2005-02-24 |
| CN1638765A (zh) | 2005-07-13 |
| KR20040031782A (ko) | 2004-04-13 |
| JP2005507860A (ja) | 2005-03-24 |
| PL366799A1 (en) | 2005-02-07 |
| EP1482928A4 (en) | 2005-10-12 |
| NO20040342L (no) | 2004-03-26 |
| EP1482928B1 (en) | 2009-09-23 |
| ATE443518T1 (de) | 2009-10-15 |
| NZ530580A (en) | 2007-02-23 |
| US20130190350A1 (en) | 2013-07-25 |
| MXPA04000803A (es) | 2004-05-21 |
| WO2003011219A3 (en) | 2004-09-23 |
| DE60233823D1 (de) | 2009-11-05 |
| US8354397B2 (en) | 2013-01-15 |
| US8772275B2 (en) | 2014-07-08 |
| CA2455100A1 (en) | 2003-02-13 |
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