JP2004524032A5 - - Google Patents

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JP2004524032A5
JP2004524032A5 JP2002571915A JP2002571915A JP2004524032A5 JP 2004524032 A5 JP2004524032 A5 JP 2004524032A5 JP 2002571915 A JP2002571915 A JP 2002571915A JP 2002571915 A JP2002571915 A JP 2002571915A JP 2004524032 A5 JP2004524032 A5 JP 2004524032A5
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Japan
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oligomer
combination
block
linker
blocks
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JP2002571915A
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Japanese (ja)
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JP4408628B2 (ja
JP2004524032A (ja
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Priority claimed from PCT/US2002/007050 external-priority patent/WO2002072865A2/en
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Publication of JP2004524032A5 publication Critical patent/JP2004524032A5/ja
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Publication of JP4408628B2 publication Critical patent/JP4408628B2/ja
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JP2002571915A 2001-03-09 2002-03-09 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物 Expired - Fee Related JP4408628B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27454701P 2001-03-09 2001-03-09
PCT/US2002/007050 WO2002072865A2 (en) 2001-03-09 2002-03-09 Methods, kits and compositions of combination oligomers

Related Child Applications (1)

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JP2007095671A Division JP2007209346A (ja) 2001-03-09 2007-03-30 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物

Publications (3)

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JP2004524032A JP2004524032A (ja) 2004-08-12
JP2004524032A5 true JP2004524032A5 (https=) 2005-07-07
JP4408628B2 JP4408628B2 (ja) 2010-02-03

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JP2002571915A Expired - Fee Related JP4408628B2 (ja) 2001-03-09 2002-03-09 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物
JP2007095671A Pending JP2007209346A (ja) 2001-03-09 2007-03-30 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物

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JP2007095671A Pending JP2007209346A (ja) 2001-03-09 2007-03-30 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物

Country Status (9)

Country Link
US (9) US7256275B2 (https=)
EP (2) EP1412517B1 (https=)
JP (2) JP4408628B2 (https=)
AT (2) ATE496139T1 (https=)
AU (1) AU2002250262B9 (https=)
CA (1) CA2439750A1 (https=)
DE (2) DE60239020D1 (https=)
DK (1) DK1412517T3 (https=)
WO (1) WO2002072865A2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256275B2 (en) * 2001-03-09 2007-08-14 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
DE60330182D1 (de) 2002-09-08 2009-12-31 Applera Corp Festphasengebundene PNA-Dimere und deren Synthese
EP1594984A2 (en) * 2003-02-18 2005-11-16 Applera Corporation Compositions and methods for multiplex analysis of polynucleotides
EP1674581A1 (en) * 2004-12-21 2006-06-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Twin probes, a tool for the detection of SNPs
US7892737B2 (en) * 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
US9677123B2 (en) * 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
EP2031074A4 (en) * 2006-08-08 2010-09-08 Arkray Inc METHOD FOR VARIATION DETECTION AND KIT THEREFOR
US20100120031A1 (en) * 2006-09-22 2010-05-13 The United States Of America, As Represented By The Secretary, Dept. Of Synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate
GB0718255D0 (en) * 2007-09-19 2007-10-31 Univ Edinburgh Nucleobase characterisation
JP2012502911A (ja) * 2008-09-14 2012-02-02 インサイター インコーポレイテッド ナノスケール分子合成
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
EP2553123B1 (en) * 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Methods for enhancing nucleic acid hybridization
AU2011299233B2 (en) 2010-09-07 2016-09-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
JP5852222B2 (ja) * 2011-03-29 2016-02-03 シージーン アイエヌシー Ｐｔｏ切断及び延長−依存的切断によるターゲット核酸配列の検出
CN104039961A (zh) * 2012-01-07 2014-09-10 株式会社博纳克 具有氨基酸骨架的单链核酸分子
EP2823061B1 (en) * 2012-03-05 2018-02-14 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay
WO2013180038A1 (ja) 2012-05-26 2013-12-05 株式会社ボナック デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子
CN104703971B (zh) 2012-08-02 2018-08-21 株式会社百奥尼 新型偶氮化合物及其利用、以及其制造方法
GB201316644D0 (en) * 2013-09-19 2013-11-06 Kymab Ltd Expression vector production & High-Throughput cell screening
WO2015099122A1 (ja) 2013-12-26 2015-07-02 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
CN106068324B (zh) 2013-12-27 2020-12-29 株式会社博纳克 控制基因表达的人工匹配型miRNA及其用途
KR20170098914A (ko) 2014-12-27 2017-08-30 가부시키가이샤 보낙 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도
WO2016158809A1 (ja) 2015-03-27 2016-10-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
JP2019508037A (ja) 2016-02-16 2019-03-28 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ 標的化遺伝子編集を増強するための組成物およびその使用方法
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
KR102403904B1 (ko) * 2019-12-24 2022-06-02 주식회사 시선바이오머티리얼스 용액공정상 pna 올리고머의 제조방법
JP2023542867A (ja) * 2020-09-11 2023-10-12 グリンプス バイオ， インコーポレイテッド 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出
CN113322523B (zh) * 2021-06-17 2024-03-19 翌圣生物科技(上海)股份有限公司 Rna快速建库方法及其应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5252293A (en) 1989-01-17 1993-10-12 Vladimir Drbal Analytical slide with porous filter membrane
DE3943522A1 (de) * 1989-07-26 1991-02-07 Boehringer Mannheim Gmbh Heterobifunktionelle verbindungen
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5700922A (en) 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2289677A (en) 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6280964B1 (en) 1995-04-14 2001-08-28 The Regents Of The University Of California Binding sites for phosphotyrosine binding domains
DE69632324T2 (de) 1995-06-07 2005-06-16 PerSeptive Biosystems, Inc., Framingham Pna-dna-chimäre und pna-synthone zu deren herstellung
DE19532553A1 (de) 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
CA2218440A1 (en) 1996-12-21 1998-06-21 Boehringer Mannheim Gmbh Method of analysis using signal amplification
EP0857791B1 (en) * 1996-12-21 2004-03-31 PNA Diagnostics A/S Method of analysis using signal amplification
US6080418A (en) 1997-04-07 2000-06-27 3M Innovative Properties Company Suspensions of microcapsules containing biologically active ingredients and adhesive microspheres
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
AU745094B2 (en) 1997-06-13 2002-03-14 Gryphon Sciences Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
EP0897991B1 (en) 1997-08-22 2004-12-08 PNA Diagnostics ApS Small Triplex Forming PNA Oligos
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
ATE478090T1 (de) 1997-10-27 2010-09-15 Boston Probes Inc SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
CA2320390C (en) 1998-02-11 2010-06-08 Applied Biosystems, Llc Pna and dna conjugates and methods for preparation thereof
WO1999049293A2 (en) 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
DE69941690D1 (de) 1998-04-29 2010-01-07 Boston Probes Inc Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
AU4965499A (en) 1998-07-09 2000-02-01 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
US6248884B1 (en) 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
US6316230B1 (en) 1999-08-13 2001-11-13 Applera Corporation Polymerase extension at 3′ terminus of PNA-DNA chimera
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6297016B1 (en) * 1999-10-08 2001-10-02 Applera Corporation Template-dependent ligation with PNA-DNA chimeric probes
US6472153B1 (en) 1999-10-26 2002-10-29 Epoch Biosciences, Inc. Hybridization-triggered fluorescent detection of nucleic acids
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US7256275B2 (en) * 2001-03-09 2007-08-14 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation

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