JP2004536072A5 - - Google Patents
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- JP2004536072A5 JP2004536072A5 JP2002592967A JP2002592967A JP2004536072A5 JP 2004536072 A5 JP2004536072 A5 JP 2004536072A5 JP 2002592967 A JP2002592967 A JP 2002592967A JP 2002592967 A JP2002592967 A JP 2002592967A JP 2004536072 A5 JP2004536072 A5 JP 2004536072A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- agent
- pharmaceutical composition
- hngf
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 230000004968 inflammatory condition Effects 0.000 claims 10
- 206010003246 arthritis Diseases 0.000 claims 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 6
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 6
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 201000004681 Psoriasis Diseases 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 101100404651 Mus musculus Ngf gene Proteins 0.000 claims 2
- 101150111783 NTRK1 gene Proteins 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000057041 human TNF Human genes 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 1
- 108091008604 NGF receptors Proteins 0.000 claims 1
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000046917 human NGF Human genes 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29439201P | 2001-05-30 | 2001-05-30 | |
| PCT/US2002/015284 WO2002096458A1 (en) | 2001-05-30 | 2002-05-09 | Anti-ngf antibodies for the treatment of various disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009211917A Division JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536072A JP2004536072A (ja) | 2004-12-02 |
| JP2004536072A5 true JP2004536072A5 (https=) | 2005-12-22 |
| JP4567944B2 JP4567944B2 (ja) | 2010-10-27 |
Family
ID=23133215
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592967A Expired - Lifetime JP4567944B2 (ja) | 2001-05-30 | 2002-05-09 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2009211917A Expired - Lifetime JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2013025893A Withdrawn JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2014215231A Pending JP2015061840A (ja) | 2001-05-30 | 2014-10-22 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2016079748A Expired - Lifetime JP6271631B2 (ja) | 2001-05-30 | 2016-04-12 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009211917A Expired - Lifetime JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2013025893A Withdrawn JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2014215231A Pending JP2015061840A (ja) | 2001-05-30 | 2014-10-22 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2016079748A Expired - Lifetime JP6271631B2 (ja) | 2001-05-30 | 2016-04-12 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US7727527B2 (https=) |
| EP (2) | EP2340849A1 (https=) |
| JP (5) | JP4567944B2 (https=) |
| KR (3) | KR20100132559A (https=) |
| CN (2) | CN101653604A (https=) |
| AT (1) | ATE522229T1 (https=) |
| AU (7) | AU2002308722B2 (https=) |
| BR (1) | BR0210231A (https=) |
| CA (2) | CA2448956C (https=) |
| CY (1) | CY1112425T1 (https=) |
| DK (1) | DK1401498T3 (https=) |
| ES (1) | ES2371748T3 (https=) |
| IL (2) | IL158921A0 (https=) |
| MX (1) | MXPA03010911A (https=) |
| NZ (2) | NZ529612A (https=) |
| PT (1) | PT1401498E (https=) |
| WO (1) | WO2002096458A1 (https=) |
| ZA (1) | ZA200308999B (https=) |
Families Citing this family (75)
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| DK1401498T3 (da) * | 2001-05-30 | 2011-11-21 | Genentech Inc | Anti-NGF-antistoffer til behandlingen af forskellige sygdomme |
| US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| AU2011201157C1 (en) * | 2002-12-24 | 2017-09-07 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| CN101014364B (zh) | 2002-12-24 | 2012-01-18 | 里纳特神经系统学公司 | 抗ngf抗体及其使用方法 |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| EP2191846A1 (en) * | 2003-02-19 | 2010-06-02 | Rinat Neuroscience Corp. | Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing the same |
| CN102408483B (zh) * | 2003-07-15 | 2016-06-08 | 安姆根有限公司 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
| KR100894191B1 (ko) | 2003-07-15 | 2009-04-22 | 암젠 인코포레이티드 | 선택적인 ｎｇｆ 경로 저해제로서의 인체 항-ｎｇｆ 중화 항체 및 이 항체를 포함하는 약학적 조성물 |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
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| BRPI0815370B8 (pt) | 2007-08-10 | 2021-05-25 | Regeneron Pharma | anticorpos humanos de alta afinidade contra o fator de crescimento neural humano e seu uso, molécula de ácido nucleico, vetor de expressão, método para produção de um anticorpo anti-ngf humano e composiçao farmacêutica |
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| DK1401498T3 (da) * | 2001-05-30 | 2011-11-21 | Genentech Inc | Anti-NGF-antistoffer til behandlingen af forskellige sygdomme |
| EP1545615A4 (en) * | 2002-10-04 | 2006-03-01 | Rinat Neuroscience Corp | METHODS OF TREATING CARDIAC ARRHYTHMIA AND PREVENTING DEATH OF CARDIAC ARRHYTHMIA USING NGF ANTAGONISTS |
| UA80447C2 (en) * | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| EP2191846A1 (en) * | 2003-02-19 | 2010-06-02 | Rinat Neuroscience Corp. | Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing the same |
| JP5301152B2 (ja) * | 2004-04-07 | 2013-09-25 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法 |
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2002
- 2002-05-09 DK DK02774103.2T patent/DK1401498T3/da active
- 2002-05-09 CA CA2448956A patent/CA2448956C/en not_active Expired - Lifetime
- 2002-05-09 NZ NZ529612A patent/NZ529612A/xx not_active IP Right Cessation
- 2002-05-09 CA CA2975521A patent/CA2975521A1/en not_active Abandoned
- 2002-05-09 MX MXPA03010911A patent/MXPA03010911A/es not_active Application Discontinuation
- 2002-05-09 US US10/479,872 patent/US7727527B2/en not_active Expired - Lifetime
- 2002-05-09 NZ NZ544410A patent/NZ544410A/en not_active IP Right Cessation
- 2002-05-09 ES ES02774103T patent/ES2371748T3/es not_active Expired - Lifetime
- 2002-05-09 AU AU2002308722A patent/AU2002308722B2/en not_active Expired
- 2002-05-09 JP JP2002592967A patent/JP4567944B2/ja not_active Expired - Lifetime
- 2002-05-09 KR KR1020107027004A patent/KR20100132559A/ko not_active Withdrawn
- 2002-05-09 KR KR1020087027819A patent/KR101004353B1/ko not_active Expired - Lifetime
- 2002-05-09 EP EP10010557A patent/EP2340849A1/en not_active Ceased
- 2002-05-09 PT PT02774103T patent/PT1401498E/pt unknown
- 2002-05-09 WO PCT/US2002/015284 patent/WO2002096458A1/en not_active Ceased
- 2002-05-09 KR KR10-2003-7015659A patent/KR20040049829A/ko not_active Ceased
- 2002-05-09 IL IL15892102A patent/IL158921A0/xx unknown
- 2002-05-09 BR BR0210231-5A patent/BR0210231A/pt not_active Application Discontinuation
- 2002-05-09 CN CN200910171008A patent/CN101653604A/zh active Pending
- 2002-05-09 CN CNA028149920A patent/CN1684708A/zh active Pending
- 2002-05-09 AT AT02774103T patent/ATE522229T1/de active
- 2002-05-09 EP EP02774103A patent/EP1401498B1/en not_active Revoked
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2003
- 2003-11-18 IL IL158921A patent/IL158921A/en active IP Right Grant
- 2003-11-19 ZA ZA2003/08999A patent/ZA200308999B/en unknown
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2007
- 2007-08-16 AU AU2007207881A patent/AU2007207881B2/en not_active Expired
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2009
- 2009-09-14 JP JP2009211917A patent/JP5761902B2/ja not_active Expired - Lifetime
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2010
- 2010-01-15 AU AU2010200170A patent/AU2010200170B2/en not_active Expired
- 2010-04-06 US US12/755,279 patent/US20100254990A1/en not_active Abandoned
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2011
- 2011-04-19 US US13/090,048 patent/US20110268725A1/en not_active Abandoned
- 2011-11-28 CY CY20111101167T patent/CY1112425T1/el unknown
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2012
- 2012-09-06 US US13/605,722 patent/US20130004495A1/en not_active Abandoned
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2013
- 2013-02-13 JP JP2013025893A patent/JP2013139453A/ja not_active Withdrawn
- 2013-10-10 AU AU2013242812A patent/AU2013242812A1/en not_active Abandoned
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2014
- 2014-03-24 US US14/223,881 patent/US20140294829A1/en not_active Abandoned
- 2014-10-22 JP JP2014215231A patent/JP2015061840A/ja active Pending
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2016
- 2016-04-12 US US15/097,225 patent/US20170066819A1/en not_active Abandoned
- 2016-04-12 JP JP2016079748A patent/JP6271631B2/ja not_active Expired - Lifetime
- 2016-11-03 AU AU2016253605A patent/AU2016253605A1/en not_active Abandoned
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2018
- 2018-06-04 AU AU2018203920A patent/AU2018203920A1/en not_active Abandoned
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2020
- 2020-05-11 US US16/871,525 patent/US20200399357A1/en not_active Abandoned
- 2020-05-12 AU AU2020203115A patent/AU2020203115A1/en not_active Abandoned
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