JP2004528294A5 - - Google Patents
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- Publication number
- JP2004528294A5 JP2004528294A5 JP2002560674A JP2002560674A JP2004528294A5 JP 2004528294 A5 JP2004528294 A5 JP 2004528294A5 JP 2002560674 A JP2002560674 A JP 2002560674A JP 2002560674 A JP2002560674 A JP 2002560674A JP 2004528294 A5 JP2004528294 A5 JP 2004528294A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- derivative
- hypocrellin
- sound
- exposing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 21
- VANSZAOQCMTTPB-SETSBSEESA-N hypocrellin Chemical compound C1[C@@](C)(O)[C@@H](C(C)=O)C2=C(OC)C(O)=C3C(=O)C=C(OC)C4=C3C2=C2C3=C4C(OC)=CC(=O)C3=C(O)C(OC)=C21 VANSZAOQCMTTPB-SETSBSEESA-N 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- IYYMDGDZPDXTGT-UHFFFAOYSA-N perylene-1,2-dione Chemical class C1=CC(C2=C3C(=CC(C2=O)=O)C=CC=C32)=C3C2=CC=CC3=C1 IYYMDGDZPDXTGT-UHFFFAOYSA-N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 230000003213 activating effect Effects 0.000 claims 3
- APTUSGMALOMQQL-UHFFFAOYSA-N chembl2029624 Chemical class O=C1C(OC)=C2C(C(C)=O)=C(C)CC3=C(OC)C(=O)C4=C(O)C=C(OC)C5=C4C3=C2C2=C1C(O)=CC(OC)=C25 APTUSGMALOMQQL-UHFFFAOYSA-N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- SYKMKCFGVGJEJY-UHFFFAOYSA-N 7,18-dihydroxy-12,13-bis(5-hydroxy-3-oxohexan-2-yl)-5,6,19,20-tetramethoxyhexacyclo[12.8.0.02,11.03,8.04,21.017,22]docosa-1,3(8),4,6,10,12,14,17(22),18,20-decaene-9,16-dione Chemical compound COc1c(O)c2c3c(c1OC)c1c(OC)c(OC)c(O)c4c1c1c(cc4=O)c(C(C)C(=O)CC(C)O)c(C(C)C(=O)CC(C)O)c(cc2=O)c31 SYKMKCFGVGJEJY-UHFFFAOYSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- KGHNSNSWRMJVND-UHFFFAOYSA-N Hypocrellin Natural products COC1=CC(=O)C2=C3C4C(C(C(=O)C)C(C)(O)Cc5c(OC)c(O)c6C(=O)C=C(OC)C(=C13)c6c45)C(=C2O)OC KGHNSNSWRMJVND-UHFFFAOYSA-N 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- -1 N, N-dimethylamino Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229930194791 calphostin Natural products 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- DGAZLNHJYDOWLG-QWRGUYRKSA-N cercosporin Chemical compound C[C@H](O)CC1=C(OC)C(=O)C2=C(O)C=C3OCOC4=CC(O)=C5C6=C4C3=C2C1=C6C(C[C@H](C)O)=C(OC)C5=O DGAZLNHJYDOWLG-QWRGUYRKSA-N 0.000 claims 1
- JWFLIMIGORGZMQ-UHFFFAOYSA-N cercosporin Natural products COC1=C(CC(C)O)c2c3c(CC(C)O)c(OC)c(O)c4C(=O)C=C5OCOc6cc(O)c(C1=O)c2c6c5c34 JWFLIMIGORGZMQ-UHFFFAOYSA-N 0.000 claims 1
- 229930192362 cladochrome Natural products 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- MXLWQNCWIIZUQT-UHFFFAOYSA-N isocercosporin Natural products O=C1C=C2OCOC3=CC(=O)C4=C5C3=C2C2=C1C(O)=C(OC)C(CC(C)O)=C2C5=C(CC(C)O)C(OC)=C4O MXLWQNCWIIZUQT-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- BQJKVFXDDMQLBE-UHFFFAOYSA-N shiraiachrome A Natural products COC1=C2C3=C(OC)C=C(O)C4=C3C3=C5C(CC(C)(O)C(C(C)=O)C3=C(OC)C4=O)=C(OC)C(=O)C(C(O)=C1)=C25 BQJKVFXDDMQLBE-UHFFFAOYSA-N 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/771,555 US6627664B2 (en) | 2001-01-30 | 2001-01-30 | Perylenequinones for use as sonosensitizers |
| PCT/IB2002/000269 WO2002060483A2 (en) | 2001-01-30 | 2002-01-29 | Perylenequinones for use as photosensitizers and sonosensitizers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528294A JP2004528294A (ja) | 2004-09-16 |
| JP2004528294A5 true JP2004528294A5 (https=) | 2005-12-22 |
Family
ID=25092202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002560674A Pending JP2004528294A (ja) | 2001-01-30 | 2002-01-29 | 光増感剤および音増感剤として使用するためのペリレンキノン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6627664B2 (https=) |
| EP (1) | EP1399188B1 (https=) |
| JP (1) | JP2004528294A (https=) |
| CN (1) | CN1531442A (https=) |
| AT (1) | ATE383874T1 (https=) |
| AU (1) | AU2002234811B2 (https=) |
| CA (1) | CA2436572C (https=) |
| DE (1) | DE60224667D1 (https=) |
| WO (1) | WO2002060483A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349965A (zh) * | 2000-10-25 | 2002-05-22 | 中国科学院感光化学研究所 | 带有脂肪环或芳香环的脂肪胺基取代去甲氧基竹红菌素及其合成方法和用途 |
| EP1357944B1 (en) * | 2001-01-30 | 2007-06-13 | Altachem Pharma Ltd. | Perylenequinones for use with immunotherapy agents |
| JP2007500227A (ja) * | 2003-05-29 | 2007-01-11 | ミトス・ファーマシューティカルズ・インコーポレーテッド | 光増感剤及び音増感剤と関連してのニトロキシドの使用方法 |
| WO2007016762A1 (en) | 2005-08-10 | 2007-02-15 | Quest Pharmatech Inc. | Perylenequinone derivatives and uses thereof |
| WO2007025244A2 (en) * | 2005-08-25 | 2007-03-01 | Houle Philip R | Treatment systems for delivery of sensitizer solutions |
| US8454991B2 (en) | 2006-07-24 | 2013-06-04 | Quest Pharmatech Inc. | Method and device for photodynamic therapy |
| US20090062724A1 (en) * | 2007-08-31 | 2009-03-05 | Rixen Chen | System and apparatus for sonodynamic therapy |
| KR101344303B1 (ko) * | 2011-10-07 | 2013-12-24 | 동성제약주식회사 | 표적 치료에 관한 종양에 선택성이 있는 콘쥬게이트 |
| KR101702227B1 (ko) | 2015-07-10 | 2017-02-07 | 성균관대학교산학협력단 | 산화티타늄 나노입자를 유효성분으로 함유하는 음파감작용 조성물, 이를 포함하는 암의 예방 또는 치료용 조성물 및 이의 제조방법 |
| CN109422640A (zh) * | 2017-08-25 | 2019-03-05 | 中国科学院化学研究所 | 竹红菌素衍生物及其制备方法与应用 |
| CN108187068B (zh) * | 2018-01-15 | 2019-04-23 | 江南大学 | 一种光敏剂复合纳米多功能材料的制备及其应用 |
| JP7103855B2 (ja) * | 2018-06-11 | 2022-07-20 | ニューデルタ工業株式会社 | 歩行型農作業機 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1015033A2 (en) * | 1997-01-10 | 2000-07-05 | AltaRex, Corp. | Substituted perylenequinones for use in photodynamic therapy |
| GB9710049D0 (en) * | 1997-05-19 | 1997-07-09 | Nycomed Imaging As | Method |
| IL120891A0 (en) * | 1997-05-22 | 1997-09-30 | Technion Res & Dev Foundation | Photodynamic and sonodynamic therapy and agents for use therefor |
| US6123923A (en) * | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| CA2335808A1 (en) * | 1998-07-06 | 2000-01-13 | David Kessel | Intracellular sensitizers for sonodynamic therapy |
| ATE290879T1 (de) * | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
| EP1357944B1 (en) * | 2001-01-30 | 2007-06-13 | Altachem Pharma Ltd. | Perylenequinones for use with immunotherapy agents |
-
2001
- 2001-01-30 US US09/771,555 patent/US6627664B2/en not_active Expired - Lifetime
-
2002
- 2002-01-29 CN CNA028067258A patent/CN1531442A/zh active Pending
- 2002-01-29 AT AT02701468T patent/ATE383874T1/de not_active IP Right Cessation
- 2002-01-29 WO PCT/IB2002/000269 patent/WO2002060483A2/en not_active Ceased
- 2002-01-29 CA CA002436572A patent/CA2436572C/en not_active Expired - Fee Related
- 2002-01-29 JP JP2002560674A patent/JP2004528294A/ja active Pending
- 2002-01-29 EP EP02701468A patent/EP1399188B1/en not_active Expired - Lifetime
- 2002-01-29 DE DE60224667T patent/DE60224667D1/de not_active Expired - Lifetime
- 2002-01-29 AU AU2002234811A patent/AU2002234811B2/en not_active Ceased
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