HUP0103303A2 - Imidazolvegyületek, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Imidazolvegyületek, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0103303A2
HUP0103303A2 HU0103303A HUP0103303A HUP0103303A2 HU P0103303 A2 HUP0103303 A2 HU P0103303A2 HU 0103303 A HU0103303 A HU 0103303A HU P0103303 A HUP0103303 A HU P0103303A HU P0103303 A2 HUP0103303 A2 HU P0103303A2
Authority
HU
Hungary
Prior art keywords
group
hydroxyl group
optionally substituted
compounds
lower alkyl
Prior art date
Application number
HU0103303A
Other languages
English (en)
Inventor
Takayoshi Kinoshita
Masako Kuno
Katsuya Nakamura
Isao Nakanishi
Nobuya Nishio
Hiroyuki Okumura
Akihiro Sato
Nobuo Seki
Tadashi Terasaka
Kiyoshi Tsuji
Susumu Tsujimoto
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPP4840A external-priority patent/AUPP484098A0/en
Priority claimed from AUPP7355A external-priority patent/AUPP735598A0/en
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HUP0103303A2 publication Critical patent/HUP0103303A2/hu
Publication of HUP0103303A3 publication Critical patent/HUP0103303A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A tal lm ny t rgy t (I) ltal nos képletű, adenozin deamin z g tló hatssal rendelkező imidazol-vegyületek, e vegyületek gyógyszerprekurzoraiilletve sói képezik, ahol R1 jelentése hidrogénatom, hidroxilcsoport,védett hidroxilcsoport, vagy alkalmas szubsztituenssel(szubsztituensekkel) tetszőlegesen szubsztitu lt arilcsoport; R2jelentése hidrogénatom vagy alacsony szénatomsz mú alkilcsoport; R3jelentése hidroxilcsoport vagy védett hidroxilcsoport; R4 jelentésecianocsoport, (hidroxi)-iminoamino-(alacsony szénatomsz mú alkil)-csoport, karboxil-, védett karboxilcsoport, aminocsoporttaltetszőlegesen szubsztitu lt heterociklusos csoport, vagy alkalmasszubsztituenssel (szubsztituensekkel) tetszőlegesen szubsz- titu ltkarbamoilcsoport; és -A- jelentése -Q- vagy -O-Q-csoport, ahol Qjelentése egyszeres k"tés vagy alacsony szénatomsz mú alkiléncsoport,feltéve, hogy amikor R2 jelentése alacsony szénatomsz mú alkilcsoport,akkor R1 jelentése hidroxilcsoport, védett hidroxilcsoport, vagyalkalmas szubsztituenssel (szubsztituensekkel) tetszőlegesenszubsztitu lt arilcsoport. A vegyületek hasznosak az olyan betegségekkezelésében és/vagy megelőzésében, melyekben az adenozin hat st fejtki. A bejelentés kiterjed az (I) ltal nos képletű vegyületekettartalmazó gyógyszerkészítményekre is. Ó
HU0103303A 1998-07-23 1999-07-22 Imidazole compounds, process for producing them, their use and medicaments containing them HUP0103303A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP4840A AUPP484098A0 (en) 1998-07-23 1998-07-23 Novel imidazole compounds
AUPP7355A AUPP735598A0 (en) 1998-11-27 1998-11-27 Novel imidazole compounds
PCT/JP1999/003939 WO2000005217A1 (en) 1998-07-23 1999-07-22 Imidazole compounds and their use as adenosine deaminase inhibitors

Publications (2)

Publication Number Publication Date
HUP0103303A2 true HUP0103303A2 (hu) 2002-04-29
HUP0103303A3 HUP0103303A3 (en) 2002-09-30

Family

ID=25645831

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103303A HUP0103303A3 (en) 1998-07-23 1999-07-22 Imidazole compounds, process for producing them, their use and medicaments containing them

Country Status (16)

Country Link
US (1) US6359145B1 (hu)
EP (1) EP1098885B9 (hu)
JP (1) JP4525883B2 (hu)
KR (1) KR100429754B1 (hu)
CN (1) CN1291979C (hu)
AT (1) ATE282599T1 (hu)
BR (1) BR9912684A (hu)
CA (1) CA2338305A1 (hu)
DE (1) DE69922009T2 (hu)
ES (1) ES2234269T3 (hu)
HK (1) HK1041264B (hu)
HU (1) HUP0103303A3 (hu)
MX (1) MXPA01000549A (hu)
PT (1) PT1098885E (hu)
RU (1) RU2243220C2 (hu)
WO (1) WO2000005217A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP921299A0 (en) 1999-03-15 1999-04-15 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
US6103702A (en) * 1999-05-24 2000-08-15 Board Of Trustees Of The University Of Illinois Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
AUPQ515700A0 (en) 2000-01-19 2000-02-10 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds
AUPR636301A0 (en) 2001-07-13 2001-08-02 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds
AUPS058102A0 (en) 2002-02-15 2002-03-14 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds
US20040175804A1 (en) * 2003-03-04 2004-09-09 Skonezny Paul M. Process for preparing dideoxyinosine using adenosine deaminase enzyme
TW200815388A (en) * 2006-04-18 2008-04-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
US8314136B1 (en) 2006-05-23 2012-11-20 MedDEV, Inc. Method for treatment of alzheimer's disease and autism spectrum disorders
NZ555337A (en) * 2006-05-23 2009-03-31 Elaine A Delack Adhesive patch of methyl imidazole carboxylate for the treatment of neurodegenerative disorders
EP2167474A1 (en) * 2007-06-11 2010-03-31 Valletta Health IP EE B.V. Urocanic acid derivatives useful for the treatment of immune-related and inflammatory diseases
JP5454458B2 (ja) * 2010-11-25 2014-03-26 信越化学工業株式会社 ポジ型レジスト材料及びパターン形成方法
CN108318594A (zh) * 2018-01-12 2018-07-24 上海中医药大学 一种液相色谱串联质谱法测定腺苷脱氨酶活性及筛选其抑制剂的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906965D0 (en) * 1989-03-28 1989-05-10 Schering Agrochemicals Ltd Fungicides
DE69401486T2 (de) * 1993-11-12 1997-04-30 Ishihara Sangyo Kaisha Verfahren zur Herstellung 2-cyanoimidazol Derivate
CA2261591A1 (en) * 1996-07-15 1998-01-22 Elie Abushanab Adenosine deaminase inhibitors

Also Published As

Publication number Publication date
DE69922009T2 (de) 2005-04-07
EP1098885B1 (en) 2004-11-17
HUP0103303A3 (en) 2002-09-30
BR9912684A (pt) 2001-05-02
KR100429754B1 (ko) 2004-05-03
RU2243220C2 (ru) 2004-12-27
MXPA01000549A (es) 2002-04-08
EP1098885B9 (en) 2005-05-18
CN1291979C (zh) 2006-12-27
KR20010072037A (ko) 2001-07-31
US6359145B1 (en) 2002-03-19
EP1098885A1 (en) 2001-05-16
JP2002521369A (ja) 2002-07-16
JP4525883B2 (ja) 2010-08-18
CA2338305A1 (en) 2000-02-03
DE69922009D1 (de) 2004-12-23
HK1041264B (zh) 2007-08-17
CN1319095A (zh) 2001-10-24
HK1041264A1 (en) 2002-07-05
ES2234269T3 (es) 2005-06-16
ATE282599T1 (de) 2004-12-15
PT1098885E (pt) 2005-01-31
WO2000005217A1 (en) 2000-02-03

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ASTELLAS PHARMA INC., JP

Free format text: FORMER OWNER(S): FUJISAWA PHARMACEUTICAL CO., LTD., JP