JP2004529143A5 - - Google Patents
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- JP2004529143A5 JP2004529143A5 JP2002578993A JP2002578993A JP2004529143A5 JP 2004529143 A5 JP2004529143 A5 JP 2004529143A5 JP 2002578993 A JP2002578993 A JP 2002578993A JP 2002578993 A JP2002578993 A JP 2002578993A JP 2004529143 A5 JP2004529143 A5 JP 2004529143A5
- Authority
- JP
- Japan
- Prior art keywords
- ischemic heart
- heart disease
- apolipoprotein
- fragment
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101232A SE0101232D0 (sv) | 2001-04-05 | 2001-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein |
| SE0103754A SE0103754L (sv) | 2001-04-05 | 2001-11-09 | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| PCT/SE2002/000679 WO2002080954A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008015545A Division JP2008169215A (ja) | 2001-04-05 | 2008-01-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2009133383A Division JP5270456B2 (ja) | 2001-04-05 | 2009-06-02 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2010239477A Division JP5300819B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2010239478A Division JP5300820B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529143A JP2004529143A (ja) | 2004-09-24 |
| JP2004529143A5 true JP2004529143A5 (enExample) | 2009-07-23 |
Family
ID=26655437
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578993A Withdrawn JP2004529143A (ja) | 2001-04-05 | 2002-04-05 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2008015545A Withdrawn JP2008169215A (ja) | 2001-04-05 | 2008-01-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2009133383A Expired - Fee Related JP5270456B2 (ja) | 2001-04-05 | 2009-06-02 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2010239478A Expired - Lifetime JP5300820B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2010239477A Expired - Lifetime JP5300819B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2013034312A Expired - Lifetime JP5613890B2 (ja) | 2001-04-05 | 2013-02-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008015545A Withdrawn JP2008169215A (ja) | 2001-04-05 | 2008-01-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2009133383A Expired - Fee Related JP5270456B2 (ja) | 2001-04-05 | 2009-06-02 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2010239478A Expired - Lifetime JP5300820B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2010239477A Expired - Lifetime JP5300819B2 (ja) | 2001-04-05 | 2010-10-26 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
| JP2013034312A Expired - Lifetime JP5613890B2 (ja) | 2001-04-05 | 2013-02-25 | アテローム性動脈硬化症の治療のためのペプチドに基づいた免疫治療、及び酸化した低密度リポ蛋白質に対する免疫応答の測定のためのペプチドベースのアッセーの開発 |
Country Status (18)
| Country | Link |
|---|---|
| EP (42) | EP2289914A1 (enExample) |
| JP (6) | JP2004529143A (enExample) |
| CN (4) | CN1505525B (enExample) |
| AT (2) | ATE415423T1 (enExample) |
| AU (1) | AU2002246484B8 (enExample) |
| BR (1) | BR0208685A (enExample) |
| CA (3) | CA2443223C (enExample) |
| CY (1) | CY1108817T1 (enExample) |
| DE (1) | DE60230029D1 (enExample) |
| DK (3) | DK2006301T3 (enExample) |
| EE (2) | EE200700052A (enExample) |
| ES (2) | ES2546293T3 (enExample) |
| IL (4) | IL158285A0 (enExample) |
| PL (4) | PL215401B1 (enExample) |
| PT (1) | PT1383526E (enExample) |
| RU (1) | RU2296582C2 (enExample) |
| SE (1) | SE0103754L (enExample) |
| WO (1) | WO2002080954A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0103754L (sv) * | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| US20030105003A1 (en) | 2001-04-05 | 2003-06-05 | Jan Nilsson | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
| MXPA04002848A (es) | 2001-09-28 | 2005-06-06 | Esperion Therapeutics Inc | Prevencion y tratamiento de restenosis por administracion local de medicamento. |
| SE0302312D0 (sv) | 2002-10-04 | 2003-08-27 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| AU2003267905B2 (en) * | 2002-10-04 | 2009-02-05 | Biolnvent International Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| SE0302422D0 (sv) | 2003-09-11 | 2003-09-11 | Forskarpatent I Syd Ab | Peptide-based immunization therapy for treatment of atherosclerosis |
| SE0400683D0 (sv) | 2004-03-19 | 2004-03-19 | Forskarpatent I Syd Ab | Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis |
| EP1732383A4 (en) | 2004-04-06 | 2007-05-02 | Cedars Sinai Medical Center | PREVENTION AND TREATMENT OF VASCULAR DISEASES WITH RECOMBINANT ADENO ASSOCIATED VIRUS VECTORS THAT CODE APOLIPOPROTEIN A-I AND APOLIPOPROTEIN A-I MILANO |
| WO2005100405A2 (en) | 2004-04-15 | 2005-10-27 | Athera Biotechnologies Ab | Phosphorylcholine conjugates and corresponding antibodies |
| EP1676602A1 (en) * | 2005-01-04 | 2006-07-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis |
| GB0517878D0 (en) | 2005-09-02 | 2005-10-12 | Bioinvent Int Ab | Immunotherapeutic treatment |
| JP2010515023A (ja) * | 2006-12-22 | 2010-05-06 | アボット・ラボラトリーズ | 心血管系自己免疫疾患パネルおよびその使用方法 |
| WO2008104194A1 (en) * | 2007-02-28 | 2008-09-04 | Bioinvent International Ab | Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques |
| SG182205A1 (en) | 2007-03-15 | 2012-07-30 | Novartis Ag | Organic compounds and their uses |
| DK2208073T3 (da) * | 2007-11-05 | 2020-03-30 | Nordic Bioscience As | Biokemiske markører til cvd-risikovurdering |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| CN102099470B (zh) * | 2008-08-15 | 2014-11-12 | 藤仓化成株式会社 | 用于诊断动脉硬化的多肽标记、用该标记等检测动脉硬化的方法以及用于诊断动脉硬化的试剂盒 |
| WO2011060329A1 (en) | 2009-11-14 | 2011-05-19 | Kuang-Yuh Chyu | Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis |
| US8506964B2 (en) | 2010-02-05 | 2013-08-13 | Cardiovax, Llc | Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis |
| US20130142760A1 (en) | 2010-08-18 | 2013-06-06 | Cedars-Sinai Medical Center | Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer |
| EP2637689A2 (en) | 2010-11-12 | 2013-09-18 | Cedars-Sinai Medical Center | Immunomodulatory methods and systems for treatment and/or prevention of hypertension |
| US9205139B2 (en) | 2010-11-12 | 2015-12-08 | Cardiovax, Llc | Immunomodulatory methods and systems for treatment and/or prevention of aneurysms |
| CN103561760A (zh) * | 2010-11-12 | 2014-02-05 | 赛达斯西奈医疗中心 | 包含apob100的免疫原性片段的免疫调节组合物、方法和系统 |
| CN103906532B (zh) | 2011-08-09 | 2018-01-26 | 阿瑟拉生物技术公司 | 结合磷酰胆碱(pc)和/或pc结合物的抗体 |
| HRP20190988T1 (hr) | 2011-08-09 | 2019-09-20 | Athera Biotechnologies Ab | Nova protutijela protiv fosforilkolina |
| RU2495048C1 (ru) * | 2012-04-18 | 2013-10-10 | Андрей Валентинович Исаев | Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов |
| BR112015010276A2 (pt) | 2012-11-06 | 2019-10-15 | Hoffmann La Roche | peptídeos miméticos |
| CN103520713B (zh) * | 2013-10-16 | 2015-10-28 | 西北农林科技大学 | 一种ApoB100酵母重组疫苗及其制备方法和应用 |
| CN103860470A (zh) * | 2014-03-05 | 2014-06-18 | 贵州中泰生物科技有限公司 | 一种口服高密度脂蛋白脂质体的制备方法 |
| CN105315364B (zh) * | 2014-06-17 | 2018-09-18 | 广州文瑞生物科技有限公司 | 胶原蛋白vi疫苗预防动脉粥样硬化 |
| CN108135973B (zh) * | 2015-05-19 | 2021-10-19 | 拉·约拉过敏反应及免疫医学研究所 | 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途 |
| US10858422B2 (en) | 2016-05-31 | 2020-12-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
| CN108478817B (zh) * | 2018-03-16 | 2020-10-27 | 北京大学 | 一种动脉粥样硬化检测试剂及其制备方法 |
| CA3129373A1 (en) | 2018-05-29 | 2019-12-05 | Abcentra, Llc | Compositions and methods for treatment of rheumatoid arthritis and accelerated atherosclerosis |
| IL278978B1 (en) | 2018-05-29 | 2025-09-01 | Abcentra Llc | Preparations and methods for treating psoriasis |
| CN115025210B (zh) * | 2021-03-05 | 2025-09-05 | 香港中文大学 | 减少动脉粥样硬化进展的肽疫苗组合物和药物制剂 |
| CN115025211A (zh) * | 2021-11-02 | 2022-09-09 | 南京理工大学 | 用于动脉粥样硬化治疗的纳米疫苗及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970144A (en) | 1984-12-31 | 1990-11-13 | International Genetic Engineering | Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use |
| US5972890A (en) | 1988-05-02 | 1999-10-26 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| WO1993018067A1 (en) * | 1992-03-06 | 1993-09-16 | Abbott Laboratories | Immunocapture assay for direct quantitation of specific lipoprotein cholesterol levels |
| WO1994000592A1 (en) * | 1992-06-26 | 1994-01-06 | Exocell, Inc. | Monoclonal antibodies against glycated low density lipoprotein |
| EP0671926B1 (en) * | 1992-08-11 | 2002-11-13 | President And Fellows Of Harvard College | Immunomodulatory peptides |
| KR0185334B1 (ko) | 1995-11-02 | 1999-04-01 | 김은영 | 인간 혈장 아포지단백질 비-100에 결합하는 생쥐 항체를 암호하는 씨디엔에이 |
| GB9609702D0 (en) * | 1996-05-09 | 1996-07-10 | Royal Free Hosp School Med | Anticoagulant peptides |
| GB9620153D0 (en) * | 1996-09-27 | 1996-11-13 | Univ Strathclyde | Non-naturally occurring lipoprotein particle |
| GB9705831D0 (en) * | 1997-03-20 | 1997-05-07 | Univ Leicester | Oxidised ldl |
| US6635623B1 (en) * | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| US6225070B1 (en) | 1997-08-07 | 2001-05-01 | The Regents Of The University Of California | Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma |
| US6156315A (en) * | 1997-10-10 | 2000-12-05 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting the binding of low density lipoprotein to blood vessel matrix |
| EP0911344B1 (en) * | 1997-10-15 | 2004-03-03 | Fujirebio Inc. | Anti-Apo-B-48 monoclonal antibody, hybridoma, and methods of use |
| AU760794B2 (en) * | 1998-03-10 | 2003-05-22 | Regents Of The University Of California, The | Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding |
| AU5200699A (en) * | 1998-07-13 | 2000-02-01 | University Of Otago | Inhibition of lipoprotein formation |
| IL126447A (en) * | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
| DE60045869D1 (de) * | 1999-10-26 | 2011-06-01 | Univ California | Reagenzien und verfahren für diagnose, 'imaging' und behandlung von atherosklerotischen krankheiten |
| AU3087801A (en) * | 2000-02-04 | 2001-08-14 | Molecular Dynamics Inc | Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells |
| CN1418106A (zh) * | 2000-03-03 | 2003-05-14 | 史密丝克莱恩比彻姆生物有限公司 | 疫苗 |
| SE0000855D0 (sv) * | 2000-03-15 | 2000-03-15 | Karolinska Innovations Ab | Antigenic composition useful as a vaccine against atherosclerosis |
| GB0017641D0 (en) * | 2000-07-18 | 2000-09-06 | Medigene Oy | Peptides and their use |
| EP1186299A1 (en) * | 2000-09-12 | 2002-03-13 | Universitair Medisch Centrum Utrecht | The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system |
| JP2004529080A (ja) * | 2000-10-25 | 2004-09-24 | アグネッロ,ヴィンセント | Hcv、他のフラビウイルス科ウイルス、および血液中で低密度リポタンパク質または超低密度リポタンパク質と複合体を形成するその他のあらゆるウイルスによる感染を細胞中へのウイルス侵入を抑制することによって防止する方法 |
| AU2002241603A1 (en) * | 2000-11-10 | 2002-06-03 | University Of Utah Research Foundation | Carrier system for specific artery wall gene delivery |
| SE0103754L (sv) * | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| WO2002092630A1 (en) * | 2001-05-15 | 2002-11-21 | Japan Immunoresearch Laboratories Co., Ltd. | High density lipoprotein-reactive peptides |
| CA2454418A1 (en) * | 2001-07-20 | 2003-01-30 | Eidgenoessische Technische Hochschule Zurich (Ethz) | Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids |
-
2001
- 2001-11-09 SE SE0103754A patent/SE0103754L/xx not_active Application Discontinuation
-
2002
- 2002-04-05 WO PCT/SE2002/000679 patent/WO2002080954A1/en not_active Ceased
- 2002-04-05 AU AU2002246484A patent/AU2002246484B8/en not_active Expired
- 2002-04-05 EP EP10180111A patent/EP2289914A1/en not_active Withdrawn
- 2002-04-05 PL PL385189A patent/PL215401B1/pl unknown
- 2002-04-05 EP EP10180823A patent/EP2289919A1/en not_active Withdrawn
- 2002-04-05 EP EP07119130A patent/EP1918300A3/en not_active Withdrawn
- 2002-04-05 EP EP10181245A patent/EP2289933A1/en not_active Withdrawn
- 2002-04-05 DK DK08151489.5T patent/DK2006301T3/da active
- 2002-04-05 DK DK10181267.5T patent/DK2295464T3/en active
- 2002-04-05 EP EP10180156A patent/EP2295459A1/en not_active Withdrawn
- 2002-04-05 EP EP10181227A patent/EP2289932A1/en not_active Withdrawn
- 2002-04-05 EP EP10180845A patent/EP2289924A1/en not_active Withdrawn
- 2002-04-05 EP EP10180188A patent/EP2289916A1/en not_active Withdrawn
- 2002-04-05 EP EP10180835A patent/EP2289922A1/en not_active Withdrawn
- 2002-04-05 EP EP10180168A patent/EP2295461A1/en not_active Withdrawn
- 2002-04-05 EP EP10181263A patent/EP2295463A1/en not_active Withdrawn
- 2002-04-05 CN CN028089405A patent/CN1505525B/zh not_active Expired - Fee Related
- 2002-04-05 EP EP10180828A patent/EP2289921A1/en not_active Withdrawn
- 2002-04-05 EP EP10181203A patent/EP2289929A1/en not_active Withdrawn
- 2002-04-05 EP EP10181253.5A patent/EP2289934B1/en not_active Expired - Lifetime
- 2002-04-05 EP EP10180162.9A patent/EP2295460B1/en not_active Expired - Lifetime
- 2002-04-05 ES ES10181267.5T patent/ES2546293T3/es not_active Expired - Lifetime
- 2002-04-05 CA CA2443223A patent/CA2443223C/en not_active Expired - Lifetime
- 2002-04-05 EP EP10181173A patent/EP2289926A1/en not_active Withdrawn
- 2002-04-05 EP EP10180176A patent/EP2305708A1/en not_active Withdrawn
- 2002-04-05 EP EP10180199A patent/EP2289918A1/en not_active Withdrawn
- 2002-04-05 EP EP10180109A patent/EP2289913A1/en not_active Withdrawn
- 2002-04-05 PL PL391615A patent/PL217858B1/pl unknown
- 2002-04-05 EE EEP200700052A patent/EE200700052A/xx unknown
- 2002-04-05 CA CA2827167A patent/CA2827167A1/en not_active Abandoned
- 2002-04-05 EP EP10180115A patent/EP2305707A1/en not_active Withdrawn
- 2002-04-05 EP EP10180193A patent/EP2289917A1/en not_active Withdrawn
- 2002-04-05 DK DK02714667T patent/DK1383526T3/da active
- 2002-04-05 CA CA2606839A patent/CA2606839C/en not_active Expired - Lifetime
- 2002-04-05 EP EP10180106A patent/EP2289912A1/en not_active Withdrawn
- 2002-04-05 EP EP10180026A patent/EP2295457A1/en not_active Withdrawn
- 2002-04-05 BR BR0208685-9A patent/BR0208685A/pt not_active Application Discontinuation
- 2002-04-05 EP EP08167532A patent/EP2147680A3/en not_active Withdrawn
- 2002-04-05 CN CN201210322795.9A patent/CN103122031B/zh not_active Expired - Lifetime
- 2002-04-05 RU RU2003132443/15A patent/RU2296582C2/ru active
- 2002-04-05 EP EP08167533A patent/EP2147930A3/en not_active Withdrawn
- 2002-04-05 EP EP08158141A patent/EP2147928A3/en not_active Withdrawn
- 2002-04-05 EP EP10181213A patent/EP2289930A1/en not_active Withdrawn
- 2002-04-05 PL PL400308A patent/PL400308A1/pl unknown
- 2002-04-05 PL PL02367301A patent/PL367301A1/xx unknown
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2003
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2007
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2008
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