JP2005506981A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005506981A5 JP2005506981A5 JP2003526405A JP2003526405A JP2005506981A5 JP 2005506981 A5 JP2005506981 A5 JP 2005506981A5 JP 2003526405 A JP2003526405 A JP 2003526405A JP 2003526405 A JP2003526405 A JP 2003526405A JP 2005506981 A5 JP2005506981 A5 JP 2005506981A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- alkyl
- hydrogen
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 58
- 229910052739 hydrogen Inorganic materials 0.000 claims 52
- 239000001257 hydrogen Substances 0.000 claims 52
- -1 2-imidazolinyl Chemical group 0.000 claims 46
- 150000001875 compounds Chemical class 0.000 claims 40
- 150000002431 hydrogen Chemical class 0.000 claims 37
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 30
- 125000000547 substituted alkyl group Chemical group 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 23
- 125000003342 alkenyl group Chemical group 0.000 claims 22
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 125000000304 alkynyl group Chemical group 0.000 claims 20
- 229910052760 oxygen Inorganic materials 0.000 claims 19
- 229910052717 sulfur Inorganic materials 0.000 claims 19
- 125000003282 alkyl amino group Chemical group 0.000 claims 16
- 125000004663 dialkyl amino group Chemical group 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 16
- 229940002612 prodrug Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 239000012453 solvate Substances 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 150000001356 alkyl thiols Chemical class 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 13
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004076 pyridyl group Chemical group 0.000 claims 11
- 125000006323 alkenyl amino group Chemical group 0.000 claims 9
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 9
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 9
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 claims 9
- 125000005126 aryl alkyl carbonyl amino group Chemical group 0.000 claims 9
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 9
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- MKRVOXRLAFVYCF-UHFFFAOYSA-N C(#N)NN([N+](=O)[O-])O Chemical compound C(#N)NN([N+](=O)[O-])O MKRVOXRLAFVYCF-UHFFFAOYSA-N 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 7
- 125000004423 acyloxy group Chemical group 0.000 claims 7
- 229910052783 alkali metal Inorganic materials 0.000 claims 7
- 150000001340 alkali metals Chemical class 0.000 claims 7
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 125000005018 aryl alkenyl group Chemical group 0.000 claims 7
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000005015 aryl alkynyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 150000001540 azides Chemical class 0.000 claims 7
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 7
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000000842 isoxazolyl group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003573 thiols Chemical class 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 6
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 4
- 125000004864 4-thiomethylphenyl group Chemical group 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 108010052164 Sodium Channels Proteins 0.000 claims 2
- 102000018674 Sodium Channels Human genes 0.000 claims 2
- 150000005840 aryl radicals Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 235000005152 nicotinamide Nutrition 0.000 claims 2
- 239000011570 nicotinamide Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- WLRQGJFLMSNZAK-UHFFFAOYSA-N 2-(4-phenoxyphenyl)pyridine-4-carboxamide Chemical compound NC(=O)C1=CC=NC(C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 WLRQGJFLMSNZAK-UHFFFAOYSA-N 0.000 claims 1
- VNPFVKSKEFHPRR-UHFFFAOYSA-N 2-(4-phenylphenyl)pyridine-4-carboxamide Chemical compound NC(=O)C1=CC=NC(C=2C=CC(=CC=2)C=2C=CC=CC=2)=C1 VNPFVKSKEFHPRR-UHFFFAOYSA-N 0.000 claims 1
- UTHASJFQCPZOKF-UHFFFAOYSA-N 2-(4-tert-butylphenyl)pyridine-4-carboxamide Chemical compound C1=CC(C(C)(C)C)=CC=C1C1=CC(C(N)=O)=CC=N1 UTHASJFQCPZOKF-UHFFFAOYSA-N 0.000 claims 1
- XAFONVMAPPEAIT-UHFFFAOYSA-N 2-[4-(4-fluorophenoxy)phenyl]pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1C(C=C1)=CC=C1OC1=CC=C(F)C=C1 XAFONVMAPPEAIT-UHFFFAOYSA-N 0.000 claims 1
- FHYAIJCEEYITHI-UHFFFAOYSA-N 2-[4-(4-fluorophenoxy)phenyl]pyridine-4-carboxamide Chemical compound NC(=O)C1=CC=NC(C=2C=CC(OC=3C=CC(F)=CC=3)=CC=2)=C1 FHYAIJCEEYITHI-UHFFFAOYSA-N 0.000 claims 1
- CJNRGSHEMCMUOE-UHFFFAOYSA-N 2-piperidin-1-ylethanamine Chemical compound NCCN1CCCCC1 CJNRGSHEMCMUOE-UHFFFAOYSA-N 0.000 claims 1
- RHODAQXTNFLOAE-UHFFFAOYSA-N 5-(4-phenoxyphenyl)pyridine-3-carboxamide Chemical compound NC(=O)C1=CN=CC(C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 RHODAQXTNFLOAE-UHFFFAOYSA-N 0.000 claims 1
- GRKCWUVREMQJCO-UHFFFAOYSA-N 5-(4-tert-butylphenyl)pyridine-3-carboxamide Chemical compound C1=CC(C(C)(C)C)=CC=C1C1=CN=CC(C(N)=O)=C1 GRKCWUVREMQJCO-UHFFFAOYSA-N 0.000 claims 1
- MNOULQLXILYKNV-UHFFFAOYSA-N 5-[4-(trifluoromethyl)phenyl]-1h-pyrazole Chemical group C1=CC(C(F)(F)F)=CC=C1C1=CC=NN1 MNOULQLXILYKNV-UHFFFAOYSA-N 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- FNVGBCQVTXYPPL-UHFFFAOYSA-N NCCN1CCCCC1.OC(C(C=C1)=CN=C1C(C=C1)=CC=C1OC(C=C1)=CC=C1F)=O Chemical compound NCCN1CCCCC1.OC(C(C=C1)=CN=C1C(C=C1)=CC=C1OC(C=C1)=CC=C1F)=O FNVGBCQVTXYPPL-UHFFFAOYSA-N 0.000 claims 1
- MERFVOREMSEJAU-UHFFFAOYSA-N NCCN1CCCCC1.OC(C1=CC(C(C=C2)=CC=C2OC(C=C2)=CC=C2F)=CN=C1)=O Chemical compound NCCN1CCCCC1.OC(C1=CC(C(C=C2)=CC=C2OC(C=C2)=CC=C2F)=CN=C1)=O MERFVOREMSEJAU-UHFFFAOYSA-N 0.000 claims 1
- 208000009205 Tinnitus Diseases 0.000 claims 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002287 radioligand Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 claims 1
- 231100000886 tinnitus Toxicity 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31752601P | 2001-09-07 | 2001-09-07 | |
| PCT/US2002/028298 WO2003022276A1 (en) | 2001-09-07 | 2002-09-06 | Aryl substituted pyridinecarboxamides and their use as sodium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506981A JP2005506981A (ja) | 2005-03-10 |
| JP2005506981A5 true JP2005506981A5 (enExample) | 2005-12-08 |
Family
ID=23234074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003526405A Withdrawn JP2005506981A (ja) | 2001-09-07 | 2002-09-06 | アリール置換ピリジンカルボキサミドおよびナトリウムチャンネル遮断薬としてのそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7105549B2 (enExample) |
| EP (1) | EP1432419A1 (enExample) |
| JP (1) | JP2005506981A (enExample) |
| KR (1) | KR20040031053A (enExample) |
| AR (1) | AR037233A1 (enExample) |
| BR (1) | BR0212338A (enExample) |
| CA (1) | CA2459527A1 (enExample) |
| HU (1) | HUP0500131A3 (enExample) |
| IL (1) | IL160716A0 (enExample) |
| MX (1) | MXPA04002171A (enExample) |
| RU (1) | RU2004110721A (enExample) |
| WO (1) | WO2003022276A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004538285A (ja) * | 2001-07-16 | 2004-12-24 | ユーロ−セルティック エス． ア． | アリール置換チアゾリジノンおよびその使用 |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| WO2003068747A1 (en) | 2002-02-12 | 2003-08-21 | Smithkline Beecham Corporation | Nicotinamide derivates useful as p38 inhibitors |
| EP1483247B1 (en) * | 2002-03-13 | 2009-06-24 | Euro-Celtique S.A. | Aryl substituted pyrimidines and the use thereof |
| EP1532119A2 (en) * | 2002-07-31 | 2005-05-25 | Euro-Celtique S.A. | Aryl substituted benzimidazoles and their use as sodium channel blockers |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
| US20040152696A1 (en) * | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
| AU2004224392A1 (en) * | 2003-03-24 | 2004-10-07 | Merck & Co., Inc. | Biaryl substituted 6-membered heterocyles as sodium channel blockers |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| CN1922156A (zh) * | 2003-11-10 | 2007-02-28 | 默克公司 | 作为钠通道阻断剂的取代的三唑 |
| GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| WO2006011050A2 (en) | 2004-07-23 | 2006-02-02 | Pfizer Limited | Pyridine derivatives |
| US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
| GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| TW200728258A (en) * | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| JP4159586B2 (ja) * | 2006-08-03 | 2008-10-01 | エヌイーシーコンピュータテクノ株式会社 | 情報処理装置および情報処理の高速化方法 |
| JP4657384B2 (ja) | 2007-05-03 | 2011-03-23 | ファイザー・リミテッド | ナトリウムチャンネルモジュレーターとしての２−ピリジンカルボキサミド誘導体 |
| KR200451955Y1 (ko) * | 2008-05-09 | 2011-01-25 | 박영주 | 차량진입 방지대 |
| NZ601483A (en) | 2008-08-04 | 2013-10-25 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP2013518046A (ja) | 2010-01-25 | 2013-05-20 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 特定のキヌレニン−３−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法 |
| WO2012007836A1 (en) | 2010-07-16 | 2012-01-19 | Purdue Pharma .Lp. | Pyridine compounds as sodium channel blockers |
| AR083023A1 (es) | 2010-09-17 | 2013-01-23 | Purdue Pharma Lp | Compuestos de piridina y una composicion farmaceutica que los comprende |
| KR20130095772A (ko) | 2010-10-05 | 2013-08-28 | 퍼듀 퍼머 엘피 | 나트륨 채널 차단제로서 퀴나졸린 화합물 |
| AU2011346751A1 (en) | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| EA032526B1 (ru) | 2011-08-30 | 2019-06-28 | Схди Фаундейшн, Инк. | Применение ингибитора кинуренин-3-монооксигеназы для лечения заболеваний и состояний, опосредованных активностью кинуренин-3-монооксигеназы |
| US9428464B2 (en) | 2011-08-30 | 2016-08-30 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| RS56342B1 (sr) | 2011-09-02 | 2017-12-29 | Purdue Pharma Lp | Pirimidini kao blokatori natrijumskog kanala |
| AU2012321111A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| WO2013064883A1 (en) * | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| WO2013072758A1 (en) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| WO2013136170A1 (en) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| US9143309B2 (en) * | 2012-04-13 | 2015-09-22 | Dominant Technologies, LLC | Hopping master in wireless conference |
| US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| ES2859148T3 (es) | 2013-03-04 | 2021-10-01 | Purdue Pharma Lp | Carboxamidas de pirimidina como bloqueantes de los canales de sodio |
| CA2939549C (en) * | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| US9884865B2 (en) | 2013-08-26 | 2018-02-06 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
| AU2014324595B2 (en) * | 2013-09-30 | 2018-12-20 | Beijing Innocare Pharma Tech Co., Ltd | Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease |
| US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| US9834543B2 (en) | 2013-12-23 | 2017-12-05 | Purdue Pharma L.P. | Indazoles and use thereof |
| US9902726B2 (en) | 2013-12-30 | 2018-02-27 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| WO2015112801A1 (en) | 2014-01-24 | 2015-07-30 | Purdue Pharma L.P. | Pyridines and pyrimidines and use thereof |
| EP3105217B1 (en) | 2014-02-12 | 2019-05-29 | Purdue Pharma LP | Isoquinoline derivatives and use thereof |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| MA39956A (fr) | 2014-05-06 | 2015-11-12 | Purdue Pharma Lp | Analogues du benzomorphane et leur utilisation |
| US10202382B2 (en) | 2014-06-13 | 2019-02-12 | Purdue Pharma L.P. | Azamorphinan derivatives and use thereof |
| MA40170A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés hétérocycliques de morphinan et leur utilisation |
| UA120856C2 (uk) | 2014-07-17 | 2020-02-25 | Кхді Фаундейшн, Інк. | Способи та композиції для лікування розладів, пов'язаних з віл |
| EP3186228A4 (en) * | 2014-08-28 | 2018-04-18 | X-Chem, Inc. | Soluble epoxide hydrolase inhibitors and uses thereof |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3149109A (en) | 1962-02-20 | 1964-09-15 | Searle & Co | Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines |
| FR1477021A (fr) | 1965-04-21 | 1967-04-14 | Ilford Ltd | Matières photographiques |
| GB1121922A (en) | 1966-06-17 | 1968-07-31 | Ici Ltd | Pyrimidine derivatives |
| FR1536093A (fr) | 1966-09-10 | 1968-08-09 | Basf Ag | Nouvelles amino-4-alcoylmercapto-6-triazines-s |
| US3631036A (en) | 1969-11-04 | 1971-12-28 | American Home Prod | 5-amino-2 6-substituted-7h-pyrrolo(2 3-d) pyrimidines and related compounds |
| US3660414A (en) | 1970-06-01 | 1972-05-02 | Sandoz Ag | Certain 5-aryl-2-amino-nicotinonitriles |
| US3709888A (en) | 1970-06-01 | 1973-01-09 | Sandoz Ag | Aryl-substituted-pyrido(2,3-d)pyrimidin-2-ones |
| US3886167A (en) | 1974-03-06 | 1975-05-27 | Us Army | 2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials |
| US3940404A (en) | 1974-03-06 | 1976-02-24 | The United States Of America As Represented By The Secretary Of The Army | 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines |
| DE2643753A1 (de) | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
| US4133956A (en) | 1977-07-27 | 1979-01-09 | Eli Lilly And Company | Preparation of benzoylureas |
| US4293552A (en) | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
| ES490122A0 (es) | 1979-04-05 | 1981-04-01 | Lilly Industries Ltd | Procedimiento para preparar piranonas 5-sustituidas |
| JPS56104883A (en) | 1980-01-25 | 1981-08-20 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
| JPS56115784A (en) | 1980-02-15 | 1981-09-11 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
| US4769462A (en) | 1980-06-02 | 1988-09-06 | American Cyanamid Co. | Novel 2-carbamoylnicotinic and 3-quinolinecarboxylic acids and esters |
| GB2095240A (en) | 1981-03-05 | 1982-09-29 | Fujisawa Pharmaceutical Co | Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
| DE3239573A1 (de) * | 1981-10-28 | 1983-05-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Substituierte picolinsaeuren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel |
| DE3245950A1 (de) * | 1981-12-24 | 1983-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur herstellung substituierter pyridine |
| FR2527206B1 (fr) * | 1982-05-18 | 1986-12-05 | Sandoz Sa | Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments |
| DE3379544D1 (en) | 1982-06-08 | 1989-05-11 | Ciba Geigy Ag | 2-phenyl-2-naphthyl and 2-heterocyclic pyrimidines as antidotes for protecting cultured plants before phytotoxic damages caused by herbicides |
| FR2531948B1 (fr) * | 1982-06-28 | 1986-05-09 | Nat Res Dev | Pesticide et procedes pour sa preparation et pour son utilisation |
| EP0123700A1 (de) | 1983-04-27 | 1984-11-07 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte Picolinsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel |
| US4701208A (en) | 1983-08-02 | 1987-10-20 | American Cyanamid Company | Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof |
| SU1790172A1 (ru) | 1984-05-17 | 1995-05-10 | Всесоюзный Государственный Научно-Исследовательский И Проектный Институт Химико-Фотографической Промышленности | Бисчетвертичные соли пиридина в качестве активаторов спектральной сенсибилизации фотографических бромйодсеребряных эмульсий, содержащих анионные или катион-анионные цианины |
| DE3685840D1 (de) | 1985-04-30 | 1992-08-06 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| GB8531637D0 (en) | 1985-12-23 | 1986-02-05 | Ici Plc | Pyrimidine derivatives |
| US4962109A (en) | 1985-12-23 | 1990-10-09 | Imperial Chemical Industries Plc | Insecticidally and acaricidally active pyrimidine esters and intermediates therefor |
| JPS6320234A (ja) | 1986-07-11 | 1988-01-27 | Daihatsu Motor Co Ltd | 自動車の２輪・４輪駆動切換装置 |
| PH23565A (en) | 1986-09-05 | 1989-08-25 | Sumitomo Chemical Co | Novel pyrimidinylpyrimidine derivatives and a plant disease protectant containing them as the active ingredient |
| GB8627059D0 (en) | 1986-11-12 | 1986-12-10 | Cookson Group Plc | Substituted trialine derivatives |
| ZW21687A1 (en) | 1986-12-12 | 1988-07-20 | Hoffmann La Roche | Triazine derivatives |
| US5116989A (en) | 1987-11-06 | 1992-05-26 | Baxter Diagnostics Inc. | Fluorescent poly(arylpyridine) rare earth chelates |
| US5084462A (en) | 1988-04-26 | 1992-01-28 | The Du Pont Merck Pharmaceutical Company | 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents |
| EP0356672B1 (en) | 1988-07-13 | 1993-04-07 | Canon Kabushiki Kaisha | Ferroelectric chiral smectic liquid crystal composition and liquid crystal device using same |
| JPH0252360A (ja) | 1988-08-15 | 1990-02-21 | Fujitsu Ltd | 電子写真感光体 |
| EP0362578A1 (en) | 1988-09-14 | 1990-04-11 | E.I. Du Pont De Nemours And Company | Treatment of cancer in mammals by concurrent administration of 4-quinoline carboxylic acid derivatives and interleukin-2 |
| GB8918893D0 (en) | 1989-08-18 | 1989-09-27 | Wellcome Found | Pharmacologically active cns compounds |
| FI895821A7 (fi) | 1988-12-07 | 1990-06-08 | The Wellcome Foundation Ltd | Farmaseuttisesti aktivisia CNS-yhdisteitä |
| US4968702A (en) | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
| GB8906470D0 (en) | 1989-03-21 | 1989-05-04 | Cookson Group Plc | Photopolymerisable composition |
| DE4134467A1 (de) | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPH03503138A (ja) * | 1989-06-12 | 1991-07-18 | ゼネラル・エレクトリック・カンパニイ | 平担な基体にコーティングを施すためのラミナインプレッサ |
| DE3940476A1 (de) | 1989-12-07 | 1991-06-13 | Bayer Ag | Pyridinylpyrimidin-derivate |
| GB8923131D0 (en) | 1989-10-13 | 1989-11-29 | Smith Kline French Lab | Chemical compounds |
| US5136080A (en) | 1989-12-04 | 1992-08-04 | Burroughs Wellcome Co. | Nitrile compounds |
| US5403934A (en) | 1990-03-12 | 1995-04-04 | Burroughs Wellcome Co. | Heterocyclic compounds |
| EP0446604A3 (en) | 1990-03-16 | 1992-02-19 | American Cyanamid Company | Pyridine and related aza heterocycle derivatives as cardiovascular agents |
| AU644016B2 (en) | 1990-09-28 | 1993-12-02 | Smith Kline & French Laboratories Limited | Phenylpyridinol derivatives as medicaments |
| DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| CA2066641C (en) | 1990-10-25 | 2003-04-01 | Fumiaki Takabe | Picolinic acid derivative, method for preparing the same and herbicidal composition |
| JPH0597706A (ja) | 1991-04-09 | 1993-04-20 | Chemex Block Drug Jv | アフタ性潰瘍および他の粘膜皮膚障害の処置方法 |
| GB9124578D0 (en) | 1991-11-20 | 1992-01-08 | Smithkline Beecham Plc | Chemical compounds |
| DE4200323A1 (de) | 1992-01-09 | 1993-07-15 | Bayer Ag | Herbizide und pflanzennematizide mittel auf basis von mercaptonicotinsaeurederivaten |
| US5389632A (en) | 1992-02-24 | 1995-02-14 | Laboratoires Upsa | Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists |
| TW237456B (enExample) | 1992-04-09 | 1995-01-01 | Ciba Geigy | |
| JPH0776542A (ja) | 1993-09-06 | 1995-03-20 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
| US5602156A (en) | 1993-09-17 | 1997-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method for inhibiting metalloproteinase expression |
| US5744492A (en) | 1993-09-17 | 1998-04-28 | United States Of America | Method for inhibiting angiogenesis |
| IL112290A (en) | 1994-01-12 | 1999-01-26 | Novartis Ag | Transformed aryl and the troiryl pyrimidines and herbicides containing them |
| GB9405347D0 (en) | 1994-03-18 | 1994-05-04 | Agrevo Uk Ltd | Fungicides |
| US5563143A (en) | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
| US6057346A (en) | 1994-12-12 | 2000-05-02 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of retroviral LTR promoters by calcium response modifiers |
| CZ290330B6 (cs) | 1995-01-26 | 2002-07-17 | American Cyanamid Company | 2,6-Disubstituované pyridinové a 2,4-disubstituované pyrimidinové deriváty, způsob a meziprodukty pro jejich výrobu, jejich pouľití a herbicidní prostředky na jejich bázi a způsob potlačování růstu neľádoucích rostlin |
| US5849758A (en) | 1995-05-30 | 1998-12-15 | American Cyanamid Company | Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines |
| US6008161A (en) | 1995-05-30 | 1999-12-28 | American Cyanamid Company | Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines |
| US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
| JP2002515854A (ja) | 1995-08-02 | 2002-05-28 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗薬 |
| AU6320998A (en) | 1997-02-21 | 1998-09-09 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
| JP2001526648A (ja) | 1997-04-22 | 2001-12-18 | コセンシス・インコーポレイテッド | 炭素環及びヘテロ環で置換されたセミカルバゾン及びチオセミカルバゾン、及びその使用 |
| HUP0202076A3 (en) | 1997-12-12 | 2003-12-29 | Abbott Lab | Triazine angiogenesis inhibitors |
| AU1504599A (en) | 1997-12-17 | 1999-07-05 | Shionogi & Co., Ltd. | Novel pyridine compounds |
| HUP0100261A2 (hu) | 1997-12-19 | 2001-05-28 | Takeda Chemical Industries, Ltd. | Anilidszármazékok, eljárás előállításukra és alkalmazásuk |
| WO1999038829A1 (en) | 1998-01-28 | 1999-08-05 | Shionogi & Co., Ltd. | Novel tricyclic compound |
| AU1409100A (en) | 1998-11-27 | 2000-06-19 | Takeda Chemical Industries Ltd. | Drugs |
| EP1140901A2 (en) | 1998-12-24 | 2001-10-10 | Aventis Pharmaceuticals Products Inc. | Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds as factor xa inhibitors |
| PL351439A1 (en) | 1999-03-26 | 2003-04-22 | Euro Celtique Sa | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| AU770600B2 (en) | 1999-10-07 | 2004-02-26 | Amgen, Inc. | Triazine kinase inhibitors |
| DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| IL150650A0 (en) | 2000-01-20 | 2003-02-12 | Eisai Co Ltd | Piperidine derivatives and pharmaceutical compositions containing the same |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| BR0108819A (pt) | 2000-03-24 | 2002-12-10 | Euro Celtique Sa | Pirazóis triazóis e tetrazóis substituìdos de arila, e o uso dos mesmos |
| JP2003529589A (ja) | 2000-03-31 | 2003-10-07 | ユーロ−セルティック エス． ア． | アミノピリジンならびにこれらの鎮痙薬およびナトリウムチャンネル遮断薬としての使用 |
| JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| US6394753B1 (en) * | 2001-02-07 | 2002-05-28 | Hypro Corporation | Flexible impeller removal and installation method |
| US6552188B2 (en) * | 2001-06-29 | 2003-04-22 | Kowa Co., Ltd. | Unsymmetrical cyclic diamine compound |
| US6395753B1 (en) * | 2001-08-30 | 2002-05-28 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| EP1483247B1 (en) | 2002-03-13 | 2009-06-24 | Euro-Celtique S.A. | Aryl substituted pyrimidines and the use thereof |
-
2002
- 2002-08-27 AR ARP020103213A patent/AR037233A1/es unknown
- 2002-09-06 RU RU2004110721/04A patent/RU2004110721A/ru not_active Application Discontinuation
- 2002-09-06 WO PCT/US2002/028298 patent/WO2003022276A1/en not_active Ceased
- 2002-09-06 IL IL16071602A patent/IL160716A0/xx unknown
- 2002-09-06 HU HU0500131A patent/HUP0500131A3/hu unknown
- 2002-09-06 JP JP2003526405A patent/JP2005506981A/ja not_active Withdrawn
- 2002-09-06 MX MXPA04002171A patent/MXPA04002171A/es unknown
- 2002-09-06 US US10/235,673 patent/US7105549B2/en not_active Expired - Lifetime
- 2002-09-06 CA CA002459527A patent/CA2459527A1/en not_active Abandoned
- 2002-09-06 KR KR10-2004-7003314A patent/KR20040031053A/ko not_active Withdrawn
- 2002-09-06 EP EP02773292A patent/EP1432419A1/en not_active Withdrawn
- 2002-09-06 BR BR0212338-0A patent/BR0212338A/pt not_active Application Discontinuation
-
2006
- 2006-09-11 US US11/518,448 patent/US7579367B2/en not_active Expired - Fee Related
-
2009
- 2009-08-24 US US12/546,572 patent/US7943643B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005506981A5 (enExample) | ||
| RU2004110721A (ru) | Арилзамещенные пиридины, использование их в качестве блокаторов натриевых каналов, фармацевтическая композиция | |
| JP2014517068A5 (enExample) | ||
| CA2480356A1 (en) | Benzamide derivatives useful as histone deacetylase inhibitors | |
| CA2412968A1 (en) | Substituted pyridines as selective cyclooxygenase-2 inhibitors | |
| WO2006124490A3 (en) | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia | |
| RU2019123404A (ru) | Производное пиримидина | |
| CA2094390A1 (en) | N-substituted imidazol-2-one compounds for treatment of circulatory disorders | |
| WO2007014940A8 (en) | Quinoline derivatives as antibacterical agents | |
| EP2573079A3 (en) | Benzimidazole quinolinones and uses thereof | |
| CA2566160A1 (en) | Pyrrolopyrimidine derivatives useful in cancer treatment | |
| JP2010534654A5 (enExample) | ||
| CA2409741A1 (en) | Tnf-.alpha. production inhibitors | |
| MX2009010491A (es) | Derivado heterociclico de 5 miembros y su uso para propositos medicos. | |
| JP2010031025A5 (enExample) | ||
| WO2003101932A3 (en) | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | |
| RU2002128916A (ru) | Арилзамещенные пиразолы, триазолы или тетразолы (варианты), фармацевтическая композиция, способ лечения заболевания, связанного с блокированием натриевых каналов, у млекопитающего, способ лечения, профилактики или снижения интенсивности различных нарушений или состояний, способ снижения интенсивности или профилактики приступов у животного | |
| RU2008141509A (ru) | Mglur5 модуляторы 1 | |
| JP2005501120A5 (enExample) | ||
| JP2009544602A5 (enExample) | ||
| MX337527B (es) | Derivado de (aza)indol y su uso para propositos medicos. | |
| WO2007134678A3 (de) | Triazolderivate ii | |
| JP2014524461A5 (enExample) | ||
| RU2003103780A (ru) | Соединения фенилпиридазина и содержащие их лекарственные средства | |
| JP2012509263A5 (enExample) |