JP2005505271A5 - - Google Patents
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- JP2005505271A5 JP2005505271A5 JP2003527060A JP2003527060A JP2005505271A5 JP 2005505271 A5 JP2005505271 A5 JP 2005505271A5 JP 2003527060 A JP2003527060 A JP 2003527060A JP 2003527060 A JP2003527060 A JP 2003527060A JP 2005505271 A5 JP2005505271 A5 JP 2005505271A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- protein
- steap
- polynucleotide
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 55
- 108090000623 proteins and genes Proteins 0.000 claims 50
- 102000004169 proteins and genes Human genes 0.000 claims 44
- 108091033319 polynucleotide Proteins 0.000 claims 23
- 102000040430 polynucleotide Human genes 0.000 claims 23
- 239000002157 polynucleotide Substances 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 239000000126 substance Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 239000000523 sample Substances 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 7
- 210000003719 b-lymphocyte Anatomy 0.000 claims 6
- 230000005907 cancer growth Effects 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 210000000987 immune system Anatomy 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000053642 Catalytic RNA Human genes 0.000 claims 3
- 108090000994 Catalytic RNA Proteins 0.000 claims 3
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091092562 ribozyme Proteins 0.000 claims 3
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31784001P | 2001-09-06 | 2001-09-06 | |
| US37038702P | 2002-04-05 | 2002-04-05 | |
| PCT/US2002/028371 WO2003022995A2 (en) | 2001-09-06 | 2002-09-06 | Nucleic acid and corresponding protein entitled steap-1 useful in treatment and detection of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008110791A Division JP2008285483A (ja) | 2001-09-06 | 2008-04-21 | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505271A JP2005505271A (ja) | 2005-02-24 |
| JP2005505271A5 true JP2005505271A5 (enExample) | 2005-12-22 |
Family
ID=26981182
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527060A Withdrawn JP2005505271A (ja) | 2001-09-06 | 2002-09-06 | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
| JP2008110791A Withdrawn JP2008285483A (ja) | 2001-09-06 | 2008-04-21 | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
| JP2010109716A Expired - Lifetime JP5787487B2 (ja) | 2001-09-06 | 2010-05-11 | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008110791A Withdrawn JP2008285483A (ja) | 2001-09-06 | 2008-04-21 | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
| JP2010109716A Expired - Lifetime JP5787487B2 (ja) | 2001-09-06 | 2010-05-11 | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060073150A1 (enExample) |
| EP (2) | EP1429793B1 (enExample) |
| JP (3) | JP2005505271A (enExample) |
| AU (2) | AU2002336446B2 (enExample) |
| CA (1) | CA2459318C (enExample) |
| ES (2) | ES2537074T3 (enExample) |
| WO (1) | WO2003022995A2 (enExample) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US20060052321A1 (en) | 2002-04-05 | 2006-03-09 | Raitano Arthur B | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| US20040141975A1 (en) | 1998-06-01 | 2004-07-22 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| ES2629442T3 (es) | 1998-06-01 | 2017-08-09 | Agensys, Inc. | Nuevos antígenos transmembranales en serpentina expresados en cánceres humanos y utilizaciones de los mismos |
| US20060073150A1 (en) | 2001-09-06 | 2006-04-06 | Mary Faris | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
| US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| AU2003256912A1 (en) * | 2002-08-16 | 2004-03-03 | Yeda Research And Development Co. Ltd. | Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines |
| JP5840351B2 (ja) | 2002-09-06 | 2016-01-06 | アジェンシス，インコーポレイテッド | 癌の処置および検出において有用な９８ｐ４ｂ６と称される、核酸および対応タンパク質 |
| CN103394083B (zh) | 2003-11-06 | 2017-07-18 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| BRPI0418766B8 (pt) * | 2004-04-22 | 2021-05-25 | Agensys Inc | anticorpo ou seu fragmento, vetor, composição farmacêutica, ensaio e método para detectar a presença de proteína steap-1, bem como método para distribuir um agente citotóxico ou um agente de diagnóstico |
| CA2567520A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Maytansinoid-antibody conjugates |
| CN104447992A (zh) | 2004-09-23 | 2015-03-25 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| JP5129122B2 (ja) | 2005-04-26 | 2013-01-23 | トリオン ファーマ ゲーエムベーハー | 癌治療のための抗体およびグルココルチコイドの組み合わせ |
| WO2007109321A2 (en) | 2006-03-20 | 2007-09-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| FR2907681B1 (fr) * | 2006-10-26 | 2012-10-19 | Vincience | Composition pharmaceutique et/ou cosmetique contenant des polypeptides ou des peptides. |
| WO2008052187A2 (en) | 2006-10-27 | 2008-05-02 | Genentech. Inc. | Antibodies and immunoconjugates and uses therefor |
| JP2008289380A (ja) * | 2007-05-22 | 2008-12-04 | Sapporo Medical Univ | 新規癌抗原ペプチドおよびその利用 |
| PL2176296T3 (pl) | 2007-07-16 | 2012-07-31 | Genentech Inc | Przeciwciała anty-CD79B i immunokoniugaty i sposoby stosowania |
| CN101802013B (zh) | 2007-07-16 | 2014-07-02 | 健泰科生物技术公司 | 人源化抗cd79b抗体和免疫偶联物及使用方法 |
| WO2009032949A2 (en) | 2007-09-04 | 2009-03-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| CA2700410C (en) * | 2007-10-03 | 2020-10-06 | Cornell University | Treatment of proliferative disorders using antibodies to psma |
| SI2247620T1 (sl) | 2008-01-31 | 2016-09-30 | Genentech, Inc. | Protitelesa proti CD79b in imunokonjugati in postopki za uporabo |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| WO2010096486A1 (en) * | 2009-02-17 | 2010-08-26 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| EP2475391B1 (en) | 2009-09-09 | 2018-09-12 | Centrose, LLC | Extracellular targeted drug conjugates |
| EP2506876B1 (en) | 2009-12-02 | 2016-10-12 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| CN102933236B (zh) | 2010-04-15 | 2014-10-08 | 斯皮罗根有限公司 | 吡咯并苯二氮卓类及其结合物 |
| HUE049886T2 (hu) * | 2010-05-14 | 2020-10-28 | Massachusetts Gen Hospital | Tumorspecifikus neoantigéneket tartalmazó készítmények, tumorok kezelésében történõ alkalmazásra |
| MX336540B (es) | 2010-06-08 | 2016-01-22 | Genentech Inc | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
| KR101939150B1 (ko) * | 2010-11-12 | 2019-01-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 공통 전립선 항원, 이것을 암호화하는 핵산 분자, 그리고 이것을 포함하는 백신 및 용도 |
| ES2544608T3 (es) | 2010-11-17 | 2015-09-02 | Genentech, Inc. | Conjugados de anticuerpo y de alaninil-maitansinol |
| JPWO2012141201A1 (ja) * | 2011-04-11 | 2014-07-28 | 公立大学法人大阪市立大学 | 癌免疫療法のためのペプチド及びその利用 |
| WO2012155019A1 (en) | 2011-05-12 | 2012-11-15 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides |
| DK2750713T3 (en) | 2011-10-14 | 2015-12-21 | Medimmune Ltd | PYRROLOBENZODIAZEPINS AND CONJUGATES THEREOF |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| BR112015008173A2 (pt) | 2012-10-12 | 2017-11-28 | Adc Therapeutics Sarl | conjugados de pirrolobenzodiazepina-anticorpo anti-psma |
| DK2906298T3 (en) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| ES2660029T3 (es) | 2012-10-12 | 2018-03-20 | Medimmune Limited | Conjugados de anticuerpo-pirrolobenzodiazepinas |
| EP2906251B1 (en) | 2012-10-12 | 2017-09-27 | ADC Therapeutics SA | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
| AU2013328625B2 (en) | 2012-10-12 | 2016-12-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| SI2766048T1 (sl) | 2012-10-12 | 2015-03-31 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
| WO2014096365A1 (en) | 2012-12-21 | 2014-06-26 | Spirogen Sàrl | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
| US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CN105209077B (zh) | 2013-03-13 | 2019-06-11 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓以及其结合物 |
| EP2968594B1 (en) | 2013-03-13 | 2019-04-24 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| EA027910B1 (ru) | 2013-03-13 | 2017-09-29 | Медимьюн Лимитед | Пирролобензодиазепины и их конъюгаты |
| TWI636792B (zh) | 2013-08-12 | 2018-10-01 | 建南德克公司 | １－（氯甲基）－２，３－二氫－１ｈ－苯并［ｅ］吲哚二聚體抗體－藥物結合物化合物及使用與治療方法 |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| KR102354207B1 (ko) | 2013-12-16 | 2022-01-20 | 제넨테크, 인크. | 펩티드모방체 화합물 및 그의 항체-약물 접합체 |
| MX2016007578A (es) | 2013-12-16 | 2016-10-03 | Genentech Inc | Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento. |
| JP6895254B2 (ja) | 2013-12-16 | 2021-06-30 | ジェネンテック， インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
| BR112016014410A2 (pt) | 2013-12-20 | 2018-02-20 | The Broad Institute Inc. | terapia de combinação com vacina de neoantígeno |
| US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| MX2017003123A (es) | 2014-09-12 | 2017-05-12 | Genentech Inc | Anticuerpos y conjugados modificados geneticamente con cisteina. |
| EP3191134B1 (en) | 2014-09-12 | 2019-11-20 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| BR112017005393A2 (pt) | 2014-09-17 | 2017-12-05 | Genentech Inc | composto de fórmula i, método de preparação de um conjugado de fórmula a, conjugado de fórmula a1, composição compreendendo uma mistura dos compostos de conjugado de anticorpo-fármaco, composição farmacêutica, e uso de um conjugado ou de uma composição |
| CA2979671C (en) | 2014-09-23 | 2020-03-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates |
| BR112017011111A2 (pt) | 2014-11-25 | 2017-12-26 | Adc Therapeutics Sa | conjugados de pirrolobenzodiazepina-anticorpo |
| KR20170086121A (ko) | 2014-12-03 | 2017-07-25 | 제넨테크, 인크. | 4급 아민 화합물 및 그의 항체-약물 접합체 |
| EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
| EP3234130B1 (en) | 2014-12-19 | 2020-11-25 | The Broad Institute, Inc. | Methods for profiling the t-cell- receptor repertoire |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| BR112017024797A2 (pt) | 2015-05-20 | 2018-08-07 | The Broad Institute Inc. | neoantígenos partilhados |
| RU2765242C2 (ru) | 2015-08-07 | 2022-01-27 | Имаджинаб, Инк. | Антигенсвязывающие конструкции против молекул-мишеней |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EP3433621A1 (en) | 2016-03-25 | 2019-01-30 | H. Hoffnabb-La Roche Ag | Multiplexed total antibody and antibody-conjugated drug quantification assay |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
| EP3465221B1 (en) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| CN109476648B (zh) | 2016-06-06 | 2022-09-13 | 豪夫迈·罗氏有限公司 | 司维司群抗体-药物缀合物和使用方法 |
| EP3496763A1 (en) | 2016-08-11 | 2019-06-19 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
| WO2018058001A1 (en) * | 2016-09-23 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
| CN110139674B (zh) | 2016-10-05 | 2023-05-16 | 豪夫迈·罗氏有限公司 | 制备抗体药物缀合物的方法 |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| US11160872B2 (en) | 2017-02-08 | 2021-11-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| WO2018184966A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Antibodies binding to steap-1 |
| PL3612537T3 (pl) | 2017-04-18 | 2022-11-07 | Medimmune Limited | Koniugaty pirolobenzodiazepin |
| MX2019012464A (es) | 2017-04-20 | 2019-12-11 | Adc Therapeutics Sa | Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl. |
| UA127900C2 (uk) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Схема дозування для введення adc до cd19 |
| SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
| AU2018337815A1 (en) | 2017-09-20 | 2020-03-12 | Ph Pharma Co., Ltd. | Thailanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| UY38289A (es) * | 2018-07-02 | 2020-01-31 | Amgen Inc | Proteína de unión al antígeno anti-steap1 |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| CN113056287A (zh) | 2018-10-24 | 2021-06-29 | 豪夫迈·罗氏有限公司 | 缀合的化学降解诱导剂及使用方法 |
| JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック， インコーポレイテッド | Ｆｃ含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| CA3130174A1 (en) | 2019-03-15 | 2020-09-24 | Medimmune Limited | Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer |
| US10659173B1 (en) | 2019-07-18 | 2020-05-19 | Amazing Microelectronic Corp. | Digital isolator module for high level common mode transient immunity |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| AR128330A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpo y métodos de estos |
| AR128331A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpos y métodos de estos |
| WO2024138128A2 (en) | 2022-12-23 | 2024-06-27 | Genentech, Inc. | Cereblon degrader conjugates, and uses thereof |
| AU2024257248A1 (en) | 2023-04-17 | 2025-11-06 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
Family Cites Families (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4736866A (en) | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| GB8724885D0 (en) | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| AU625013B2 (en) | 1989-11-03 | 1992-06-25 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| EP1013666B1 (en) | 1990-06-27 | 2006-05-10 | Princeton University | Protein complex p53/p90 |
| SE9002480D0 (sv) | 1990-07-23 | 1990-07-23 | Hans Lilja | Assay of free and complexed prostate-specific antigen |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| WO1993025673A1 (en) | 1992-06-04 | 1993-12-23 | The Regents Of The University Of California | In vivo gene therapy with intron-free sequence of interest |
| EP0656788B1 (en) | 1992-08-07 | 2006-10-18 | Pharmexa Inc. | Hla binding peptides and their uses |
| US5489525A (en) | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
| EP0703783B1 (en) | 1993-03-05 | 2010-05-05 | Epimmune Inc. | Methods of making immunogenic hla-a2.1 binding peptides |
| US5837501A (en) | 1993-07-09 | 1998-11-17 | Akzo Nobel N.V. | Nucleic acid quantitation by co-amplification of target with multiple internal controls |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| ATE415173T1 (de) | 1993-09-14 | 2008-12-15 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
| EP0679716A4 (en) | 1993-11-12 | 1999-06-09 | Kenichi Matsubara | GENE SIGNATURE. |
| CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| DK0773952T3 (da) | 1994-07-20 | 2004-03-22 | Inst Genetics Llc | Interaktionsfældesystemer til påvisning af proteininteraktioner |
| US5919652A (en) | 1994-11-09 | 1999-07-06 | The Regents Of The University Of California | Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| NZ306767A (en) | 1995-04-11 | 2000-03-27 | Univ Johns Hopkins | Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| CU22559A1 (es) | 1996-01-17 | 1999-05-03 | Ct Ingenieria Genetica Biotech | Sistema de expresión de antígenos heterologos en e. coli como proteínas de fusión |
| AU2203797A (en) | 1996-03-11 | 1997-10-01 | Epimmune, Inc. | Peptides with increased binding affinity for hla molecules |
| EP0907750B1 (en) | 1996-04-26 | 2002-09-18 | Massachusetts Institute Of Technology | Three-hybrid screening assay |
| US5859045A (en) * | 1996-05-08 | 1999-01-12 | Novo Nordisk A/S Novo Alle | Crystalline -! 3R 4R-trans-7 methoxy 2,2-dimethyl1-3-phenyl 1-4 4-12 pyrrolidin-1 -Y1!ethoxyl 1!chromane hydrogen fumarate |
| WO1998004720A1 (en) | 1996-07-26 | 1998-02-05 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| US5824504A (en) | 1996-09-26 | 1998-10-20 | Elshourbagy; Nabil A. | Human 7-transmembrane receptor and DNA |
| WO1998016628A1 (en) | 1996-10-15 | 1998-04-23 | The Regents Of The University Of California | Animal models of human prostate cancer progression |
| US5846722A (en) | 1996-10-16 | 1998-12-08 | Terrapin Technologies, Inc. | System to detect small molecule/peptide interaction |
| US5840501A (en) | 1996-10-25 | 1998-11-24 | Bayer Corporation | Determination of cPSA |
| WO1998018489A1 (en) | 1996-10-30 | 1998-05-07 | The Uab Research Foundation | Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain intracellular antibodies |
| WO1998024893A2 (en) | 1996-12-03 | 1998-06-11 | Abgenix, Inc. | TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM |
| IL131560A0 (en) | 1997-02-25 | 2001-01-28 | Corixa Corp | Compounds for immunotherapy of prostate cancer and methods for their use |
| BR9807734A (pt) | 1997-02-25 | 2000-10-31 | Corixa Corp | Composto para imunodiagnose de câncer de próstata e métodos para o uso dos memos |
| US6800746B2 (en) * | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| EP0983357A1 (en) | 1997-05-23 | 2000-03-08 | Biogen, Inc. | Modulators of tissue regeneration |
| CA2296287A1 (en) | 1997-08-01 | 1999-02-11 | Genset | 5' ests for secreted proteins expressed in prostate |
| JP2001512011A (ja) | 1997-08-01 | 2001-08-21 | ジェンセット | 組織非特異的分泌タンパク質の５’ｅｓｔ |
| JPH11164691A (ja) | 1997-10-03 | 1999-06-22 | Rikagaku Kenkyusho | 胚盤胞ｃＤＮＡ |
| US20030060612A1 (en) * | 1997-10-28 | 2003-03-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20030064397A1 (en) * | 1998-05-22 | 2003-04-03 | Incyte Genomics, Inc. | Transmembrane protein differentially expressed in prostate and lung tumors |
| US6048970A (en) * | 1998-05-22 | 2000-04-11 | Incyte Pharmaceuticals, Inc. | Prostate growth-associated membrane proteins |
| ES2629442T3 (es) * | 1998-06-01 | 2017-08-09 | Agensys, Inc. | Nuevos antígenos transmembranales en serpentina expresados en cánceres humanos y utilizaciones de los mismos |
| TW200728465A (en) | 1998-07-14 | 2007-08-01 | Corixa Corp | Compositions and methods for the therapy and diagnosis of prostate cancer |
| EP1140970A4 (en) | 1998-12-17 | 2003-10-22 | Human Genome Sciences Inc | 47 HUMAN SECRETED PROTEINS |
| US6416758B1 (en) * | 1999-04-28 | 2002-07-09 | Board Of Regents, The University Of Texax System | Antibody conjugate kits for selectively inhibiting VEGF |
| US20060073150A1 (en) * | 2001-09-06 | 2006-04-06 | Mary Faris | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
| JP2003502061A (ja) | 1999-06-11 | 2003-01-21 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ４８個のヒト分泌タンパク質 |
| JP2003527089A (ja) | 1999-08-17 | 2003-09-16 | インサイト・ゲノミックス・インコーポレイテッド | 膜関連タンパク質 |
| WO2001025272A2 (en) | 1999-10-04 | 2001-04-12 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| CA2391369A1 (en) | 1999-11-12 | 2001-05-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| JP4827357B2 (ja) * | 1999-12-06 | 2011-11-30 | アジェンシス，インコーポレイテッド | ヒト前立腺癌において発現されるヘビ状膜貫通抗原およびその使用方法 |
| RU2002121771A (ru) * | 2000-01-14 | 2004-03-10 | Корикса Корпорейшн (Us) | Композиции и способы для терапии и диагностики рака предстательной железы |
| WO2001057190A2 (en) * | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| WO2001057252A2 (en) | 2000-02-04 | 2001-08-09 | Aeomica, Inc. | Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes |
| AU2001241541A1 (en) | 2000-02-17 | 2001-08-27 | Millennium Predictive Medicine, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| AU4941101A (en) * | 2000-03-24 | 2001-10-08 | Fahri Saatcioglu | Novel prostate-specific or testis-specific nucleic acid molecules, polypeptides,and diagnostic and therapeutic methods |
| JP2004504808A (ja) | 2000-03-27 | 2004-02-19 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| JP2004509612A (ja) | 2000-06-05 | 2004-04-02 | アバロン ファーマシューティカルズ | ガン遺伝子決定および特徴的な遺伝子群を用いた治療用スクリーニング |
| JP2004512022A (ja) | 2000-06-09 | 2004-04-22 | コリクサ コーポレイション | 結腸癌の治療および診断のための組成物および方法 |
| EP1305450A2 (en) | 2000-07-28 | 2003-05-02 | Compugen Inc. | Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome |
| KR20030029847A (ko) | 2000-08-24 | 2003-04-16 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 조성물 및 방법 |
| EP1474528A4 (en) | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | METHODS FOR DIAGNOSING PROSTATE CANCER, COMPOSITIONS AND METHODS FOR SCREENING PROSTATE CANCER MODULATORS |
| EP1661986A1 (en) | 2000-11-17 | 2006-05-31 | Nuvelo, Inc. | Nucleic acids and polypeptides enocoded thereby that are member of the kallikrein gene familyNovel nucleic acids and polypeptides |
| AU2002235871A1 (en) | 2001-01-12 | 2002-07-30 | Hybrigenics | Protein-protein interactions between shigella flexneri polypeptides and mammalian polypeptides |
| CA2441755A1 (en) | 2001-03-21 | 2003-05-08 | Human Genome Sciences, Inc. | Human secreted proteins |
| AU2002337657A1 (en) | 2001-07-25 | 2003-02-17 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer |
| EP1308459A3 (en) | 2001-11-05 | 2003-07-09 | Research Association for Biotechnology | Full-length cDNA sequences |
| BRPI0418766B8 (pt) | 2004-04-22 | 2021-05-25 | Agensys Inc | anticorpo ou seu fragmento, vetor, composição farmacêutica, ensaio e método para detectar a presença de proteína steap-1, bem como método para distribuir um agente citotóxico ou um agente de diagnóstico |
| CN104447992A (zh) | 2004-09-23 | 2015-03-25 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
-
2002
- 2002-09-06 US US10/236,878 patent/US20060073150A1/en not_active Abandoned
- 2002-09-06 JP JP2003527060A patent/JP2005505271A/ja not_active Withdrawn
- 2002-09-06 ES ES02773295.7T patent/ES2537074T3/es not_active Expired - Lifetime
- 2002-09-06 WO PCT/US2002/028371 patent/WO2003022995A2/en not_active Ceased
- 2002-09-06 ES ES10008771.7T patent/ES2532757T3/es not_active Expired - Lifetime
- 2002-09-06 EP EP02773295.7A patent/EP1429793B1/en not_active Expired - Lifetime
- 2002-09-06 CA CA2459318A patent/CA2459318C/en not_active Expired - Lifetime
- 2002-09-06 EP EP10008771.7A patent/EP2287186B1/en not_active Expired - Lifetime
- 2002-09-06 AU AU2002336446A patent/AU2002336446B2/en not_active Expired
-
2006
- 2006-10-12 US US11/581,227 patent/US7884179B2/en not_active Expired - Lifetime
-
2008
- 2008-04-21 JP JP2008110791A patent/JP2008285483A/ja not_active Withdrawn
- 2008-06-06 AU AU2008202540A patent/AU2008202540A1/en not_active Abandoned
-
2010
- 2010-05-11 JP JP2010109716A patent/JP5787487B2/ja not_active Expired - Lifetime
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