JP2006505587A5 - - Google Patents
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- Publication number
- JP2006505587A5 JP2006505587A5 JP2004546863A JP2004546863A JP2006505587A5 JP 2006505587 A5 JP2006505587 A5 JP 2006505587A5 JP 2004546863 A JP2004546863 A JP 2004546863A JP 2004546863 A JP2004546863 A JP 2004546863A JP 2006505587 A5 JP2006505587 A5 JP 2006505587A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroalcoholic gel
- therapeutic agent
- phosphodiesterase inhibitor
- gel
- type phosphodiesterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 7
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000035936 sexual power Effects 0.000 claims 2
- 229960002639 sildenafil citrate Drugs 0.000 claims 2
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/273,484 US20030139384A1 (en) | 2000-08-30 | 2002-10-18 | Method for treating erectile dysfunction and increasing libido in men |
| PCT/US2003/032597 WO2004037173A2 (en) | 2002-10-18 | 2003-10-16 | Method for treating erectile dysfunction and increasing libido in men |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006505587A JP2006505587A (ja) | 2006-02-16 |
| JP2006505587A5 true JP2006505587A5 (https=) | 2006-11-30 |
Family
ID=32174519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004546863A Pending JP2006505587A (ja) | 2002-10-18 | 2003-10-16 | 男性における勃起機能不全を治療し、性欲を増進する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20030139384A1 (https=) |
| EP (1) | EP1551416A4 (https=) |
| JP (1) | JP2006505587A (https=) |
| AU (1) | AU2003277388A1 (https=) |
| CA (1) | CA2502607A1 (https=) |
| MX (1) | MXPA05004093A (https=) |
| WO (1) | WO2004037173A2 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US7235625B2 (en) * | 1999-06-29 | 2007-06-26 | Palatin Technologies, Inc. | Multiple agent therapy for sexual dysfunction |
| US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| ATE355854T1 (de) | 2000-08-03 | 2007-03-15 | Antares Pharma Ipl Ag | Neue zusammensetzung zur transdermalen und/oder transmukosalen wirkstoffanwendung mit geeignetem therapeutischen spiegel |
| US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| KR20050045946A (ko) | 2002-06-25 | 2005-05-17 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
| US8883769B2 (en) * | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| DK1670433T3 (da) | 2003-10-10 | 2012-03-12 | Ferring Bv | Transdermal farmaceutisk formulering til mindskelse af hudrester |
| US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
| ATE319426T1 (de) * | 2003-11-11 | 2006-03-15 | Mattern Udo | Nasenformulierung mit kontrollierter freisetzung von sexualhormonen |
| US7425340B2 (en) * | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
| SI1750766T1 (sl) | 2004-05-11 | 2013-11-29 | Emotional Brain B.V. | Farmacevtske formulacije in njihove uporabe pri zdravljenju spolne disfunkcije pri Ĺľenskah |
| EP1634583A1 (en) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| CN101146535A (zh) * | 2005-03-25 | 2008-03-19 | 默克公司 | 用睾酮补充剂和5α-还原酶抑制剂治疗男性病人的方法 |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| WO2006125642A1 (en) * | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
| EP1896038B1 (en) * | 2005-06-03 | 2016-11-09 | Acrux DDS Pty Ltd | Method and composition for testosterone transdermal delivery |
| ZA200711040B (en) | 2005-06-03 | 2009-04-29 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| AU2006254742C1 (en) * | 2005-06-03 | 2011-11-03 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| ES3012497T3 (en) * | 2005-10-12 | 2025-04-09 | Besins Healthcare Lu Sarl | Improved testosterone gel and method of use |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| CA2646667C (en) | 2006-04-21 | 2014-03-11 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
| WO2008040488A1 (en) | 2006-10-04 | 2008-04-10 | M & P Patent Aktiengesellschaft | Controlled release delivery system for nasal application of neurotransmitters |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| WO2008067991A2 (en) * | 2006-12-08 | 2008-06-12 | Antares Pharma Ipl Ag | Skin-friendly drug complexes for transdermal administration |
| JP2010521519A (ja) * | 2007-03-23 | 2010-06-24 | ユニメッド・ファーマシューティカルズ・エルエルシー | 小児性腺機能低下症の治療用組成物及び治療方法 |
| DE102007028869A1 (de) * | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| KR20110090892A (ko) * | 2008-10-31 | 2011-08-10 | 모베르그 데르마 아베 | 두 개 이상의 침투 증강제의 조합으로 구성되는 국소 조성물 |
| JP2010163425A (ja) * | 2008-12-18 | 2010-07-29 | Daiichi Sankyo Healthcare Co Ltd | ホスホジエステラーゼ５阻害剤とパンテチンを含有する医薬組成物 |
| DE102009033396A1 (de) | 2009-07-16 | 2011-01-20 | Ratiopharm Gmbh | Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung |
| DE102009035211A1 (de) | 2009-07-29 | 2011-02-17 | Ratiopharm Gmbh | Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung |
| US9642862B2 (en) | 2010-11-18 | 2017-05-09 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
| TWI422399B (zh) * | 2011-01-21 | 2014-01-11 | Tritech Biopharmaceuticals Co Ltd | 促進第五型磷酸二酯酶抑制劑經皮吸收的醫藥組成物 |
| JO3755B1 (ar) * | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| AR086400A1 (es) | 2011-05-13 | 2013-12-11 | Trimel Pharmaceuticals Corp | Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| JP5872060B2 (ja) * | 2011-12-26 | 2016-03-01 | トライテック バイオファーマシューティカルズ カンパニー リミテッドＴｒｉｔｅｃｈ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． | Ｐｄｅ−５インヒビターの経皮送達を増強するための方法および改良された医薬組成物 |
| US20150290217A1 (en) * | 2012-11-21 | 2015-10-15 | Trimel Biopharma Srl | Male testosterone titration methods, male intranasal testosterone bio-adhesive gel formulations and use thereof for treating hypogonadism and trt |
| WO2014080282A2 (en) * | 2012-11-22 | 2014-05-30 | Trimel Biopharma Srl | One-and two-point titration methods to determine daily treatment regimens to treat hypogonadism or male testosterone deficiency with an intranasal testosterone bio-adhesive gel, and primary and secondary efficacy and safety endpoints |
| EP2965085B1 (en) * | 2013-03-04 | 2020-07-01 | Function Promoting Therapies, LLC | Methods and systems for the diagnosis and treatment of androgen disorders |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| US10213440B2 (en) * | 2014-08-20 | 2019-02-26 | Professional Compounding Centers Of America (Pcca) | Oral transmucosal pharmaceutical compositions including testosterone and an aromatase inhibitor |
| DK3277283T3 (da) * | 2015-04-03 | 2021-04-12 | Benuvia Therapeutics Llc | Sublinguale sildenafilsprayformuerlinger |
| US20170014417A1 (en) | 2015-07-14 | 2017-01-19 | Lipp Life Sciences Llc | Pharmaceutical administration system for the transdermal application of vardenafil |
| US20170035764A1 (en) * | 2015-08-03 | 2017-02-09 | Synergistic Therapeutics, Llc | Sexual dysfunction therapeutic gel |
| KR20180074707A (ko) * | 2015-10-15 | 2018-07-03 | 모세 로고스니츠키 | 저 용량 경구 디피리다몰 조성물 및 이의 용도 |
| US11590209B2 (en) | 2020-01-21 | 2023-02-28 | Palatin Technologies, Inc. | Use of bremelanotide in patients with controlled hypertension |
| CN119112770B (zh) * | 2023-12-27 | 2025-09-05 | 江苏澳德智科医疗科技有限公司 | 一种功能凝胶的制备方法 |
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| US4078060A (en) * | 1976-05-10 | 1978-03-07 | Richardson-Merrell Inc. | Method of inducing an estrogenic response |
| US4861764A (en) * | 1986-11-17 | 1989-08-29 | Macro Chem. Corp. | Percutaneous absorption enhancers, compositions containing same and method of use |
| US4855305A (en) * | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
| US5231087A (en) * | 1988-03-16 | 1993-07-27 | Cellegy Pharmaceuticals, Inc. | Treatment of skin diseases and tumors with esters and amides of monocarboxylic acids |
| HU210549B (en) * | 1988-10-27 | 1995-05-29 | Schering Ag | Process for producing transdermally applicable pharmaceutical composition containing gestodene |
| ES2077675T3 (es) * | 1989-03-10 | 1995-12-01 | Endorecherche Inc | Terapia combinada para el tratamiento de enfermedades sensibles a los estrogenos. |
| US5788983A (en) * | 1989-04-03 | 1998-08-04 | Rutgers, The State University Of New Jersey | Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| JPH08501529A (ja) * | 1992-06-11 | 1996-02-20 | セラテック・インコーポレイテッド | 皮膚透過薬剤投与緩和のグリセリン使用 |
| ES2145052T3 (es) * | 1992-06-19 | 2000-07-01 | Univ California | Lipidos para la humidificacion epidermica y la reparacion de la funcion de barrera. |
| DE4223004A1 (de) * | 1992-07-13 | 1994-01-20 | Liedtke Pharmed Gmbh | Einzeldosierte halbfeste topische Arzneiform zur Transdermaltherapie |
| US5723114A (en) * | 1993-03-19 | 1998-03-03 | Cellegy Pharmaceuticals Inc. | Penetration enhancing compositions and methods of their use |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| WO1996008229A2 (en) * | 1994-09-14 | 1996-03-21 | Minnesota Mining And Manufacturing Company | Matrix for transdermal drug delivery |
| US5730987A (en) * | 1996-06-10 | 1998-03-24 | Omar; Lotfy Ismail | Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba |
| US5760096A (en) * | 1996-10-18 | 1998-06-02 | Thornfeldt; Carl R. | Potent penetration enhancers |
| JP2001503749A (ja) * | 1996-10-30 | 2001-03-21 | セラテック・インコーポレーテッド | 透過促進剤としてのグリコール酸の脂肪酸エステル及びその塩 |
| US6019997A (en) * | 1997-01-09 | 2000-02-01 | Minnesota Mining And Manufacturing | Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents |
| US5968919A (en) * | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
| US6319913B1 (en) * | 1997-11-10 | 2001-11-20 | Cellegy Pharmaceuticals, Inc. | Penetration enhancing and irritation reducing systems |
| US5942545A (en) * | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
| US6200591B1 (en) * | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
| DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
| US6586000B2 (en) * | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
| US6562370B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
| US6562369B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers |
| WO2002017927A1 (en) * | 2000-08-30 | 2002-03-07 | Unimed Pharmaceuticals, Inc. | Method for treating erectile dysfunction and increasing libido in men |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20030027804A1 (en) * | 2001-06-27 | 2003-02-06 | Van Der Hoop Roland Gerritsen | Therapeutic combinations for the treatment of hormone deficiencies |
| US20040072810A1 (en) * | 2001-11-07 | 2004-04-15 | Besins International Belgique | Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof |
| US20060088579A1 (en) * | 2002-02-07 | 2006-04-27 | Shastri Venkatram P | Transdermal drug delivery systems |
| MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| FR2848112B1 (fr) * | 2002-12-10 | 2007-02-16 | Besins Int Belgique | Composition pharmaceutique pour administration transdermique ou transmuqueuse comprenant au moins un progestatif et/ou au moins un oestrogene, son procede de preparation et ses utilisations |
| US20050020552A1 (en) * | 2003-07-16 | 2005-01-27 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| US20070082039A1 (en) * | 2004-10-18 | 2007-04-12 | Jones Gerald S Jr | Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
-
2002
- 2002-10-18 US US10/273,484 patent/US20030139384A1/en not_active Abandoned
-
2003
- 2003-10-16 CA CA002502607A patent/CA2502607A1/en not_active Abandoned
- 2003-10-16 AU AU2003277388A patent/AU2003277388A1/en not_active Abandoned
- 2003-10-16 EP EP03809561A patent/EP1551416A4/en not_active Withdrawn
- 2003-10-16 JP JP2004546863A patent/JP2006505587A/ja active Pending
- 2003-10-16 US US10/531,526 patent/US20060211664A1/en not_active Abandoned
- 2003-10-16 WO PCT/US2003/032597 patent/WO2004037173A2/en not_active Ceased
- 2003-10-16 MX MXPA05004093A patent/MXPA05004093A/es active IP Right Grant
-
2004
- 2004-06-14 US US10/867,435 patent/US20050049233A1/en not_active Abandoned
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