JP2006514949A5 - - Google Patents
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- Publication number
- JP2006514949A5 JP2006514949A5 JP2004560487A JP2004560487A JP2006514949A5 JP 2006514949 A5 JP2006514949 A5 JP 2006514949A5 JP 2004560487 A JP2004560487 A JP 2004560487A JP 2004560487 A JP2004560487 A JP 2004560487A JP 2006514949 A5 JP2006514949 A5 JP 2006514949A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy tamoxifen
- medicament
- formulated
- medicament according
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- TXUZVZSFRXZGTL-QPLCGJKRSA-N Afimoxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=C(O)C=C1 TXUZVZSFRXZGTL-QPLCGJKRSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 235000019441 ethanol Nutrition 0.000 claims 3
- 206010006298 Breast pain Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 claims 1
- 208000006662 Mastodynia Diseases 0.000 claims 1
- XAPRFLSJBSXESP-UHFFFAOYSA-N Oxycinchophen Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=C(O)C=1C1=CC=CC=C1 XAPRFLSJBSXESP-UHFFFAOYSA-N 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229940074928 isopropyl myristate Drugs 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
Claims (6)
- ４−ヒドロキシタモキシフェンを含む乳房痛の治療のための医薬。
- 経皮投与に好適な形態のものである請求項１に記載の医薬。
- 前記４−ヒドロキシタモキシフェンが浸透促進剤を含む媒体中のものである請求項１または２に記載の医薬。
- 前記４−ヒドロキシタモキシフェンがアルコール溶液に製剤されている請求項１〜３のいずれかに記載の医薬。
- 前記４−ヒドロキシタモキシフェンが水性アルコールゲルに製剤されている請求項１〜４のいずれかに記載の医薬。
- 前記水性アルコールゲルがエチルアルコール、ミリスチン酸イソプロピルおよびヒドロキシプロピルセルロースを含む請求項５に記載の医薬。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43395902P | 2002-12-18 | 2002-12-18 | |
| US60/433,959 | 2002-12-18 | ||
| PCT/EP2003/015028 WO2004054557A2 (en) | 2002-12-18 | 2003-12-15 | Treatment of mastalgia with 4-hydroxy tamoxifen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514949A JP2006514949A (ja) | 2006-05-18 |
| JP2006514949A5 true JP2006514949A5 (ja) | 2007-02-08 |
| JP4938237B2 JP4938237B2 (ja) | 2012-05-23 |
Family
ID=32595255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004560487A Expired - Lifetime JP4938237B2 (ja) | 2002-12-18 | 2003-12-15 | ４−ヒドロキシタモキシフェンによる乳房痛の治療 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7786172B2 (ja) |
| EP (1) | EP1572178B1 (ja) |
| JP (1) | JP4938237B2 (ja) |
| AT (1) | ATE324880T1 (ja) |
| AU (1) | AU2003303033B2 (ja) |
| CA (1) | CA2509660C (ja) |
| CY (1) | CY1106131T1 (ja) |
| DE (1) | DE60305068T2 (ja) |
| DK (1) | DK1572178T3 (ja) |
| ES (1) | ES2263072T3 (ja) |
| HK (1) | HK1075403A1 (ja) |
| MX (1) | MXPA05006526A (ja) |
| NZ (1) | NZ540494A (ja) |
| PT (1) | PT1572178E (ja) |
| SI (1) | SI1572178T1 (ja) |
| WO (1) | WO2004054557A2 (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1572171B1 (en) * | 2002-12-18 | 2009-04-22 | Laboratoires Besins International | Reduction of breast density with 4-hydroxy tamoxifen |
| EP1952810B1 (en) * | 2003-04-01 | 2014-01-08 | Besins Healthcare Luxembourg SARL | Treatment of breast cancer with 4-hydroxytamoxifen |
| WO2004110420A1 (en) * | 2003-06-09 | 2004-12-23 | Ascend Therapeutics, Inc. | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
| US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| ATE391499T1 (de) * | 2004-03-22 | 2008-04-15 | Besins Int Lab | 4-hydroxytamoxifen zur behandlung und prophylaxe von benignen brusterkrankungen |
| EP1579857A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Chemically stable compositions of 4-hydroxy tamoxifen |
| US7507769B2 (en) | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1579856A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
| EP1799201B1 (en) * | 2004-10-14 | 2008-11-26 | Laboratoires Besins International | 4-hydroxy tamoxifen gel formulations |
| JP5544458B2 (ja) * | 2005-07-12 | 2014-07-09 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 疾病を治療するための医薬製品の製造においてトリロスタンｉｉｉを使用する方法及びトリロスタンｉｉｉを含む医薬製品 |
| SG2014008171A (en) | 2009-06-22 | 2014-04-28 | Ampio Pharmaceuticals Inc | Method for treatment of diseases |
| US9351979B2 (en) | 2012-12-19 | 2016-05-31 | Ampio Pharmaceuticals, Inc. | Methods of treatment of diseases |
| AU2018329202B2 (en) | 2017-09-11 | 2022-10-27 | Atossa Therapeutics, Inc. | Methods for making and using endoxifen |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2558373B1 (fr) * | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee |
| DE3781546D1 (de) * | 1987-04-21 | 1992-10-08 | Heumann Pharma Gmbh & Co | Stabile loesungsmitteladdukte von z-1-(p-beta-dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en. |
| US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| DE3836862A1 (de) | 1988-10-27 | 1990-05-03 | Schering Ag | Mittel zur transdermalen applikation von steroidhormonen |
| US5189212A (en) * | 1990-09-07 | 1993-02-23 | University Of Georgia Research Foundation, Inc. | Triarylethylene carboxylic acids with estrogenic activity |
| TW218849B (ja) | 1991-05-17 | 1994-01-11 | Bristol Myers Squibb Co | |
| US5613958A (en) * | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| US5720963A (en) * | 1994-08-26 | 1998-02-24 | Mary Kay Inc. | Barrier disruption treatments for structurally deteriorated skin |
| IL120266A (en) * | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| IL120268A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Use of (E)-1-[4'-(2-alkylaminoethioxy)phenyl]1-(3'-hydroxyphenyl)-2-phenylbut-1-enes in inhibiting pathological conditions |
| US6548491B2 (en) * | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6013270A (en) * | 1998-04-20 | 2000-01-11 | The Procter & Gamble Company | Skin care kit |
| ES2239057T3 (es) * | 1999-12-16 | 2005-09-16 | Dermatrends, Inc. | Agentes de liberacion de hidroxido utilizados como potenciadores de la permeacion cutanea. |
| DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| EP1177787A3 (en) | 2000-07-28 | 2003-09-10 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating cataracts |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| DE10054294A1 (de) * | 2000-11-02 | 2002-05-16 | Heinrich Wieland | Topische Behandlung bei der Mastalgie |
| ES2233570T3 (es) * | 2000-11-30 | 2005-06-16 | Pfizer Products Inc. | Composicion que contiene agonistas/antagosnistas de estrogenos y testosterona para tratar un descenso en el nivel de la hormona testosterona. |
| WO2003011282A1 (en) * | 2001-07-31 | 2003-02-13 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
| ES2330188T3 (es) * | 2001-12-07 | 2009-12-07 | Besins Manufacturing Belgium | Composicion farmaceutica en forma de gel o de solucion a base de dihidrotestoterona, su procedimiento de preparacion y sus utilizaciones. |
| EP1572171B1 (en) * | 2002-12-18 | 2009-04-22 | Laboratoires Besins International | Reduction of breast density with 4-hydroxy tamoxifen |
| EP1952810B1 (en) * | 2003-04-01 | 2014-01-08 | Besins Healthcare Luxembourg SARL | Treatment of breast cancer with 4-hydroxytamoxifen |
| WO2004110420A1 (en) * | 2003-06-09 | 2004-12-23 | Ascend Therapeutics, Inc. | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
| US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1579856A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
| EP1579857A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Chemically stable compositions of 4-hydroxy tamoxifen |
| EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
-
2003
- 2003-12-15 JP JP2004560487A patent/JP4938237B2/ja not_active Expired - Lifetime
- 2003-12-15 NZ NZ540494A patent/NZ540494A/en not_active IP Right Cessation
- 2003-12-15 AT AT03813146T patent/ATE324880T1/de active
- 2003-12-15 AU AU2003303033A patent/AU2003303033B2/en not_active Expired
- 2003-12-15 MX MXPA05006526A patent/MXPA05006526A/es active IP Right Grant
- 2003-12-15 US US10/734,640 patent/US7786172B2/en active Active
- 2003-12-15 CA CA2509660A patent/CA2509660C/en not_active Expired - Lifetime
- 2003-12-15 DE DE60305068T patent/DE60305068T2/de not_active Expired - Lifetime
- 2003-12-15 EP EP03813146A patent/EP1572178B1/en not_active Expired - Lifetime
- 2003-12-15 ES ES03813146T patent/ES2263072T3/es not_active Expired - Lifetime
- 2003-12-15 DK DK03813146T patent/DK1572178T3/da active
- 2003-12-15 WO PCT/EP2003/015028 patent/WO2004054557A2/en active IP Right Grant
- 2003-12-15 PT PT03813146T patent/PT1572178E/pt unknown
- 2003-12-15 SI SI200330296T patent/SI1572178T1/sl unknown
-
2005
- 2005-10-05 HK HK05108810A patent/HK1075403A1/xx not_active IP Right Cessation
-
2006
- 2006-07-27 CY CY20061101041T patent/CY1106131T1/el unknown
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