JP2005287333A5 - - Google Patents
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- JP2005287333A5 JP2005287333A5 JP2004103652A JP2004103652A JP2005287333A5 JP 2005287333 A5 JP2005287333 A5 JP 2005287333A5 JP 2004103652 A JP2004103652 A JP 2004103652A JP 2004103652 A JP2004103652 A JP 2004103652A JP 2005287333 A5 JP2005287333 A5 JP 2005287333A5
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- JP
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- Prior art keywords
- gene
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- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 192
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 121
- 150000001413 amino acids Chemical group 0.000 claims description 85
- 235000018102 proteins Nutrition 0.000 claims description 68
- 102000004169 proteins and genes Human genes 0.000 claims description 68
- 235000013878 L-cysteine Nutrition 0.000 claims description 56
- 239000004201 L-cysteine Substances 0.000 claims description 56
- 244000005700 microbiome Species 0.000 claims description 46
- 230000029142 excretion Effects 0.000 claims description 38
- 235000001014 amino acid Nutrition 0.000 claims description 25
- 239000002157 polynucleotide Substances 0.000 claims description 20
- 102000040430 polynucleotide Human genes 0.000 claims description 20
- 108091033319 polynucleotide Proteins 0.000 claims description 20
- 241000588724 Escherichia coli Species 0.000 claims description 9
- 239000002773 nucleotide Substances 0.000 claims description 9
- 125000003729 nucleotide group Chemical group 0.000 claims description 9
- 101150049556 Bcr gene Proteins 0.000 claims description 8
- 101150063582 cusA gene Proteins 0.000 claims description 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 8
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
- 108091022908 Serine O-acetyltransferase Proteins 0.000 claims description 4
- 241000588722 Escherichia Species 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000012634 fragment Substances 0.000 description 7
- 239000013612 plasmid Substances 0.000 description 4
- 101150056082 emrA gene Proteins 0.000 description 3
- 101150117890 emrB gene Proteins 0.000 description 3
- 229960000723 ampicillin Drugs 0.000 description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 101150055530 sat gene Proteins 0.000 description 2
- 102220478437 Atypical chemokine receptor 2_M256I_mutation Human genes 0.000 description 1
- 101100080241 Bacillus subtilis (strain 168) norM gene Proteins 0.000 description 1
- 101100531630 Bacillus subtilis (strain 168) rsbRC gene Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000020018 Cystathionine gamma-Lyase Human genes 0.000 description 1
- 108010045283 Cystathionine gamma-lyase Proteins 0.000 description 1
- 102100036094 Endogenous retrovirus group 3 member 1 Env polyprotein Human genes 0.000 description 1
- 101100215313 Escherichia coli (strain K12) acrB gene Proteins 0.000 description 1
- 101100279587 Escherichia coli (strain K12) emrK gene Proteins 0.000 description 1
- 101100279588 Escherichia coli (strain K12) emrY gene Proteins 0.000 description 1
- 101100320938 Escherichia coli (strain K12) yojI gene Proteins 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 101000876380 Homo sapiens Endogenous retrovirus group 3 member 1 Env polyprotein Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 101150107447 acrE gene Proteins 0.000 description 1
- 101150044703 acrF gene Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 101150050892 cusR gene Proteins 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 101150059869 evgS gene Proteins 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 101150056718 mprA gene Proteins 0.000 description 1
- 101150094267 mqo gene Proteins 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004103652A JP4604537B2 (ja) | 2004-03-31 | 2004-03-31 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US10/957,828 US20050221453A1 (en) | 2004-03-31 | 2004-10-05 | L-cysteine producing microorganism and method for producing L-cysteine |
| US11/776,306 US20090226982A1 (en) | 2004-03-31 | 2007-07-11 | L-cysteine producing microorganism and method for producing l-cysteine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004103652A JP4604537B2 (ja) | 2004-03-31 | 2004-03-31 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005287333A JP2005287333A (ja) | 2005-10-20 |
| JP2005287333A5 true JP2005287333A5 (https=) | 2007-02-22 |
| JP4604537B2 JP4604537B2 (ja) | 2011-01-05 |
Family
ID=35054867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004103652A Expired - Fee Related JP4604537B2 (ja) | 2004-03-31 | 2004-03-31 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US20050221453A1 (https=) |
| JP (1) | JP4604537B2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| WO2005014839A2 (en) * | 2003-08-01 | 2005-02-17 | Cargill, Incorporated | Monatin tabletop sweetener compositions and methods of making same |
| WO2005020721A1 (en) * | 2003-08-25 | 2005-03-10 | Cargill, Incorporated | Beverage compositions comprising monatin and methods of making same |
| EP1678313B1 (en) * | 2003-10-21 | 2011-02-16 | Cargill, Incorporated | Production of monatin and monatin precursors |
| US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8153405B2 (en) * | 2005-04-20 | 2012-04-10 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| MX2008011477A (es) * | 2006-03-07 | 2008-09-23 | Cargill Inc | Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas. |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| WO2007140195A2 (en) * | 2006-05-24 | 2007-12-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| DE102007007333A1 (de) * | 2007-02-14 | 2008-08-21 | Wacker Chemie Ag | Verfahren zur Reinigung von L-Cystein |
| JP5319521B2 (ja) * | 2007-04-06 | 2013-10-16 | 協和発酵バイオ株式会社 | ジペプチドの製造法 |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| WO2009104731A1 (ja) | 2008-02-21 | 2009-08-27 | 味の素株式会社 | Ｌ－システイン生産菌及びｌ－システインの製造法 |
| US8383372B2 (en) | 2008-03-06 | 2013-02-26 | Ajinomoto Co., Inc. | L-cysteine producing bacterium and a method for producing L-cysteine |
| JP5332237B2 (ja) | 2008-03-06 | 2013-11-06 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP5521347B2 (ja) | 2009-02-16 | 2014-06-11 | 味の素株式会社 | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| JP5463528B2 (ja) | 2009-02-25 | 2014-04-09 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP5359409B2 (ja) | 2009-03-12 | 2013-12-04 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP5817529B2 (ja) | 2009-11-30 | 2015-11-18 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| RU2460793C2 (ru) * | 2010-01-15 | 2012-09-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae |
| BR112013006031A2 (pt) | 2010-09-14 | 2016-06-07 | Ajinomoto Kk | bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos. |
| JP2014087259A (ja) * | 2011-02-22 | 2014-05-15 | Ajinomoto Co Inc | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| EP2695940B1 (en) | 2011-04-01 | 2016-11-30 | Ajinomoto Co., Inc. | Method for producing l-cysteine |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| JP2014131487A (ja) | 2011-04-18 | 2014-07-17 | Ajinomoto Co Inc | Ｌ−システインの製造法 |
| DE102011075656A1 (de) | 2011-05-11 | 2012-03-29 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystin |
| DE102011078481A1 (de) | 2011-06-30 | 2013-01-03 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von natürlichem L-Cystein |
| DE102012208359A1 (de) | 2012-05-18 | 2013-11-21 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure |
| DE102012216527A1 (de) | 2012-09-17 | 2014-03-20 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure |
| EP2868745B1 (en) | 2013-05-13 | 2017-06-21 | Ajinomoto Co., Inc. | Method for manufacturing an L-amino acid |
| JP2016165225A (ja) | 2013-07-09 | 2016-09-15 | 味の素株式会社 | 有用物質の製造方法 |
| EP2886651B1 (en) | 2013-10-21 | 2018-08-22 | Ajinomoto Co., Inc. | Method for producing l-amino acid |
| JP6519476B2 (ja) | 2013-10-23 | 2019-05-29 | 味の素株式会社 | 目的物質の製造法 |
| JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| KR20190092951A (ko) * | 2018-01-31 | 2019-08-08 | 씨제이제일제당 (주) | 연속식 크로마토그래피 공정을 이용한 천연 l-시스테인 결정의 제조 방법 |
| KR20190092950A (ko) | 2018-01-31 | 2019-08-08 | 씨제이제일제당 (주) | 연속식 크로마토그래피 공정을 이용한 천연 l-시스테인 염산염 수화물 결정의 제조 방법 |
| EP3861109A1 (en) | 2018-10-05 | 2021-08-11 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| BR112021014194A2 (pt) | 2019-02-22 | 2021-12-28 | Ajinomoto Kk | Método para a produção de um l-aminoácido |
| BR112021017870A2 (pt) | 2019-04-05 | 2021-12-07 | Ajinomoto Kk | Método para produzir um l-aminoácido |
| JP7655312B2 (ja) | 2019-09-25 | 2025-04-02 | 味の素株式会社 | 細菌の発酵によるｌ－アミノ酸の製造方法 |
| EP4172310A1 (de) | 2020-06-26 | 2023-05-03 | Wacker Chemie AG | Verbesserte cystein produzierende stämme |
| JP7620698B2 (ja) | 2021-07-05 | 2025-01-23 | ワッカー ケミー アクチエンゲゼルシャフト | スルフィン酸をスルホン酸に酵素的に酸化する方法 |
| JP2025507906A (ja) * | 2022-03-01 | 2025-03-21 | ワッカー ケミー アクチエンゲゼルシャフト | 改善されたシステイン産生株 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19726083A1 (de) * | 1997-06-19 | 1998-12-24 | Consortium Elektrochem Ind | Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten |
| JP4186564B2 (ja) * | 2001-09-28 | 2008-11-26 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| RU2229513C2 (ru) * | 2001-11-23 | 2004-05-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты) |
-
2004
- 2004-03-31 JP JP2004103652A patent/JP4604537B2/ja not_active Expired - Fee Related
- 2004-10-05 US US10/957,828 patent/US20050221453A1/en not_active Abandoned
-
2007
- 2007-07-11 US US11/776,306 patent/US20090226982A1/en not_active Abandoned
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