JP2004535384A5 - - Google Patents
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- Publication number
- JP2004535384A5 JP2004535384A5 JP2002582950A JP2002582950A JP2004535384A5 JP 2004535384 A5 JP2004535384 A5 JP 2004535384A5 JP 2002582950 A JP2002582950 A JP 2002582950A JP 2002582950 A JP2002582950 A JP 2002582950A JP 2004535384 A5 JP2004535384 A5 JP 2004535384A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polymer
- serum glucose
- glucose
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 19
- 229920000642 polymer Polymers 0.000 claims 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 10
- 239000008103 glucose Substances 0.000 claims 10
- 210000002966 serum Anatomy 0.000 claims 8
- 239000004971 Cross linker Substances 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 230000003247 decreasing effect Effects 0.000 claims 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- POILWHVDKZOXJZ-ARJAWSKDSA-M (z)-4-oxopent-2-en-2-olate Chemical group C\C([O-])=C\C(C)=O POILWHVDKZOXJZ-ARJAWSKDSA-M 0.000 claims 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical group [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical group [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 150000001336 alkenes Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- RBFQJDQYXXHULB-UHFFFAOYSA-N arsane Chemical group [AsH3] RBFQJDQYXXHULB-UHFFFAOYSA-N 0.000 claims 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical group NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 claims 1
- 150000007942 carboxylates Chemical group 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000012990 dithiocarbamate Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Chemical group CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-M phenolate Chemical group [O-]C1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-M 0.000 claims 1
- 229940031826 phenolate Drugs 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 229920000083 poly(allylamine) Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28444501P | 2001-04-18 | 2001-04-18 | |
| US30556401P | 2001-07-13 | 2001-07-13 | |
| PCT/US2002/011493 WO2002085377A1 (en) | 2001-04-18 | 2002-04-10 | Method for lowering serum glucose |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010009197A Division JP2010090172A (ja) | 2001-04-18 | 2010-01-19 | 血清グルコースの減少方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004535384A JP2004535384A (ja) | 2004-11-25 |
| JP2004535384A5 true JP2004535384A5 (enExample) | 2005-12-22 |
| JP4499363B2 JP4499363B2 (ja) | 2010-07-07 |
Family
ID=26962623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582950A Expired - Lifetime JP4499363B2 (ja) | 2001-04-18 | 2002-04-10 | 血清グルコースの減少方法 |
| JP2010009197A Pending JP2010090172A (ja) | 2001-04-18 | 2010-01-19 | 血清グルコースの減少方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010009197A Pending JP2010090172A (ja) | 2001-04-18 | 2010-01-19 | 血清グルコースの減少方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7229613B2 (enExample) |
| EP (1) | EP1392331B1 (enExample) |
| JP (2) | JP4499363B2 (enExample) |
| KR (1) | KR20040018358A (enExample) |
| CN (1) | CN1511039A (enExample) |
| AT (1) | ATE390927T1 (enExample) |
| AU (1) | AU2002257145B2 (enExample) |
| BR (1) | BRPI0209134B8 (enExample) |
| CA (1) | CA2444046C (enExample) |
| CY (1) | CY1119486T1 (enExample) |
| DE (1) | DE60225908T2 (enExample) |
| DK (2) | DK1392331T3 (enExample) |
| ES (2) | ES2637020T3 (enExample) |
| MX (1) | MXPA03009568A (enExample) |
| NZ (1) | NZ528831A (enExample) |
| PT (1) | PT1923064T (enExample) |
| WO (1) | WO2002085377A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| ES2637020T3 (es) * | 2001-04-18 | 2017-10-10 | Genzyme Corporation | Uso de polímero de amina para reducir la glucosa sérica |
| AU2003282867A1 (en) * | 2002-10-22 | 2004-05-13 | Genzyme Corporation | Amine polymers for promoting bone formation |
| US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7335795B2 (en) * | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7385012B2 (en) * | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| ES2397159T3 (es) * | 2004-03-26 | 2013-03-05 | Mitsubishi Tanabe Pharma Corporation | Agente mejorador de la resistencia a insulina |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| WO2006072054A1 (en) * | 2004-12-30 | 2006-07-06 | Genzyme Corporation | Zinc-containing treatments for hyperphosphatemia |
| JP2009507019A (ja) * | 2005-09-02 | 2009-02-19 | ジェンザイム・コーポレーション | リン酸塩を除去する方法およびそれに使用される重合体 |
| KR101547925B1 (ko) | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
| WO2007056405A2 (en) * | 2005-11-08 | 2007-05-18 | Genzyme Corporation | Magnesium-containing polymers for the treatment of hyperphosphatemia |
| EP2043627A2 (en) * | 2006-07-05 | 2009-04-08 | Genzyme Corporation | Iron(ii)-containing treatments for hyperphosphatemia |
| US7964182B2 (en) * | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
| BRPI0717008A2 (pt) * | 2006-09-01 | 2014-01-21 | Usv Ltd | Processo para o preparo de cloridrato de sevelamer e formulação do mesmo |
| WO2008042222A2 (en) | 2006-09-29 | 2008-04-10 | Genzyme Corporation | Amide dendrimer compositions |
| WO2008076242A1 (en) | 2006-12-14 | 2008-06-26 | Genzyme Corporation | Amido-amine polymer compositions |
| EP2361171A4 (en) * | 2008-09-15 | 2014-11-05 | Shasun Chemicals And Drugs Ltd | PROCESS FOR PREPARING NETWORKED POLYMERS IN A NON-AQUEOUS SOLUTION |
| AU2010209293A1 (en) * | 2009-01-22 | 2011-09-08 | Usv Limited | Pharmaceutical compositions comprising phosphate-binding polymer |
| US9566299B2 (en) | 2013-02-08 | 2017-02-14 | Wockhardt Limited | Oral pharmaceutical composition of aliphatic amine polymer or salts thereof |
| CA2906501A1 (en) * | 2013-03-15 | 2014-09-25 | Genzyme Corporation | Sequestrants of advanced glycation end product (age) precursors |
| EP3164155B1 (en) | 2014-06-13 | 2022-02-09 | United Therapeutics Corporation | Treprostinil formulations |
| MA41202A (fr) * | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| WO2018124264A1 (ja) | 2016-12-28 | 2018-07-05 | 富士フイルム株式会社 | 窒素原子含有ポリマー又はその塩の乳化液、その製造方法、及び粒子の製造方法 |
| JP6992084B2 (ja) | 2017-10-16 | 2022-01-13 | 富士フイルム株式会社 | 高リン血症治療剤 |
| CN116018146A (zh) * | 2021-08-24 | 2023-04-25 | 中美华世通生物医药科技(武汉)股份有限公司 | 用于治疗高尿酸血症的聚合物、组合物和方法 |
| ES2980624T3 (es) * | 2021-08-24 | 2024-10-02 | Waterstone Pharmaceuticals Wuhan Co Ltd | Polímeros, composiciones y métodos para tratar hiperuricemia |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528847A (en) * | 1983-10-04 | 1985-07-16 | D. Halmi And Associates, Inc. | Flow metering device with recessed pressure taps |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| US4528347A (en) | 1983-11-10 | 1985-07-09 | 501 Nitto Boseki, Co. Ltd | Process for producing polymers of monoallylamine |
| US5468727A (en) * | 1990-12-13 | 1995-11-21 | Board Of Regents, The University Of Texas System | Methods of normalizing metabolic parameters in diabetics |
| JP3507523B2 (ja) | 1993-05-12 | 2004-03-15 | 積水化学工業株式会社 | 糖質吸収抑制剤 |
| US5487888A (en) | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5624963A (en) | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5900475A (en) | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5703188A (en) | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| JP4156684B2 (ja) * | 1996-03-05 | 2008-09-24 | 三菱化学株式会社 | 高リン血症予防および／または治療剤 |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| US5925379A (en) | 1997-03-27 | 1999-07-20 | Geltex Pharmaceuticals, Inc. | Interpenetrating polymer networks for sequestration of bile acids |
| TW592727B (en) | 1997-04-04 | 2004-06-21 | Chugai Pharmaceutical Co Ltd | Phosphate-binding polymer preparations |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| FR2766195A1 (fr) | 1997-07-21 | 1999-01-22 | Transgene Sa | Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique |
| US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| US5985938A (en) | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| WO1999040990A1 (en) | 1998-02-17 | 1999-08-19 | University Of Maryland | Anion binding polymers and the use thereof |
| EP1340510A1 (en) * | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| AU7856200A (en) * | 1999-10-07 | 2001-05-10 | University Of Maryland | Sugar binding polymers and the use thereof |
| TWI241195B (en) * | 2000-04-10 | 2005-10-11 | Shionogi & Co | Preventive agent for bile acidic diarrhea |
| ES2637020T3 (es) * | 2001-04-18 | 2017-10-10 | Genzyme Corporation | Uso de polímero de amina para reducir la glucosa sérica |
| US20020198202A1 (en) | 2001-06-07 | 2002-12-26 | Wyeth | Combination of a PTPase inhibitor and an antilipemic agent |
-
2002
- 2002-04-10 ES ES08002418.5T patent/ES2637020T3/es not_active Expired - Lifetime
- 2002-04-10 DK DK02726733T patent/DK1392331T3/da active
- 2002-04-10 NZ NZ528831A patent/NZ528831A/en unknown
- 2002-04-10 AU AU2002257145A patent/AU2002257145B2/en not_active Expired
- 2002-04-10 DE DE60225908T patent/DE60225908T2/de not_active Expired - Lifetime
- 2002-04-10 ES ES02726733T patent/ES2304437T3/es not_active Expired - Lifetime
- 2002-04-10 KR KR10-2003-7013678A patent/KR20040018358A/ko not_active Withdrawn
- 2002-04-10 MX MXPA03009568A patent/MXPA03009568A/es unknown
- 2002-04-10 WO PCT/US2002/011493 patent/WO2002085377A1/en not_active Ceased
- 2002-04-10 DK DK08002418.5T patent/DK1923064T3/en active
- 2002-04-10 CN CNA028099958A patent/CN1511039A/zh active Pending
- 2002-04-10 EP EP02726733A patent/EP1392331B1/en not_active Expired - Lifetime
- 2002-04-10 JP JP2002582950A patent/JP4499363B2/ja not_active Expired - Lifetime
- 2002-04-10 CA CA2444046A patent/CA2444046C/en not_active Expired - Fee Related
- 2002-04-10 PT PT80024185T patent/PT1923064T/pt unknown
- 2002-04-10 AT AT02726733T patent/ATE390927T1/de active
- 2002-04-10 BR BR0209134-8 patent/BRPI0209134B8/pt not_active IP Right Cessation
- 2002-04-17 US US10/125,700 patent/US7229613B2/en not_active Expired - Lifetime
-
2007
- 2007-04-25 US US11/789,698 patent/US20070286841A1/en not_active Abandoned
-
2010
- 2010-01-19 JP JP2010009197A patent/JP2010090172A/ja active Pending
-
2017
- 2017-09-27 CY CY20171101019T patent/CY1119486T1/el unknown
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