JP2004529067A5 - - Google Patents

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Publication number
JP2004529067A5
JP2004529067A5 JP2002533901A JP2002533901A JP2004529067A5 JP 2004529067 A5 JP2004529067 A5 JP 2004529067A5 JP 2002533901 A JP2002533901 A JP 2002533901A JP 2002533901 A JP2002533901 A JP 2002533901A JP 2004529067 A5 JP2004529067 A5 JP 2004529067A5
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Japan
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xaa
ile
leu
val
ala
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JP2002533901A
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Japanese (ja)
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JP2004529067A (ja
JP5196700B2 (ja
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Priority claimed from PCT/US2001/032100 external-priority patent/WO2002030462A2/en
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Publication of JP2004529067A5 publication Critical patent/JP2004529067A5/ja
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Publication of JP5196700B2 publication Critical patent/JP5196700B2/ja
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JP2002533901A 2000-10-13 2001-10-15 ヘッジホッグアンタゴニスト、それらに関する方法及び利用 Expired - Fee Related JP5196700B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24056400P 2000-10-13 2000-10-13
US60/240,564 2000-10-13
PCT/US2001/032100 WO2002030462A2 (en) 2000-10-13 2001-10-15 Hedgehog antagonists, methods and uses related thereto

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2008101692A Division JP2008214356A (ja) 2000-10-13 2008-04-09 ヘッジホッグアンタゴニスト、それらに関する方法及び利用
JP2009113082A Division JP2009179630A (ja) 2000-10-13 2009-05-07 ヘッジホッグアンタゴニスト、それらに関する方法及び利用

Publications (3)

Publication Number Publication Date
JP2004529067A JP2004529067A (ja) 2004-09-24
JP2004529067A5 true JP2004529067A5 (cg-RX-API-DMAC10.html) 2009-07-02
JP5196700B2 JP5196700B2 (ja) 2013-05-15

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ID=22907059

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002533901A Expired - Fee Related JP5196700B2 (ja) 2000-10-13 2001-10-15 ヘッジホッグアンタゴニスト、それらに関する方法及び利用
JP2008101692A Abandoned JP2008214356A (ja) 2000-10-13 2008-04-09 ヘッジホッグアンタゴニスト、それらに関する方法及び利用
JP2009113082A Pending JP2009179630A (ja) 2000-10-13 2009-05-07 ヘッジホッグアンタゴニスト、それらに関する方法及び利用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008101692A Abandoned JP2008214356A (ja) 2000-10-13 2008-04-09 ヘッジホッグアンタゴニスト、それらに関する方法及び利用
JP2009113082A Pending JP2009179630A (ja) 2000-10-13 2009-05-07 ヘッジホッグアンタゴニスト、それらに関する方法及び利用

Country Status (8)

Country Link
US (2) US20040060568A1 (cg-RX-API-DMAC10.html)
EP (1) EP1387674B1 (cg-RX-API-DMAC10.html)
JP (3) JP5196700B2 (cg-RX-API-DMAC10.html)
AU (3) AU2001296844B2 (cg-RX-API-DMAC10.html)
CA (1) CA2425356C (cg-RX-API-DMAC10.html)
DK (1) DK1387674T3 (cg-RX-API-DMAC10.html)
ES (1) ES2623711T3 (cg-RX-API-DMAC10.html)
WO (1) WO2002030462A2 (cg-RX-API-DMAC10.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019490B1 (en) 1997-02-10 2009-11-25 The President And Fellows Of Harvard College Methods for modulating hematopoiesis and vascular growth
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP2002524528A (ja) * 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
AU773044B2 (en) 1998-09-11 2004-05-13 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
JP5420128B2 (ja) 1999-10-13 2014-02-19 ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
DK1387674T3 (en) * 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
CA2452152A1 (en) 2001-07-02 2002-10-10 Sinan Tas Use of cyclopamine in the treatment of psoriasis
US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
WO2003097053A1 (en) 2002-05-09 2003-11-27 Cytokinetics, Inc. Compounds, compositions, and methods
US7038048B2 (en) 2002-05-23 2006-05-02 Cytokinetics, Inc. 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
WO2004009036A2 (en) 2002-07-23 2004-01-29 Cytokinetics, Inc. Compounds compositions and methods
GB0221539D0 (en) * 2002-09-17 2002-10-23 Medical Res Council Methods of treatment
JP2006501306A (ja) 2002-09-30 2006-01-12 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
FR2850022B1 (fr) * 2003-01-22 2006-09-08 Centre Nat Rech Scient Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications
WO2005013800A2 (en) * 2003-07-15 2005-02-17 The Johns Hopkins University Elevated hedgehog pathway activity in digestive system tumors, and methods of treating digestive system tumors having elevated hedgehog pathway activity
US20080095761A1 (en) * 2003-10-01 2008-04-24 The Johns Hopkins University Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis
US20070231828A1 (en) * 2003-10-01 2007-10-04 Johns Hopkins University Methods of predicting behavior of cancers
WO2005042700A2 (en) * 2003-10-20 2005-05-12 The Johns Hopkins University Use of hedgehog pathway inhibitors in small-cell lung cancer
WO2005097207A2 (en) 2004-03-26 2005-10-20 Curis, Inc. Rna interference modulators of hedgehog signaling and uses thereof
ZA200701535B (en) * 2004-08-27 2008-12-31 Infinity Pharmaceuticals Inc Cyclopamine analogues and methods of use thereof
BRPI0514444A (pt) 2004-08-27 2008-06-10 Infinity Pharmaceuticals Inc análogos de ciclopamina e métodos de uso destes
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
US8653083B2 (en) 2005-08-22 2014-02-18 The Johns Hopkins University Hedgehog pathway antagonists to treat disease
US7625759B2 (en) 2005-12-19 2009-12-01 Genentech, Inc. Method for using BOC/CDO to modulate hedgehog signaling
CA2634743C (en) 2005-12-23 2014-07-29 Zealand Pharma A/S Modified lysine-mimetic compounds
WO2008121102A2 (en) * 2006-02-21 2008-10-09 The Regents Of The University Of Michigan Hedgehog signaling pathway antagonist cancer treatment
EP2007428A2 (en) * 2006-04-05 2008-12-31 Genentech, Inc. Method for using boc/cdo to modulate hedgehog signaling
CA2650338C (en) * 2006-04-27 2013-04-16 Illinois Tool Works Inc. Pan chiller system with single state coolant
WO2007136250A2 (en) * 2006-05-24 2007-11-29 Stichting Voor De Technische Wetenschappen A pharmaceutical composition suitable for the treatment of cancer and method of preparing said pharmaceutical composition
PL2468724T3 (pl) 2006-12-21 2016-05-31 Zealand Pharma As Synteza związków pirolidynowych
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
CN101687877B (zh) 2007-03-07 2014-07-23 无限发现股份有限公司 杂环环杷明类似物及其使用方法
MX2009009429A (es) 2007-03-07 2010-07-05 Infinity Discovery Inc Analogos de ciclopamina lactama y metodos de uso de los mismos.
WO2009058945A1 (en) 2007-10-30 2009-05-07 The Wistar Institute Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer
US8669243B2 (en) 2007-10-30 2014-03-11 The Wistar Institute Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer
US8716479B2 (en) 2007-12-27 2014-05-06 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
JP5715420B2 (ja) * 2007-12-28 2015-05-07 ジェネンテック， インコーポレイテッド 抗ヘッジホッグ抗体
FR2948367A1 (fr) 2009-07-24 2011-01-28 Centre Nat Rech Scient Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog
CN102574791A (zh) 2009-08-05 2012-07-11 无限药品股份有限公司 环杷明类似物的酶促转氨基反应
JP5326962B2 (ja) * 2009-09-17 2013-10-30 住友大阪セメント株式会社 防汚加工製品及びその製造方法
RU2490267C2 (ru) * 2010-05-28 2013-08-20 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран Способ получения конъюгата (6-гидрокси-2,5,7,8-тетраметилхроман-2-ил)ацетальдегида с 20-гидроксиэкдизоном и его применение в качестве антиоксидантного средства, ингибирующего процесс перекисного окисления липидов
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
FR2967498B1 (fr) 2010-11-16 2015-01-02 Centre Nat Rech Scient Utilisation de derives de quinolinone comme outil de recherche
US9708299B2 (en) 2011-01-03 2017-07-18 Genentech, Inc. Hedgehog antagonists having zinc binding moieties
CA2837852A1 (en) * 2011-06-02 2012-12-06 Novartis Ag Biomarkers for hedgehog inhibitor therapy
EP3520793B1 (en) * 2011-06-06 2023-03-29 University of Iowa Research Foundation Substances and compostions for use in methods of inhibiting muscle atrophy
FR2980477B1 (fr) 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
JP6233932B2 (ja) 2012-08-30 2017-11-22 国立大学法人広島大学 ＢＢＦ２Ｈ７（ＢＢＦ２ ｈｕｍａｎ ｈｏｍｏｌｏｇｕｅ ｏｎ ｃｈｒｏｍｏｓｏｍｅ７）部分アミノ酸配列を有するペプチドまたはそれに結合する抗体を含む細胞増殖調節用組成物
RU2692595C2 (ru) 2013-06-11 2019-06-25 Президент Энд Феллоус Оф Гарвард Колледж КЛЕТКИ SC-β И КОМПОЗИЦИИ И СПОСОБЫ ДЛЯ ИХ СОЗДАНИЯ
US10369147B2 (en) 2015-06-04 2019-08-06 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
EP3618847B1 (en) 2017-05-05 2021-04-07 Zealand Pharma A/S Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease
WO2019099725A1 (en) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
AU2021319209A1 (en) 2020-07-31 2023-03-02 Vertex Pharmaceuticals Incorporated Differentiation of pancreatic endocrine cells
WO2023077140A2 (en) 2021-11-01 2023-05-04 Vertex Pharmaceuticals Incorporated Stem cell derived pancreatic islet differentiation

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6610656B1 (en) * 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US6165747A (en) * 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
AU704178B2 (en) 1993-12-30 1999-04-15 Imperial Cancer Research Technology Ltd Vertebrate embryonic pattern-inducing hedgehog-like proteins
US6271363B1 (en) * 1993-12-30 2001-08-07 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6884775B1 (en) * 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US6261786B1 (en) * 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
AU706024B2 (en) 1994-02-25 1999-06-03 Trustees Of Columbia University In The City Of New York, The DNA encoding the vertebrate homolog of hedgehog, VHH-1, expressed by the notochord, and uses thereof
EP1616942A3 (en) * 1994-10-07 2006-11-22 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and their use
US6429354B1 (en) * 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
US6027882A (en) * 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
US6946257B1 (en) * 1994-10-07 2005-09-20 Regents Of The University Of California Patched genes and uses related thereto
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5759811A (en) 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
JPH10215867A (ja) * 1997-02-04 1998-08-18 Asahi Glass Co Ltd タンパク質誘導体、該タンパク質をコードする遺伝子および該タンパク質の製造法
EP1019490B1 (en) 1997-02-10 2009-11-25 The President And Fellows Of Harvard College Methods for modulating hematopoiesis and vascular growth
WO1999010004A2 (en) 1997-08-29 1999-03-04 Ontogeny, Inc. Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US6867216B1 (en) * 1998-04-09 2005-03-15 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signal pathways, compositions and uses related thereto
IL138645A0 (en) * 1998-04-09 2001-10-31 Univ Johns Hopkins Med Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways
AU773044B2 (en) * 1998-09-11 2004-05-13 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
JP2002524528A (ja) * 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
JP4574012B2 (ja) * 1998-11-02 2010-11-04 キュリス，インコーポレイテッド ヘッジホッグ活性の機能的アンタゴニスト
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
EP1183040B1 (en) 1999-06-08 2004-12-01 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog signalling pathway
US20050080138A1 (en) * 1999-09-16 2005-04-14 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE60017157T2 (de) * 1999-09-16 2005-12-22 Curis, Inc., Cambridge Vermittler von igel signalwegen, deren zusammenstellungen und verwendungen
JP5420128B2 (ja) * 1999-10-13 2014-02-19 ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法
US6552016B1 (en) * 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
AU780612C (en) 1999-10-14 2005-10-20 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
WO2001074344A2 (en) 2000-03-30 2001-10-11 Curis, Inc. Small organic molecule regulators of cell proliferation
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
IL153115A0 (en) * 2000-06-16 2003-06-24 Curis Inc Angiogenesis-modulating compositions and uses
DK1387674T3 (en) * 2000-10-13 2017-04-10 Curis Inc Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
WO2002080952A2 (en) 2001-04-09 2002-10-17 Lorantis Limited Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways
KR20040031782A (ko) 2001-07-27 2004-04-13 쿠리스 인코퍼레이션 헤지호그 신호전달 경로의 조절물질, 이를 함유하는조성물 및 이의 용도
FR2834403B1 (fr) * 2001-12-27 2004-02-06 France Telecom Systeme cryptographique de signature de groupe

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