JP2004536108A5 - - Google Patents
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- JP2004536108A5 JP2004536108A5 JP2003510069A JP2003510069A JP2004536108A5 JP 2004536108 A5 JP2004536108 A5 JP 2004536108A5 JP 2003510069 A JP2003510069 A JP 2003510069A JP 2003510069 A JP2003510069 A JP 2003510069A JP 2004536108 A5 JP2004536108 A5 JP 2004536108A5
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- weight
- parts
- acid
- aceclofenac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 20
- 235000014113 dietary fatty acids Nutrition 0.000 claims 12
- 239000000194 fatty acid Substances 0.000 claims 12
- 229930195729 fatty acid Natural products 0.000 claims 12
- MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 claims 11
- 229960004420 aceclofenac Drugs 0.000 claims 11
- 150000004665 fatty acids Chemical class 0.000 claims 11
- 239000004094 surface-active agent Substances 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 9
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 9
- 238000009472 formulation Methods 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 5
- 239000003963 antioxidant agent Substances 0.000 claims 5
- 235000006708 antioxidants Nutrition 0.000 claims 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 5
- 230000003078 antioxidant effect Effects 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
- 229920000136 polysorbate Polymers 0.000 claims 3
- 229920000053 polysorbate 80 Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- -1 sorbitan ester Chemical class 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000005639 Lauric acid Substances 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 1
- 229960002747 betacarotene Drugs 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 1
- 238000000975 co-precipitation Methods 0.000 claims 1
- 229940047642 disodium cocoamphodiacetate Drugs 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 235000004515 gallic acid Nutrition 0.000 claims 1
- 229940074391 gallic acid Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 229960002446 octanoic acid Drugs 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229940068965 polysorbates Drugs 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 229960005055 sodium ascorbate Drugs 0.000 claims 1
- 229940001607 sodium bisulfite Drugs 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
- JWZSXZWCWMCYPE-RSAXXLAASA-M sodium;(4s)-4-amino-5-dodecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O JWZSXZWCWMCYPE-RSAXXLAASA-M 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 claims 1
- 229940042585 tocopherol acetate Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2001-0039387A KR100425226B1 (ko) | 2001-07-03 | 2001-07-03 | 아세클로페낙을 함유하는 경제적인 경구용 제제의 조성 및제법 |
| PCT/KR2002/001210 WO2003004060A1 (en) | 2001-07-03 | 2002-06-25 | Compositions and preparation methods for bioavailable oral aceaceclofenac dosage forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536108A JP2004536108A (ja) | 2004-12-02 |
| JP2004536108A5 true JP2004536108A5 (https=) | 2005-09-29 |
Family
ID=19711694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510069A Pending JP2004536108A (ja) | 2001-07-03 | 2002-06-25 | アセクロフェナックを含有する経済的な経口用製剤の組成及び製法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040180961A1 (https=) |
| EP (1) | EP1409023A1 (https=) |
| JP (1) | JP2004536108A (https=) |
| KR (1) | KR100425226B1 (https=) |
| CN (1) | CN1543359A (https=) |
| WO (1) | WO2003004060A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60320940D1 (de) | 2002-02-01 | 2008-06-26 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| EP1920766B1 (en) * | 2002-02-01 | 2017-08-23 | Bend Research, Inc | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
| BRPI0413277A (pt) | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
| US20060019933A1 (en) * | 2004-07-22 | 2006-01-26 | David Boardman | Process for preparing stabilized vitamin D |
| PT1814517E (pt) * | 2004-11-22 | 2010-11-03 | Venus Remedies Ltd | Formulação parentérica líquida não aquosa de aceclofenac |
| CN1301709C (zh) * | 2005-02-17 | 2007-02-28 | 西安东盛集团有限公司 | 一种含醋氯芬酸的皮肤用贴剂 |
| KR100806541B1 (ko) * | 2005-05-11 | 2008-02-26 | 한국유나이티드제약 주식회사 | 아세클로페낙을 함유하는 제어 방출성 제제 |
| GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
| CN102046147B (zh) * | 2007-06-06 | 2013-03-20 | 巴斯夫欧洲公司 | 用于制备快速崩解的片剂的药物配制剂 |
| KR100911517B1 (ko) * | 2007-08-31 | 2009-08-10 | 주식회사 드림파마 | 신규한 서방출형 아세클로페낙 제제 조성물 및 그의제조방법 |
| KR101003204B1 (ko) * | 2008-02-14 | 2010-12-21 | 메콕스큐어메드 주식회사 | 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제 |
| AR071375A1 (es) * | 2008-04-22 | 2010-06-16 | Solvay Pharm Gmbh | Formulaciones para ingredientes farmaceuticos activos de permeabilidad deficiente, proceso de preparacion y producto |
| US20090281136A1 (en) * | 2008-05-08 | 2009-11-12 | Sandeep Mhetre | Prasugrel pharmaceutical formulations |
| AU2009270768A1 (en) * | 2008-07-18 | 2010-01-21 | Valeant Pharmaceuticals International | Modified release formulation and methods of use |
| KR100986531B1 (ko) * | 2008-07-18 | 2010-10-07 | 한국콜마 주식회사 | 액상의 아세클로페낙을 함유하는 캡슐제 |
| KR101018894B1 (ko) * | 2008-08-27 | 2011-03-04 | 근화제약주식회사 | 체내 흡수가 증진된 탈니플루메이트 함유 서방정 |
| MX2011005167A (es) * | 2008-11-20 | 2011-05-30 | Avantor Performance Mat Inc | Excipiente co-procesado basado en fosfato dibasico de calcio, granular, de alta funcionalidad, directamente compresible. |
| KR101050076B1 (ko) * | 2009-02-04 | 2011-07-19 | 한국유나이티드제약 주식회사 | 제어 방출성 아세클로페낙을 함유하는 경구 제제의 조성물 및 그의 제조방법 |
| KR101234254B1 (ko) * | 2010-06-01 | 2013-02-18 | 한국유나이티드제약 주식회사 | 1일 1회 투여로 최적의 약리학적 임상 효과를 제공하는 아세클로페낙 서방성 제제 |
| MX378845B (es) * | 2014-01-21 | 2025-03-10 | Bpsi Holdings Llc | Revestimientos de pelicula de liberacion inmediata que contienen gliceridos de cadena media y sustratos revestidos con los mismos. |
| TWI586379B (zh) | 2015-06-29 | 2017-06-11 | 永信藥品工業股份有限公司 | 一種製作難溶藥物固體劑型的方法 |
| KR102840190B1 (ko) * | 2022-04-19 | 2025-07-29 | (의) 삼성의료재단 | 생리활성물질 전달체 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756450A (en) * | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| JPH08157362A (ja) * | 1994-12-06 | 1996-06-18 | Sankyo Co Ltd | 油性物質含有固形製剤の製法 |
| KR100239799B1 (ko) * | 1995-01-21 | 2000-02-01 | 손경식 | 경구투여용 사이클로스포린 에이 고체미셀분산체, 이의 제조 방법 및 고형제제 |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| KR100320361B1 (ko) * | 1998-05-08 | 2002-05-13 | 류덕희 | 비스테로이드성소염진통약물의마이크로에멀젼외용제 |
| KR100336090B1 (ko) * | 1998-06-27 | 2002-05-27 | 윤승원 | 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제 |
| GB9908014D0 (en) * | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
-
2001
- 2001-07-03 KR KR10-2001-0039387A patent/KR100425226B1/ko not_active Expired - Fee Related
-
2002
- 2002-06-25 WO PCT/KR2002/001210 patent/WO2003004060A1/en not_active Ceased
- 2002-06-25 US US10/481,972 patent/US20040180961A1/en not_active Abandoned
- 2002-06-25 CN CNA028134176A patent/CN1543359A/zh active Pending
- 2002-06-25 JP JP2003510069A patent/JP2004536108A/ja active Pending
- 2002-06-25 EP EP02743915A patent/EP1409023A1/en not_active Withdrawn
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