JP2004536317A5 - - Google Patents

Download PDF

Info

Publication number
JP2004536317A5
JP2004536317A5 JP2003514953A JP2003514953A JP2004536317A5 JP 2004536317 A5 JP2004536317 A5 JP 2004536317A5 JP 2003514953 A JP2003514953 A JP 2003514953A JP 2003514953 A JP2003514953 A JP 2003514953A JP 2004536317 A5 JP2004536317 A5 JP 2004536317A5
Authority
JP
Japan
Prior art keywords
nucleic acid
conjugate
component
unit
sbu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003514953A
Other languages
English (en)
Japanese (ja)
Other versions
JP4388369B2 (ja
JP2004536317A (ja
Filing date
Publication date
Priority claimed from US09/910,469 external-priority patent/US6893822B2/en
Application filed filed Critical
Publication of JP2004536317A publication Critical patent/JP2004536317A/ja
Publication of JP2004536317A5 publication Critical patent/JP2004536317A5/ja
Application granted granted Critical
Publication of JP4388369B2 publication Critical patent/JP4388369B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003514953A 2001-07-19 2002-02-14 合成結合システムを用いる核酸のための選別および固定化システム Expired - Fee Related JP4388369B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/910,469 US6893822B2 (en) 2001-07-19 2001-07-19 Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
PCT/EP2002/001532 WO2003008638A2 (en) 2001-07-19 2002-02-14 Sorting and immobilization system for nucleic acids using synthetic bidning systems

Publications (3)

Publication Number Publication Date
JP2004536317A JP2004536317A (ja) 2004-12-02
JP2004536317A5 true JP2004536317A5 (enExample) 2005-12-22
JP4388369B2 JP4388369B2 (ja) 2009-12-24

Family

ID=25428823

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003514953A Expired - Fee Related JP4388369B2 (ja) 2001-07-19 2002-02-14 合成結合システムを用いる核酸のための選別および固定化システム

Country Status (9)

Country Link
US (2) US6893822B2 (enExample)
EP (3) EP2298929A1 (enExample)
JP (1) JP4388369B2 (enExample)
AT (1) ATE467686T1 (enExample)
AU (1) AU2002254892A1 (enExample)
DE (1) DE60236361D1 (enExample)
DK (1) DK1412518T3 (enExample)
ES (1) ES2345036T3 (enExample)
WO (1) WO2003008638A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
DE19837387A1 (de) * 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
AU2002327730A1 (en) * 2001-09-26 2003-04-07 University Of North Carolina At Chapel Hill Variants of alpha-fetoprotein coding and expression sequences
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US20040175737A1 (en) * 2002-12-23 2004-09-09 Wyeth Assay for RNase H activity
US7598227B2 (en) 2003-04-16 2009-10-06 Isis Pharmaceuticals Inc. Modulation of apolipoprotein C-III expression
JP4518754B2 (ja) * 2003-06-30 2010-08-04 パナソニック株式会社 ヌクレオチド鎖修飾方法
WO2006011673A1 (ja) * 2004-07-30 2006-02-02 Reverse Proteomics Research Institute Co., Ltd. 光切断型リンカーを利用したリガンド固定化固相担体
US20070048759A1 (en) * 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
US20070148246A1 (en) * 2005-08-11 2007-06-28 Dan Luo Nucleic Acid-Based Matrixes
US8486621B2 (en) * 2005-08-11 2013-07-16 Cornell Research Foundation, Inc. Nucleic acid-based matrixes
EP2069534A4 (en) * 2006-08-02 2010-08-11 California Inst Of Techn METHOD AND SYSTEMS FOR DETECTING AND / OR SORTING TARGETS
US20080044821A1 (en) * 2006-08-21 2008-02-21 Gafur Zainiev Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes
EP2395113A1 (en) * 2007-06-29 2011-12-14 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
EP2176395A2 (en) * 2007-08-13 2010-04-21 University of Utah Research Foundation Method of making microarrays suitable for high-throughput detection
US9518288B2 (en) 2008-04-11 2016-12-13 University Of Utah Research Foundation Methods and compositions related to quantitative, array based methylation analysis
WO2010017264A2 (en) * 2008-08-05 2010-02-11 Cornell University Photo-crosslinked nucleic acid hydrogels
CA2679750A1 (en) * 2008-09-23 2010-03-23 Nexus Dx, Inc. Methods for detecting nucleic acids in a sample
US8778848B2 (en) * 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
JP6403572B2 (ja) 2011-09-08 2018-10-10 ネクサス・ディーエックス・インコーポレイテッドＮｅｘｕｓ Ｄｘ， Ｉｎｃ． マルチレベル分析物アッセイ

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB8432118D0 (en) 1984-12-19 1985-01-30 Malcolm A D B Sandwich hybridisation technique
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
IL79112A (en) 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US4787963A (en) 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
EP0305145A3 (en) 1987-08-24 1990-05-02 Ortho Diagnostic Systems Inc. Methods and probes for detecting nucleic acids
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
WO1990001564A1 (en) 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
US5219726A (en) 1989-06-02 1993-06-15 The Salk Institute For Biological Studies Physical mapping of complex genomes
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
JPH03151900A (ja) 1989-11-09 1991-06-28 Canon Inc 核酸の検出方法
DE4001154A1 (de) 1990-01-17 1991-07-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von modifizierten nukleinsaeuren
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JPH07502657A (ja) 1991-12-23 1995-03-23 バイエル　コーポレイション 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのｈｔｌｖ−１プローブ
CA2124797C (en) 1991-12-23 2004-03-30 Bruce D. Irvine Hiv probes for use in solution phase sandwich hybridization assays
JP3151900B2 (ja) 1992-01-14 2001-04-03 株式会社デンソー 部品供給装置
JPH08500722A (ja) * 1992-01-29 1996-01-30 日立化成工業株式会社 ポリヌクレオチド固定化担体
JPH06509946A (ja) 1992-06-17 1994-11-10 シティ・オブ・ホープ 核酸を検出し識別する方法
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US6077668A (en) * 1993-04-15 2000-06-20 University Of Rochester Highly sensitive multimeric nucleic acid probes
EP1408122A3 (en) * 1993-09-27 2004-10-06 Arch Development Corporation Methods and compositions for efficient nucleic acid sequencing
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6207373B1 (en) 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5718915A (en) 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
US5780231A (en) 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
DE19619373A1 (de) 1996-05-14 1997-11-20 Hoechst Ag Neue Substanzbibliothek und damit hergestellte supramolekulare Komplexe
DE19651560A1 (de) 1996-12-11 1998-06-18 Hoechst Ag Neue funktionelle supramolekulare Nanosysteme
EP0998347A1 (en) * 1997-07-22 2000-05-10 Rapigene, Inc. Polyethylenimine-based biomolecule arrays
DE19741739B4 (de) 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
DE19741715A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741716A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
DE19741738A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
CN1237165C (zh) 1998-02-20 2006-01-18 内诺金有限公司 分子生物学分析和诊断用的有源装置和方法
WO2000004192A1 (en) 1998-07-17 2000-01-27 Emory University Methods for detecting and mapping genes, mutations and variant polynucleotide sequences
DE19837387A1 (de) 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US6399302B1 (en) * 1998-08-21 2002-06-04 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
US6125272A (en) 1998-09-25 2000-09-26 Motorola, Inc. Method and apparatus providing improved intermodulation distortion protection
DE19859912C2 (de) 1998-12-23 2001-06-21 Aventis Res & Tech Gmbh & Co Testsystem zur Erkennung verschiedener Marker, seine Herstellung sowie Verwendung
CA2366459A1 (en) 1999-03-26 2000-10-05 Affymetrix, Inc. Universal arrays
US6261782B1 (en) 1999-04-06 2001-07-17 Yale University Fixed address analysis of sequence tags
ES2219374T3 (es) 1999-07-02 2004-12-01 Clondiag Chip Technologies Gmbh Dispositivo de matriz de microchip para la multiplicacion y la caracterizacion de acidos nucleicos.
EP1196637B1 (en) 1999-07-27 2007-04-25 Adnexus Therapeutics, Inc. Peptide acceptor ligation methods
JP2001108683A (ja) * 1999-10-14 2001-04-20 Fuji Photo Film Co Ltd Ｄｎａ断片固定固相担体、ｄｎａ断片の固定方法および核酸断片の検出方法
JP3996307B2 (ja) * 1999-11-05 2007-10-24 富士フイルム株式会社 Ｄｎａ断片の固定方法、ｄｎａチップおよび核酸断片の検出方法

Similar Documents

Publication Publication Date Title
JP2004536317A5 (enExample)
CA2172722C (en) Methods and compositions for efficient nucleic acid sequencing
CN103649335B (zh) 定量核酸酶保护测定（qnpa）和测序（qnps）的改进
US9657339B2 (en) Method for amplification of target nucleic acid
JP3789817B2 (ja) Ｐｎａ−ｄｎａキメラプローブを用いたテンプレート依存型ライゲーション
CA1341495C (en) Method for detecting nucleic acid sequences
EP1692152B1 (en) Improvements in or relating to polynucleotide arrays
US6300070B1 (en) Solid phase methods for amplifying multiple nucleic acids
EP1247815A2 (en) Modified oligonucleotides and uses thereof
US5324829A (en) High specific activity nucleic acid probes having target recognition and signal generating moieties
JP3739423B2 (ja) 核酸固定化方法
US20090092967A1 (en) Method for generating target nucleic acid sequences
AU7691796A (en) A cascade nucleic acid amplification reaction
AU5783899A (en) Ligation assembly and detection of polynucleotides on solid-support
JP4388369B2 (ja) 合成結合システムを用いる核酸のための選別および固定化システム
JP2000509278A (ja) 試験サンプル中の複数の核酸配列を検出するための方法および試薬
US20050147973A1 (en) Immobilized probes
WO2018048911A1 (en) Tri-nucleotide rolling circle amplification
US20050176014A1 (en) Fluorescent hybridization probes with reduced background
JP2002360247A (ja) 核酸固定化物