JP2006514949A5 - - Google Patents
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- Publication number
- JP2006514949A5 JP2006514949A5 JP2004560487A JP2004560487A JP2006514949A5 JP 2006514949 A5 JP2006514949 A5 JP 2006514949A5 JP 2004560487 A JP2004560487 A JP 2004560487A JP 2004560487 A JP2004560487 A JP 2004560487A JP 2006514949 A5 JP2006514949 A5 JP 2006514949A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy tamoxifen
- medicament
- formulated
- medicament according
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 235000019441 ethanol Nutrition 0.000 claims 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- 206010006298 Breast pain Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 208000006662 Mastodynia Diseases 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43395902P | 2002-12-18 | 2002-12-18 | |
| US60/433,959 | 2002-12-18 | ||
| PCT/EP2003/015028 WO2004054557A2 (en) | 2002-12-18 | 2003-12-15 | Treatment of mastalgia with 4-hydroxy tamoxifen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514949A JP2006514949A (ja) | 2006-05-18 |
| JP2006514949A5 true JP2006514949A5 (https=) | 2007-02-08 |
| JP4938237B2 JP4938237B2 (ja) | 2012-05-23 |
Family
ID=32595255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004560487A Expired - Lifetime JP4938237B2 (ja) | 2002-12-18 | 2003-12-15 | ４−ヒドロキシタモキシフェンによる乳房痛の治療 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7786172B2 (https=) |
| EP (1) | EP1572178B1 (https=) |
| JP (1) | JP4938237B2 (https=) |
| AT (1) | ATE324880T1 (https=) |
| AU (1) | AU2003303033B2 (https=) |
| CA (1) | CA2509660C (https=) |
| CY (1) | CY1106131T1 (https=) |
| DE (1) | DE60305068T2 (https=) |
| DK (1) | DK1572178T3 (https=) |
| ES (1) | ES2263072T3 (https=) |
| MX (1) | MXPA05006526A (https=) |
| NZ (1) | NZ540494A (https=) |
| PT (1) | PT1572178E (https=) |
| SI (1) | SI1572178T1 (https=) |
| WO (1) | WO2004054557A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4684655B2 (ja) * | 2002-12-18 | 2011-05-18 | ラボラトワール ブザン アンテルナスィヨナル | ４−ヒドロキシタモキシフェンによる乳房密度低下 |
| CA2519980C (en) * | 2003-04-01 | 2012-04-10 | Laboratoires Besins International | Prevention and treatment of breast cancer with 4-hydroxy tamoxifen |
| US7767717B2 (en) * | 2003-06-09 | 2010-08-03 | Ascend Therapeutics, Inc. | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
| US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| EP1579856A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1579857A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Chemically stable compositions of 4-hydroxy tamoxifen |
| US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| CN1946387B (zh) * | 2004-03-22 | 2011-08-31 | 法国法杏大药厂 | 4-羟基三苯氧胺在制备治疗和预防良性乳房疾病的药物中的应用 |
| EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
| EP1799201B1 (en) * | 2004-10-14 | 2008-11-26 | Laboratoires Besins International | 4-hydroxy tamoxifen gel formulations |
| JP5544458B2 (ja) * | 2005-07-12 | 2014-07-09 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 疾病を治療するための医薬製品の製造においてトリロスタンｉｉｉを使用する方法及びトリロスタンｉｉｉを含む医薬製品 |
| JP5833549B2 (ja) | 2009-06-22 | 2015-12-16 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 血管透過性亢進を抑制するためのダナゾールを含む製薬組成物 |
| CN104968350A (zh) | 2012-12-19 | 2015-10-07 | 安皮奥制药股份有限公司 | 疾病的治疗方法 |
| IL304863B2 (en) | 2017-09-11 | 2025-08-01 | Atossa Therapeutics Inc | Methods for making and using endoxifen |
| JP7662204B2 (ja) | 2019-07-03 | 2025-04-15 | アトッサ・セラピューティクス・インコーポレイテッド | エンドキシフェンの徐放性組成物 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2558373B1 (fr) | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee |
| ATE80152T1 (de) | 1987-04-21 | 1992-09-15 | Heumann Pharma Gmbh & Co | Stabile loesungsmitteladdukte von z-1-(p-betadimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl) 2-phenylbut-1-en. |
| US5045553A (en) | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| DE3836862A1 (de) | 1988-10-27 | 1990-05-03 | Schering Ag | Mittel zur transdermalen applikation von steroidhormonen |
| US5189212A (en) | 1990-09-07 | 1993-02-23 | University Of Georgia Research Foundation, Inc. | Triarylethylene carboxylic acids with estrogenic activity |
| TW218849B (https=) | 1991-05-17 | 1994-01-11 | Bristol Myers Squibb Co | |
| US5613958A (en) * | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| US5720963A (en) | 1994-08-26 | 1998-02-24 | Mary Kay Inc. | Barrier disruption treatments for structurally deteriorated skin |
| IL120268A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Use of (E)-1-[4'-(2-alkylaminoethioxy)phenyl]1-(3'-hydroxyphenyl)-2-phenylbut-1-enes in inhibiting pathological conditions |
| IL120266A (en) | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| US6548491B2 (en) * | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6013270A (en) | 1998-04-20 | 2000-01-11 | The Procter & Gamble Company | Skin care kit |
| CA2393762A1 (en) * | 1999-12-16 | 2001-06-21 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
| DE10033853A1 (de) | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| EP1177787A3 (en) * | 2000-07-28 | 2003-09-10 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating cataracts |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| DE10054294A1 (de) | 2000-11-02 | 2002-05-16 | Heinrich Wieland | Topische Behandlung bei der Mastalgie |
| ATE288303T1 (de) | 2000-11-30 | 2005-02-15 | Pfizer Prod Inc | Östrogen agonist-antagonist und testosteron enthaltende zusammensetzung zur behandlung abnehmender testosteronspiegel |
| JP2005504032A (ja) | 2001-07-31 | 2005-02-10 | ファイザー・プロダクツ・インク | エストロゲン・アゴニスト／アンタゴニスト、エストロゲン及びプロゲスチンの組み合わせを含む医薬組成物、キット及び方法 |
| PT1317921E (pt) | 2001-12-07 | 2009-11-06 | Besins Mfg Belgium | Composição farmacêutica sob a forma de gel ou de solução à base de di-hidrotestosterona, seu processo de preparação e suas utilizações |
| JP4684655B2 (ja) | 2002-12-18 | 2011-05-18 | ラボラトワール ブザン アンテルナスィヨナル | ４−ヒドロキシタモキシフェンによる乳房密度低下 |
| CA2519980C (en) | 2003-04-01 | 2012-04-10 | Laboratoires Besins International | Prevention and treatment of breast cancer with 4-hydroxy tamoxifen |
| US7767717B2 (en) | 2003-06-09 | 2010-08-03 | Ascend Therapeutics, Inc. | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
| US7968532B2 (en) | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| US7507769B2 (en) | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1579856A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1579857A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Chemically stable compositions of 4-hydroxy tamoxifen |
| EP1647271A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
-
2003
- 2003-12-15 WO PCT/EP2003/015028 patent/WO2004054557A2/en not_active Ceased
- 2003-12-15 AT AT03813146T patent/ATE324880T1/de active
- 2003-12-15 MX MXPA05006526A patent/MXPA05006526A/es active IP Right Grant
- 2003-12-15 SI SI200330296T patent/SI1572178T1/sl unknown
- 2003-12-15 DE DE60305068T patent/DE60305068T2/de not_active Expired - Lifetime
- 2003-12-15 US US10/734,640 patent/US7786172B2/en active Active
- 2003-12-15 DK DK03813146T patent/DK1572178T3/da active
- 2003-12-15 NZ NZ540494A patent/NZ540494A/en not_active IP Right Cessation
- 2003-12-15 PT PT03813146T patent/PT1572178E/pt unknown
- 2003-12-15 ES ES03813146T patent/ES2263072T3/es not_active Expired - Lifetime
- 2003-12-15 JP JP2004560487A patent/JP4938237B2/ja not_active Expired - Lifetime
- 2003-12-15 AU AU2003303033A patent/AU2003303033B2/en not_active Expired
- 2003-12-15 EP EP03813146A patent/EP1572178B1/en not_active Expired - Lifetime
- 2003-12-15 CA CA2509660A patent/CA2509660C/en not_active Expired - Lifetime
-
2006
- 2006-07-27 CY CY20061101041T patent/CY1106131T1/el unknown
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