JP2004529091A5 - - Google Patents
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- Publication number
- JP2004529091A5 JP2004529091A5 JP2002560673A JP2002560673A JP2004529091A5 JP 2004529091 A5 JP2004529091 A5 JP 2004529091A5 JP 2002560673 A JP2002560673 A JP 2002560673A JP 2002560673 A JP2002560673 A JP 2002560673A JP 2004529091 A5 JP2004529091 A5 JP 2004529091A5
- Authority
- JP
- Japan
- Prior art keywords
- hypocrellin
- composition
- group
- diseases
- immunotherapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 10
- KGHNSNSWRMJVND-UHFFFAOYSA-N Hypocrellin Natural products COC1=CC(=O)C2=C3C4C(C(C(=O)C)C(C)(O)Cc5c(OC)c(O)c6C(=O)C=C(OC)C(=C13)c6c45)C(=C2O)OC KGHNSNSWRMJVND-UHFFFAOYSA-N 0.000 claims 7
- VANSZAOQCMTTPB-SETSBSEESA-N hypocrellin Chemical class C1[C@@](C)(O)[C@@H](C(C)=O)C2=C(OC)C(O)=C3C(=O)C=C(OC)C4=C3C2=C2C3=C4C(OC)=CC(=O)C3=C(O)C(OC)=C21 VANSZAOQCMTTPB-SETSBSEESA-N 0.000 claims 7
- BQJKVFXDDMQLBE-UHFFFAOYSA-N shiraiachrome A Natural products COC1=C2C3=C(OC)C=C(O)C4=C3C3=C5C(CC(C)(O)C(C(C)=O)C3=C(OC)C4=O)=C(OC)C(=O)C(C(O)=C1)=C25 BQJKVFXDDMQLBE-UHFFFAOYSA-N 0.000 claims 7
- 239000002955 immunomodulating agent Substances 0.000 claims 4
- -1 amino-substituted hypocrellin Chemical class 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- APTUSGMALOMQQL-UHFFFAOYSA-N chembl2029624 Chemical class O=C1C(OC)=C2C(C(C)=O)=C(C)CC3=C(OC)C(=O)C4=C(O)C=C(OC)C5=C4C3=C2C2=C1C(O)=CC(OC)=C25 APTUSGMALOMQQL-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000001571 immunoadjuvant effect Effects 0.000 claims 1
- 239000000568 immunological adjuvant Substances 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26467701P | 2001-01-30 | 2001-01-30 | |
| PCT/IB2002/000267 WO2002060482A2 (en) | 2001-01-30 | 2002-01-29 | Perylenequinones for use with immunotherapy agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529091A JP2004529091A (ja) | 2004-09-24 |
| JP2004529091A5 true JP2004529091A5 (https=) | 2005-12-22 |
Family
ID=23007123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002560673A Pending JP2004529091A (ja) | 2001-01-30 | 2002-01-29 | 免疫療法剤と共に使用するためのペリレンキノン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040110846A1 (https=) |
| EP (1) | EP1357944B1 (https=) |
| JP (1) | JP2004529091A (https=) |
| CN (1) | CN1665535A (https=) |
| AT (1) | ATE364398T1 (https=) |
| AU (1) | AU2002234809B2 (https=) |
| CA (1) | CA2436233C (https=) |
| DE (1) | DE60220642T2 (https=) |
| WO (1) | WO2002060482A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349965A (zh) * | 2000-10-25 | 2002-05-22 | 中国科学院感光化学研究所 | 带有脂肪环或芳香环的脂肪胺基取代去甲氧基竹红菌素及其合成方法和用途 |
| US6627664B2 (en) * | 2001-01-30 | 2003-09-30 | Altachem Pharma Ltd. | Perylenequinones for use as sonosensitizers |
| AU2004297235A1 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| WO2007016762A1 (en) * | 2005-08-10 | 2007-02-15 | Quest Pharmatech Inc. | Perylenequinone derivatives and uses thereof |
| US8454991B2 (en) * | 2006-07-24 | 2013-06-04 | Quest Pharmatech Inc. | Method and device for photodynamic therapy |
| CN102138640B (zh) * | 2011-01-14 | 2012-12-05 | 江南大学 | 苝醌化合物在制备防治禽类病毒饲料中的应用 |
| CN109456210B (zh) * | 2017-09-06 | 2020-09-25 | 中国科学院理化技术研究所 | 一种竹红菌素迫位和2-位同时氨基取代的衍生物及其制备方法和应用 |
| CN109453408A (zh) * | 2018-11-16 | 2019-03-12 | 江南大学 | 抗菌创伤敷料及其制备方法 |
| CA3135291A1 (en) * | 2019-03-29 | 2020-10-08 | The Brigham And Women's Hospital, Inc. | Targeted synergistic cancer immunotherapy |
| CN115282133A (zh) * | 2021-12-06 | 2022-11-04 | 温州医科大学 | 竹红菌乙素在制备抗结肠癌药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1015033A2 (en) * | 1997-01-10 | 2000-07-05 | AltaRex, Corp. | Substituted perylenequinones for use in photodynamic therapy |
| GB9710049D0 (en) * | 1997-05-19 | 1997-07-09 | Nycomed Imaging As | Method |
| DK1009413T3 (da) * | 1997-09-05 | 2007-06-11 | Univ California | Anvendelse af immunstimulerende oligonukleotider til forebyggelse eller behandling af astma |
| EP1820514A3 (en) * | 1998-06-15 | 2007-10-17 | AltaRex Medical Corporation | Therapeutic compositions that produce an immune response by altering the antigen |
| US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| ATE290879T1 (de) * | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
| EP1276501B9 (en) * | 2000-04-25 | 2007-01-24 | Immunex Corporation | Method for treatment of tumors using photodynamic therapy |
| US6627664B2 (en) * | 2001-01-30 | 2003-09-30 | Altachem Pharma Ltd. | Perylenequinones for use as sonosensitizers |
| US8034803B2 (en) * | 2001-02-06 | 2011-10-11 | Qlt Inc. | Photodynamic therapy of occult age-related macular degeneration |
-
2002
- 2002-01-29 EP EP02701466A patent/EP1357944B1/en not_active Expired - Lifetime
- 2002-01-29 CA CA2436233A patent/CA2436233C/en not_active Expired - Fee Related
- 2002-01-29 JP JP2002560673A patent/JP2004529091A/ja active Pending
- 2002-01-29 AU AU2002234809A patent/AU2002234809B2/en not_active Ceased
- 2002-01-29 US US10/470,519 patent/US20040110846A1/en not_active Abandoned
- 2002-01-29 WO PCT/IB2002/000267 patent/WO2002060482A2/en not_active Ceased
- 2002-01-29 AT AT02701466T patent/ATE364398T1/de not_active IP Right Cessation
- 2002-01-29 DE DE60220642T patent/DE60220642T2/de not_active Expired - Lifetime
- 2002-01-29 CN CN028066456A patent/CN1665535A/zh active Pending
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