JP2002525329A5 - - Google Patents
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- JP2002525329A5 JP2002525329A5 JP2000571925A JP2000571925A JP2002525329A5 JP 2002525329 A5 JP2002525329 A5 JP 2002525329A5 JP 2000571925 A JP2000571925 A JP 2000571925A JP 2000571925 A JP2000571925 A JP 2000571925A JP 2002525329 A5 JP2002525329 A5 JP 2002525329A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- drug
- independently
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCCCCCCC(C)CC(C)C(C1)C11C(*CC(CC)C*CC(C)(C2C*C2)C2(*3)C3C(C)(C)CCC2)C1 Chemical compound CCCCCCCC(C)CC(C)C(C1)C11C(*CC(CC)C*CC(C)(C2C*C2)C2(*3)C3C(C)(C)CCC2)C1 0.000 description 4
- GDOPTJXRTPNYNR-UHFFFAOYSA-N CC1CCCC1 Chemical compound CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- YVQSQSGQOUWMCL-UHFFFAOYSA-N CCCCC(C)(C)C(CC1C2)C2C1N Chemical compound CCCCC(C)(C)C(CC1C2)C2C1N YVQSQSGQOUWMCL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10176398P | 1998-09-25 | 1998-09-25 | |
| US60/101,763 | 1998-09-25 | ||
| PCT/US1999/021780 WO2000018407A1 (en) | 1998-09-25 | 1999-09-24 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014273A Division JP5190125B2 (ja) | 1998-09-25 | 2011-01-26 | 感覚毛細胞及び蝸牛ニューロンへの損傷を予防する／処置するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002525329A JP2002525329A (ja) | 2002-08-13 |
| JP2002525329A5 true JP2002525329A5 (https=) | 2006-11-24 |
Family
ID=22286288
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000571925A Pending JP2002525329A (ja) | 1998-09-25 | 1999-09-24 | 感覚毛細胞及び蝸牛ニューロンへの損傷を予防する／処置するための方法 |
| JP2011014273A Expired - Fee Related JP5190125B2 (ja) | 1998-09-25 | 2011-01-26 | 感覚毛細胞及び蝸牛ニューロンへの損傷を予防する／処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011014273A Expired - Fee Related JP5190125B2 (ja) | 1998-09-25 | 2011-01-26 | 感覚毛細胞及び蝸牛ニューロンへの損傷を予防する／処置するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6448283B1 (https=) |
| EP (1) | EP1126855B1 (https=) |
| JP (2) | JP2002525329A (https=) |
| KR (1) | KR100628847B1 (https=) |
| CN (1) | CN1329034C (https=) |
| AT (1) | ATE361752T1 (https=) |
| AU (1) | AU763435B2 (https=) |
| CA (1) | CA2345295C (https=) |
| DE (1) | DE69936059T2 (https=) |
| ES (1) | ES2288042T3 (https=) |
| HK (1) | HK1040053B (https=) |
| NZ (1) | NZ511024A (https=) |
| WO (1) | WO2000018407A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US20030108539A1 (en) * | 2000-02-14 | 2003-06-12 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US6630500B2 (en) * | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
| WO2004096256A1 (en) * | 2001-01-23 | 2004-11-11 | The United States Of America, As Represented By The Secretary Of The Navy | Methods for preventing and treating loss of balance function due to oxidative stress |
| US7129225B2 (en) * | 2001-10-22 | 2006-10-31 | The Research Foundation Of State University Of New York | Protection against and treatment of hearing loss |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| US20100030301A1 (en) * | 2001-11-09 | 2010-02-04 | Cochlear Limited | Electrical stimulation for modulation of neural plasticity |
| AUPR879201A0 (en) * | 2001-11-09 | 2001-12-06 | Cochlear Limited | Subthreshold stimulation of a cochlea |
| US20100030130A1 (en) * | 2001-11-09 | 2010-02-04 | Cochlear Limited | Pharmaceutical intervention for modulation of neural plasticity |
| US20050171579A1 (en) * | 2001-11-09 | 2005-08-04 | Claudia Tasche | Stimulating device |
| DE60332215D1 (de) | 2002-02-28 | 2010-06-02 | Eisai R&D Man Co Ltd | Neue indazolverbindungen mit kondensiertem ring |
| EP1585431A2 (en) * | 2002-10-10 | 2005-10-19 | Neurorecovery, Inc. | System and method of active neuro-protection for detecting and arresting traumatic brain injury and spinal cord injury |
| CA2569724A1 (en) | 2004-06-15 | 2005-12-29 | Cochlear Americas | Automatic determination of the threshold of an evoked neural response |
| WO2007031098A1 (en) * | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| US8080517B2 (en) * | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| WO2009143864A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
| WO2009143865A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| JP5457813B2 (ja) * | 2009-12-16 | 2014-04-02 | ルネサスエレクトロニクス株式会社 | Ａｄｐｌｌ回路、半導体装置及び携帯情報機器 |
| DE102010007281A1 (de) * | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| AU2010362444B2 (en) | 2010-10-14 | 2015-08-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| ES2870085T3 (es) | 2013-06-26 | 2021-10-26 | Xigen Inflammation Ltd | Inhibidores peptídicos permeables a células de la ruta de transducción de señales de JNK para el tratamiento de la cistitis |
| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| CN110248650A (zh) | 2016-10-31 | 2019-09-17 | 霍夫耳科研究所 | 用于增强突触发生和神经突发生的方法 |
| US11857551B1 (en) | 2020-07-10 | 2024-01-02 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3752123T2 (de) * | 1987-03-09 | 1998-05-14 | Kyowa Hakko Kogyo Kk | Derivate des physiologisch aktiven mittels k-252 |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| JPH07113027B2 (ja) | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| WO1993008809A1 (en) | 1991-11-08 | 1993-05-13 | The University Of Southern California | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| DE69409641T2 (de) | 1993-05-28 | 1998-11-26 | Cephalon, Inc., West Chester, Pa. | Anwendung von indolocarbazol-derivaten zur behandlung von prostataerkrankungen |
| US5468872A (en) | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
| AU1911095A (en) | 1994-02-18 | 1995-09-04 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
| US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5475110A (en) | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
| US5591855A (en) | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5594009A (en) | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5686444A (en) * | 1995-04-05 | 1997-11-11 | Cephalon, Inc. | Selected soluble esters of hydroxyl-containing indolocarbazoles |
| US5616724A (en) * | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
| US5929041A (en) | 1996-02-23 | 1999-07-27 | Amgen Inc. | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product |
| UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
| PT912184E (pt) | 1996-06-25 | 2002-12-31 | Cephalon Inc | Utilizacao de um derivado de k-252a para o tratamento de doencas do sietma nervoso central ou periferico e sobre-producao de citoquina |
| AU758241B2 (en) | 1998-03-13 | 2003-03-20 | University Of British Columbia, The | Granulatimide derivatives for use in cancer treatment |
| US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
-
1999
- 1999-09-24 WO PCT/US1999/021780 patent/WO2000018407A1/en not_active Ceased
- 1999-09-24 DE DE69936059T patent/DE69936059T2/de not_active Expired - Lifetime
- 1999-09-24 KR KR1020017003848A patent/KR100628847B1/ko not_active Expired - Fee Related
- 1999-09-24 ES ES99969678T patent/ES2288042T3/es not_active Expired - Lifetime
- 1999-09-24 NZ NZ511024A patent/NZ511024A/en not_active IP Right Cessation
- 1999-09-24 CA CA002345295A patent/CA2345295C/en not_active Expired - Fee Related
- 1999-09-24 AU AU60532/99A patent/AU763435B2/en not_active Ceased
- 1999-09-24 US US09/404,187 patent/US6448283B1/en not_active Expired - Lifetime
- 1999-09-24 CN CNB998136123A patent/CN1329034C/zh not_active Expired - Fee Related
- 1999-09-24 HK HK02101420.6A patent/HK1040053B/en not_active IP Right Cessation
- 1999-09-24 EP EP99969678A patent/EP1126855B1/en not_active Expired - Lifetime
- 1999-09-24 AT AT99969678T patent/ATE361752T1/de not_active IP Right Cessation
- 1999-09-24 JP JP2000571925A patent/JP2002525329A/ja active Pending
-
2002
- 2002-01-08 US US10/041,224 patent/US7789610B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 JP JP2011014273A patent/JP5190125B2/ja not_active Expired - Fee Related
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