JP2004520411A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004520411A5 JP2004520411A5 JP2002567278A JP2002567278A JP2004520411A5 JP 2004520411 A5 JP2004520411 A5 JP 2004520411A5 JP 2002567278 A JP2002567278 A JP 2002567278A JP 2002567278 A JP2002567278 A JP 2002567278A JP 2004520411 A5 JP2004520411 A5 JP 2004520411A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- group
- alkyl
- formula
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 40
- 239000001257 hydrogen Substances 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 150000002431 hydrogen Chemical class 0.000 claims 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
- 150000003146 progesterones Chemical class 0.000 claims 22
- 230000002357 endometrial effect Effects 0.000 claims 21
- 229940123788 Progesterone receptor antagonist Drugs 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 230000003637 steroidlike Effects 0.000 claims 16
- 241000124008 Mammalia Species 0.000 claims 15
- 210000001672 ovary Anatomy 0.000 claims 12
- 230000035558 fertility Effects 0.000 claims 11
- 230000035935 pregnancy Effects 0.000 claims 9
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 8
- 150000007513 acids Chemical class 0.000 claims 8
- 125000004423 acyloxy group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 8
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims 8
- 125000001589 carboacyl group Chemical group 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 8
- 210000001161 mammalian embryo Anatomy 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 230000035800 maturation Effects 0.000 claims 7
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 6
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 6
- 239000002269 analeptic agent Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 6
- 229940121912 Progesterone receptor agonist Drugs 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 210000003101 oviduct Anatomy 0.000 claims 4
- 230000004936 stimulating effect Effects 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75628601A | 2001-01-09 | 2001-01-09 | |
| US09/801,925 US20020143000A1 (en) | 2001-01-09 | 2001-03-09 | Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment |
| PCT/IB2002/001764 WO2002067910A2 (en) | 2001-01-09 | 2002-01-09 | The use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004520411A JP2004520411A (ja) | 2004-07-08 |
| JP2004520411A5 true JP2004520411A5 (enExample) | 2005-12-22 |
Family
ID=27116200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567278A Pending JP2004520411A (ja) | 2001-01-09 | 2002-01-09 | 不妊症処理の間の促進された子宮内膜成熟を阻害するための抗ゲスタゲンの使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20040152684A1 (enExample) |
| EP (1) | EP1365765B1 (enExample) |
| JP (1) | JP2004520411A (enExample) |
| CN (1) | CN1244329C (enExample) |
| AR (1) | AR032390A1 (enExample) |
| AT (1) | ATE367817T1 (enExample) |
| AU (1) | AU2002253488B2 (enExample) |
| BG (1) | BG107977A (enExample) |
| BR (1) | BR0206367A (enExample) |
| CA (1) | CA2433776A1 (enExample) |
| CZ (1) | CZ20031864A3 (enExample) |
| DE (1) | DE60221359T2 (enExample) |
| DK (1) | DK1365765T3 (enExample) |
| EE (1) | EE200300321A (enExample) |
| ES (1) | ES2290284T3 (enExample) |
| HR (1) | HRP20030628A2 (enExample) |
| HU (1) | HUP0302632A2 (enExample) |
| IL (1) | IL156729A0 (enExample) |
| MX (1) | MXPA03006156A (enExample) |
| NO (1) | NO20033125L (enExample) |
| NZ (1) | NZ526908A (enExample) |
| PL (1) | PL361689A1 (enExample) |
| SK (1) | SK8612003A3 (enExample) |
| WO (1) | WO2002067910A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009034362A1 (de) * | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034367A1 (de) * | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034526A1 (de) * | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| US20130029953A1 (en) * | 2011-07-28 | 2013-01-31 | Klaus Nickisch | Progesterone antagonists |
| EP3501533B1 (en) * | 2014-12-22 | 2025-07-09 | Ferring B.V. | Obe001 for use in the treatment in implantation and pregnancy in women undergoing assisted reproductive technologies |
| EP3214092A1 (en) | 2016-03-04 | 2017-09-06 | Bayer Pharma Aktiengesellschaft | Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3533175A1 (de) * | 1985-09-13 | 1987-03-19 | Schering Ag | Antigestagene zur verschiebung der endometrialen reifung |
| DE19706061A1 (de) * | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
| DE19860719A1 (de) * | 1998-12-23 | 2000-06-29 | Schering Ag | Neue Testosteronderivate und ihre Verwendung zur Langzeittherapie von Androgen-abhängigen Erkrankungen |
-
2002
- 2002-01-09 EE EEP200300321A patent/EE200300321A/xx unknown
- 2002-01-09 NZ NZ526908A patent/NZ526908A/en unknown
- 2002-01-09 CN CNB028061462A patent/CN1244329C/zh not_active Expired - Fee Related
- 2002-01-09 CA CA002433776A patent/CA2433776A1/en not_active Abandoned
- 2002-01-09 JP JP2002567278A patent/JP2004520411A/ja active Pending
- 2002-01-09 EP EP02722637A patent/EP1365765B1/en not_active Expired - Lifetime
- 2002-01-09 DE DE60221359T patent/DE60221359T2/de not_active Expired - Fee Related
- 2002-01-09 CZ CZ20031864A patent/CZ20031864A3/cs unknown
- 2002-01-09 DK DK02722637T patent/DK1365765T3/da active
- 2002-01-09 ES ES02722637T patent/ES2290284T3/es not_active Expired - Lifetime
- 2002-01-09 SK SK861-2003A patent/SK8612003A3/sk unknown
- 2002-01-09 BR BR0206367-0A patent/BR0206367A/pt not_active IP Right Cessation
- 2002-01-09 HU HU0302632A patent/HUP0302632A2/hu unknown
- 2002-01-09 PL PL36168902A patent/PL361689A1/xx not_active Application Discontinuation
- 2002-01-09 HR HR20030628A patent/HRP20030628A2/hr not_active Application Discontinuation
- 2002-01-09 AT AT02722637T patent/ATE367817T1/de not_active IP Right Cessation
- 2002-01-09 IL IL15672902A patent/IL156729A0/xx unknown
- 2002-01-09 AU AU2002253488A patent/AU2002253488B2/en not_active Ceased
- 2002-01-09 AR ARP020100053A patent/AR032390A1/es unknown
- 2002-01-09 MX MXPA03006156A patent/MXPA03006156A/es unknown
- 2002-01-09 WO PCT/IB2002/001764 patent/WO2002067910A2/en not_active Ceased
-
2003
- 2003-07-08 BG BG107977A patent/BG107977A/bg unknown
- 2003-07-08 NO NO20033125A patent/NO20033125L/no not_active Application Discontinuation
- 2003-12-30 US US10/747,060 patent/US20040152684A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bhavnani | Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism | |
| JP4945052B2 (ja) | 女性の性機能障害を治療するための方法および製剤 | |
| US8026228B2 (en) | Estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy | |
| JP3113269B2 (ja) | 骨粗鬆症治療剤 | |
| US8415332B2 (en) | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens | |
| KR20070067235A (ko) | 폐경기 이후 여성의 질 건조증과 성기능 장애의 예방 및치료를 위한 성스테로이드 전구체 단독 또는 선택적인에스트로겐 수용체 조절자 및/또는 에스트로겐 및/또는타입 5 ｃＧＭＰ 포스포디에스테라제 억제제와의 배합물상태의 성스테로이드 전구체 | |
| JP2002541126A (ja) | 低用量エストロゲン断続的ホルモン補充療法 | |
| WO2003017973A1 (en) | A method of treating benign gynaecological disorders and a drug delivery vehicle for use in such a method | |
| RU2003105159A (ru) | Способ лечения климактерических расстройств у женщин во время или после менопаузы | |
| JP2021098702A (ja) | 選択的プロゲステロン受容体モジュレーター（ｓｐｒｍ）レジメン | |
| JP2004520411A5 (enExample) | ||
| AU2005294269B2 (en) | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens | |
| JP2004521951A (ja) | Ｈｒｔのためのドロスピレノン及びエストロゲンスルファメートの組み合わせ | |
| JP2019034969A (ja) | プロゲステロン受容体アンタゴニスト剤形 | |
| PT1365765E (pt) | Utilização de antigestagénios para a inibição da maturação endometrial acelerada, durante o tratamento da infertilidade | |
| UA73956C2 (en) | Method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction due to extrauterine proliferation of endometrial tissue | |
| US10369159B2 (en) | Estrogen receptor β partial agonist having estrogen receptor α inhibitory effect, and gynecological disease therapeutic agent using same | |
| AU2002253488B2 (en) | The use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment | |
| JPH01249724A (ja) | 陣痛誘発および避妊用の医薬製剤 | |
| Yang et al. | The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women | |
| Sorbera et al. | Trimegestone | |
| TW200942242A (en) | New drospirenone/17β-estradiol regimen, pharmaceutical combination product and kit for performing this regimen | |
| JP2014210728A (ja) | 子宮内膜症の予防剤及び／又は治療剤 | |
| AU2011203526A1 (en) | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens |