BRPI0209134B8 - uso de um sevelamer ou um sal do mesmo e uso de um colesevelam ou um sal do mesmo - Google Patents
uso de um sevelamer ou um sal do mesmo e uso de um colesevelam ou um sal do mesmoInfo
- Publication number
- BRPI0209134B8 BRPI0209134B8 BRPI0209134A BRPI0209134B8 BR PI0209134 B8 BRPI0209134 B8 BR PI0209134B8 BR PI0209134 A BRPI0209134 A BR PI0209134A BR PI0209134 B8 BRPI0209134 B8 BR PI0209134B8
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- polymer
- colesevelam
- amine
- patient
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 title abstract 2
- 229920002905 Colesevelam Polymers 0.000 title abstract 2
- 229960001152 colesevelam Drugs 0.000 title abstract 2
- ZNSIZMQNQCNRBW-UHFFFAOYSA-N sevelamer Chemical compound NCC=C.ClCC1CO1 ZNSIZMQNQCNRBW-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003693 sevelamer Drugs 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 abstract 5
- 150000001412 amines Chemical class 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 229920006037 cross link polymer Polymers 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28444501P | 2001-04-18 | 2001-04-18 | |
| US30556401P | 2001-07-13 | 2001-07-13 | |
| PCT/US2002/011493 WO2002085377A1 (en) | 2001-04-18 | 2002-04-10 | Method for lowering serum glucose |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0209134A BR0209134A (pt) | 2004-06-15 |
| BRPI0209134B1 BRPI0209134B1 (pt) | 2019-08-27 |
| BRPI0209134B8 true BRPI0209134B8 (pt) | 2021-05-25 |
Family
ID=26962623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0209134 BRPI0209134B8 (pt) | 2001-04-18 | 2002-04-10 | uso de um sevelamer ou um sal do mesmo e uso de um colesevelam ou um sal do mesmo |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7229613B2 (enExample) |
| EP (1) | EP1392331B1 (enExample) |
| JP (2) | JP4499363B2 (enExample) |
| KR (1) | KR20040018358A (enExample) |
| CN (1) | CN1511039A (enExample) |
| AT (1) | ATE390927T1 (enExample) |
| AU (1) | AU2002257145B2 (enExample) |
| BR (1) | BRPI0209134B8 (enExample) |
| CA (1) | CA2444046C (enExample) |
| CY (1) | CY1119486T1 (enExample) |
| DE (1) | DE60225908T2 (enExample) |
| DK (2) | DK1392331T3 (enExample) |
| ES (2) | ES2637020T3 (enExample) |
| MX (1) | MXPA03009568A (enExample) |
| NZ (1) | NZ528831A (enExample) |
| PT (1) | PT1923064T (enExample) |
| WO (1) | WO2002085377A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| CA2444046C (en) * | 2001-04-18 | 2011-06-07 | Steven K. Burke | Use of colesevelam in reducing serum glucose |
| US7220406B2 (en) * | 2002-10-22 | 2007-05-22 | Genzyme Corporation | Method for promoting bone formation |
| US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7608674B2 (en) | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7385012B2 (en) * | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| US7335795B2 (en) * | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| WO2005092349A1 (ja) * | 2004-03-26 | 2005-10-06 | Mitsubishi Pharma Corporation | インスリン抵抗性改善剤 |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| EP1830832A1 (en) * | 2004-12-30 | 2007-09-12 | Genzyme Corporation | Zinc-containing treatments for hyperphosphatemia |
| WO2007027566A2 (en) * | 2005-09-02 | 2007-03-08 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
| CA2622693C (en) | 2005-09-15 | 2015-05-05 | Genzyme Corporation | Sachet formulation for amine polymers |
| JP2009514966A (ja) * | 2005-11-08 | 2009-04-09 | ジェンザイム・コーポレーション | 高リン血症のためのマグネシウム含有重合体 |
| WO2008005217A2 (en) * | 2006-07-05 | 2008-01-10 | Genzyme Corporation | Iron(ii)-containing treatments for hyperphosphatemia |
| WO2008062437A2 (en) * | 2006-09-01 | 2008-05-29 | Usv Limited | Process for the preparation of sevelamer hydrochloride and formulation thereof |
| US7964182B2 (en) * | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
| EP2066293A2 (en) | 2006-09-29 | 2009-06-10 | Genzyme Corporation | Amide dendrimer compositions |
| US8163799B2 (en) | 2006-12-14 | 2012-04-24 | Genzyme Corporation | Amido-amine polymer compositions |
| EP2361171A4 (en) * | 2008-09-15 | 2014-11-05 | Shasun Chemicals And Drugs Ltd | PROCESS FOR PREPARING NETWORKED POLYMERS IN A NON-AQUEOUS SOLUTION |
| US20110081413A1 (en) * | 2009-01-22 | 2011-04-07 | Ashok Omray | Pharmaceutical Compositions Comprising Phosphate-Binding Polymer |
| US9566299B2 (en) | 2013-02-08 | 2017-02-14 | Wockhardt Limited | Oral pharmaceutical composition of aliphatic amine polymer or salts thereof |
| PE20151766A1 (es) * | 2013-03-15 | 2015-12-11 | Genzyme Corp | Agentes quelantes de precursores de producto final de glicacion avanzada (age) |
| ES2908142T3 (es) | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| JP6792640B2 (ja) | 2016-12-28 | 2020-11-25 | 富士フイルム株式会社 | 窒素原子含有ポリマー又はその塩の乳化液、その製造方法、及び粒子の製造方法 |
| EP3698799B1 (en) | 2017-10-16 | 2022-01-26 | FUJIFILM Corporation | Hyperphosphatemia treatment agent |
| ES2980624T3 (es) | 2021-08-24 | 2024-10-02 | Waterstone Pharmaceuticals Wuhan Co Ltd | Polímeros, composiciones y métodos para tratar hiperuricemia |
| WO2023023938A1 (en) * | 2021-08-24 | 2023-03-02 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Polymers, compositions and methods for treating hyperuricemia |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528847A (en) * | 1983-10-04 | 1985-07-16 | D. Halmi And Associates, Inc. | Flow metering device with recessed pressure taps |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| CA1220896A (en) | 1983-11-10 | 1987-04-21 | Susumu Harada | Process for producing polymers of monoallylamine |
| US5468727A (en) * | 1990-12-13 | 1995-11-21 | Board Of Regents, The University Of Texas System | Methods of normalizing metabolic parameters in diabetics |
| JP3507523B2 (ja) | 1993-05-12 | 2004-03-15 | 積水化学工業株式会社 | 糖質吸収抑制剤 |
| US5487888A (en) | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5900475A (en) | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5624963A (en) | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5703188A (en) | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| JP4156684B2 (ja) * | 1996-03-05 | 2008-09-24 | 三菱化学株式会社 | 高リン血症予防および／または治療剤 |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| US5925379A (en) | 1997-03-27 | 1999-07-20 | Geltex Pharmaceuticals, Inc. | Interpenetrating polymer networks for sequestration of bile acids |
| TW592727B (en) | 1997-04-04 | 2004-06-21 | Chugai Pharmaceutical Co Ltd | Phosphate-binding polymer preparations |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| FR2766195A1 (fr) | 1997-07-21 | 1999-01-22 | Transgene Sa | Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| US5985938A (en) | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
| WO1999040990A1 (en) | 1998-02-17 | 1999-08-19 | University Of Maryland | Anion binding polymers and the use thereof |
| DK1140185T3 (da) * | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
| AU7856200A (en) * | 1999-10-07 | 2001-05-10 | University Of Maryland | Sugar binding polymers and the use thereof |
| TWI241195B (en) * | 2000-04-10 | 2005-10-11 | Shionogi & Co | Preventive agent for bile acidic diarrhea |
| CA2444046C (en) * | 2001-04-18 | 2011-06-07 | Steven K. Burke | Use of colesevelam in reducing serum glucose |
| US20020198202A1 (en) | 2001-06-07 | 2002-12-26 | Wyeth | Combination of a PTPase inhibitor and an antilipemic agent |
-
2002
- 2002-04-10 CA CA2444046A patent/CA2444046C/en not_active Expired - Fee Related
- 2002-04-10 MX MXPA03009568A patent/MXPA03009568A/es unknown
- 2002-04-10 AU AU2002257145A patent/AU2002257145B2/en not_active Expired
- 2002-04-10 CN CNA028099958A patent/CN1511039A/zh active Pending
- 2002-04-10 EP EP02726733A patent/EP1392331B1/en not_active Expired - Lifetime
- 2002-04-10 AT AT02726733T patent/ATE390927T1/de active
- 2002-04-10 PT PT80024185T patent/PT1923064T/pt unknown
- 2002-04-10 ES ES08002418.5T patent/ES2637020T3/es not_active Expired - Lifetime
- 2002-04-10 NZ NZ528831A patent/NZ528831A/en unknown
- 2002-04-10 DK DK02726733T patent/DK1392331T3/da active
- 2002-04-10 WO PCT/US2002/011493 patent/WO2002085377A1/en not_active Ceased
- 2002-04-10 KR KR10-2003-7013678A patent/KR20040018358A/ko not_active Withdrawn
- 2002-04-10 ES ES02726733T patent/ES2304437T3/es not_active Expired - Lifetime
- 2002-04-10 DE DE60225908T patent/DE60225908T2/de not_active Expired - Lifetime
- 2002-04-10 BR BRPI0209134 patent/BRPI0209134B8/pt not_active IP Right Cessation
- 2002-04-10 DK DK08002418.5T patent/DK1923064T3/en active
- 2002-04-10 JP JP2002582950A patent/JP4499363B2/ja not_active Expired - Lifetime
- 2002-04-17 US US10/125,700 patent/US7229613B2/en not_active Expired - Lifetime
-
2007
- 2007-04-25 US US11/789,698 patent/US20070286841A1/en not_active Abandoned
-
2010
- 2010-01-19 JP JP2010009197A patent/JP2010090172A/ja active Pending
-
2017
- 2017-09-27 CY CY20171101019T patent/CY1119486T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20020187121A1 (en) | 2002-12-12 |
| EP1392331B1 (en) | 2008-04-02 |
| AU2002257145B2 (en) | 2005-06-02 |
| BR0209134A (pt) | 2004-06-15 |
| KR20040018358A (ko) | 2004-03-03 |
| MXPA03009568A (es) | 2004-02-12 |
| US7229613B2 (en) | 2007-06-12 |
| JP2010090172A (ja) | 2010-04-22 |
| ES2637020T3 (es) | 2017-10-10 |
| CY1119486T1 (el) | 2018-03-07 |
| BRPI0209134B1 (pt) | 2019-08-27 |
| ES2304437T3 (es) | 2008-10-16 |
| DK1392331T3 (da) | 2008-06-23 |
| CA2444046C (en) | 2011-06-07 |
| WO2002085377A1 (en) | 2002-10-31 |
| DK1923064T3 (en) | 2017-10-02 |
| JP4499363B2 (ja) | 2010-07-07 |
| DE60225908D1 (de) | 2008-05-15 |
| WO2002085377A8 (en) | 2002-11-28 |
| NZ528831A (en) | 2005-07-29 |
| US20070286841A1 (en) | 2007-12-13 |
| CA2444046A1 (en) | 2002-10-31 |
| PT1923064T (pt) | 2017-08-23 |
| DE60225908T2 (de) | 2009-05-14 |
| CN1511039A (zh) | 2004-07-07 |
| JP2004535384A (ja) | 2004-11-25 |
| ATE390927T1 (de) | 2008-04-15 |
| EP1392331A1 (en) | 2004-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: GENZYME CORPORATION (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 018080029522/SP DE 14/05/2008. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2019, OBSERVADAS AS CONDICOES LEGAIS |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/04/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 10/04/2022 |