JP2004527511A5 - - Google Patents
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- Publication number
- JP2004527511A5 JP2004527511A5 JP2002573759A JP2002573759A JP2004527511A5 JP 2004527511 A5 JP2004527511 A5 JP 2004527511A5 JP 2002573759 A JP2002573759 A JP 2002573759A JP 2002573759 A JP2002573759 A JP 2002573759A JP 2004527511 A5 JP2004527511 A5 JP 2004527511A5
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- water
- distilled
- imidazolidinyl
- dioxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- GBDUCGXTDYLIIL-UHFFFAOYSA-N 1-(4-phenylphenyl)sulfanylpropan-2-one;1-(4-phenylphenyl)sulfonylpropan-2-one Chemical compound C1=CC(SCC(=O)C)=CC=C1C1=CC=CC=C1.C1=CC(S(=O)(=O)CC(=O)C)=CC=C1C1=CC=CC=C1 GBDUCGXTDYLIIL-UHFFFAOYSA-N 0.000 description 1
- -1 2,5-dioxo-4-imidazolidinyl Chemical group 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000004133 Sodium thiosulphate Substances 0.000 description 1
- QRPMKCBTJIZVKF-REOHCLBHSA-N [(4r)-2,5-dioxoimidazolidin-4-yl]methanesulfonyl chloride Chemical compound ClS(=O)(=O)C[C@@H]1NC(=O)NC1=O QRPMKCBTJIZVKF-REOHCLBHSA-N 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 125000000107 disulfanyl group Chemical group [*]SS[H] 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- UKJFVOWPUXSBOM-UHFFFAOYSA-N hexane;oxolane Chemical compound C1CCOC1.CCCCCC UKJFVOWPUXSBOM-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100903A SE0100903D0 (sv) | 2001-03-15 | 2001-03-15 | Compounds |
| SE0100902A SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Compounds |
| PCT/SE2002/000475 WO2002074750A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527511A JP2004527511A (ja) | 2004-09-09 |
| JP2004527511A5 true JP2004527511A5 (https=) | 2006-01-05 |
Family
ID=26655413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573759A Withdrawn JP2004527511A (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040147573A1 (https=) |
| EP (1) | EP1370536A1 (https=) |
| JP (1) | JP2004527511A (https=) |
| KR (1) | KR20030082990A (https=) |
| CN (1) | CN1509275A (https=) |
| BR (1) | BR0208105A (https=) |
| CA (1) | CA2440632A1 (https=) |
| CZ (1) | CZ20032502A3 (https=) |
| EE (1) | EE200300439A (https=) |
| HU (1) | HUP0400206A3 (https=) |
| IL (1) | IL157570A0 (https=) |
| IS (1) | IS6944A (https=) |
| MX (1) | MXPA03008180A (https=) |
| NO (1) | NO20034025L (https=) |
| PL (1) | PL364714A1 (https=) |
| RU (1) | RU2003127732A (https=) |
| SK (1) | SK10932003A3 (https=) |
| WO (1) | WO2002074750A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| CA2447475A1 (en) | 2001-05-25 | 2002-12-05 | Chu-Biao Xue | Hydantion derivatives as inhibitors of matrix metalloproteinases |
| SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| CA2486350A1 (en) * | 2002-06-05 | 2003-12-24 | Kaneka Corporation | Process for producing optically active .alpha.-methylcysteine derivative |
| SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| SE0202692D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| SE0202693D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| GB0221250D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| WO2005016910A1 (ja) * | 2003-08-18 | 2005-02-24 | Sankio Chemical Co., Ltd. | ピリジルテトラヒドロピリジン類およびピリジルピペリジン類とそれらの製造方法 |
| WO2005090316A1 (en) * | 2004-03-12 | 2005-09-29 | Wyeth | HYDANTOINS HAVING RNase MODULATORY ACTIVITY |
| SE0401763D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0401762D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| US7504424B2 (en) | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| KR20070032787A (ko) | 2004-07-16 | 2007-03-22 | 쉐링 코포레이션 | 염증 질환 치료용 히단토인 유도체 |
| EP1827438B2 (en) * | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
| AU2005286790A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD) |
| MX2007003318A (es) * | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| BRPI0515482A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| CN101084211A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| MX2007003332A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| AU2005286728A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| BRPI0515500A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| CA2618646A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| PE20071241A1 (es) | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
| TW200740769A (en) * | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200800954A (en) * | 2006-03-16 | 2008-01-01 | Astrazeneca Ab | Novel crystal modifications |
| TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| WO2009007747A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | Hydantoin derivatives used as mmp12 inhibitors |
| AR073307A1 (es) | 2008-09-24 | 2010-10-28 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| WO2010036640A2 (en) | 2008-09-24 | 2010-04-01 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| EP2356111A1 (en) | 2008-11-10 | 2011-08-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US8569336B2 (en) | 2008-11-10 | 2013-10-29 | Ling Tong | Compounds for the treatment of inflammatory disorders |
| HU1000676D0 (en) * | 2010-12-17 | 2011-02-28 | Pharmahungary 2000 Kft | Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved |
| CA2914178C (en) | 2013-01-07 | 2023-06-13 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| AU2014275835B2 (en) * | 2013-06-07 | 2018-08-16 | Kaken Pharmaceutical Co., Ltd. | (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imidazolidine-2,4-dione and drug containing same |
| WO2017006270A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| PT3319939T (pt) | 2015-07-08 | 2025-03-05 | Cv6 Therapeutics Ni Ltd | Inibidores de desoxiuridina-trifosfatase contendo hidantoína |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018098204A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US11168059B2 (en) | 2016-11-23 | 2021-11-09 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| WO2018128720A1 (en) | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| AR110963A1 (es) | 2017-02-07 | 2019-05-22 | Dae Woong Pharma | Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende |
| KR102861502B1 (ko) * | 2018-05-15 | 2025-09-18 | 포시 파마슈티컬스 유에스에이 인코포레이티드 | 기질 금속단백분해효소 (mmp) 억제제 및 이의 사용 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3529019A (en) * | 1968-04-23 | 1970-09-15 | Colgate Palmolive Co | Alkylaryloxy alanines |
| CS151744B1 (https=) * | 1971-01-19 | 1973-11-19 | ||
| US3849574A (en) * | 1971-05-24 | 1974-11-19 | Colgate Palmolive Co | Alpha-substituted-beta-arylthioalkyl amino-acids,for increasing heart rate |
| US5268291A (en) * | 1983-01-19 | 1993-12-07 | Genentech, Inc. | Human t-PA production using vectors coding for DHFR protein |
| EP0640594A1 (en) * | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
| PL337854A1 (en) * | 1997-07-31 | 2000-09-11 | Abbott Lab | Inverse hydroxamines as inhibitors of intercellular substance metaloproteinases |
| BR9814147A (pt) * | 1997-11-12 | 2000-10-03 | Darwin Discovery Ltd | "derivados de ácido carboxìlico e hidroxâmico tendo atividade inibitória de mmp e tnf" |
| AU1817700A (en) * | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Inc. | 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12 |
| US6294694B1 (en) * | 1999-06-04 | 2001-09-25 | Wisconsin Alumni Research Foundation | Matrix metalloproteinase inhibitors and method of using same |
| GB9916562D0 (en) * | 1999-07-14 | 1999-09-15 | Pharmacia & Upjohn Spa | 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora |
-
2002
- 2002-03-13 KR KR10-2003-7011989A patent/KR20030082990A/ko not_active Withdrawn
- 2002-03-13 CZ CZ20032502A patent/CZ20032502A3/cs unknown
- 2002-03-13 CA CA002440632A patent/CA2440632A1/en not_active Abandoned
- 2002-03-13 BR BR0208105-9A patent/BR0208105A/pt not_active IP Right Cessation
- 2002-03-13 IL IL15757002A patent/IL157570A0/xx unknown
- 2002-03-13 US US10/471,808 patent/US20040147573A1/en not_active Abandoned
- 2002-03-13 EP EP02704034A patent/EP1370536A1/en not_active Withdrawn
- 2002-03-13 CN CNA028100417A patent/CN1509275A/zh active Pending
- 2002-03-13 JP JP2002573759A patent/JP2004527511A/ja not_active Withdrawn
- 2002-03-13 SK SK1093-2003A patent/SK10932003A3/sk not_active Application Discontinuation
- 2002-03-13 EE EEP200300439A patent/EE200300439A/xx unknown
- 2002-03-13 WO PCT/SE2002/000475 patent/WO2002074750A1/en not_active Ceased
- 2002-03-13 MX MXPA03008180A patent/MXPA03008180A/es unknown
- 2002-03-13 HU HU0400206A patent/HUP0400206A3/hu unknown
- 2002-03-13 PL PL02364714A patent/PL364714A1/xx not_active Application Discontinuation
- 2002-03-13 RU RU2003127732/04A patent/RU2003127732A/ru not_active Application Discontinuation
-
2003
- 2003-09-10 IS IS6944A patent/IS6944A/is unknown
- 2003-09-11 NO NO20034025A patent/NO20034025L/no not_active Application Discontinuation
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