JP2004525068A5 - - Google Patents

Info

Publication number

JP2004525068A5

JP2004525068A5 JP2002503255A JP2002503255A JP2004525068A5 JP 2004525068 A5 JP2004525068 A5 JP 2004525068A5 JP 2002503255 A JP2002503255 A JP 2002503255A JP 2002503255 A JP2002503255 A JP 2002503255A JP 2004525068 A5 JP2004525068 A5 JP 2004525068A5

Authority

JP

Japan

Prior art keywords

oil

composition

amphotericin

structured emulsion

coated

Prior art date

2001-06-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 description 30
• 239000000839 emulsion Substances 0.000 description 22
• 239000003921 oil Substances 0.000 description 22
• 235000019198 oils Nutrition 0.000 description 22
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 20
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 19
• 229960003942 amphotericin b Drugs 0.000 description 19
• 239000008346 aqueous phase Substances 0.000 description 10
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
• 239000012071 phase Substances 0.000 description 7
• 239000011521 glass Substances 0.000 description 5
• 235000012424 soybean oil Nutrition 0.000 description 5
• 239000003549 soybean oil Substances 0.000 description 5
• 239000003995 emulsifying agent Substances 0.000 description 4
• 235000011187 glycerol Nutrition 0.000 description 4
• 238000000034 method Methods 0.000 description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 241000699670 Mus sp. Species 0.000 description 2
• 239000012299 nitrogen atmosphere Substances 0.000 description 2
• 238000002360 preparation method Methods 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 229930183010 Amphotericin Natural products 0.000 description 1
• QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
• 241000699666 Mus <mouse, genus> Species 0.000 description 1
• 229940009444 amphotericin Drugs 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 238000004945 emulsification Methods 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1