JP2005503345A5 - - Google Patents
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- JP2005503345A5 JP2005503345A5 JP2002585436A JP2002585436A JP2005503345A5 JP 2005503345 A5 JP2005503345 A5 JP 2005503345A5 JP 2002585436 A JP2002585436 A JP 2002585436A JP 2002585436 A JP2002585436 A JP 2002585436A JP 2005503345 A5 JP2005503345 A5 JP 2005503345A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- halogen
- atoms
- alkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 1001
- 229910052717 sulfur Inorganic materials 0.000 claims 180
- 125000000217 alkyl group Chemical group 0.000 claims 178
- 125000003342 alkenyl group Chemical group 0.000 claims 155
- 229910052757 nitrogen Inorganic materials 0.000 claims 154
- 125000000304 alkynyl group Chemical group 0.000 claims 151
- 125000005843 halogen group Chemical group 0.000 claims 151
- 229910052760 oxygen Inorganic materials 0.000 claims 136
- 125000005842 heteroatom Chemical group 0.000 claims 111
- 125000003118 aryl group Chemical group 0.000 claims 101
- 125000003545 alkoxy group Chemical group 0.000 claims 90
- 229910052736 halogen Inorganic materials 0.000 claims 90
- 150000002367 halogens Chemical class 0.000 claims 90
- 125000001188 haloalkyl group Chemical group 0.000 claims 80
- 125000004438 haloalkoxy group Chemical group 0.000 claims 71
- 229910052739 hydrogen Inorganic materials 0.000 claims 49
- 239000001257 hydrogen Substances 0.000 claims 49
- 125000001072 heteroaryl group Chemical group 0.000 claims 47
- 125000000753 cycloalkyl group Chemical group 0.000 claims 40
- 150000002431 hydrogen Chemical class 0.000 claims 35
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 33
- 229920006395 saturated elastomer Polymers 0.000 claims 31
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 30
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 125000004429 atom Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 9
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 101100407335 Dictyostelium discoideum pde7 gene Proteins 0.000 claims 6
- 230000001404 mediated effect Effects 0.000 claims 6
- -1 piperidin-4-olyl group Chemical group 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010049088 Osteopenia Diseases 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- JEBHUFMDZLZEJP-UHFFFAOYSA-N 4-(3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine Chemical compound C1C(C)(C)CCCN1C1=NC=NC2=C1C(CCCC1)=C1S2 JEBHUFMDZLZEJP-UHFFFAOYSA-N 0.000 claims 1
- ZJZQFDBFPJDURJ-UHFFFAOYSA-N 4-(3,3-dimethylpiperidin-1-yl)-6,8-dihydro-5h-pyrano[4,5]thieno[1,2-c]pyrimidine Chemical compound C1C(C)(C)CCCN1C1=NC=NC2=C1C(CCOC1)=C1S2 ZJZQFDBFPJDURJ-UHFFFAOYSA-N 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 241001111421 Pannus Species 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- YGWJEMZMNCBCCM-UHFFFAOYSA-N n-(3-methylbutan-2-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1CCCC2=C1SC1=C2C(NC(C)C(C)C)=NC=N1 YGWJEMZMNCBCCM-UHFFFAOYSA-N 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- DYTQGJLVGDSCLF-UHFFFAOYSA-N thieno[2,3-d]pyrimidin-4-amine Chemical compound NC1=NC=NC2=C1C=CS2 DYTQGJLVGDSCLF-UHFFFAOYSA-N 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28762901P | 2001-04-30 | 2001-04-30 | |
| PCT/US2002/013630 WO2002088138A1 (en) | 2001-04-30 | 2002-04-29 | Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010030397A Division JP2010155847A (ja) | 2001-04-30 | 2010-02-15 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503345A JP2005503345A (ja) | 2005-02-03 |
| JP2005503345A5 true JP2005503345A5 (OSRAM) | 2005-12-22 |
Family
ID=23103719
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585436A Withdrawn JP2005503345A (ja) | 2001-04-30 | 2002-04-29 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
| JP2010030397A Pending JP2010155847A (ja) | 2001-04-30 | 2010-02-15 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010030397A Pending JP2010155847A (ja) | 2001-04-30 | 2010-02-15 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6849638B2 (OSRAM) |
| EP (1) | EP1401840A4 (OSRAM) |
| JP (2) | JP2005503345A (OSRAM) |
| CN (2) | CN101100472A (OSRAM) |
| MX (1) | MXPA03009925A (OSRAM) |
| WO (1) | WO2002088138A1 (OSRAM) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| CN1777612A (zh) * | 2003-03-31 | 2006-05-24 | 普雷迪克医药品控股公司 | 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物 |
| JP4712702B2 (ja) * | 2003-07-24 | 2011-06-29 | バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト | 高増殖性疾患を処置するために有用な置換されたテトラヒドロベンゾチエノピリミジンアミン化合物 |
| US8207172B2 (en) * | 2004-08-20 | 2012-06-26 | Bayer Intellectual Property Gmbh | Pyrimidinothienoindazoles useful for the treatment of hyperproliferative disorders |
| JP5070059B2 (ja) * | 2004-10-27 | 2012-11-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | 新規ピリミドチエノインダゾール類 |
| AU2006261082B2 (en) * | 2005-06-22 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Thienopyrimidines for pharmaceutical compositions |
| US7846664B2 (en) * | 2005-12-07 | 2010-12-07 | The Regents Of The University Of California | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) |
| WO2007115822A1 (en) * | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnkl /mnk2 inhibiting activity for pharmaceutical compositions |
| EP1889847A1 (en) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| NZ580413A (en) | 2007-03-27 | 2012-11-30 | Omeros Corp | The use of pde7 inhibitors for the treatment of movement disorders |
| US7982035B2 (en) | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
| JP5461402B2 (ja) | 2007-09-14 | 2014-04-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換三環式化合物およびその使用方法 |
| CA2702518A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | New piperazino-dihydrothienopyrimidine derivatives |
| JP2011500621A (ja) * | 2007-10-19 | 2011-01-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規フェニル置換ピペラジノ−ジヒドロチエノピリミジン |
| BRPI0817781A2 (pt) | 2007-10-19 | 2019-09-24 | Boehringer Ingelheim Int | piperazino-diidroteinopirimidinas substituídas com heterociclo |
| PT2215092E (pt) | 2007-10-19 | 2012-04-10 | Boehringer Ingelheim Int | Piperidino-di-hidrotienopirimidinas substituídas |
| WO2009104026A1 (en) * | 2008-02-19 | 2009-08-27 | Vichem Chemie Kutató Kft | Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use |
| CN102186857A (zh) | 2008-08-26 | 2011-09-14 | 贝林格尔·英格海姆国际有限公司 | 用于药物组合物的噻吩并嘧啶 |
| WO2011029054A1 (en) | 2009-09-04 | 2011-03-10 | The Regents Of The University Of Michigan | Compositions and methods for treatment of leukemia |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| TW201141483A (en) | 2010-02-26 | 2011-12-01 | Boehringer Ingelheim Int | Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions |
| TW201141872A (en) | 2010-02-26 | 2011-12-01 | Boehringer Ingelheim Int | Cycloalkyl containing thienopyrimidines for pharmaceutical compositions |
| EP2595993B1 (en) * | 2010-07-23 | 2018-04-18 | President and Fellows of Harvard College | Tricyclic proteasome activity enhancing compounds |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| MX2013004943A (es) | 2010-11-08 | 2013-09-02 | Omeros Corp | Tratamiento de trastornos de adicion y control de impulsos usando inhibidores de pde7. |
| CN102552274B (zh) * | 2010-11-12 | 2013-10-23 | 姚雪彪 | 动点马达蛋白小分子抑制剂在抑制肿瘤细胞增殖中的应用 |
| US8703941B2 (en) * | 2011-01-10 | 2014-04-22 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| TWI589579B (zh) * | 2012-01-10 | 2017-07-01 | 林伯士艾瑞斯公司 | Ｉｒａｋ抑制劑及其用途 |
| AU2013202373B2 (en) * | 2012-01-25 | 2016-04-14 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| JP2015504919A (ja) | 2012-01-25 | 2015-02-16 | プロテオステイシス セラピューティクス，インコーポレイテッド | プロテアソーム活性を調節する化合物 |
| JP6235001B2 (ja) * | 2012-05-21 | 2017-11-22 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換ベンゾチエノピリミジン |
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| HK1210732A1 (en) | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| HK1210696A1 (en) | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
| BR112015014034A2 (pt) | 2013-01-10 | 2017-07-11 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| WO2014118229A1 (en) | 2013-02-01 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Substituted thienopyrimidines and pharmaceutical use thereof |
| WO2014134306A1 (en) | 2013-03-01 | 2014-09-04 | Zalicus Pharmaceuticals, Ltd. | Heterocyclic inhibitors of the sodium channel |
| US9675612B2 (en) | 2013-03-06 | 2017-06-13 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| RU2016110852A (ru) | 2013-09-27 | 2017-10-30 | Нимбус Айрис, Инк. | Ингибиторы irak и их применения |
| TW201605867A (zh) * | 2013-11-20 | 2016-02-16 | 拜耳製藥公司 | 噻吩并嘧啶 |
| EP3110799A4 (en) * | 2014-02-27 | 2017-10-11 | Epirus Biopharmaceuticals, Inc. | Heterocyclic inhibitors of the sodium channel |
| CN106661049A (zh) * | 2014-05-26 | 2017-05-10 | 拜耳制药股份公司 | 取代的四氢吡啶并噻吩并嘧啶 |
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
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| CN114539284A (zh) | 2016-03-16 | 2022-05-27 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
| BR112018068702A2 (pt) | 2016-03-16 | 2019-01-15 | Kura Oncology Inc | inibidores bicíclicos em ponte de menin-mll e métodos de uso |
| US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
| CN107158003B (zh) * | 2017-05-19 | 2020-10-30 | 中山大学 | 4n杂环化合物的衍生物在制备用于治疗自身免疫疾病的药物中的应用 |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| WO2019060365A1 (en) | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE |
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| WO2023097341A2 (en) | 2023-03-20 | 2023-06-01 | Fmc Corporation | Bicyclic amides and esters for controlling invertebrate pests |
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| CA1328333C (en) * | 1988-03-04 | 1994-04-05 | Quirico Branca | Amino acid derivatives |
| JPH01313480A (ja) * | 1988-06-14 | 1989-12-18 | Nippon Soda Co Ltd | ピリミジン誘導体、その製造方法及び農園芸用殺菌剤 |
| US4879309A (en) * | 1988-09-27 | 1989-11-07 | Schering Corporation | Mercapto-acylamino acids as antihypertensives |
| BR9101256A (pt) * | 1990-03-30 | 1991-11-05 | Dowelanco | Composto,composicao fungicida,processo fungicida,composicao inseticida ou acaricida e processo inseticida ou acaricida |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US5356903A (en) * | 1993-04-22 | 1994-10-18 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolines |
| JPH07126255A (ja) * | 1993-09-10 | 1995-05-16 | Eisai Co Ltd | キナゾリン系化合物 |
| US6316439B1 (en) * | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| DE19632423A1 (de) * | 1996-08-12 | 1998-02-19 | Merck Patent Gmbh | Thienopyrimidine |
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| JP3919272B2 (ja) * | 1996-12-18 | 2007-05-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キナゾリン系化合物 |
| RU2116309C1 (ru) * | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| WO1999043674A1 (en) * | 1998-02-27 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Remedies for erectile dysfunction |
| WO1999046267A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| CA2326324C (en) * | 1998-03-31 | 2010-05-11 | Kyowa Hakko Kogyo Co., Ltd. | Nitrogen-containing heterocyclic compound |
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| EP1323719A1 (en) | 1999-03-30 | 2003-07-02 | Nippon Soda Co., Ltd. | Thienopyrimidine compounds and salts thereof and process for the preparation of the same |
| IL148903A0 (en) * | 1999-09-30 | 2002-09-12 | Neurogen Corp | Certain alkylene diamine-substituted heterocycles |
| DE10042997A1 (de) * | 2000-09-01 | 2002-03-14 | Merck Patent Gmbh | Thienopyrimidine |
| DE10064994A1 (de) * | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
-
2002
- 2002-04-29 US US10/136,575 patent/US6849638B2/en not_active Expired - Fee Related
- 2002-04-29 EP EP02734103A patent/EP1401840A4/en not_active Withdrawn
- 2002-04-29 MX MXPA03009925A patent/MXPA03009925A/es active IP Right Grant
- 2002-04-29 WO PCT/US2002/013630 patent/WO2002088138A1/en not_active Ceased
- 2002-04-29 CN CNA2007101410179A patent/CN101100472A/zh active Pending
- 2002-04-29 CN CNB028133102A patent/CN100343258C/zh not_active Expired - Fee Related
- 2002-04-29 JP JP2002585436A patent/JP2005503345A/ja not_active Withdrawn
-
2010
- 2010-02-15 JP JP2010030397A patent/JP2010155847A/ja active Pending
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