CN1244329C - 抗促孕素在制备用于抑制雌性哺乳动物中发生子宫内膜加速成熟的药物中的应用 - Google Patents

抗促孕素在制备用于抑制雌性哺乳动物中发生子宫内膜加速成熟的药物中的应用 Download PDF

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Publication number
CN1244329C
CN1244329C CNB028061462A CN02806146A CN1244329C CN 1244329 C CN1244329 C CN 1244329C CN B028061462 A CNB028061462 A CN B028061462A CN 02806146 A CN02806146 A CN 02806146A CN 1244329 C CN1244329 C CN 1244329C
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CN
China
Prior art keywords
alkyl
group
hydrogen
female
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028061462A
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English (en)
Chinese (zh)
Other versions
CN1496263A (zh
Inventor
克里斯塔·黑格勒－哈尔通
霍尔格·赫斯-施通普
亨宁·M·拜尔
克劳迪娅·克鲁舍
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/801,925 external-priority patent/US20020143000A1/en
Application filed by Schering AG filed Critical Schering AG
Publication of CN1496263A publication Critical patent/CN1496263A/zh
Application granted granted Critical
Publication of CN1244329C publication Critical patent/CN1244329C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CNB028061462A 2001-01-09 2002-01-09 抗促孕素在制备用于抑制雌性哺乳动物中发生子宫内膜加速成熟的药物中的应用 Expired - Fee Related CN1244329C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75628601A 2001-01-09 2001-01-09
US09/756,286 2001-01-09
US09/801,925 US20020143000A1 (en) 2001-01-09 2001-03-09 Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
US09/801,925 2001-03-09

Publications (2)

Publication Number Publication Date
CN1496263A CN1496263A (zh) 2004-05-12
CN1244329C true CN1244329C (zh) 2006-03-08

Family

ID=27116200

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028061462A Expired - Fee Related CN1244329C (zh) 2001-01-09 2002-01-09 抗促孕素在制备用于抑制雌性哺乳动物中发生子宫内膜加速成熟的药物中的应用

Country Status (24)

Country Link
US (1) US20040152684A1 (enExample)
EP (1) EP1365765B1 (enExample)
JP (1) JP2004520411A (enExample)
CN (1) CN1244329C (enExample)
AR (1) AR032390A1 (enExample)
AT (1) ATE367817T1 (enExample)
AU (1) AU2002253488B2 (enExample)
BG (1) BG107977A (enExample)
BR (1) BR0206367A (enExample)
CA (1) CA2433776A1 (enExample)
CZ (1) CZ20031864A3 (enExample)
DE (1) DE60221359T2 (enExample)
DK (1) DK1365765T3 (enExample)
EE (1) EE200300321A (enExample)
ES (1) ES2290284T3 (enExample)
HR (1) HRP20030628A2 (enExample)
HU (1) HUP0302632A2 (enExample)
IL (1) IL156729A0 (enExample)
MX (1) MXPA03006156A (enExample)
NO (1) NO20033125L (enExample)
NZ (1) NZ526908A (enExample)
PL (1) PL361689A1 (enExample)
SK (1) SK8612003A3 (enExample)
WO (1) WO2002067910A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) * 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
EP3501533B1 (en) * 2014-12-22 2025-07-09 Ferring B.V. Obe001 for use in the treatment in implantation and pregnancy in women undergoing assisted reproductive technologies
EP3214092A1 (en) 2016-03-04 2017-09-06 Bayer Pharma Aktiengesellschaft Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3533175A1 (de) * 1985-09-13 1987-03-19 Schering Ag Antigestagene zur verschiebung der endometrialen reifung
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
DE19860719A1 (de) * 1998-12-23 2000-06-29 Schering Ag Neue Testosteronderivate und ihre Verwendung zur Langzeittherapie von Androgen-abhängigen Erkrankungen

Also Published As

Publication number Publication date
US20040152684A1 (en) 2004-08-05
ES2290284T3 (es) 2008-02-16
BR0206367A (pt) 2003-12-23
BG107977A (bg) 2004-08-31
IL156729A0 (en) 2004-02-08
NO20033125L (no) 2003-09-09
HK1065953A1 (en) 2005-03-11
WO2002067910A2 (en) 2002-09-06
ATE367817T1 (de) 2007-08-15
CZ20031864A3 (en) 2004-03-17
DK1365765T3 (da) 2007-10-29
DE60221359D1 (de) 2007-09-06
WO2002067910A3 (en) 2003-02-06
NZ526908A (en) 2005-07-29
CA2433776A1 (en) 2002-09-06
EP1365765A2 (en) 2003-12-03
EP1365765B1 (en) 2007-07-25
HUP0302632A2 (hu) 2003-11-28
DE60221359T2 (de) 2008-04-17
CN1496263A (zh) 2004-05-12
NO20033125D0 (no) 2003-07-08
HRP20030628A2 (en) 2005-06-30
SK8612003A3 (en) 2004-03-02
PL361689A1 (en) 2004-10-04
AU2002253488B2 (en) 2007-02-15
EE200300321A (et) 2003-10-15
AR032390A1 (es) 2003-11-05
JP2004520411A (ja) 2004-07-08
MXPA03006156A (es) 2003-09-16

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