JP2005506992A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005506992A5 JP2005506992A5 JP2003537557A JP2003537557A JP2005506992A5 JP 2005506992 A5 JP2005506992 A5 JP 2005506992A5 JP 2003537557 A JP2003537557 A JP 2003537557A JP 2003537557 A JP2003537557 A JP 2003537557A JP 2005506992 A5 JP2005506992 A5 JP 2005506992A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- acid
- active compound
- pharmaceutically acceptable
- pharmacologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 45
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 39
- 239000002904 solvent Substances 0.000 claims 37
- 238000000034 method Methods 0.000 claims 31
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 24
- 241000124008 Mammalia Species 0.000 claims 14
- 229940074076 glycerol formal Drugs 0.000 claims 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 239000005639 Lauric acid Substances 0.000 claims 12
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims 11
- 239000000194 fatty acid Substances 0.000 claims 11
- 229930195729 fatty acid Natural products 0.000 claims 11
- 150000004665 fatty acids Chemical class 0.000 claims 10
- 229960000223 tilmicosin Drugs 0.000 claims 10
- JTSDBFGMPLKDCD-XVFHVFLVSA-N tilmicosin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O JTSDBFGMPLKDCD-XVFHVFLVSA-N 0.000 claims 10
- 239000004100 Oxytetracycline Substances 0.000 claims 9
- 230000003115 biocidal effect Effects 0.000 claims 9
- 229960000625 oxytetracycline Drugs 0.000 claims 9
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 9
- 235000019366 oxytetracycline Nutrition 0.000 claims 9
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 8
- 239000007972 injectable composition Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 8
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 239000002244 precipitate Substances 0.000 claims 7
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 6
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims 6
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 6
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims 6
- 229960003722 doxycycline Drugs 0.000 claims 6
- 239000004098 Tetracycline Substances 0.000 claims 5
- 229960002180 tetracycline Drugs 0.000 claims 5
- 229930101283 tetracycline Natural products 0.000 claims 5
- 235000019364 tetracycline Nutrition 0.000 claims 5
- 150000003522 tetracyclines Chemical class 0.000 claims 5
- FCGXLCNBWYIEAA-UHFFFAOYSA-N 1,3-benzothiazol-6-ylmethanamine Chemical compound NCC1=CC=C2N=CSC2=C1 FCGXLCNBWYIEAA-UHFFFAOYSA-N 0.000 claims 4
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 4
- 229930182566 Gentamicin Natural products 0.000 claims 4
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 4
- 229930193140 Neomycin Natural products 0.000 claims 4
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 claims 4
- 229940126575 aminoglycoside Drugs 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 4
- 229960002518 gentamicin Drugs 0.000 claims 4
- -1 glycerol formal Chemical compound 0.000 claims 4
- 239000001087 glyceryl triacetate Substances 0.000 claims 4
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 229960004927 neomycin Drugs 0.000 claims 4
- 229960004063 propylene glycol Drugs 0.000 claims 4
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 4
- 229960005322 streptomycin Drugs 0.000 claims 4
- 229940124530 sulfonamide Drugs 0.000 claims 4
- 150000003456 sulfonamides Chemical class 0.000 claims 4
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims 4
- 229960002622 triacetin Drugs 0.000 claims 4
- 229960001082 trimethoprim Drugs 0.000 claims 4
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims 4
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 3
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 3
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 3
- 235000021360 Myristic acid Nutrition 0.000 claims 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 3
- NOSIYYJFMPDDSA-UHFFFAOYSA-N acepromazine Chemical compound C1=C(C(C)=O)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 NOSIYYJFMPDDSA-UHFFFAOYSA-N 0.000 claims 3
- 229960005054 acepromazine Drugs 0.000 claims 3
- 229960005274 benzocaine Drugs 0.000 claims 3
- 229960003150 bupivacaine Drugs 0.000 claims 3
- 229960001747 cinchocaine Drugs 0.000 claims 3
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 229960004130 itraconazole Drugs 0.000 claims 3
- 229960002372 tetracaine Drugs 0.000 claims 3
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims 2
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 229920000805 Polyaspartic acid Polymers 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229960002464 fluoxetine Drugs 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 235000020778 linoleic acid Nutrition 0.000 claims 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 2
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims 2
- 229960002237 metoprolol Drugs 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 235000021313 oleic acid Nutrition 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- 108010064470 polyaspartate Proteins 0.000 claims 2
- 229960005224 roxithromycin Drugs 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 2
- 229960002722 terbinafine Drugs 0.000 claims 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34362501P | 2001-10-19 | 2001-10-19 | |
| US60/343,625 | 2001-10-19 | ||
| PCT/US2002/033300 WO2003034988A2 (en) | 2001-10-19 | 2002-10-18 | Injectable compositions for the controlled delivery of pharmacologically active compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506992A JP2005506992A (ja) | 2005-03-10 |
| JP2005506992A5 true JP2005506992A5 (https=) | 2006-01-05 |
| JP4850390B2 JP4850390B2 (ja) | 2012-01-11 |
Family
ID=23346878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003537557A Expired - Lifetime JP4850390B2 (ja) | 2001-10-19 | 2002-10-18 | 薬理学的に活性な化合物の制御送達のための注射用組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US6887487B2 (https=) |
| EP (1) | EP1446103B1 (https=) |
| JP (1) | JP4850390B2 (https=) |
| CN (2) | CN101785861B (https=) |
| AU (1) | AU2002335077B2 (https=) |
| BG (1) | BG108634A (https=) |
| BR (1) | BRPI0213425B8 (https=) |
| CA (1) | CA2463896C (https=) |
| ES (1) | ES2561108T3 (https=) |
| IL (1) | IL160282A (https=) |
| MX (1) | MXPA04003608A (https=) |
| NZ (1) | NZ531460A (https=) |
| PL (1) | PL211116B1 (https=) |
| RU (1) | RU2292871C2 (https=) |
| WO (1) | WO2003034988A2 (https=) |
| ZA (1) | ZA200401076B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946137B2 (en) * | 2001-10-19 | 2005-09-20 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| WO2003034988A2 (en) * | 2001-10-19 | 2003-05-01 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
| US20070060604A1 (en) * | 2002-03-25 | 2007-03-15 | Council Of Scientific And Industrial Research | Antibiotic pharmaceutical composition with lysergol as bio-enhancer and method of treatment |
| US20050049210A1 (en) * | 2003-08-27 | 2005-03-03 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| US7858115B2 (en) * | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
| US7618651B2 (en) | 2004-06-24 | 2009-11-17 | Idexx Laboratories | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
| US7854943B2 (en) | 2004-06-24 | 2010-12-21 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
| US7282487B2 (en) * | 2004-10-28 | 2007-10-16 | Idexx Laboratories | Method for treating bacterial infections in horses or pigs with tilmicosin |
| CN101048139A (zh) | 2004-10-28 | 2007-10-03 | 艾德克斯实验室公司 | 药物活性化合物的控释组合物 |
| WO2007016153A2 (en) * | 2005-07-28 | 2007-02-08 | Eli Lilly And Company | Tilmicosin formulation |
| US8114440B2 (en) * | 2005-11-16 | 2012-02-14 | Idexx Laboratories Inc. | Pharmaceutical compositions for the administration of aptamers |
| US7754679B2 (en) * | 2005-11-16 | 2010-07-13 | Idexx Laboratories, Inc. | Pharmaceutical compositions for the administration of aptamers |
| US7973022B2 (en) * | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
| US20070196398A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone fatty acid salt compositions |
| US20090239891A1 (en) * | 2006-03-01 | 2009-09-24 | Shukla Atul J | Sustained Release Dosage Forms of Analgesic Medications |
| EP2162540A2 (en) | 2007-05-22 | 2010-03-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| US20090005326A1 (en) * | 2007-06-26 | 2009-01-01 | Idexx Laboratories, Inc. | Single dose roxithromycin |
| US8828960B2 (en) * | 2007-07-17 | 2014-09-09 | Idexx Laboratories, Inc. | Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds |
| US8920843B2 (en) * | 2007-11-07 | 2014-12-30 | Svip5 Llc | Slow release of organic salts of local anesthetics for pain relief |
| CN101496811B (zh) * | 2008-12-24 | 2011-03-16 | 天津瑞普生物技术股份有限公司 | 一种可溶且稳定的替米考星组合物 |
| CN101690713B (zh) * | 2009-09-28 | 2011-12-28 | 普莱柯生物工程股份有限公司 | 一种喹诺酮注射液的制备方法 |
| US20110177157A1 (en) * | 2010-01-19 | 2011-07-21 | Idexx Laboratories, Inc. | Compositions for Controlled Delivery of Pharmaceutically Active Compounds |
| PH12013501865A1 (en) | 2011-03-16 | 2014-01-06 | Amgen Inc | Potent and selective inhibitors of nav1.3 and nav1.7 |
| US20160067347A1 (en) | 2012-12-20 | 2016-03-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| DK3116475T3 (da) | 2014-03-13 | 2020-12-07 | Neuroderm Ltd | Dopa-decarboxylasehæmmersammensætninger |
| WO2015191781A2 (en) | 2014-06-10 | 2015-12-17 | Amgen Inc. | Apelin polypeptides |
| US11318190B2 (en) | 2017-05-05 | 2022-05-03 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating liver disease |
| CN108042491B (zh) * | 2018-01-23 | 2021-02-09 | 山东迅达康兽药有限公司 | 一种替米考星纳米乳及其制备方法 |
| UY38599A (es) * | 2019-03-01 | 2020-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones inyectables de clorsulón, sus métodos y usos |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| CN113730340A (zh) * | 2021-09-17 | 2021-12-03 | 中国药科大学 | 一种注射用脂肪酸缓释组合物及其制备方法和应用 |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB674784A (en) * | 1949-05-25 | 1952-07-02 | Chimiotherapie Lab Franc | Penicillin preparations for injection |
| GB731933A (en) * | 1951-04-28 | 1955-06-15 | Fougera And Company E | Liquid preparations of therapeutically active substances for sub-cutaneous or intramuscular injection |
| US4259331A (en) * | 1979-04-16 | 1981-03-31 | Pfizer Inc. | Oxytetracycline compositions |
| US4298375A (en) | 1979-10-01 | 1981-11-03 | Monsanto Company | 2-Substituted-5-phenyl-4-thiazolecarboxylic acids and their derivatives as safening agents |
| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| DE3248328A1 (de) * | 1982-12-28 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe |
| GB8725427D0 (en) * | 1987-10-30 | 1987-12-02 | Lilly Industries Ltd | Somatotropin formulations |
| JPH027314A (ja) | 1988-06-27 | 1990-01-11 | Asahi Denso Kk | スイッチ |
| JPH02115118A (ja) * | 1988-10-24 | 1990-04-27 | Wakunaga Pharmaceut Co Ltd | 注射剤 |
| US5574020A (en) * | 1989-09-28 | 1996-11-12 | Eli Lilly And Company | Tilmicosin formulation |
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| RU2097025C1 (ru) * | 1990-11-06 | 1997-11-27 | Ниппон Синяку Компани, Лимитед | Лиофилизированный препарат жировой эмульсии и способ его получения |
| US5658956A (en) | 1991-03-01 | 1997-08-19 | Warner-Lambert Company | Bioadhesive-wound healing compositions and methods for preparing and using same |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| SE9202128D0 (sv) * | 1992-07-09 | 1992-07-09 | Astra Ab | Precipitation of one or more active compounds in situ |
| US5817321A (en) * | 1992-10-08 | 1998-10-06 | Supratek Pharma, Inc. | Biological agent compositions |
| ZA939428B (en) * | 1992-12-21 | 1995-06-15 | Lilly Co Eli | Therapeutic for gram-positive diseases of aquatic species |
| US6110905A (en) | 1994-07-09 | 2000-08-29 | Norbrook Laboratories Limited | Long-acting oxytetracycline composition |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| JP3277735B2 (ja) * | 1994-12-07 | 2002-04-22 | 富士レビオ株式会社 | ナフトエ酸誘導体の吸収促進組成物 |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| US6310053B1 (en) | 1995-07-05 | 2001-10-30 | Norbrook Laboratories Limited | Long-acting oxytetracycline composition |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US5958888A (en) * | 1996-07-02 | 1999-09-28 | Merial, Inc. | Water miscible macrolide solutions |
| US5723447A (en) | 1996-07-02 | 1998-03-03 | Rhone Merieux, Inc. | Water miscible erythromycin solutions |
| IL119029A0 (en) | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
| WO1998006438A2 (en) * | 1996-08-12 | 1998-02-19 | Medlogic Global Corporation | Composition for pharmaceutical applications |
| SE511313C2 (sv) | 1997-01-13 | 1999-09-06 | Gs Dev Ab | Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol |
| US6630168B1 (en) * | 1997-02-20 | 2003-10-07 | Biomedicines, Inc. | Gel delivery vehicles for anticellular proliferative agents |
| US6074657A (en) | 1997-03-20 | 2000-06-13 | Pharmacia & Upjohn Company | Administration of an injectable antibiotic in the ear of an animal |
| TR199902748T2 (xx) | 1997-05-06 | 2000-05-22 | Norbrook Laboratories Limited | Uzun s�re etkili antimikrobik maddelerle ilgili geli�meler |
| JPH11171794A (ja) * | 1997-12-04 | 1999-06-29 | Shoji Awazu | 動脈注射製剤 |
| SI0948967T1 (en) | 1998-03-02 | 2005-06-30 | Eli Lilly And Company | Treatment of viral disease in swine |
| BE1011899A6 (fr) * | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
| US6239112B1 (en) * | 1998-07-09 | 2001-05-29 | Merial, Inc. | Water miscible macrolide solutions |
| US6328961B1 (en) | 1998-08-20 | 2001-12-11 | Bristol-Myers Squibb Company | Tyrissamycin antibiotic |
| US6174540B1 (en) * | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| US6677321B1 (en) | 1999-12-09 | 2004-01-13 | Bruce Levin | Methods and compositions for treatment of inflammatory disease |
| AU781682B2 (en) * | 2000-03-20 | 2005-06-09 | Zoetis Services Llc | Sustained-release compositions for parenteral administration |
| US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
| US20030219461A1 (en) | 2000-09-12 | 2003-11-27 | Britten Nancy J. | Parenteral combination therapy for infective conditions |
| US20040033938A1 (en) | 2000-09-12 | 2004-02-19 | Britten Nancy J. | Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis |
| WO2003034988A2 (en) | 2001-10-19 | 2003-05-01 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
| US6946137B2 (en) * | 2001-10-19 | 2005-09-20 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| US6790867B2 (en) | 2002-05-20 | 2004-09-14 | Schering-Plough Animal Health Corporation | Compositions and method for treating infection in cattle and swine |
| US20050049210A1 (en) * | 2003-08-27 | 2005-03-03 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
-
2002
- 2002-10-18 WO PCT/US2002/033300 patent/WO2003034988A2/en not_active Ceased
- 2002-10-18 AU AU2002335077A patent/AU2002335077B2/en not_active Expired
- 2002-10-18 CN CN201010124253.1A patent/CN101785861B/zh not_active Expired - Lifetime
- 2002-10-18 EP EP02802160.8A patent/EP1446103B1/en not_active Expired - Lifetime
- 2002-10-18 NZ NZ531460A patent/NZ531460A/en not_active IP Right Cessation
- 2002-10-18 CN CNA028192842A patent/CN1607937A/zh active Pending
- 2002-10-18 US US10/274,445 patent/US6887487B2/en not_active Expired - Lifetime
- 2002-10-18 CA CA2463896A patent/CA2463896C/en not_active Expired - Lifetime
- 2002-10-18 BR BRPI0213425A patent/BRPI0213425B8/pt not_active IP Right Cessation
- 2002-10-18 ES ES02802160.8T patent/ES2561108T3/es not_active Expired - Lifetime
- 2002-10-18 JP JP2003537557A patent/JP4850390B2/ja not_active Expired - Lifetime
- 2002-10-18 RU RU2004115103/15A patent/RU2292871C2/ru active
- 2002-10-18 PL PL368338A patent/PL211116B1/pl unknown
-
2003
- 2003-03-28 US US10/403,100 patent/US7033599B2/en not_active Expired - Fee Related
-
2004
- 2004-02-09 IL IL160282A patent/IL160282A/en active IP Right Grant
- 2004-02-10 ZA ZA2004/01076A patent/ZA200401076B/en unknown
- 2004-03-16 BG BG108634A patent/BG108634A/xx unknown
- 2004-04-16 MX MXPA04003608A patent/MXPA04003608A/es active IP Right Grant
-
2005
- 2005-03-25 US US11/088,922 patent/US7404964B2/en not_active Expired - Lifetime
-
2007
- 2007-01-31 US US11/700,068 patent/US20070141162A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005506992A5 (https=) | ||
| RU2004115103A (ru) | Инъецируемые композиции для контролируемоей доставки фармакологически активного соединения | |
| CA2430091A1 (en) | An antibiotic/analgesic formulation and a method of making this formulation | |
| US20120129819A1 (en) | Gel compositions for administration of pharmaceutically active compounds | |
| CN104797252B (zh) | 减轻噪音厌恶的兽医方法 | |
| HUP0100606A2 (hu) | Keményített ricinusolajat tartalmazó tartós hatású injektálható készítmény | |
| BRPI0618891A2 (pt) | composições farmacêuticas | |
| RU2010123282A (ru) | Твердая лекарственная форма с быстрым высвобождением активного вещества, ее получение и применение | |
| CN1148174C (zh) | 供局部应用的尼美舒利凝胶体系 | |
| CA2522009A1 (en) | Methods for the controlled delivery of pharmacologically active compounds | |
| AU2020283738B2 (en) | Long-acting injectable formulations and use thereof | |
| JP2007503433A5 (https=) | ||
| EP3082762B1 (en) | Long-acting ketoprofen compositions | |
| JP2006523723A5 (https=) | ||
| JP2021520400A (ja) | エダラボン医薬組成物 | |
| CZ129899A3 (cs) | Anestetický prostředek pro místní znecitlivění | |
| ME00483B (me) | Parenteralni sastav paracetamola | |
| ES2204958T3 (es) | Compuesto de oxitetraciclina de largo efecto. | |
| BRPI0517719B1 (pt) | composição veterinária farmacêutica na forma de um gel transmucosal e kit veterinário | |
| RU2019109695A (ru) | Лекарственная форма для пролонгированного ослабления симптомов | |
| JP2002509154A5 (https=) | ||
| WO2018070940A1 (en) | An injectable composition for localized controlled and sustained delivery system | |
| JP2007509949A5 (https=) | ||
| JP2008504272A5 (https=) | ||
| KR101458611B1 (ko) | 동물용 복합항생제 조성물 |