JP2004524267A5 - - Google Patents
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- Publication number
- JP2004524267A5 JP2004524267A5 JP2002522900A JP2002522900A JP2004524267A5 JP 2004524267 A5 JP2004524267 A5 JP 2004524267A5 JP 2002522900 A JP2002522900 A JP 2002522900A JP 2002522900 A JP2002522900 A JP 2002522900A JP 2004524267 A5 JP2004524267 A5 JP 2004524267A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroalcoholic gel
- gel according
- testosterone
- hydroalcoholic
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 229960003604 testosterone Drugs 0.000 description 9
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003961 penetration enhancing agent Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 150000003431 steroids Chemical class 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 3
- 239000004584 polyacrylic acid Substances 0.000 description 3
- 230000035936 sexual power Effects 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229960002639 sildenafil citrate Drugs 0.000 description 2
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- QADHLRWLCPCEKT-UHFFFAOYSA-N Androstenediol Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)O)C4C3CC=C21 QADHLRWLCPCEKT-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 description 1
- 206010052649 Primary hypogonadism Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 description 1
- QADHLRWLCPCEKT-LOVVWNRFSA-N androst-5-ene-3beta,17beta-diol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC=C21 QADHLRWLCPCEKT-LOVVWNRFSA-N 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 229950009148 androstenediol Drugs 0.000 description 1
- 229960005471 androstenedione Drugs 0.000 description 1
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/651,777 US6503894B1 (en) | 2000-08-30 | 2000-08-30 | Pharmaceutical composition and method for treating hypogonadism |
| US70375300A | 2000-11-01 | 2000-11-01 | |
| PCT/US2001/027205 WO2002017927A1 (en) | 2000-08-30 | 2001-08-29 | Method for treating erectile dysfunction and increasing libido in men |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524267A JP2004524267A (ja) | 2004-08-12 |
| JP2004524267A5 true JP2004524267A5 (https=) | 2008-09-11 |
Family
ID=27096141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522900A Pending JP2004524267A (ja) | 2000-08-30 | 2001-08-29 | 男性の勃起障害の治療方法、及び性衝動の増強方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20050054623A1 (https=) |
| EP (2) | EP1315502B1 (https=) |
| JP (1) | JP2004524267A (https=) |
| KR (1) | KR100861603B1 (https=) |
| CN (1) | CN1473047A (https=) |
| AT (1) | ATE460939T1 (https=) |
| AU (2) | AU8699501A (https=) |
| BR (1) | BR0113651A (https=) |
| CA (2) | CA2746787A1 (https=) |
| CY (1) | CY1110085T1 (https=) |
| DE (1) | DE60141587D1 (https=) |
| DK (1) | DK1315502T3 (https=) |
| ES (1) | ES2341090T3 (https=) |
| IL (1) | IL154692A0 (https=) |
| MX (1) | MXPA03001858A (https=) |
| NO (1) | NO332649B1 (https=) |
| NZ (1) | NZ524601A (https=) |
| PL (1) | PL205279B1 (https=) |
| PT (1) | PT1315502E (https=) |
| SI (1) | SI1315502T1 (https=) |
| TR (1) | TR200300776T2 (https=) |
| WO (1) | WO2002017927A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| JP5039252B2 (ja) * | 2000-08-31 | 2012-10-03 | ユニメッド ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 性機能低下を治療するための医薬組成物及び方法 |
| MY139721A (en) | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| KR20050045946A (ko) | 2002-06-25 | 2005-05-17 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
| AUPS317302A0 (en) * | 2002-06-25 | 2002-07-18 | Drug Delivery Solutions Pty Ltd | Metastable pharmaceutical compositions |
| IL152575A (en) | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
| IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| US8883769B2 (en) | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| EP1750766B1 (en) | 2004-05-11 | 2013-07-03 | Emotional Brain B.V. | Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction |
| EP1634583A1 (en) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| KR20130114229A (ko) | 2005-06-03 | 2013-10-16 | 애크럭스 디디에스 피티와이 리미티드 | 경피 약물 전달 방법 및 조성물 |
| CA2610708C (en) * | 2005-06-03 | 2013-10-08 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| GEP20125432B (en) | 2005-10-12 | 2012-03-26 | Unimed Pharmaceuticals Llc | Improved testosterone gel and use thereof |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| US8613360B2 (en) | 2006-09-29 | 2013-12-24 | M-I L.L.C. | Shaker and degasser combination |
| EP1925307A1 (en) * | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| GB2461725B (en) | 2008-07-10 | 2012-06-13 | United Wire Ltd | Improved sifting screen |
| US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
| US20100022487A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100022494A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20110190201A1 (en) * | 2008-07-24 | 2011-08-04 | Searete Llc | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100022497A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject |
| CN105064939A (zh) | 2010-05-12 | 2015-11-18 | 波默洛机械公司 | 模块扩展系统及振荡器系统 |
| RU2474424C2 (ru) * | 2010-09-24 | 2013-02-10 | Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин |
| EP2640398A4 (en) | 2010-11-18 | 2014-05-14 | White Mountain Pharma Inc | METHOD FOR TREATING CHRONIC OR BZW. NON-RELIABLE PAIN AND / OR INCREASE OF PATIENT PAIN THRESHOLD AND PHARMACEUTICAL COMPOSITION FOR USE THEREOF |
| US9795639B1 (en) * | 2013-03-16 | 2017-10-24 | BioDlogics, LLC | Methods for the treatment of erectile dysfunction by human birth tissue material compostion |
| US8785426B1 (en) | 2013-12-13 | 2014-07-22 | Upsher-Smith Laboratories, Inc. | Testosterone gel compositions and related methods |
| CA3090262A1 (en) * | 2018-02-02 | 2019-08-08 | Aytu Bioscience, Inc. | Methods of testosterone therapy |
| JP7515582B2 (ja) | 2019-11-06 | 2024-07-12 | スマーテック トピカル，インコーポレイテッド | シクロオキシゲナーゼ阻害剤の局所配合剤およびその使用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496556A (en) * | 1982-08-16 | 1985-01-29 | Norman Orentreich | Topical applications for preventing dry skin |
| US4855305A (en) * | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| TW224048B (https=) * | 1992-03-30 | 1994-05-21 | Hoechst Roussel Pharma | |
| DE69326461T2 (de) * | 1992-06-11 | 2000-05-04 | Theratech Inc., Salt Lake City | Verwendung von glyzerin zur dämpfung der transdermalen arzneimittelverabreichung |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| JP4036496B2 (ja) * | 1995-10-24 | 2008-01-23 | リンテック株式会社 | ゲル製剤の製造方法 |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5730987A (en) * | 1996-06-10 | 1998-03-24 | Omar; Lotfy Ismail | Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| GB9700878D0 (en) * | 1997-01-17 | 1997-03-05 | Scherer Ltd R P | Dosage forms and method for ameliorating male erectile dysfunction |
| AU6265998A (en) * | 1997-02-07 | 1998-08-26 | Theratech, Inc. | Composition and method for supplementing testosterone in women with symptoms of testosterone deficiency |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| JP4139860B2 (ja) * | 1997-11-10 | 2008-08-27 | ストラカン インターナショナル リミティッド | 浸透増強および刺激減少システム |
| CA2335736A1 (en) * | 1998-06-25 | 1999-12-29 | Lavipharm Laboratories, Inc. | A device and method for the treatment of erectile dysfunction |
| JP2000225116A (ja) * | 1998-12-04 | 2000-08-15 | Eisai Co Ltd | 陰茎径の測定法 |
| JP2000212080A (ja) * | 1999-01-26 | 2000-08-02 | Hiroshi Azuma | 勃起機能不全改善剤 |
| DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| CA2359640C (en) * | 1999-02-05 | 2008-11-18 | Cipla Limited | Topical sprays |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
-
2001
- 2001-08-29 ES ES01966486T patent/ES2341090T3/es not_active Expired - Lifetime
- 2001-08-29 MX MXPA03001858A patent/MXPA03001858A/es active IP Right Grant
- 2001-08-29 AU AU8699501A patent/AU8699501A/xx active Pending
- 2001-08-29 DE DE60141587T patent/DE60141587D1/de not_active Expired - Lifetime
- 2001-08-29 WO PCT/US2001/027205 patent/WO2002017927A1/en not_active Ceased
- 2001-08-29 KR KR1020037003148A patent/KR100861603B1/ko not_active Expired - Lifetime
- 2001-08-29 CA CA2746787A patent/CA2746787A1/en not_active Abandoned
- 2001-08-29 PL PL366037A patent/PL205279B1/pl unknown
- 2001-08-29 EP EP01966486A patent/EP1315502B1/en not_active Expired - Lifetime
- 2001-08-29 CA CA002420895A patent/CA2420895C/en not_active Expired - Lifetime
- 2001-08-29 PT PT01966486T patent/PT1315502E/pt unknown
- 2001-08-29 DK DK01966486.1T patent/DK1315502T3/da active
- 2001-08-29 SI SI200130964T patent/SI1315502T1/sl unknown
- 2001-08-29 IL IL15469201A patent/IL154692A0/xx active IP Right Grant
- 2001-08-29 JP JP2002522900A patent/JP2004524267A/ja active Pending
- 2001-08-29 NZ NZ524601A patent/NZ524601A/en not_active IP Right Cessation
- 2001-08-29 TR TR2003/00776T patent/TR200300776T2/xx unknown
- 2001-08-29 AT AT01966486T patent/ATE460939T1/de active
- 2001-08-29 EP EP10184108A patent/EP2283865A1/en not_active Withdrawn
- 2001-08-29 CN CNA018172660A patent/CN1473047A/zh active Pending
- 2001-08-29 AU AU2001286995A patent/AU2001286995B2/en not_active Expired
- 2001-08-29 BR BR0113651-8A patent/BR0113651A/pt not_active Application Discontinuation
-
2003
- 2003-02-28 NO NO20030955A patent/NO332649B1/no not_active IP Right Cessation
-
2004
- 2004-02-25 US US10/787,071 patent/US20050054623A1/en not_active Abandoned
-
2010
- 2010-06-15 CY CY20101100550T patent/CY1110085T1/el unknown
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