JP2005052149A5 - - Google Patents
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- Publication number
- JP2005052149A5 JP2005052149A5 JP2004293969A JP2004293969A JP2005052149A5 JP 2005052149 A5 JP2005052149 A5 JP 2005052149A5 JP 2004293969 A JP2004293969 A JP 2004293969A JP 2004293969 A JP2004293969 A JP 2004293969A JP 2005052149 A5 JP2005052149 A5 JP 2005052149A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9815879.3A GB9815879D0 (en) | 1998-07-21 | 1998-07-21 | A polynucleotide |
| US10768898P | 1998-11-09 | 1998-11-09 | |
| GBGB9906712.6A GB9906712D0 (en) | 1999-03-23 | 1999-03-23 | A polynucleotide |
| US12741099P | 1999-04-01 | 1999-04-01 | |
| GBGB9909494.8A GB9909494D0 (en) | 1999-04-23 | 1999-04-23 | A plasmid |
| US13401699P | 1999-05-12 | 1999-05-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561339A Division JP4220673B2 (ja) | 1998-07-21 | 1999-07-21 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007285560A Division JP2008109931A (ja) | 1998-07-21 | 2007-11-01 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005052149A JP2005052149A (ja) | 2005-03-03 |
| JP2005052149A5 true JP2005052149A5 (https=) | 2005-09-29 |
Family
ID=27547316
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561339A Expired - Lifetime JP4220673B2 (ja) | 1998-07-21 | 1999-07-21 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2004293969A Pending JP2005052149A (ja) | 1998-07-21 | 2004-10-06 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2007285560A Withdrawn JP2008109931A (ja) | 1998-07-21 | 2007-11-01 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2008305611A Withdrawn JP2009102331A (ja) | 1998-07-21 | 2008-11-28 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561339A Expired - Lifetime JP4220673B2 (ja) | 1998-07-21 | 1999-07-21 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007285560A Withdrawn JP2008109931A (ja) | 1998-07-21 | 2007-11-01 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2008305611A Withdrawn JP2009102331A (ja) | 1998-07-21 | 2008-11-28 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP2348118A1 (https=) |
| JP (4) | JP4220673B2 (https=) |
| KR (3) | KR100795626B1 (https=) |
| CN (1) | CN100365127C (https=) |
| AU (1) | AU771111B2 (https=) |
| CA (1) | CA2333852C (https=) |
| MX (1) | MXPA01000830A (https=) |
| WO (1) | WO2000005393A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1430124B1 (en) | 2000-09-20 | 2013-11-06 | EMD Millipore Corporation | Artificial ubiquitous chromatin opening elements (ucoe) |
| DK1395669T3 (da) | 2001-01-26 | 2009-11-16 | Selexis Sa | Matriks bindingsregioner og fremgangsmåder til anvendelse af disse |
| US7812148B2 (en) | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| KR100955756B1 (ko) * | 2001-04-05 | 2010-04-30 | 밀리포어 코포레이션 | 개량된 유전자 발현 |
| EP2224010B1 (en) * | 2001-04-05 | 2012-06-20 | EMD Millipore Corporation | Improved gene expression |
| AU2002310275B2 (en) | 2001-05-30 | 2006-08-31 | Glaxo Group Limited | Chromosome-based platforms |
| WO2002099070A2 (en) * | 2001-06-04 | 2002-12-12 | Corixa Corporation | Compositions and methods for high-level, large-scale production of recombinant proteins |
| ATE466941T1 (de) | 2001-07-04 | 2010-05-15 | Chromagenics Bv | Dns-sequenzen mit anti-repressor-aktivität |
| CA2470277A1 (en) | 2002-01-09 | 2003-07-17 | Minos Biosystems Limited | Inducible transposition in transgenic organism using transposon vector |
| CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
| AU2003243059A1 (en) | 2002-06-14 | 2003-12-31 | Chromagenics B.V. | Use of repression blocking sequences in methods for enhancing gene expression |
| EP1573058B1 (en) | 2002-12-18 | 2011-09-14 | ChromaGenics B.V. | A method for improving protein production |
| ATE354645T1 (de) * | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
| WO2004067701A2 (en) * | 2003-02-01 | 2004-08-12 | Innovata Plc | Improved genetic elements providing high levels of expression |
| WO2005040377A2 (en) | 2003-10-24 | 2005-05-06 | Selexis S.A. | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
| WO2005065348A2 (en) | 2003-12-31 | 2005-07-21 | Kalobios, Inc. | Transactivation system for mammalian cells |
| KR20070038556A (ko) | 2004-07-20 | 2007-04-10 | 심포젠 에이/에스 | 항-ｒｈｅｓｕｓ ｄ 재조합 폴리클로날 항체 및 이의 제조방법 |
| EP1809750B1 (en) | 2004-11-08 | 2012-03-21 | ChromaGenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20060172382A1 (en) | 2004-11-08 | 2006-08-03 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| GB0504587D0 (en) | 2005-03-05 | 2005-04-13 | Ml Lab Plc | Vectors comprising guinea pig CMV regulatory elements |
| GB0509965D0 (en) * | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
| WO2007081336A1 (en) * | 2006-01-13 | 2007-07-19 | Five Prime Therapeutics, Inc. | Mammalian vectors for high-level expression of recombinant proteins |
| US7968700B2 (en) | 2006-03-20 | 2011-06-28 | Chromagenics B.V. | Expression augmenting DNA fragments, use thereof, and methods for finding thereof |
| JP2010525789A (ja) * | 2007-01-08 | 2010-07-29 | ミリポア・コーポレイション | １つ又はそれ以上のきょう雑物の低下したレベルの存在下で組換えタンパク質を生産するための細胞培養法 |
| CN104531699B (zh) * | 2014-10-09 | 2017-03-15 | 河南农业大学 | 一种增强外源基因表达的猪的ucoe调控元件片段 |
| KR102893385B1 (ko) * | 2014-12-16 | 2025-12-02 | 가반 인스티튜트 오브 메디컬 리서치 | 시퀀싱 컨트롤 |
| WO2018175153A1 (en) | 2017-03-19 | 2018-09-27 | Applied Stemcell, Inc. | Novel integration sites and uses thereof |
| CN110799643B (zh) | 2017-04-03 | 2023-12-22 | 小利兰·斯坦福大学托管委员会 | 用于细胞谱系的多重定量分析的组合物和方法 |
| US20200385754A1 (en) * | 2017-12-07 | 2020-12-10 | Integrity Biosolutions, Llc | Engineered ubiquitous chromatin opening elements and uses thereof |
| CN112135909A (zh) * | 2018-05-24 | 2020-12-25 | 国立大学法人北海道大学 | 新载体及其应用 |
| AU2019320771B2 (en) * | 2018-08-15 | 2025-12-18 | Illumina Cambridge Limited | Compositions and methods for improving library enrichment |
| AU2019354390A1 (en) * | 2018-10-02 | 2021-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for multiplexed quantitative analysis of cell lineages |
| WO2020223160A1 (en) * | 2019-04-30 | 2020-11-05 | Chan Zuckerberg Biohub, Inc. | A novel chromatin-opening element for stable long term gene expression |
| CN112575031B (zh) * | 2019-09-29 | 2023-04-07 | 新乡医学院 | 一种遍在染色质开放表达元件、重组表达载体、表达系统及其制备方法、应用 |
| CN116574735B (zh) * | 2023-07-03 | 2023-11-10 | 艾米能斯(苏州)生物科技有限公司 | 一种多核苷酸及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| GB8718779D0 (en) | 1987-08-07 | 1987-09-16 | Grosveld F G | Dna sequence & expression vector |
| ATE174058T1 (de) | 1989-11-06 | 1998-12-15 | Cell Genesys Inc | Herstellung von proteinen mittels homologer rekombination |
| DE59106279D1 (de) | 1990-05-18 | 1995-09-21 | Genentech Inc | Neue protein-polykation-konjugate. |
| WO1991018088A1 (en) | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
| GB9109928D0 (en) | 1991-05-08 | 1991-07-03 | Interox Chemicals Ltd | Thickened compositions |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| CA2131620A1 (en) | 1992-03-20 | 1993-09-30 | Louis C. Smith | A dna transporter system and method of use |
| US5583009A (en) * | 1992-12-08 | 1996-12-10 | University Of Washington | Method of preparing recombinant proteins in transgenic animals containing metallothionein gene elements that bestow tissue-independent copy number-dependent, position-indepedent gene expression |
| WO1995002698A1 (en) | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| EP0831922A2 (en) | 1995-06-08 | 1998-04-01 | Therexsys Limited | Improved pharmaceutical compositions for gene therapy |
| DE69704206T2 (de) | 1996-08-16 | 2001-08-30 | Medical Research Council, London | Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln |
| DE19651443A1 (de) | 1996-12-11 | 1998-06-18 | Hoechst Ag | Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme |
| WO1998035984A2 (en) | 1997-02-12 | 1998-08-20 | Cobra Therapeutics Limited | Compositions and methods for highly efficient transfection |
-
1999
- 1999-07-21 CN CNB998111554A patent/CN100365127C/zh not_active Expired - Lifetime
- 1999-07-21 CA CA002333852A patent/CA2333852C/en not_active Expired - Lifetime
- 1999-07-21 JP JP2000561339A patent/JP4220673B2/ja not_active Expired - Lifetime
- 1999-07-21 WO PCT/GB1999/002357 patent/WO2000005393A2/en not_active Ceased
- 1999-07-21 EP EP10183981A patent/EP2348118A1/en not_active Withdrawn
- 1999-07-21 AU AU50534/99A patent/AU771111B2/en not_active Expired
- 1999-07-21 MX MXPA01000830A patent/MXPA01000830A/es not_active IP Right Cessation
- 1999-07-21 EP EP99934910A patent/EP1098986B1/en not_active Expired - Lifetime
- 1999-07-21 KR KR1020017000883A patent/KR100795626B1/ko not_active Expired - Lifetime
-
2004
- 2004-10-06 JP JP2004293969A patent/JP2005052149A/ja active Pending
-
2007
- 2007-10-15 KR KR1020070103583A patent/KR20070108336A/ko not_active Ceased
- 2007-11-01 JP JP2007285560A patent/JP2008109931A/ja not_active Withdrawn
-
2008
- 2008-11-28 JP JP2008305611A patent/JP2009102331A/ja not_active Withdrawn
-
2009
- 2009-09-30 KR KR1020090093097A patent/KR20090117675A/ko not_active Ceased