|
JP4316238B2
(ja)
|
2001-02-28 |
2009-08-19 |
メルク エンド カムパニー インコーポレーテッド |
メラノコルチン−４受容体作動薬としてのアシル化ピペリジン誘導体
|
|
CA2439152C
(en)
*
|
2001-02-28 |
2008-06-17 |
Merck & Co., Inc. |
Acylated piperidine derivatives as melanocortin-4 receptor agonists
|
|
US6911447B2
(en)
|
2001-04-25 |
2005-06-28 |
The Procter & Gamble Company |
Melanocortin receptor ligands
|
|
WO2003007949A1
(en)
|
2001-07-18 |
2003-01-30 |
Merck & Co., Inc. |
Bridged piperidine derivatives as melanocortin receptor agonists
|
|
US6977264B2
(en)
|
2001-07-25 |
2005-12-20 |
Amgen Inc. |
Substituted piperidines and methods of use
|
|
US7115607B2
(en)
|
2001-07-25 |
2006-10-03 |
Amgen Inc. |
Substituted piperazinyl amides and methods of use
|
|
US7354923B2
(en)
|
2001-08-10 |
2008-04-08 |
Palatin Technologies, Inc. |
Piperazine melanocortin-specific compounds
|
|
WO2003013571A1
(en)
|
2001-08-10 |
2003-02-20 |
Palatin Technologies, Inc. |
Peptidomimetics of biologically active metallopeptides
|
|
US7456184B2
(en)
|
2003-05-01 |
2008-11-25 |
Palatin Technologies Inc. |
Melanocortin receptor-specific compounds
|
|
US7026335B2
(en)
|
2002-04-30 |
2006-04-11 |
The Procter & Gamble Co. |
Melanocortin receptor ligands
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
US7414057B2
(en)
|
2002-09-11 |
2008-08-19 |
Merck & Co., Inc. |
Piperazine urea derivatives as melanocortin-4 receptor agonists
|
|
US7132539B2
(en)
|
2002-10-23 |
2006-11-07 |
The Procter & Gamble Company |
Melanocortin receptor ligands
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
US7160886B2
(en)
|
2003-03-03 |
2007-01-09 |
Merck & Co., Inc. |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
|
|
US6998488B2
(en)
|
2003-03-10 |
2006-02-14 |
Merck & Co., Inc. |
Process and intermediates for the preparation of 4-aryl piperidines
|
|
ATE474577T1
(de)
|
2003-03-26 |
2010-08-15 |
Merck Sharp & Dohme |
Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten
|
|
CA2520114A1
(en)
|
2003-04-04 |
2004-10-21 |
Merck & Co., Inc. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists
|
|
AR044510A1
(es)
*
|
2003-04-14 |
2005-09-14 |
Merck & Co Inc |
Procedimiento e intermedios para preparar acidos carboxilicos de pirrolidina
|
|
US7049323B2
(en)
|
2003-04-25 |
2006-05-23 |
Bristol-Myers Squibb Company |
Amidoheterocycles as modulators of the melanocortin-4 receptor
|
|
CN1826116A
(zh)
|
2003-07-22 |
2006-08-30 |
麦克公司 |
作为黑皮素－4受体激动剂的哌啶衍生物
|
|
WO2005028438A1
(ja)
|
2003-09-22 |
2005-03-31 |
Banyu Pharmaceutical Co., Ltd. |
新規ピペリジン誘導体
|
|
US7649002B2
(en)
|
2004-02-04 |
2010-01-19 |
Pfizer Inc |
(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
|
|
GB0402492D0
(en)
*
|
2004-02-04 |
2004-03-10 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
WO2005087824A1
(en)
*
|
2004-03-02 |
2005-09-22 |
Bridgestone Corporation |
Bulk polymerization process
|
|
US20080125403A1
(en)
|
2004-04-02 |
2008-05-29 |
Merck & Co., Inc. |
Method of Treating Men with Metabolic and Anthropometric Disorders
|
|
JP2008506779A
(ja)
*
|
2004-07-19 |
2008-03-06 |
メルク エンド カムパニー インコーポレーテッド |
メラノコルチン−４受容体作用薬としてのアシル化ピペリジン誘導体
|
|
DK1814590T4
(da)
|
2004-11-01 |
2014-02-24 |
Amylin Pharmaceuticals Llc |
Behandling af obesitet og beslægtede sygdomme.
|
|
GB0428514D0
(en)
*
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
EP1892241B1
(en)
|
2005-05-30 |
2016-03-30 |
Msd K.K. |
Novel piperidine derivative
|
|
US20070021433A1
(en)
|
2005-06-03 |
2007-01-25 |
Jian-Qiang Fan |
Pharmacological chaperones for treating obesity
|
|
CA2616366A1
(en)
|
2005-07-29 |
2007-02-08 |
Concert Pharmaceuticals Inc. |
Novel pharmaceutical compounds
|
|
CA2617654A1
(en)
*
|
2005-08-04 |
2007-02-08 |
Pfizer Limited |
Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
|
|
EP1916239A4
(en)
|
2005-08-10 |
2009-10-21 |
Banyu Pharma Co Ltd |
PYRIDOLVERBINDUNG
|
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
EP1922336B1
(en)
|
2005-08-11 |
2012-11-21 |
Amylin Pharmaceuticals, LLC |
Hybrid polypeptides with selectable properties
|
|
US7875633B2
(en)
|
2005-08-24 |
2011-01-25 |
Banyu Pharmaceutical Co., Ltd. |
Phenylpyridone derivative
|
|
WO2007029847A1
(ja)
|
2005-09-07 |
2007-03-15 |
Banyu Pharmaceutical Co., Ltd. |
二環性芳香族置換ピリドン誘導体
|
|
KR20080048502A
(ko)
*
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
|
|
CA2625877A1
(en)
|
2005-10-18 |
2007-04-26 |
Merck & Co., Inc. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
RU2008119687A
(ru)
|
2005-10-21 |
2009-11-27 |
Новартис АГ (CH) |
Комбинации органических соединений
|
|
AU2006307046A1
(en)
|
2005-10-27 |
2007-05-03 |
Msd K.K. |
Novel benzoxathiin derivative
|
|
RU2428423C2
(ru)
|
2005-11-10 |
2011-09-10 |
Баниу Фармасьютикал Ко., Лтд. |
Азазамещенные спиропроизводные
|
|
AU2007219236B2
(en)
|
2006-02-23 |
2012-06-21 |
Pfizer Limited |
Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
|
|
CN101426782B
(zh)
*
|
2006-02-23 |
2012-10-31 |
辉瑞股份有限公司 |
黑皮质素4型受体激动剂哌啶羰基吡咯烷
|
|
AU2007300627B2
(en)
|
2006-09-22 |
2012-02-16 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
EP2072519A4
(en)
|
2006-09-28 |
2009-10-21 |
Banyu Pharma Co Ltd |
DIARYLKETIMINDERIVAT
|
|
AU2008233662B2
(en)
|
2007-04-02 |
2012-08-23 |
Msd K.K. |
Indoledione derivative
|
|
WO2008151257A2
(en)
|
2007-06-04 |
2008-12-11 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
ES2428326T3
(es)
*
|
2007-10-04 |
2013-11-07 |
Merck Sharp & Dohme Corp. |
Derivados de aril sulfona sustituida como bloqueadores de canales de calcio
|
|
AU2009220605A1
(en)
|
2008-03-06 |
2009-09-11 |
Msd K.K. |
Alkylaminopyridine derivative
|
|
CA2717384A1
(en)
|
2008-03-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
|
ES2627848T3
(es)
|
2008-06-04 |
2017-07-31 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
|
|
AU2009261248A1
(en)
|
2008-06-19 |
2009-12-23 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diarylketoxime derivative
|
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
|
US20110124674A1
(en)
|
2008-07-30 |
2011-05-26 |
Hiroyuki Kishino |
5/5-or 5/6-membered condensed ring cycloalkylamine derivative
|
|
JP5530438B2
(ja)
|
2008-08-06 |
2014-06-25 |
ファイザー・リミテッド |
Ｍｃ４作動薬としてのジアゼピンおよびジアゾカン化合物
|
|
US8410284B2
(en)
|
2008-10-22 |
2013-04-02 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
WO2010051206A1
(en)
|
2008-10-31 |
2010-05-06 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
UA99555C2
(en)
|
2008-11-12 |
2012-08-27 |
Элджи Лайф Саенсез Лтд. |
Melanocortin receptor agonists
|
|
JP5514831B2
(ja)
|
2008-11-17 |
2014-06-04 |
メルク・シャープ・アンド・ドーム・コーポレーション |
糖尿病の治療のための置換二環式アミン
|
|
WO2010069793A1
(en)
*
|
2008-12-16 |
2010-06-24 |
F. Hoffmann-La Roche Ag |
Process for the preparation of pyrollidine-3-carboxylic acids
|
|
US8324250B2
(en)
*
|
2009-03-19 |
2012-12-04 |
Hoffmann-La Roche Inc. |
Piperidine derivatives as NK3 receptor antagonists
|
|
WO2011011506A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
CA2768577A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
US9044606B2
(en)
|
2010-01-22 |
2015-06-02 |
Ethicon Endo-Surgery, Inc. |
Methods and devices for activating brown adipose tissue using electrical energy
|
|
US8476227B2
(en)
|
2010-01-22 |
2013-07-02 |
Ethicon Endo-Surgery, Inc. |
Methods of activating a melanocortin-4 receptor pathway in obese subjects
|
|
JP2013520502A
(ja)
|
2010-02-25 |
2013-06-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
|
|
US8785634B2
(en)
|
2010-04-26 |
2014-07-22 |
Merck Sharp & Dohme Corp |
Spiropiperidine prolylcarboxypeptidase inhibitors
|
|
WO2011137012A1
(en)
|
2010-04-27 |
2011-11-03 |
Merck Sharp & Dohme Corp. |
Prolylcarboxypeptidase inhibitors
|
|
WO2011143057A1
(en)
|
2010-05-11 |
2011-11-17 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
EP2579873A4
(en)
|
2010-06-11 |
2013-11-27 |
Merck Sharp & Dohme |
NOVEL PROLYLCARBOXYPEPTIDASE HEMMER
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
WO2012100342A1
(en)
|
2011-01-27 |
2012-08-02 |
Université de Montréal |
Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
|
|
CA2826649C
(en)
|
2011-02-25 |
2016-07-26 |
Merck Sharp & Dohme Corp. |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
US20140045746A1
(en)
|
2012-08-02 |
2014-02-13 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
JP2016516004A
(ja)
|
2013-02-22 |
2016-06-02 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
抗糖尿病二環式化合物
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
EP2968439A2
(en)
|
2013-03-15 |
2016-01-20 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
PL3004138T3
(pl)
|
2013-06-05 |
2024-07-29 |
Bausch Health Ireland Limited |
Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
BR112017003745A2
(pt)
|
2014-08-29 |
2017-12-05 |
Tes Pharma S R L |
inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
|
|
US10080884B2
(en)
|
2014-12-29 |
2018-09-25 |
Ethicon Llc |
Methods and devices for activating brown adipose tissue using electrical energy
|
|
US10092738B2
(en)
|
2014-12-29 |
2018-10-09 |
Ethicon Llc |
Methods and devices for inhibiting nerves when activating brown adipose tissue
|
|
AU2017342083A1
(en)
|
2016-10-14 |
2019-04-11 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
WO2018106518A1
(en)
|
2016-12-06 |
2018-06-14 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
WO2018118670A1
(en)
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic spirochroman compounds
|
|
EP3883930A1
(en)
|
2018-11-20 |
2021-09-29 |
Tes Pharma S.r.l. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|