JP2005506354A5 - - Google Patents

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Publication number

JP2005506354A5

JP2005506354A5 JP2003536196A JP2003536196A JP2005506354A5 JP 2005506354 A5 JP2005506354 A5 JP 2005506354A5 JP 2003536196 A JP2003536196 A JP 2003536196A JP 2003536196 A JP2003536196 A JP 2003536196A JP 2005506354 A5 JP2005506354 A5 JP 2005506354A5

Authority

JP

Japan

Prior art keywords

butyl

compound

group

independently selected

cho

Prior art date

2002-10-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• -1 amine compounds Chemical class 0.000 claims description 17
• 125000006239 protecting group Chemical group 0.000 claims description 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
• 150000001875 compounds Chemical class 0.000 claims 20
• 125000000217 alkyl group Chemical group 0.000 claims 12
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 10
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 6
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 6
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 230000008878 coupling Effects 0.000 claims 3
• 238000010168 coupling process Methods 0.000 claims 3
• 238000005859 coupling reaction Methods 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 229910052757 nitrogen Inorganic materials 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 125000003368 amide group Chemical group 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 125000000524 functional group Chemical group 0.000 description 3
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• HCKNRHBSGZMOOF-UHFFFAOYSA-N 1-methoxy-2-methylperoxyethane Chemical compound COCCOOC HCKNRHBSGZMOOF-UHFFFAOYSA-N 0.000 description 1
• LCDVIFFXBDYLIA-UHFFFAOYSA-N 4-[[[(3,4-dimethoxyphenyl)methoxy-nitromethoxy]-nitromethoxy]methyl]-1,2-dimethoxybenzene Chemical compound C1=C(OC)C(OC)=CC=C1COC([N+]([O-])=O)OC([N+]([O-])=O)OCC1=CC=C(OC)C(OC)=C1 LCDVIFFXBDYLIA-UHFFFAOYSA-N 0.000 description 1
• 208000019901 Anxiety disease Diseases 0.000 description 1
• 230000036506 anxiety Effects 0.000 description 1
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
• 125000003636 chemical group Chemical group 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
• NSPJNIDYTSSIIY-UHFFFAOYSA-N methoxy(methoxymethoxy)methane Chemical compound COCOCOC NSPJNIDYTSSIIY-UHFFFAOYSA-N 0.000 description 1
• 125000006502 nitrobenzyl group Chemical group 0.000 description 1
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
• 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
• 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1