JP2004528334A5 - - Google Patents
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- Publication number
- JP2004528334A5 JP2004528334A5 JP2002583393A JP2002583393A JP2004528334A5 JP 2004528334 A5 JP2004528334 A5 JP 2004528334A5 JP 2002583393 A JP2002583393 A JP 2002583393A JP 2002583393 A JP2002583393 A JP 2002583393A JP 2004528334 A5 JP2004528334 A5 JP 2004528334A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- moiety
- methyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 26
- -1 cyano, acetoxymethyl Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052757 nitrogen Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006690 (C2-C6) heterocyclyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 125000006224 2-tetrahydrofuranylmethyl group Chemical group [H]C([H])(*)C1([H])OC([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Chemical group 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101387A SE0101387D0 (sv) | 2001-04-20 | 2001-04-20 | Novel compounds |
| PCT/SE2002/000769 WO2002085866A1 (en) | 2001-04-20 | 2002-04-18 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528334A JP2004528334A (ja) | 2004-09-16 |
| JP2004528334A5 true JP2004528334A5 (enExample) | 2005-12-22 |
Family
ID=20283822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002583393A Pending JP2004528334A (ja) | 2001-04-20 | 2002-04-18 | 新規な化合物 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7030139B2 (enExample) |
| EP (1) | EP1390350A1 (enExample) |
| JP (1) | JP2004528334A (enExample) |
| KR (1) | KR20040022421A (enExample) |
| CN (1) | CN1250531C (enExample) |
| AR (1) | AR035959A1 (enExample) |
| BG (1) | BG108271A (enExample) |
| BR (1) | BR0208907A (enExample) |
| CA (1) | CA2444381A1 (enExample) |
| CZ (1) | CZ20032833A3 (enExample) |
| EE (1) | EE200300524A (enExample) |
| HU (1) | HUP0303825A3 (enExample) |
| IL (1) | IL158142A0 (enExample) |
| IS (1) | IS6971A (enExample) |
| MX (1) | MXPA03009558A (enExample) |
| MY (1) | MY134568A (enExample) |
| NO (1) | NO20034665L (enExample) |
| NZ (1) | NZ528403A (enExample) |
| PL (1) | PL366517A1 (enExample) |
| RU (1) | RU2312864C2 (enExample) |
| SE (1) | SE0101387D0 (enExample) |
| SK (1) | SK13032003A3 (enExample) |
| UA (1) | UA76743C2 (enExample) |
| WO (1) | WO2002085866A1 (enExample) |
| ZA (1) | ZA200307752B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487436A4 (en) | 2002-03-08 | 2009-06-03 | Signal Pharm Inc | POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS |
| SE0203070D0 (en) * | 2002-10-16 | 2002-10-16 | Astrazeneca Ab | Novel compounds |
| US7381825B2 (en) * | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| SE0300908D0 (sv) * | 2003-03-31 | 2003-03-31 | Astrazeneca Ab | Azaindole derivatives, preparations thereof, uses thereof and compositions containing them |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| SE0301698D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0301701D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0301699D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SI1637527T1 (sl) * | 2003-06-26 | 2013-07-31 | Takeda Pharmaceutical Company Limited | Modulator kanabinoidnega receptorja |
| US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| WO2005021547A2 (en) * | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
| SE0302573D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302570D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302572D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302571D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| WO2005037798A2 (en) * | 2003-10-16 | 2005-04-28 | Cara Therapeutics, Inc | Amide or thiomide derivatives and their use in the treatment of pain |
| EP1797075A1 (en) * | 2004-09-24 | 2007-06-20 | AstraZeneca AB | Benzimidazole derivatives and their use as cannabinoid receptor ligands |
| JP2008514589A (ja) * | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | 化合物、それらを含有する組成物、それらの製造及びそれらの使用ｉｉｉｉ |
| WO2006033628A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| BRPI0515897A (pt) * | 2004-09-24 | 2008-08-12 | Astrazeneca Ab | composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto |
| UA87327C2 (ru) * | 2004-09-24 | 2009-07-10 | Астразенека Аб | Производные бензимидазола, композиция, которая их содержит, их получение и применение |
| CA2582512A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparations thereof and uses thereof ii |
| EP1797077B1 (en) * | 2004-09-24 | 2012-02-15 | AstraZeneca AB | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i |
| JP2008514594A (ja) * | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | ベンゾイミダゾール誘導体及びカンナビノイド受容体リガンドとしてのその使用ｉ |
| WO2006033630A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparation thereof and uses thereof iii |
| BRPI0517369A (pt) | 2004-10-27 | 2008-10-07 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições que os compreendem, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com a modulação de receptores de cb1 e sua utilização |
| EP1809607B1 (en) * | 2004-11-02 | 2008-12-17 | Pfizer, Inc. | Sulfonyl benzimidazole derivatives |
| SE0402762D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Indazole sulphonamide derivatives |
| SE0402763D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Nitro indazole derivatives |
| WO2006097808A1 (en) * | 2005-03-15 | 2006-09-21 | Pfizer Japan Inc. | Benzimidazolone derivatives as cb2 receptor ligands |
| WO2006116399A2 (en) | 2005-04-28 | 2006-11-02 | Ferring B.V. | Use of novel compounds for ibd treatment |
| TW200736227A (en) | 2005-12-23 | 2007-10-01 | Astrazeneca Ab | New compounds III |
| WO2007091950A1 (en) * | 2006-02-07 | 2007-08-16 | Astrazeneca Ab | Benzimidazoles and imidazopyridines useful in the treatment of diseases or disorders associated with cannabinoid receptor 2 (cb2) such as pain |
| WO2007102059A1 (en) * | 2006-03-06 | 2007-09-13 | Pfizer Japan Inc. | Sulfonyl benzimidazole derivatives |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) * | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| TW200808772A (en) * | 2006-06-13 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| PL2081572T3 (pl) | 2006-07-04 | 2010-07-30 | Janssen Pharmaceutica Nv | Benzimidazolowe związki antagonistyczne wobec receptora kannabinoidowego zawierające podstawioną grupę heterocykliczną |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| FR2907784B1 (fr) * | 2006-10-27 | 2009-02-13 | Sod Conseils Rech Applic | Derives phenyliques et leur utilisation comme medicament |
| WO2009116074A2 (en) * | 2008-02-13 | 2009-09-24 | Cadila Healthcare Limited | Substituted benzimidazoles as cannabinoid modulator |
| US20120277296A1 (en) | 2009-07-23 | 2012-11-01 | Sophie Lotersztajn | Selective CB2 Receptor Agonists for Use in the Prevention or Treatment of Alcoholic Liver Disease |
| US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| DK2536285T3 (en) | 2010-02-18 | 2018-07-16 | Vtv Therapeutics Llc | Substituted fused imidazole derivatives, pharmaceutical compositions and methods for their use |
| ES2649995T3 (es) | 2011-07-18 | 2018-01-16 | Merck Patent Gmbh | Benzamidas |
| CN102977056B (zh) * | 2012-11-28 | 2014-11-26 | 深圳万乐药业有限公司 | N-苄氧羰基-3-氟-4-吗啉基苯胺的合成方法 |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| CN107531679B (zh) * | 2016-03-18 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 芳香酰胺类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2945044A (en) * | 1957-07-12 | 1960-07-12 | Ciba Pharm Prod Inc | Certain 1-(diethyl-aminoethyl), 5-amino, 2-benzyl or substituted benzyl, benzimidazoles |
| FR1481049A (fr) | 1965-11-25 | 1967-05-19 | France Ministre Des Armees | Nouveaux dialkylaminoalkyl-1 p-alkoxyphényl alkyl-2 benzimidazoles 5-substitués |
| US5620978A (en) * | 1994-01-03 | 1997-04-15 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor |
| PL182517B1 (pl) * | 1994-06-10 | 2002-01-31 | Byk Gulden Lomberg Chem Fab | Tiopirydyny do zwalczania bakterii Helicobacter |
| SE0203070D0 (en) * | 2002-10-16 | 2002-10-16 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-04-20 SE SE0101387A patent/SE0101387D0/xx unknown
-
2002
- 2002-04-18 JP JP2002583393A patent/JP2004528334A/ja active Pending
- 2002-04-18 MY MYPI20021423A patent/MY134568A/en unknown
- 2002-04-18 NZ NZ528403A patent/NZ528403A/en unknown
- 2002-04-18 UA UA2003108942A patent/UA76743C2/uk unknown
- 2002-04-18 PL PL02366517A patent/PL366517A1/xx not_active Application Discontinuation
- 2002-04-18 US US10/474,549 patent/US7030139B2/en not_active Expired - Fee Related
- 2002-04-18 KR KR10-2003-7013622A patent/KR20040022421A/ko not_active Ceased
- 2002-04-18 BR BR0208907-6A patent/BR0208907A/pt not_active IP Right Cessation
- 2002-04-18 MX MXPA03009558A patent/MXPA03009558A/es active IP Right Grant
- 2002-04-18 CZ CZ20032833A patent/CZ20032833A3/cs unknown
- 2002-04-18 SK SK1303-2003A patent/SK13032003A3/sk not_active Application Discontinuation
- 2002-04-18 EE EEP200300524A patent/EE200300524A/xx unknown
- 2002-04-18 CA CA002444381A patent/CA2444381A1/en not_active Abandoned
- 2002-04-18 CN CNB028085779A patent/CN1250531C/zh not_active Expired - Fee Related
- 2002-04-18 WO PCT/SE2002/000769 patent/WO2002085866A1/en not_active Ceased
- 2002-04-18 EP EP02764120A patent/EP1390350A1/en not_active Withdrawn
- 2002-04-18 HU HU0303825A patent/HUP0303825A3/hu unknown
- 2002-04-18 RU RU2003129638/04A patent/RU2312864C2/ru not_active IP Right Cessation
- 2002-04-18 IL IL15814202A patent/IL158142A0/xx unknown
- 2002-04-19 AR ARP020101441A patent/AR035959A1/es not_active Application Discontinuation
-
2003
- 2003-09-29 IS IS6971A patent/IS6971A/is unknown
- 2003-10-03 ZA ZA200307752A patent/ZA200307752B/en unknown
- 2003-10-14 BG BG108271A patent/BG108271A/bg unknown
- 2003-10-17 NO NO20034665A patent/NO20034665L/no not_active Application Discontinuation
-
2006
- 2006-01-04 US US11/325,124 patent/US20060135554A1/en not_active Abandoned
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